المؤلفون: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Chiesa, D, Clemenza, M, Copello, S, Cosmelli, C, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Davis, CJ, Dell’Oro, S, Di Domizio, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Ligi, C, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, Sharma, V, Singh, V, Sisti, M, Speller, D, Surukuchi, PT, Taffarello, L

المصدر: Physical Review Letters. 131(24)

مصطلحات موضوعية: Nuclear and Plasma Physics, Physical Sciences, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences

الوصف: This corrects the article DOI: 10.1103/PhysRevLett.126.171801.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6zz4d7bmTest

المؤلفون: Radtke, ND, Seiler, MJ, Aramant, RB, Petry, HM, Pidwell, DJ

مصطلحات موضوعية: retinal degeneration, retinal transplantation, safety trial, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry

الوصف: Purpose: To show the safety of transplanting sheets of fetal retina together with its RPE to patients with retinitis pigmentosa.Methods: Sheets of fetal neural retina and RPE together were transplanted into the subretinal space near the fovea unilaterally into the eyes of five patients with retinitis pigmentosa that had only light perception in both eyes. The patients were followed for six months. The main outcome measures were tissue typing of both donors and recipients, fluorescein angiography, multifocal electroretinogram (mfERG) testing, and clinical examination. No immunosuppressive medications were given. Results: No evidence of rejection was observed. Out to six months there was no evidence of tissue disintegration, retinal edema, or scarring. There was no change in vision, both by Snellen acuity and with mfERGs. Growth of the transplant was noted in two of five patients at six months versus two weeks. All patients typed were HLA mismatched with donor tissue. Conclusions: This study indicates that fetal retina can be transplanted together with its RPE and survive for at least 6 months without rejection. However, no improvement in vision was observed, possibly due to the severe retinal degeneration of the patients.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/45g3074vTest

المؤلفون: Dove, J, Kerns, B, Leung, C, McClellan, RE, Miyasaka, S, Morton, DH, Nagai, K, Prasad, S, Sanftl, F, Scott, MBC, Tadepalli, AS, Aidala, CA, Arrington, J, Ayuso, C, Barker, CT, Brown, CN, Chang, TH, Chang, WC, Chen, A, Christian, DC, Dannowitz, BP, Daugherity, M, Diefenthaler, M, Fassi, L El, Geesaman, DF, Gilman, R, Goto, Y, Guo, L, Guo, R, Hague, TJ, Holt, RJ, Isenhower, D, Kinney, ER, Kitts, ND, Klein, A, Kleinjan, DW, Kudo, Y, Lin, P-J, Liu, K, Liu, MX, Lorenzon, W, Makins, NCR, de Medeiros, M Mesquita, McGaughey, PL, Miyachi, Y, Mooney, I, Nakahara, K, Nakano, K, Nara, S, Peng, JC, Puckett, AJ, Ramson, BJ, Reimer, PE, Rubin, JG, Sawada, S, Sawada, T, Shibata, T-A, Shiu, SH, Su, D, Teo, M, Tice, BG, Towell, RS, Uemura, S, Watson, TS, Wang, SG, Wickes, AB, Wu, J, Xi, Z, Ye, Z

المصدر: Physical Review C. 108(3)

مصطلحات موضوعية: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Nuclear and plasma physics

الوصف: Evidence for a flavor asymmetry between the ū and d¯ quark distributions in the proton has been found in deep-inelastic scattering and Drell-Yan experiments. The pronounced dependence of this flavor asymmetry on x (fraction of nucleon momentum carried by partons) observed in the Fermilab E866 Drell-Yan experiment suggested a drop of the d¯(x)/ū(x) ratio in the x>0.15 region. We report results from the SeaQuest Fermilab E906 experiment with improved statistical precision for d¯(x)/ū(x) in the large x region up to x=0.45 using the 120 GeV proton beam. Two different methods for extracting the Drell-Yan cross section ratios, σpd/2σpp, from the SeaQuest data give consistent results. The d¯(x)/ū(x) ratios and the d¯(x)-ū(x) differences are deduced from these cross section ratios for 0.13

