-
1دورية أكاديمية
المؤلفون: Vitale, Martina, Orsi, Emanuela, Solini, Anna, Garofolo, Monia, Resi, Veronica, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Penno, Giuseppe, Pugliese, Giuseppe
المساهمون: Fondazione Diabete Ricerca, Diabetes, Endocrinology and Metabolism Foundation, Eli Lilly and Company, Sigma-tau, Boehringer Ingelheim, Chiesi Farmaceutici, Takeda Pharmaceutical Company
المصدر: Cardiovascular Diabetology ; volume 23, issue 1 ; ISSN 1475-2840
مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism
الوصف: Background Foot ulcers and/or infections are common long-term complications of diabetes and are associated with increased mortality, especially from cardiovascular disease, though only a few studies have investigated the independent contribution of these events to risk of death. This study aimed at assessing the association of history of diabetic foot with all-cause mortality in individuals with type 2 diabetes, independent of cardiovascular risk factors, other complications, and comorbidities. Methods This prospective cohort study enrolled 15,773 Caucasian patients in 19 Italian centers in the years 2006–2008. Prior lower extremity, coronary, and cerebrovascular events and major comorbidities were ascertained by medical records, diabetic retinopathy by fundoscopy, diabetic kidney disease by albuminuria and estimated glomerular filtration rate, cardiovascular risk factors by standard methods. All-cause mortality was retrieved for 15,656 patients on 31 October 2015. Results At baseline, 892 patients (5.7%) had a history of diabetic foot, including ulcer/gangrene and/or amputation (n = 565; 3.58%), with (n = 126; 0.80%) or without (n = 439; 2.78%) lower limb revascularization, and revascularization alone (n = 330; 2.09%). History of diabetic foot was associated with all-cause death over a 7.42-year follow-up (adjusted hazard ratio, 1.502 [95% confidence interval, 1.346–1.676], p < 0.0001), independent of confounders, among which age, male sex, smoking, hemoglobin A 1c , current treatments, other complications, comorbidities and, inversely, physical activity level and total and HDL cholesterol were correlated independently with mortality. Both ulcer/gangrene and amputation alone were independently associated with death, with a higher strength of association for amputation than for ulcer/gangrene (1.874 [1.144–3.070], p = 0.013 vs. 1.567 [1.353–1.814], p < 0.0001). Both ulcer/gangrene/amputation and lower limb revascularization alone were independently associated with death; mortality risk was much ...
-
2دورية أكاديمية
المؤلفون: Solini, Anna, Orsi, Emanuela, Vitale, Martina, Garofolo, Monia, Resi, Veronica, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Nicolucci, Antonio, Penno, Giuseppe, Pugliese, Giuseppe
المساهمون: Solini, Anna, Orsi, Emanuela, Vitale, Martina, Garofolo, Monia, Resi, Veronica, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Nicolucci, Antonio, Penno, Giuseppe, Pugliese, Giuseppe
مصطلحات موضوعية: arterial stiffne, estimated pulse wave velocity, all-cause mortality
الوصف: Background Estimated pulse-wave velocity (ePWV), a surrogate measure of arterial stiffness, was shown to independently predict morbidity and mortality from cardiovascular disease and other causes in both the general population and high-risk individuals. However, in people with type 2 diabetes, it is unknown whether ePWV adds prognostic information beyond the parameters used for calculating it.Aims To assess the independent association of ePWV with all-cause mortality in individuals with type 2 diabetes.Design Prospective cohort study that enrolled 15 773 patients in 19 Italian centres in 2006-08.Methods ePWV was calculated from a regression equation using age and mean blood pressure (BP). All-cause mortality was retrieved for 15 656 patients in 2015.Results Percentage and rate of deaths, Kaplan-Meier estimates and unadjusted hazard ratios increased from Quartile I to Quartile IV of ePWV. After adjustment for age, sex, BP