المؤلفون: Kaya, Emine¹, Egrilmez, Sait², Palamar, Melis³

المصدر: ACADEMICIA: An International Multidisciplinary Research Journal 10(5):1135-1143. 2020

المؤلفون: Kiyat, Pelin, Selver, Ozlem Barut, Akalin, Taner, Palamar, Melis

المصدر: Arquivos Brasileiros de Oftalmologia. September 2020 83(5)

مصطلحات موضوعية: Neuroma, Multiple endocrine neoplasia type 2b, Conjunctival neoplasms, Diagnosis, differential, Human, Case reports

الوصف: A 42-year-old male presented with a 4-week history of a mass in the right inferior palpebral conjunctiva close to the punctum. An excisional biopsy of the lesion and histopathological examination revealed that the mass was composed of Schwann cells with thin conical nuclei, fine chromatin, and unnoticeable nucleoli. Immunohistochemically, the spindle cells were diffusely and strongly positive for S100 protein. Neurofilament immunostaining was also positive, which highlighted axons. In light of these findings, the tumor was diagnosed as solitary circumscribed neuroma. A comprehensive evaluation for multiple endocrine neoplasia type 2b was performed. However, no multiple endocrine neoplasia type 2b stigmata and no family history were detected. The diagnosis was therefore finalized as solitary circumscribed neuroma, which is considered as a rare condition. The differential diagnosis is based on the histopathological examination and immunohistochemical evaluation. As the tumor can be related with multiple endocrine neoplasia type 2b, it is essential to systematically investigate for multiple endocrine neoplasia type 2b in such cases.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000500427Test

المؤلفون: Kaya, Emine¹, Egrilmez, Sait², Palamar, Melis³

المصدر: ACADEMICIA: An International Multidisciplinary Research Journal 9(2):74-82. 2019

المؤلفون: Değirmenci, Cumali, Korkmaz, İlayda, Akkin, Cezmi, Palamar, Melis, Nalcacı, Serhad, Afrashi, Filiz

الوصف: Purpose: The purpose of the study was to evaluate Ocular Response Analyzer (ORA) measurements and endothelial cell density (ECD) in patients who received intravitreal dexamethasone implant (Ozurdex®) injection for diabetic macular edema. Methods: Twenty-three eyes of 13 patients who receive intravitreal dexamethasone implant injection (Group 1) for diabetic macular edema and 33 eyes of 33 healthy individuals (Group 2) were included in the study. All participants underwent a complete ophthalmologic examination including intraocular pressure measurement with Goldmann applanation tonome- ter (IOP-GAT), ORA measurements, and specular microscopy. Results: The mean age of the patients was 65.43±8.20 (49–75) in Group 1 and 61.94±4.52 (56–71) in Group 2 (p=0.114). The mean IOP-GAT was significantly higher in Group 1 (18.22±3.41; range 12–28 mmHg) than in Group 2 (15.41±3.07; range 8–21 mmHg) (p=0.02). The mean ECD was 2632.4±209.6 (2232–3067) cell/mm 2 in Group 1 and 2567±206.37 (2140–2854) cell/mm2 in Group 2 (p=0.60). The mean corneal resistance factor (CRF) was 12.16±2.35 (7.4–15.3) mmHg in Group 1 and 10.18±1.83 (6.7–14.2) mmHg in Group 2 (p=0.02). Mean corneal hysteresis (CH) in Groups 1 and 2 was 8.87±2.45 (4.1–13.4) mmHg and 10.47±1.43 (6.9–13.2) mmHg, respectively (p=0.001). Mean corneal compensated IOP and Goldman correlated IOP (IOPg) were higher in Group 1 (24.72±7.12; range 12.1–36.4 mmHg and 23.21±7.01; range 14.2–36.2 mmHg) than in Group 2 (14.95±3.6; range 8.3–22.9 mmHg and 14.33±3.84; range 6.3–21.7 mmHg) (p0.001). IOP-GAT was correlated with IOPg (p=0.01). Conclusion: Intravitreal Ozurdex® injection effects IOP, while it has no significant effect on ECD. Ozurdex® injections changed corneal biomechanical properties such as CH and CRF. Thus, ORA may be a useful to avoid underestimating the IOP and missing the alteration of elastic properties of the cornea.