الوصول الحر: https://escholarship.org/uc/item/1n88n2h5Test

المؤلفون: Adhikari, S, Afzal, F, Akondi, CS, Albrecht, M, Amaryan, M, Arroyave, V, Asaturyan, A, Austregesilo, A, Baldwin, Z, Barbosa, F, Barlow, J, Barriga, E, Barsotti, R, Beattie, TD, Berdnikov, VV, Black, T, Boeglin, W, Briscoe, WJ, Britton, T, Brooks, WK, Byer, D, Chudakov, E, Cole, PL, Cortes, O, Crede, V, Dalton, MM, Darulis, D, Deur, A, Dobbs, S, Dolgolenko, A, Dotel, R, Dugger, M, Dzhygadlo, R, Ebersole, D, Egiyan, H, Erbora, T, Eugenio, P, Fabrizi, A, Fanelli, C, Fang, S, Fegan, S, Fitches, J, Foda, AM, Furletov, S, Gan, L, Gao, H, Gardner, A, Gasparian, A, Gleason, C, Goetzen, K, Goryachev, VS, Grube, B, Guo, J, Guo, L, Hague, TJ, Hakobyan, H, Hernandez, J, Hoffman, ND, Hornidge, D, Hou, G, Huber, GM, Hurck, P, Hurley, A, Imoehl, W, Ireland, DG, Ito, MM, Jaegle, I, Jarvis, NS, Jeske, T, Jones, RT, Kakoyan, V, Kalicy, G, Khachatryan, V, Khatchatryan, M, Kourkoumelis, C, LaDuke, A, Larin, I, Lawrence, D, Lersch, DI, Li, H, Li, WB, Liu, B, Livingston, K, Lolos, GJ, Lorenti, L, Lyubovitskij, V, Mack, D, Mahmood, A, Martel, PP, Marukyan, H, Matveev, V, McCaughan, M, McCracken, M, Meyer, CA, Miskimen, R, Mitchell, RE, Mizutani, K, Neelamana, V, Ng, L, Nissen, E

المصدر: Physical Review C. 108(2)

مصطلحات موضوعية: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Nuclear and plasma physics

الوصف: We report the total and differential cross sections for J/ψ photoproduction with the large acceptance GlueX spectrometer for photon beam energies from the threshold at 8.2 GeV up to 11.44 GeV and over the full kinematic range of momentum transfer squared, t. Such coverage facilitates the extrapolation of the differential cross sections to the forward (t=0) point beyond the physical region. The forward cross section is used by many theoretical models and plays an important role in understanding J/ψ photoproduction and its relation to the J/ψ-proton interaction. These measurements of J/ψ photoproduction near threshold are also crucial inputs to theoretical models that are used to study important aspects of the gluon structure of the proton, such as the gluon generalized parton distribution of the proton, the mass radius of the proton, and the trace anomaly contribution to the proton mass. We observe possible structures in the total cross section energy dependence and find evidence for contributions beyond gluon exchange in the differential cross section close to threshold, both of which are consistent with contributions from open-charm intermediate states.

الوصول الحر: https://escholarship.org/uc/item/9bz9m0dhTest

المؤلفون: McBride, David A, Kerr, Matthew D, Johnson, Wade T, Nguyen, Anders, Zoccheddu, Martina, Yao, Mina, Prideaux, Edward B, Dorn, Nicholas C, Wang, Wei, Svensson, Mattias ND, Bottini, Nunzio, Shah, Nisarg J

المصدر: Advanced Science. 10(11)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Immunology, Autoimmune Disease, Arthritis, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Mice, Animals, Autoimmune Diseases, T-Lymphocytes, Regulatory, Inflammation, Tretinoin, Antirheumatic Agents, immune engineering, regulatory T cells, rheumatoid arthritis

