المؤلفون: Peeters S. A., Engelen L., Buijs J., Chaturvedi N., Fuller J. H., Schalkwijk C. G., Stehouwer C. D., Karamanos B., Kofinis A., Petrou K., Giorgino F., Picca G., Angarano A., de Pergola. G., Laviola L., Giorgino R., Ionescu-Tirgoviste C., Coszma A., Guja C., Songini M., Casu A., Pedron M., Pintus S., Fossarello M., Ferriss J. B., Grealy G., O'Keefe D., Toeller M., Arden C., Rottiers R., Tuyttens C., Priem H., Ebeling P., Kylliainen M., Koivisto V. A., Idzior-Walus B., Sieradzki J., Cyganek K., Solnica B., Lemkes H. H. P. J., Lemkes-Stuffken J. C., Nunes-Correa J., Rogado M. C., Gardete-Correia L., Cardoso M. C., Silva A., Boavida J., Machado Sa Marques M., Michel G., Wirion R., Cardillo S., Pozza G., Mangili R., Asnaghi V., Standl E., Schaffler B., Brand H., Harms A., Ben Soussan M., Verier-Mine O., Fallas P., Fallas M. C., Holloway J., Asbury L., Betteridge D. J., Cathelineau G., Bouallouche A., Villatte Cathelineau B., Santeusanio F., Rosi G., D'Alessandro V., Cagini C., Bottini P., Reboldi G. P., Navalesi R., Penno G., Bandinelli S., Miccoli R., Nannipieri M., Ghirlanda G., Saponara C., Cotroneo P., Manto A., Minnella A., Ward J. D., Tesfaye S., Eaton S., Mody C., Borra M., Cavallo Perin P., Giunti S., Grassi G., Pagano G. F., Porta M., Sivieri R., Vitelli F., Veglio M., Papazoglou N., Manes G., Muggeo M., Iagulli M., Cacciatori V., Cattedra di Malattie del Metabolismo V., Irsigler K., Abrahamian H., Walford S., Sinclair J., Hughes S., McLelland V., Ward J., Roglic G., Metelko Z., Pepeonik Z. R.

المساهمون: Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., Stehouwer, C. D., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, F., Picca, G., Angarano, A., Pergola. G., De, Laviola, L., Giorgino, R., Ionescu-Tirgoviste, C., Coszma, A., Guja, C., Songini, M., Casu, A., Pedron, M., Pintus, S., Fossarello, M., Ferriss, J. B., Grealy, G., O'Keefe, D., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Koivisto, V. A., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Solnica, B., Lemkes, H. H. P. J., Lemkes-Stuffken, J. C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Silva, A., Boavida, J., Machado Sa Marques, M., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, M., Verier-Mine, O., Fallas, P., Fallas, M. C., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D'Alessandro, V., Cagini, C., Bottini, P., Reboldi, G. P., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Nannipieri, M., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Borra, M., Cavallo Perin, P., Giunti, S., Grassi, G., Pagano, G. F., Porta, M., Sivieri, R., Vitelli, F., Veglio, M., Papazoglou, N., Manes, G.

مصطلحات موضوعية: Albuminuria, Cardiovascular disease, Matrix metalloproteinase, Retinopathy, Tissue inhibitor of metalloproteinase, Type 1 diabete, Adult, Biomarker, Cohort Studie, Cross-Sectional Studie, Diabetes Complication, Diabetes Mellitus, Type 1, Europe, Female, Human, Male, Matrix Metalloproteinase 10, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Middle Aged, Prospective Studie, Tissue Inhibitor of Metalloproteinase-1, Vascular Diseases

الوصف: Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, -2, -3, -9, -10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results: Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [β = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions: These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25848912; info:eu-repo/semantics/altIdentifier/wos/WOS:000350726000001; volume:14; issue:1; firstpage:31; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11586/353539Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925234995

الإتاحة: https://doi.org/10.1186/s12933-015-0195-2Test
http://hdl.handle.net/11586/353539Test

المؤلفون: Bo, S, Gambino, R, Pagani, A, Guidi, S, Gentile, L, Cassader, M, Pagano, G F

مصطلحات موضوعية: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous)

الوصف: n/a

العلاقة: url:https://www.openaccessrepository.it/communities/itmirrorTest; https://www.openaccessrepository.it/record/197520Test

الإتاحة: https://doi.org/10.1038/sj.ijo.0803037Test
https://www.openaccessrepository.it/record/197520Test

المؤلفون: VEGLIO, M., BRUNO, G., BORRA, M., MACCHIA, G., BARGERO, G., D'ERRICO, N., PAGANO, G. F., CAVALLO‐PERIN, P.