levels and anti-hypertensive treatment, the strength of association decreased but mortality risk remained significantly higher for Quartiles II (+34%), III (+82%) and IV (+181%) vs. Quartile I and was virtually unchanged when further adjusting for other cardiovascular risk factors and complications/comorbidities. Each m center dot s- 1 increase in ePWV was associated with an increased adjusted risk of death in the whole cohort (+53%) and in participants with (+52%) and without (+65%) cardiorenal complications. Moreover, ePWV significantly improved prediction of mortality risk over cardiovascular risk factors and complications/comorbidities, though the net increase was modest.Conclusions These findings suggest that ePWV may represent a simple and inexpensive tool for providing prognostic information beyond traditional cardiovascular risk factors.Trial registration ClinicalTrials.gov, NCT00715481, https://clinicaltrials.gov/ct2/show/NCT00715481Test.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38200621; info:eu-repo/semantics/altIdentifier/wos/WOS:001150424200001; journal:QJM-AN INTERNATIONAL JOURNAL OF MEDICINE; https://hdl.handle.net/11573/1706206Test
-
3دورية أكاديمية
المؤلفون: Orsi, Emanuela, Solini, Anna, Penno, Giuseppe, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Lamacchia, Olga, Haxhi, Jonida, Nicolucci, Antonio, Pugliese, Giuseppe
المساهمون: Orsi, Emanuela, Solini, Anna, Penno, Giuseppe, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Lamacchia, Olga, Haxhi, Jonida, Nicolucci, Antonio, Pugliese, Giuseppe
مصطلحات موضوعية: all-cause-mortality, body mass index, central adiposity, physical activity, type 2 diabetes
الوصف: Background: An "obesity paradox" for mortality has been shown in chronic disorders such as diabetes, and attributed to methodological bias, including the use of body mass index (BMI) for obesity definition. This analysis investigated the independent association of BMI versus surrogate measures of central adiposity with all-cause mortality in individuals with type 2 diabetes. Methods: The Renal Insufficiency And Cardiovascular Events Italian Multicentre Study is a prospective cohort study that enrolled 15,773 patients in 19 Italian centres in 2006-2008. Exposures were BMI and the surrogate measures of central adiposity waist circumference (WC), waist-to-height ratio (WHtR), and A Body Shape Index (ABSI). Vital status was retrieved on 31 October 2015 for 15,656 patients (99.3%), RESULTS: Age- and sex-adjusted hazard ratios and 95% confidence intervals were significantly higher in BMI-based underweight (1.729 [1.193-2.505), P = 0.004), moderately obese (1.214 [1.058-1.392), P = 0.006) and severely obese (1.703 [1.402-2.068), P < 0.0001), lower in overweight (0.842 [0.775-0.915), P < 0.0001) and similar in mildly obese (0.950 [0.864-1.045), P = 0.292), compared to normal-weight individuals. When further adjusting for smoking, physical activity (PA), and comorbidities, risk was lower also in mildly obese versus normal-weight patients. The BMI-mortality relationship did not change after sequentially excluding ever smokers, individuals with comorbidities, and those died within two years from enrollment and when analyzing separately participants below and above the median age. Conversely, a paradox relationship was observed among inactive/moderately inactive, but not moderately/highly active patients. Mortality risk adjusted for age, gender, smoking, PA and comorbidities was significantly higher in the highest tertile of WC (1.279 [1.089-1.501], P = 0.003), WHtR (1.372 [1.165-1.615], P < 0.0001), and ABSI (1.263 [1.067-1.495], P = 0.007) versus the lowest tertile. However, risk was lower in the intermediate ...
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36461034; info:eu-repo/semantics/altIdentifier/wos/WOS:000910925100001; volume:21; issue:1; firstpage:1; lastpage:12; numberofpages:12; journal:CARDIOVASCULAR DIABETOLOGY; https://hdl.handle.net/11573/1664741Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85143330839