العلاقة: European eye research; Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.14744/eer.2022.86580Test; https://search.trdizin.gov.tr/yayin/detay/1178327Test; https://hdl.handle.net/11454/91185Test; 11

الإتاحة: https://doi.org/10.14744/eer.2022.86580Test
https://hdl.handle.net/11454/91185Test
https://search.trdizin.gov.tr/yayin/detay/1178327Test

المؤلفون: Palamar, Melis, Korkmaz, İlayda, Yaman, Banu, Ceylan, Naim, Kantar, Mehmet, Kamer, Serra

الوصف: Orbital rhabdomyosarcoma is the most common malignant orbital tumor of child-hood originating from mesenchymal cells. The presenting symptom is usually acute onset unilateral proptosis. The rapidly progressive course of the findings may resemble infectious and inflammatory orbital diseases. Radiological imaging and histopathological examinations are crucial for differential diagnosis. The main goal of treatment with a multidisciplinary approach is to control both local and distant spread of the tumor and to prevent further damage. With the introduction of chemotherapy and radiotherapy in the treatment, the overall survival rate has in-creased. Thus, aggressive surgical approach for complete removal of the tumor has been abandoned.

العلاقة: European eye research; Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.14744/eer.2022.02996Test; https://search.trdizin.gov.tr/yayin/detay/1178336Test; https://hdl.handle.net/11454/87433Test; 26; 31; 1178336

الإتاحة: https://doi.org/10.14744/eer.2022.02996Test
https://hdl.handle.net/11454/87433Test
https://search.trdizin.gov.tr/yayin/detay/1178336Test

المؤلفون: Korkmaz, İlayda, Değirmenci, Cumali, Akkin, Cezmi, Palamar, Melis, Nalcacı, Serhad, Afrashi, Filiz

الوصف: Purpose: The purpose of the study was to evaluate Ocular Response Analyzer (ORA) measurements and endothelial cell density (ECD) in patients who received intravitreal dexamethasone implant (Ozurdex®) injection for diabetic macular edema. Methods: Twenty-three eyes of 13 patients who receive intravitreal dexamethasone implant injection (Group 1) for diabetic macular edema and 33 eyes of 33 healthy individuals (Group 2) were included in the study. All participants underwent a complete ophthalmologic examination including intraocular pressure measurement with Goldmann applanation tonome- ter (IOP-GAT), ORA measurements, and specular microscopy. Results: The mean age of the patients was 65.43±8.20 (49–75) in Group 1 and 61.94±4.52 (56–71) in Group 2 (p=0.114). The mean IOP-GAT was significantly higher in Group 1 (18.22±3.41; range 12–28 mmHg) than in Group 2 (15.41±3.07; range 8–21 mmHg) (p=0.02). The mean ECD was 2632.4±209.6 (2232–3067) cell/mm 2 in Group 1 and 2567±206.37 (2140–2854) cell/mm2 in Group 2 (p=0.60). The mean corneal resistance factor (CRF) was 12.16±2.35 (7.4–15.3) mmHg in Group 1 and 10.18±1.83 (6.7–14.2) mmHg in Group 2 (p=0.02). Mean corneal hysteresis (CH) in Groups 1 and 2 was 8.87±2.45 (4.1–13.4) mmHg and 10.47±1.43 (6.9–13.2) mmHg, respectively (p=0.001). Mean corneal compensated IOP and Goldman correlated IOP (IOPg) were higher in Group 1 (24.72±7.12; range 12.1–36.4 mmHg and 23.21±7.01; range 14.2–36.2 mmHg) than in Group 2 (14.95±3.6; range 8.3–22.9 mmHg and 14.33±3.84; range 6.3–21.7 mmHg) (p<0.001). IOP-GAT was correlated with IOPg (p=0.01). Conclusion: Intravitreal Ozurdex® injection effects IOP, while it has no significant effect on ECD. Ozurdex® injections changed corneal biomechanical properties such as CH and CRF. Thus, ORA may be a useful to avoid underestimating the IOP and missing the alteration of elastic properties of the cornea.

العلاقة: European eye research; Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.14744/eer.2022.86580Test; https://search.trdizin.gov.tr/yayin/detay/1178327Test; https://hdl.handle.net/11454/87434Test; 11; 1178327

الإتاحة: https://doi.org/10.14744/eer.2022.86580Test
https://hdl.handle.net/11454/87434Test
https://search.trdizin.gov.tr/yayin/detay/1178327Test

المؤلفون: Korkmaz, İlayda, Uçar, Sema Kalkan, Onay, Hüseyin, Sözmen, Eser Yıldırım, Çoker, Mahmut, Palamar, Melis

المصدر: Turkish Journal of Ophthalmology / Turk Oftalmoloji Dergisi; Jun2024, Vol. 54 Issue 3, p127-132, 6p

مصطلحات موضوعية: ANGIOKERATOMA corporis diffusum, CROSS-sectional method, EYE, CATARACT, EYE care, TERTIARY care, BIOCHEMISTRY, OCULAR manifestations of general diseases, LONGITUDINAL method, EYE examination, HEALTH facilities, GENETICS, SYMPTOMS