المصدر: Journal of Internal Medicine ; volume 251, issue 4, page 317-324 ; ISSN 0954-6820 1365-2796

الوصف: Veglio M, Bruno G, Borra M, Macchia G, Bargero G, D'Errico N, Pagano GF, Cavallo‐Perin P (Evangelico Valdese Hospital, Torino; University of Torino, Torino; and S. Spirito Hospital, Casale Monferrato; Italy). Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population‐based cohort. J Intern Med 2002; 251: 317–324. Objective. To evaluate the prevalence of prolonged QT interval and dispersion in a population‐based cohort of type 2 diabetic patients and their relationship with clinical and metabolic variables. Design. Cross‐sectional population‐based cohort. Setting. Diabetes clinics and general practitioners in Casale Monferrato (Northern Italy). Subjects. A total of 1357 patients with known type 2 diabetes (70% of the cohort). Main outcome measures. Albumin excretion rate and coronary heart disease (CHD); a standard supine 12‐lead electrocardiogram (ECG) was recorded and coded according to the Minnesota code criteria. QT interval corrected for heart rate (QTc) > 0.44 s and QTc dispersion > 0.080 s were considered abnormally prolonged. Results. Prevalence of increased QTc duration and QTc dispersion were 25.8% (95% CI 23.5–28.3) and 33.1% (95% CI 30.6–35.7), with no sex differences. No metabolic differences were found, apart from fibrinogen and creatinine levels, which were higher in patients with increased QTc dispersion. Patients with CHD had higher mean adjusted values of QTc and QTc dispersion, whereas no association was found with albumin excretion rate (AER) and diabetes treatment. QTc duration and QTc dispersion were significantly correlated (0.17, P < 0.001). In multiple regression analysis, only CHD was independently associated with QTc, after adjustment for age and sex (β=0.010, P < 0.001, R 2 =2.5%); as regards QTc dispersion, a similar association with CHD was found (β=0.20, P < 0.001, R 2 =4.8%). Conclusions. This population‐based study shows a considerably high prevalence of increased ...

الإتاحة: https://doi.org/10.1046/j.1365-2796.2002.00955.xTest

المؤلفون: ROSATO, Rosalba, BO, Simona, MERLETTI, Franco, GREGORI D, GRASSI G, CICCONE G, BIGGERI A, PAGANO G. F.

المساهمون: GIORGIO VITTADINI, ROSATO R, GREGORI D, BO S, GRASSI G, CICCONE G, BIGGERI A, MERLETTI F, PAGANO G.F

العلاقة: ispartofbook:Controllo e gestione dei sistemi sanitari; firstpage:-; lastpage:-; http://hdl.handle.net/2318/14069Test

الإتاحة: http://hdl.handle.net/2318/14069Test

المؤلفون: Rosato, Rosalba, Ciccone, G., Bo, S., Pagano, G. F., Merletti, F., Gregori, D.

المصدر: Journal of Evaluation in Clinical Practice ; volume 13, issue 3, page 422-428 ; ISSN 1356-1294 1365-2753

الوصف: Rationale, aims and objectives Type 2 diabetes represents a condition significantly associated with increased cardiovascular mortality. The aims of the study are: (i) to estimate the cumulative incidence function for cause‐specific mortality using Cox and Aalen model; (ii) to describe how the prediction of cardiovascular or other causes mortality changes for patients with different pattern of covariates; (iii) to show if different statistical methods may give different results. Methods Cox and Aalen additive regression model through the Markov chain approach, are used to estimate the cause‐specific hazard for cardiovascular or other causes mortality in a cohort of 2865 type 2 diabetic patients without insulin treatment. The models are compared in the estimation of the risk of death for patients of different severity. Results For younger patients with a better covariates profile, the Cumulative Incidence Function estimated by Cox and Aalen model was almost the same; for patients with the worst covariates profile, models gave different results: at the end of follow‐up cardiovascular mortality rate estimated by Cox and Aalen model was 0.26 [95% confidence interval (CI) = 0.21–0.31] and 0.14 (95% CI = 0.09–0.18). Conclusions Standard Cox and Aalen model capture the risk process for patients equally well with average profiles of co‐morbidities. The Aalen model, in addition, is shown to be better at identifying cause‐specific risk of death for patients with more severe clinical profiles. This result is relevant in the development of analytic tools for research and resource management within diabetes care.