-
4دورية أكاديمية
المؤلفون: Dardano, Angela, Lucchesi, Daniela, Garofolo, Monia, Gualdani, Elisa, Falcetta, Pierpaolo, Sancho Bornez, Veronica, Francesconi, Paolo, Del Prato, Stefano, Penno, Giuseppe
المساهمون: Dardano, Angela, Lucchesi, Daniela, Garofolo, Monia, Gualdani, Elisa, Falcetta, Pierpaolo, Sancho Bornez, Veronica, Francesconi, Paolo, Del Prato, Stefano, Penno, Giuseppe
مصطلحات موضوعية: SIRT1 gene, all-cause mortality, cardiovascular outcome, observational study, type 2 diabetes
الوصف: Aims SIRT1 exerts effects on ageing and lifespan, as well cardiovascular (CV) disease risk. SIRT1 gene is very polymorph with a few tagging single nucleotide polymorphisms (SNPs) so far identified. Some SNPs, including rs7896005, were associated with type 2 diabetes (T2DM). We aimed to ascertain whether this SNP may be associated with CV disease at baseline as well with these same outcomes and all-cause mortality over a 13-year follow-up. Materials and Methods Genotypes of SIRT1 gene were determined using TaqMan SNP assay. Results Out of 905 T2DM, 9.1% had the AA genotype, 43.2% the AG, and 47.7% the GG. Hardy-Weinberg Equilibrium was met (minor allele frequency 0.306; p = 0.8899). At baseline, there was no difference across genotypes for sex, age, diabetes duration, CV risk factors, treatments, and microangiopathy. Major CV outcomes, myocardial infarction (MI), any coronary heart disease (CHD), and peripheral artery disease (PAD) were more frequent in GG than in AA/AG (p from 0.013 to 0.027), with no association with cerebrovascular events. By fully adjusted regression, GG remained independently related to major CV outcomes, MI, CHD, and PAD. Over follow-up, we recorded 258 major CV events (28.5%; AA/AG 25.2%, GG 32.2%; p = 0.014) with an adjusted hazard ratio (HR) of GG versus AA/AG of 1.296 (95% CI 1.007-1.668, p = 0.044); 169 coronary events (18.7%; AA/AG 15.4%, GG 22.2%; p = 0.006) with HR 1.522 (1.113-2.080, p = 0.008); 79 (8.7%) hospitalisation for heart failure (AA/AG 7.0%, GG 10.6%; p = 0.045) and HR 1.457 (0.919-2.309, p = 0.109); 36 PAD (4.0%; AA/AG 2.3%, GG 5.8%; p = 0.007) with HR 2.225 (1.057-4.684, p = 0.035). No association was found with cerebrovascular events, end stage renal disease, and all-cause mortality. Conclusions The rs7896005 SNP of SIRT1 might play a role in cardiovascular disease, mainly CHD risk in T2DM. Results call for larger association studies as well as studies to ascertain mechanisms by which this variant confers increased risk.
وصف الملف: STAMPA
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35092334; info:eu-repo/semantics/altIdentifier/wos/WOS:000751855600001; volume:38; issue:4; numberofpages:14; journal:DIABETES/METABOLISM RESEARCH AND REVIEWS; https://hdl.handle.net/11568/1165051Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85124544071
-
5دورية أكاديمية
المؤلفون: Garofolo, Monia, Lucchesi, Daniela, Giambalvo, Massimo, Aragona, Michele, Bertolotto, Alessandra, Campi, Fabrizio, Bianchi, Cristina, Francesconi, Paolo, Marchetti, Piero, Del Prato, Stefano, Penno, Giuseppe
المصدر: Cardiovascular Diabetology; 2/28/2024, Vol. 23 Issue 1, p1-11, 11p, 3 Charts, 2 Graphs
مستخلص: Background Non-alcoholic fatty liver disease (NAFLD), identifed by the Fatty Liver Index (FLI), is associated with increased mortality and cardiovascular (CV) outcomes. Whether this also applies to type 1 diabetes (T1D) has not been yet reported. Methods We prospectively observed 774 subjects with type 1 diabetes (males 52%, 30.3±11.1 years old, diabetes duration (DD) 18.5±11.6 years, HbA1c 7.8±1.2%) to assess the associations between FLI (based on BMI, waist circumference, gamma-glutamyl transferase and triglycerides) and all-cause death and frst CV events. Results Over a median 11-year follow-up, 57 subjects died (7.4%) and 49 CV events (6.7%) occurred among 736 individuals with retrievable incidence data. At baseline, FLI was<30 in 515 subjects (66.5%), 30–59 in 169 (21.8%), and≥60 