الوصف: Disease modifying antirheumatic drugs (DMARDs) have improved the prognosis of autoimmune inflammatory arthritides but a large fraction of patients display partial or nonresponsiveness to front-line DMARDs. Here, an immunoregulatory approach based on sustained joint-localized release of all-trans retinoic acid (ATRA), which modulates local immune activation and enhances disease-protective T cells and leads to systemic disease control is reported. ATRA imprints a unique chromatin landscape in T cells, which is associated with an enhancement in the differentiation of naïve T cells into anti-inflammatory regulatory T cells (Treg ) and suppression of Treg destabilization. Sustained release poly-(lactic-co-glycolic) acid (PLGA)-based biodegradable microparticles encapsulating ATRA (PLGA-ATRA MP) are retained in arthritic mouse joints after intra-articular (IA) injection. IA PLGA-ATRA MP enhance migratory Treg which in turn reduce inflammation and modify disease in injected and uninjected joints, a phenotype that is also reproduced by IA injection of Treg . PLGA-ATRA MP reduce proteoglycan loss and bone erosions in the SKG and collagen-induced arthritis mouse models of autoimmune arthritis. Strikingly, systemic disease modulation by PLGA-ATRA MP is not associated with generalized immune suppression. PLGA-ATRA MP have the potential to be developed as a disease modifying agent for autoimmune arthritis.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/78s7h660Test

المؤلفون: Nutini, I, Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Dell’Oro, S, Domizio, SD, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, YG, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, O’Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, Sharma, V

المصدر: Journal of Low Temperature Physics. 209(5-6)

مصطلحات موضوعية: Mathematical Physics, Classical Physics, Condensed Matter Physics, General Physics, Classical physics, Condensed matter physics

الوصف: The Cryogenic Underground Observatory for Rare Events (CUORE) is the first cryogenic experiment searching for 0 νββ decay that has been able to reach the one-tonne mass scale. The detector, located at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, consists of an array of 988 TeO 2 crystals arranged in a compact cylindrical structure of 19 towers. CUORE began its first physics data run in 2017 at a base temperature of about 10 mK and in April 2021 released its 3 rd result of the search for 0 νββ, corresponding to a tonne-year of TeO 2 exposure. This is the largest amount of data ever acquired with a solid state detector and the most sensitive measurement of 0 νββ decay in 130Te ever conducted. We present the current status of CUORE search for 0 νββ with the updated statistics of one tonne-yr. We finally give an update of the CUORE background model and the measurement of the 130Te 2 νββ decay half-life and decay to excited states of 130Xe , studies performed using an exposure of 300.7 kg yr.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2725c9z7Test

المؤلفون: Palladino, Elisa ND, Bernas, Tytus, Green, Christopher D, Weigel, Cynthia, Singh, Sandeep K, Senkal, Can E, Martello, Andrea, Kennelly, John P, Bieberich, Erhard, Tontonoz, Peter, Ford, David A, Milstien, Sheldon, Eden, Emily R, Spiegel, Sarah

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 119(39)

مصطلحات موضوعية: 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Ceramides, Cholesterol, Endoplasmic Reticulum, Isoenzymes, Liposomes, Lysophospholipids, Phosphatidylserines, Sphingolipids, Sphingosine, Aster-B/GRAMD1b, cholesterol, membrane contact sites, sphingolipids, sphingosine kinase