مصطلحات جغرافية: TURKEY

مستخلص: Objectives: To report ocular manifestations in patients with Fabry disease (FD) from a tertiary eye care center in Türkiye. Materials and Methods: This prospective, cross-sectional study included 30 eyes of 15 patients with FD. The diagnosis of FD was made based on a combination of clinical findings, genetic analysis, and biochemical evaluation. All participants underwent a detailed ophthalmic examination with special focus on the typical ocular features of FD (cornea verticillata, conjunctival aneurysms, cataract, retinal vessel tortuosity). Results: The mean age was 45±17 years (range: 22-75 years), with a female/male ratio of 2:3. All patients had tortuous conjunctival vessels and 12 patients (80%) had conjunctival aneurysms. Cornea verticillata was present in 10 patients (66.6%), lens opacification in 4 patients (26.6%), and retinal vascular tortuosity in 8 patients (53.3%). All patients had at least two different ocular findings; most (3 heterozygotes/7 hemizygotes) had a combination of corneal verticillata and conjunctival vessel abnormality. The conjunctiva, cornea, and retina were affected together in 5 hemizygous patients (33.3%). One hemizygous patient had all FD-related ocular manifestations in both eyes. Conclusion: To our knowledge, this study is the first to describe the ocular manifestations of FD in the Turkish population. Although cornea verticillata is considered a hallmark of FD, it was absent in approximately one-third of patients. Moreover, cataract, another well-known feature of FD, was present in only 26.6% of the patients. Conjunctival vascular abnormality alone seems to be quite rare in FD, although it often accompanies other ocular manifestations. Therefore, recognition of other mild findings and special consideration of their associations may increase the diagnostic value of ocular findings in FD. [ABSTRACT FROM AUTHOR]

: Copyright of Turkish Journal of Ophthalmology / Turk Oftalmoloji Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Devebacak, Ali, Degirmenci, Cumali, Palamar, Melis

المصدر: Beyoglu Eye J ; ISSN:2587-0394 ; Volume:9 ; Issue:2

العلاقة: https://doi.org/10.14744/bej.2024.30643Test; https://pubmed.ncbi.nlm.nih.gov/38854897Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156470Test/

الإتاحة: https://doi.org/10.14744/bej.2024.30643Test
https://pubmed.ncbi.nlm.nih.gov/38854897Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11156470Test/

المؤلفون: Akgun, Zeynep, Palamar, Melis, Egrilmez, Sait, Yagci, Ayse, Barut Selver, Ozlem

المصدر: Eye & Contact Lens: Science & Clinical Practice ; volume 50, issue 4, page 159-162 ; ISSN 1542-2321

الوصف: Objectives: To examine and to understand the limbal stem-cell deficiency (LSCD) because of Steven–Johnson syndrome (SJS) in line with the new classification system for the first time in the literature. Methods: Medical records of patients with LSCD because of SJS were reviewed retrospectively. In addition to demographic data and ophthalmologic or systemic findings, anterior segment photographs of the patients were reviewed retrospectively. Limbal stem-cell deficiency severity was graded according to the classification published by the Limbal Stem Cell Working Group. Results: Twenty-four eyes of 14 patients with eye involvement secondary to SJS were included in the study. The mean age of the patients was 36.09±16.70 (9–58) years and the female-to-male ratio was 11:3. The anterior segment photographs of the patients were evaluated by two independent masked observers. Limbal stem-cell deficiency severity was graded according to the classification published by Deng et al. Corneal opacity was divided into three stages according to the area of involvement. Corneal opacity was classified as Stage I if the central 5 mm region of the cornea was not affected, as Stage II if the central 5 mm region of the cornea was affected, and as Stage III if the entire corneal surface was affected. Limbal involvement was classified as Stage A if it was below 50%, as Stage B if it was between 50% and 100%, and as Stage C if it was 100%. Conclusion: This is the first study in the literature to describe and classify LSCD because of SJS, according to the new LSCD classification. Consistent with the results, LSCD follows a bimodal distribution. Most patients demonstrated severe (Stage III—32.14%) or mild (Stage IA—21.42%) LSCD.

الإتاحة: https://doi.org/10.1097/icl.0000000000001073Test

المؤلفون: Tas, Muhammed Dara, Barut Selver, Ozlem, Palamar, Melis

المصدر: Contact Lens and Anterior Eye ; page 102161 ; ISSN 1367-0484

مصطلحات موضوعية: Optometry, Ophthalmology, General Medicine

الإتاحة: https://doi.org/10.1016/j.clae.2024.102161Test
https://api.elsevier.com/content/article/PII:S1367048424000535?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1367048424000535?httpAccept=text/plainTest