in 90 (11.6%). Mortality increased steeply with FLI: 3.9, 10.1, 22.2% (p<0.0001). In unadjusted Cox analysis, compared to FLI<30, risk of death increased in FLI 30–59 (HR 2.85, 95% CI 1.49–5.45, p=0.002) and FLI≥60 (6.07, 3.27–11.29, p<0.0001). Adjusting for Steno Type 1 Risk Engine (ST1-RE; based on age, sex, DD, systolic BP, LDL cholesterol, HbA1c, albuminuria, eGFR, smoking and exercise), HR was 1.52 (0.78–2.97) for FLI 30–59 and 3.04 (1.59–5.82, p=0.001) for FLI≥60. Inclusion of prior CV events slightly modifed HRs. FLI impact was confrmed upon adjustment for EURODIAB Risk Engine (EURO-RE; based on age, HbA1c, waist-to-hip ratio, albuminuria and HDL cholesterol): FLI 30–59: HR 1.24, 0.62–2.48; FLI≥60: 2.54, 1.30–4.95, p=0.007), even after inclusion of prior CVD. CV events incidence increased with FLI: 3.5, 10.5, 17.2% (p<0.0001). In unadjusted Cox, HR was 3.24 (1.65–6.34, p=0.001) for FLI 30–59 and 5.41 (2.70–10.83, p<0.0001) for FLI≥60. After adjustment for ST1-RE or EURO-RE, FLI≥60 remained statistically associated with risk of incident CV events, with trivial modifcation with prior CVD inclusion. Conclusions This observational prospective study shows that FLI is associated with higher all-cause mortality and increased risk of incident CV events in type 1 diabetes. [ABSTRACT FROM AUTHOR]
: Copyright of Cardiovascular Diabetology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
-
6دورية أكاديمية
المؤلفون: Penno, Giuseppe, Solini, Anna, Orsi, Emanuela, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Zerbini, Gianpaolo, Lamacchia, Olga, Nicolucci, Antonio, Pugliese, Giuseppe
المساهمون: Penno, Giuseppe, Solini, Anna, Orsi, Emanuela, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Zerbini, Gianpaolo, Lamacchia, Olga, Nicolucci, Antonio, Pugliese, Giuseppe
مصطلحات موضوعية: albuminuria, all-cause mortality, diabetic kidney disease, estimated glucose disposal rate, glomerular filtration rate, mellitu, type 2 diabetes
الوصف: BACKGROUND: It is unclear whether insulin resistance (IR) contributes to excess mortality in patients with type 2 diabetes independent of diabetic kidney disease (DKD), which is strongly associated with IR and is a major risk factor for cardiovascular disease (CVD), the main cause of death in these individuals. We tested this hypothesis in patients with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events Italian Multicentre Study.METHODS: This observational, prospective, cohort study enrolled 15,773 patients with type 2 diabetes attending 19 Italian Diabetes Clinics in 2006-2008. Insulin sensitivity was assessed as estimated glucose disposal rate (eGDR), which was validated against the euglycaemic-hyperinsulinemic clamp technique. Vital status on October 31, 2015, was retrieved for 15,656 patients (99.3%). Participants were stratified by eGDR tertiles from T1 (≥ 5.35mg/kg/min) to T3 (≤ 4.14mg/kg/min, highest IR).RESULTS: CVD risk profile was worse in T2 and T3 vs T1. eGDR tertiles were independently associated with micro- and macroalbuminuria and the albuminuric DKD phenotypes (albuminuria with preserved or reduced estimated glomerular filtration rate [eGFR]) as well as with eGFR categories or the nonalbuminuric DKD phenotype. Over a 7.4-year follow-up, unadjusted death rates and mortality risks increased progressively across eGDR tertiles, but remained significantly elevated after adjustment only in T3 vs T1 (age- and gender- adjusted death rate, 22.35 vs 16.74 per 1000 person-years, p<0.0001, and hazard ratio [HR] adjusted for multiple confounders including DKD, 1.140 [95% confidence interval [CI], 1.049-1.238], p=0.002). However, eGDR was independently associated with mortality in participants with no DKD (adjusted HR, 1.214 [95% CI, 1.072-1.375], p=0.002) and in those with nonalbuminuric DKD (1.276 [1.034-1.575], p=0.023), but not in those with the albuminuric DKD phenotypes. Moreover, the association was stronger in males and in younger individuals and was observed in those without but ...