الإتاحة: https://doi.org/10.1111/j.1365-2753.2006.00732.xTest

المؤلفون: Bo, S., Ciccone, G., Rosato, R., Gancia, R., Grassi, G., Merletti, F., Pagano, G. F.

المصدر: Diabetic Medicine ; volume 22, issue 3, page 258-265 ; ISSN 0742-3071 1464-5491

الوصف: Aims (i) To compare mortality rates in a cohort of Type 2 diabetic patients with those of the general population; (ii) to assess the prognostic role of pre‐existing chronic conditions; (iii) to evaluate the impact of different severity of renal damage on mortality. Methods All 3892 patients with Type 2 diabetes attending our Diabetic Clinic during 1995 and alive on 1 January 1996 were identified and followed for 4.5 years. Information on vital status (100% complete) and causes of death (98.5% complete) for 599 deceased subjects was derived from death certificates. Results In comparison with the general population, standardized mortality ratios (× 100) were: 125 (95% confidence interval 104–148) in patients aged < 75 and 85 (75–95) in patients ≥ 75 years. Cardiovascular diseases and diabetes were responsible for most of the excess deaths. In a Cox‐proportional hazard model, renal damage was a powerful predictor of death (hazard ratio = 2.39; 95% confidence intervals = 2.00–2.85). The severity of renal damage was associated with increasing hazard ratios for death from all‐cause mortality and from specific causes (especially coronary artery disease, other cardiovascular causes and diabetes) after multiple adjustments. Other significant predictors of death were: greater age, glycated haemoglobin, smoking, lower body mass index, pre‐existing coronary and peripheral artery disease and known co‐morbidity (cirrhosis and cancer). Conclusions Renal damage of any severity is significantly associated with subsequent mortality from all causes and from cardiovascular diseases. These associations are not confounded by pre‐existing co‐morbidity or coronary diseases.

الإتاحة: https://doi.org/10.1111/j.1464-5491.2004.01394.xTest

المؤلفون: Bo, S., Gambino, R., Uberti, B., Mangiameli, M. P., Colosso, G., Repetti, E., Gentile, L., Cassader, M., Pagano, G. F.

المصدر: European Journal of Clinical Investigation ; volume 35, issue 4, page 265-270 ; ISSN 0014-2972 1365-2362

الوصف: Background Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects. Design Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia. Results In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L −1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L −1 , and 0·8 vs. 0·2 µU mL −1 × mmol L −1 ). In a multiple regression model, insulin and insulin resistance remained significantly and independently related to hs‐CRP levels, after adjustments for age, sex, BMI, waist, alcohol consumption, level of physical activity and smoking habits. Very few individuals within lower fasting insulin quartiles showed hs‐CRP values ≥ 3 mg L −1 when compared with approximately 60% of those within the highest quartile. Conclusions The novel finding is that a state of low‐grade systemic inflammation is present in normal BMI subjects who show subclinical insulin resistance but no other metabolic abnormalities.

الإتاحة: https://doi.org/10.1111/j.1365-2362.2005.01490.xTest

المؤلفون: Bo, S., Gambino, R., Guidi, S., Silli, B., Gentile, L., Cassader, M., Pagano, G. F.

المصدر: Diabetic Medicine ; volume 22, issue 9, page 1185-1189 ; ISSN 0742-3071 1464-5491

الوصف: Aims Studies on plasma nitrotyrosine (NT) levels, a measure of oxidative injury, in diabetes are limited and discordant; the amount of antioxidants might represent a possible explanation for the discordant results. The aim of this paper is to evaluate the association between plasma NT levels and glucose tolerance status, according to antioxidant vitamin intakes. Methods In three hundred men randomly selected from a population‐based cohort, NT levels were measured and dietary intake assessed by a food‐frequency questionnaire. Results NT values were similar in patients with diabetes ( n = 34), impaired fasting glucose ( n = 77) and normoglycaemic subjects ( n = 189). However, in subjects with lower than recommended daily intakes of antioxidant vitamins C and A, NT levels were significantly higher in the diabetic patients. In a multiple regression model, after adjustments for age, body mass index (BMI) and smoking habits, NT levels were significantly associated with fasting glucose in patients with lower intakes of vitamin C (β = 11.4; 95% CI 1.3 21.5) and vitamin A (β = 14.9; 95% CI 3.9 25.9), but not in subjects with lower intake of vitamin E. Conclusion A significant positive correlation between NT levels and fasting glucose is evident only in the presence of a reduced intake of some antioxidant vitamins. These findings might explain, at least in part, the discrepant results of previous studies and, if confirmed by further studies, suggest a simple measure (a balanced diet) to alleviate the increased oxidative stress of diabetes.