الوصف: Membrane contact sites (MCS), close membrane apposition between organelles, are platforms for interorganellar transfer of lipids including cholesterol, regulation of lipid homeostasis, and co-ordination of endocytic trafficking. Sphingosine kinases (SphKs), two isoenzymes that phosphorylate sphingosine to the bioactive sphingosine-1-phosphate (S1P), have been implicated in endocytic trafficking. However, the physiological functions of SphKs in regulation of membrane dynamics, lipid trafficking and MCS are not known. Here, we report that deletion of SphKs decreased S1P with concomitant increases in its precursors sphingosine and ceramide, and markedly reduced endoplasmic reticulum (ER) contacts with late endocytic organelles. Expression of enzymatically active SphK1, but not catalytically inactive, rescued the deficit of these MCS. Although free cholesterol accumulated in late endocytic organelles in SphK null cells, surprisingly however, cholesterol transport to the ER was not reduced. Importantly, deletion of SphKs promoted recruitment of the ER-resident cholesterol transfer protein Aster-B (also called GRAMD1B) to the plasma membrane (PM), consistent with higher accessible cholesterol and ceramide at the PM, to facilitate cholesterol transfer from the PM to the ER. In addition, ceramide enhanced in vitro binding of the Aster-B GRAM domain to phosphatidylserine and cholesterol liposomes. Our study revealed a previously unknown role for SphKs and sphingolipid metabolites in governing diverse MCS between the ER network and late endocytic organelles versus the PM to control the movement of cholesterol between distinct cell membranes.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9qt16189Test

المصدر: European Journal of Education (EJED), v6 n2 p67-83 2023. 17 pp.

تمت مراجعته من قبل الزملاء: Y

Abstractor: As Provided

نوع المنشور: Journal Articles; Reports - Evaluative

المؤلفون: Shareef, V Mohammed, Mohan, ND Jerin, Mathew, Titus K

مصطلحات موضوعية: General Relativity and Quantum Cosmology

الوصف: Causal dissipative model is a plausible choice to explain the late accelerated epoch of universe. At the same time $\Lambda$CDM is considered to be standard model to explain the cosmological data corresponding to the late evolution of the universe. We consider a bulk viscus model in which the dissipation is driven by the bulk viscosity $\zeta=\alpha \rho^{1/2}$, described using the full causal Israel-Stewart theory. We computed the model parameters using the latest observational data (Pantheon). We contrasted this model with $\Lambda$CDM model for the late accelerated phase using Bayesian inference method. The Bayes factor has been obtained by calculating the likelihood for Pantheon data. Suitable prior values has been assumed for model parameters for calculating the likelihood. It shows that the evidence for $\Lambda$CDM against this viscous model is very strong according to Jeffrey's scale.
Comment: 18 pages and 4 figures

الوصول الحر: http://arxiv.org/abs/2109.04045Test

المؤلفون: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FTIII, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Dell'Oro, S, Di Domizio, S, Dompe, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, Sharma, V, Singh, V, Sisti, M, Speller, D

المصدر: Nature. 604(7904)

مصطلحات موضوعية: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, CUORE Collaboration, nucl-ex, General Science & Technology

الوصف: The possibility that neutrinos may be their own antiparticles, unique among the known fundamental particles, arises from the symmetric theory of fermions proposed by Ettore Majorana in 19371. Given the profound consequences of such Majorana neutrinos, among which is a potential explanation for the matter-antimatter asymmetry of the universe via leptogenesis2, the Majorana nature of neutrinos commands intense experimental scrutiny globally; one of the primary experimental probes is neutrinoless double beta (0νββ) decay. Here we show results from the search for 0νββ decay of 130Te, using the latest advanced cryogenic calorimeters with the CUORE experiment3. CUORE, operating just 10 millikelvin above absolute zero, has pushed the state of the art on three frontiers: the sheer mass held at such ultralow temperatures, operational longevity, and the low levels of ionizing radiation emanating from the cryogenic infrastructure. We find no evidence for 0νββ decay and set a lower bound of the process half-life as 2.2 × 1025 years at a 90 per cent credibility interval. We discuss potential applications of the advances made with CUORE to other fields such as direct dark matter, neutrino and nuclear physics searches and large-scale quantum computing, which can benefit from sustained operation of large payloads in a low-radioactivity, ultralow-temperature cryogenic environment.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/58h4472vTest