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33715620; info:eu-repo/semantics/altIdentifier/wos/WOS:000629571100001; volume:19; issue:1; firstpage:1; lastpage:13; numberofpages:13; journal:BMC MEDICINE; http://hdl.handle.net/11573/1521322Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85102449873
-
7دورية أكاديمية
المؤلفون: Orsi, Emanuela, Penno, Giuseppe, Solini, Anna, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Morano, Susanna, Baroni, Marco G, Nicolucci, Antonio, Pugliese, Giuseppe
المساهمون: Orsi, Emanuela, Penno, Giuseppe, Solini, Anna, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Morano, Susanna, Baroni, Marco G, Nicolucci, Antonio, Pugliese, Giuseppe
مصطلحات موضوعية: all-cause mortality, atherogenic dyslipidaemia, HDL cholesterol, triglyceride: HDL cholesterol ratio, triglyceride, type 2 diabetes
الوصف: Atherogenic dyslipidaemia has been implicated in the residual risk for cardiovascular morbidity and mortality, which remains despite attainment of LDL cholesterol goals especially in individuals with type 2 diabetes. However, its relationship with all-cause death has not been sufficiently explored. This analysis evaluated the independent association of increased triglycerides and triglyceride:HDL cholesterol ratio (TG:HDL) and decreased HDL cholesterol with total mortality and the possible modifying effect of gender in a large cohort of patients with type 2 diabetes.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33516215; info:eu-repo/semantics/altIdentifier/wos/WOS:000616477500001; volume:20; issue:1; firstpage:28; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11573/1486416Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100004592
-
8دورية أكاديمية
المؤلفون: Orsi, Emanuela, Bonora, Enzo, Solini, Anna, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Zerbini, Gianpaolo, Morano, Susanna, Nicolucci, Antonio, Penno, Giuseppe, Pugliese, Giuseppe
المساهمون: Orsi, Emanuela, Bonora, Enzo, Solini, Anna, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Zerbini, Gianpaolo, Morano, Susanna, Nicolucci, Antonio, Penno, Giuseppe, Pugliese, Giuseppe
مصطلحات موضوعية: HbA1c all-cause mortality, adverse treatment effects, hypoglycaemia, type 2 diabetes
الوصف: The increased mortality reported with intensive glycaemic control has been attributed to an increased risk of treatment-related hypoglycaemia. This study investigated the relationships of haemoglobin (Hb) A(1c), anti-hyperglycaemic treatment, and potential risks of adverse effects with all-cause mortality in patients with type 2 diabetes. Patients (n = 15,773) were stratified into four categories according to baseline HbA(1c) and then assigned to three target categories, based on whether HbA(1c) was <= 0.5% below or above (on-target), >0.5% below (below-target) or >0.5% above (above-target) their HbA(1c) goal, personalized according to the number of potential risks among age > 70 years, diabetes duration > 10 years, advanced complication(s), and severe comorbidity (ies). The vital status was retrieved for 15,656 patients (99.26%). Over a 7.4-year follow-up, mortality risk was increased among patients in the highest HbA(1c) category (>= 8.5%) (adjusted hazard ratio, 1.34 (95% confidence interval, 1.22-1.47), p < 0.001) and those above-target (1.42 (1.29-1.57), p < 0.001). Risk was increased among individuals in the lowest HbA(1c) category (<6.5%) and those below-target only if treated with agents causing hypoglycaemia (1.16 (1.03-1.29), p = 0.01 and 1.10 (1.01-1.22), p = 0.04, respectively). These data suggest the importance of setting both upper and lower personalized HbA(1c) goals to avoid overtreatment in high-risk individuals with type 2 diabetes treated with agents causing hypoglycaemia.
وصف الملف: STAMPA
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31963486; info:eu-repo/semantics/altIdentifier/wos/WOS:000515388400246; volume:9; issue:1; firstpage:246; lastpage:246; numberofpages:1; journal:JOURNAL OF CLINICAL MEDICINE; http://hdl.handle.net/11562/1038870Test
-
9دورية أكاديمية
المؤلفون: Penno, Giuseppe, Orsi, Emanuela, Solini, Anna, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Gruden, Gabriella, Laviola, Luigi, Nicolucci, Antonio, Pugliese, Giuseppe
المساهمون: Penno, Giuseppe, Orsi, Emanuela, Solini, Anna, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Cavalot, Franco, Gruden, Gabriella, Laviola, Luigi, Nicolucci, Antonio, Pugliese, Giuseppe
مصطلحات موضوعية: diabetes mellitus, type 2, kidney disease, mortality
الوصف: Introduction In addition to favoring renal disease progression, renal ‘hyperfiltration’ has been associated with an increased risk of death, though it is unclear whether and how excess mortality is related to increased renal function. We investigated whether renal hyperfiltration is an independent predictor of death in patients with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events Italian multicenter study. Research design and methods This observational, prospective cohort study enrolled 15 773 patients with type 2 diabetes consecutively attending 19 Italian diabetes clinics in 2006–2008. Serum creatinine, albuminuria, cardiovascular risk factors, and complications/comorbidities were assessed at baseline. Vital status on 31 October 2015 was retrieved for 15 656 patients (99.26%). Patients were stratified (A) by absolute estimated glomerular filtration rate (eGFR) values in eGFR deciles or Kidney Disease: Improving Global Outcomes (KDIGO) categories and (B) based on age-corrected thresholds or age and gender-specific 95th and 5th percentiles in hyperfiltration, hypofiltration, and normofiltration groups. Results The highest eGFR decile/category and the hyperfiltration group included (partly) different individuals with similar clinical features. Age and gender-adjusted death rates were significantly higher in deciles 1, 9, and 10 (≥103.9, 50.9–62.7, and <50.9 mL/min/1.73 m2, respectively) versus the reference decile 3 (92.9–97.5 mL/min/1.73 m2). Mortality risk, adjusted for multiple confounders, was also increased in deciles 1 (HR 1.461 (95% CI 1.175 to 1.818), p=0.001), 9 (1.312 (95% CI 1.107 to 1.555), p=0.002), and 10 (1.976 (95% CI 1.673 to 2.333), p<0.0001) versus decile 3. Similar results were obtained by stratifying patients by KDIGO categories Death rates and adjusted mortality risks were significantly higher in hyperfiltering and particularly hypofiltering versus normofiltering individuals. Conclusions In type 2 diabetes, both high-normal eGFR and hyperfiltration are associated ...