الإتاحة: https://doi.org/10.1111/j.1464-5491.2005.01588.xTest

المؤلفون: Bo, S., Signorile, A., Menato, G., Gambino, R., Bardelli, C., Gallo, M. L., Cassader, M., Massobrio, M., Pagano, G. F.

المصدر: Journal of Endocrinological Investigation ; volume 28, issue 11, page 779-786 ; ISSN 0391-4097 1720-8386

مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1007/bf03347566Test

المؤلفون: Medina B., M. L., Pagano G., F

المصدر: Revista de la Facultad de Agronomía, Volume: 20, Issue: 1, Pages: 72-86, Published: JAN 2003

مصطلحات موضوعية: pulpa, caracterización, and microbiological, química, Psidium guajava, física, chemical, guava pulp, characterization, microbiológica, guayaba, physical

الوصف: Se analizaron muestras de la pulpa del fruto intacto de guayaba tipo "criolla roja", obtenida en la planta piloto del Instituto de Ciencia y Tecnología de Alimentos, Universidad Central de Venezuela, para evaluar las características químicas, físicas y microbiológicas, de interés en el procesamiento industrial de esta pulpa. Las variables estudiadas y los resultados obtenidos fueron: firmeza 1,87 kg/cm²; consistencia 1,00 ± 0,01 cm/30 seg; viscosidad aparente 74.000,oo y 45.333,oo cp; humedad: 84,3 ± 0,1%; sólidos totales 15,7 ± 0,1%; sólidos solubles 13,82º Brix (20ºC); pH: 4,1; acidez total tiltulable: 2,48 ± 0,07%; DpH / DV: 1,8%; cenizas totales 0,75 ± 0,01%; azúcares: totales 11,00 ± 0,3%; reductores 5,72 ± 0,3% y sacarosa 5,28%. Aerobios mesófilos 1,73 x 10(4) ufc / ml; NMP coliformes totales < 1100 / 100 ml; NMP coliformes fecales 3,00 / 100 ml; hongos y levaduras < 100 ufc / ml. La pulpa se caracterizó como jugosa, ácida, con una curva de neutralización propia de los sistemas amortiguadores de pH, su comportamiento es el de un fluido no _ Newtoniano pseudoplástico y de óptima calidad microbiológica. El rendimiento de la pulpa fue de 79,8%. Chemical, physical and microbiological characteristics of interest to guava pulp processing were evaluated. The pulp from the "criolla roja" type was obtained in pilot plants at the Institute of Food Science and Technology at the Central University of Venezuela. Results for evaluated parameters were: firmness 1,87 kg / cm²; consistency 1,00 ± 0,01 cm/ 30 sec; apparent viscosity 74.000,oo and 45.333,oo cp; total solids 15,7 ± 0,1%; moisture 84,3 ± 0,1%; soluble solids 13,82º Brix (20ºC), pH: 4,1; total titratable acidity 2,48 ± 0,07%; D pH / DV: 1,8%; total ash 0,75 ± 0,01%; total sugars 11,00 ± 0,3%; reducing sugars 5,72 ± 0,3% and sucrose 5,28%; plate count 1,73 x 10(4) cfu / ml, NMP total coliforms < 1100 / 100 ml; NMP fecal coliforms 3,00 / 100 ml; molds and yeast < 100 cfu / ml. Pulp yield was 79,8% of selected raw material. The pulp was juicy, acidic and behaved as non _ Newtonian pseudoplastic material. The neutralization graph of the "criolla roja" guava pulp is characteristics of buffer systems. The pulp was of optimal microbiological quality.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______621::941296506c44c6f83338c75982319ea3Test
http://www.scielo.org.ve/scielo.php?script=sci_arttext&pid=S0378-78182003000100008&lng=en&tlng=enTest