المؤلفون: Guddeti, Rohith Kumar, Pacharla, Himavani, Yellapu, Nanda Kumar, Karyala, Prashanthi, Pakala, Suresh B.

المصدر: Medical Oncology ; volume 40, issue 3 ; ISSN 1559-131X

مصطلحات موضوعية: Cancer Research, Oncology, Hematology, General Medicine

الإتاحة: https://doi.org/10.1007/s12032-023-01974-2Test

المؤلفون: Gonsalves, Rhea Conchita, Pacharla, Himavani, Manohar, Sai, Belliraj, Siva Kumar, Tripathi, Ekta, Karyala, Prashanthi, Pakala, Suresh B.

المصدر: Pandemic Outbreaks in the 21st Century ; page 185-210

الإتاحة: https://doi.org/10.1016/b978-0-323-85662-1.00006-9Test
https://api.elsevier.com/content/article/PII:B9780323856621000069?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:B9780323856621000069?httpAccept=text/plainTest

المؤلفون: Anjana, Bosetty, Ankireddy, Seshadri Reddy, Banavath, Hemanth Naick, Belagal, Praveen, Belliraj, Siva Kumar, Bonilla-Aldana, D. Katterine, Chellasamy, Gayathri, Dakshinamurthy, Soumya, Dasari, Subramanyam, Devanathan, Vasudharani, Dhingra, Niyati, Gonsalves, Rhea Conchita, Gopal, Divi Venkata Ramana Sai, Govindaraju, Saravanan, Gurushankara, Hunasanahally Puttaswamygowda, Hense, Sibasis, Karyala, Prashanthi, Kim, Jongsung, Kiriyanthan, Rose Mary, Kishore, Kamal, Konakalla, Naga Charan, Kusuma, Kandati, Mallikarjunaiah, Shanthala, Manohar, Sai, Masarapu, Hema, Metikurki, Basavaraja, Mukherjee, Pratik, Nimgampalle, Mallikarjuna, Pacharla, Himavani, Pakala, Suresh B., Paul, Pandeeti Emmanuel Vijay, Radha, A., Rathod, Kajal, Rodriguez-Morales, Alfonso J., Sangubotla, Roopkumar, Saxena, Ambrish, Singh, Manpreet, Singh, Neha, Srinivas, Kalanghad P., Thippeswamy, Nayaka Boramuthi, Tripathi, Ekta, Viswanath, Buddolla, Yun, Kyusik

المصدر: Pandemic Outbreaks in the 21st Century ; page xxi-xxii

الإتاحة: https://doi.org/10.1016/b978-0-323-85662-1.00027-6Test
https://api.elsevier.com/content/article/PII:B9780323856621000276?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:B9780323856621000276?httpAccept=text/plainTest

المؤلفون: Padmavathy, Karthika P., Vuttaradhi, Veena Kumari, Venu, Akkanapally, D’Cruze, Lawrence, Saravanan, Roshni, Pitani, Ravishankar, Ganesh, Krishnamurthy, Pacharla, Himavani, Rayala, Suresh Kumar, Prathiba, D., Venkatraman, Ganesh

المصدر: Journal of Molecular Neuroscience ; volume 71, issue 4, page 724-733 ; ISSN 0895-8696 1559-1166

مصطلحات موضوعية: Cellular and Molecular Neuroscience, General Medicine

الإتاحة: https://doi.org/10.1007/s12031-020-01690-wTest

المؤلفون: Padmavathy, Karthika P., Vuttaradhi, Veena Kumari, Venu, Akkanapally, D'Cruze, Lawrence, Saravanan, Roshni, Pitani, Ravishankar, Ganesh, Krishnamurthy, Pacharla, Himavani, Rayala, Suresh Kumar, Prathiba, D., Venkatraman, Ganesh

المصدر: Journal of Molecular Neuroscience; Apr2021, Vol. 71 Issue 4, p724-733, 10p

مستخلص: Malignant astrocytomas presenting in humans of any age group are a challenge to diagnose and treat. Hence, there is a quest for new markers to ascertain their grades and predict disease outcomes. Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a nuclear receptor co-regulator, is an oncogene found in various cancers. We postulate that by screening for PELP1, its correlation with survival outcomes of patients across various grades can indicate a plausible novel diagnostic marker and a potential therapeutic target in gliomas. Immunostaining of 100 cases of astrocytomas for PELP1 was performed on paraffin-embedded sections. Results showed that PELP1 expression increases with higher grades; the mean H-score of PELP1 in grade-I astrocytomas was determined to be 112.3, whereas in grade-IV it was 235.1 (P value = 0.0001). Survival analysis of patients with H-score of 200–300 was only 8.8% and 68.8% in patients with scores of 0–100. PELP1 expression in high-grade astrocytomas is an important factor in determining the outcomes. [ABSTRACT FROM AUTHOR]

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