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32665314; info:eu-repo/semantics/altIdentifier/wos/WOS:000573837600022; volume:8; issue:1; firstpage:1; lastpage:13; numberofpages:13; journal:BMJ OPEN DIABETES RESEARCH AND CARE; http://hdl.handle.net/11573/1430355Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088045984
-
10دورية أكاديمية
المؤلفون: Nanayakkara, Natalie, Curtis, Andrea J., Heritier, Stephane, Gadowski, Adelle M., Pavkov, Meda E., Kenealy, Timothy, Owens, David R., Thomas, Rebecca L., Song, Soon, Wong, Jencia, Chan, Juliana C. -N., Luk, Andrea O. -Y., Penno, Giuseppe, Ji, Linong, Mohan, Viswanathan, Amutha, Anandakumar, Romero-Aroca, Pedro, Gasevic, Danijela, Magliano, Dianna J., Teede, Helena J., Chalmers, John, Zoungas, Sophia
المساهمون: Medicina i Cirurgia, Universitat Rovira i Virgili
المصدر: Diabetologia ; https://link.springer.com/article/10.1007/s00125-020-05319-wTest ; 10.1007/s00125-020-05319-w ; Diabetologia. 64 (2): 275-287
مصطلحات موضوعية: Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine, Age factors, Age of onset, Diabetes, Diabetes complications, Diabetes mellitus, Disease progression, Meta-analysis, Prognosis, Systematic review, Type 2, Biotecnología, Ciência de alimentos, Ciências biológicas i, Ciências biológicas ii, Educação física, Endocrinology & metabolism, Endocrinology, diabetes and metabolism, Enfermagem, Engenharias iv, Farmacia, General medicine, Interdisciplinar, Internal medicine, Medicina i, Medicina veterinaria, Química, Saúde coletiva
الوصف: Aims/hypothesis Few studies examine the association between age at diagnosis and subsequent complications from type 2 diabetes. This paper aims to summarise the risk of mortality, macrovascular complications and microvascular complications associated with age at diagnosis of type 2 diabetes. Methods Data were sourced from MEDLINE and All EBM (Evidence Based Medicine) databases from inception to July 2018. Observational studies, investigating the effect of age at diabetes diagnosis on macrovascular and microvascular diabetes complications in adults with type 2 diabetes were selected according to pre-specified criteria. Two investigators independently extracted data and evaluated all studies. If data were not reported in a comparable format, data were obtained from authors, presented as minimally adjusted ORs (and 95% CIs) per 1 year increase in age at diabetes diagnosis, adjusted for current age for each outcome of interest. The study protocol was recorded with PROSPERO International Prospective Register of Systematic Reviews (CRD42016043593). Results Data from 26 observational studies comprising 1,325,493 individuals from 30 countries were included. Random-effects meta-analyses with inverse variance weighting were used to obtain the pooled ORs. Age at diabetes diagnosis was inversely associated with risk of all-cause mortality and macrovascular and microvascular disease (all p < 0.001). Each 1 year increase in age at diabetes diagnosis was associated with a 4%, 3% and 5% decreased risk of all-cause mortality, macrovascular disease and microvascular disease, respectively, adjusted for current age. The effects were consistent for the individual components of the composite outcomes (all p < 0.001). Conclusions/interpretation Younger, rather than older, age at diabetes diag
النص الكامل