المؤلفون: Narangerel Jigjidkhorloo, Kohsuke Kanekura, Jun Matsubayashi, Daigo Akahane, Koji Fujita, Keiki Oikawa, Atsushi Kurata, Masakatsu Takanashi, Hitoshi Endou, Toshitaka Nagao, Akihiko Gotoh, Oyundelger Norov, Masahiko Kuroda

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remains unknown. Here, we evaluated LAT1 expression level in tissues from 138 patients with Non-Hodgkin lymphoma (NHL). Overexpression of LAT1 was confirmed in all types of NHL and we found that there is a significant correlation between the level of LAT1 expression and lymphoma grade. The LAT1 expression was higher in aggressive types of lymphomas when compared with static types of lymphomas, suggesting that active tumor proliferation requires nutrient uptake via LAT1. The expression level of LAT1 was inversely correlated with patients’ survival span. Furthermore, pharmacological inhibition of LAT1 by a specific inhibitor JPH203 inhibits lymphoma cell growth. In conclusion, our study demonstrated that LAT1 expression can be used as a prognostic marker for patients with NHL and targeting LAT1 by JPH203 can be a novel therapeutic modality for NHL.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/254f7aaec22f4688a7954b03fd1e965bTest

المؤلفون: Khishigjargal Batsukh, Oyundelger Norov, Narangerel Jigjidkhorloo, Altanshagai Boldbaatar, Saruul Tungalag, Batbaatar Gunchin, Odgerel Tsogbadrakh

المصدر: Central Asian Journal of Medical Sciences, Vol 3, Iss 2, Pp 179-184 (2017)

مصطلحات موضوعية: stem cell, transplantation, bortezomib, multiple myeloma, Medicine, Medicine (General), R5-920

الوصف: Objectives: For last 5 years, we have focused on establishing autologous stem cell transplantation (ASCT) in Mongolia. Herein, we report on three Mongolian multiple myeloma (MM) cases treated with bortezomib and dexamethasone (VD) prior to ASCT. Methods: The MM diagnosis was confirmed by bone marrow aspiration, urine protein electrophoresis, and serum protein electrophoresis. Results: Circulating white blood cells appeared 8-10 days after ASCT. Platelet levels recovered 10 -15 days after ASCT. Conclusion: In our MM cases, the VD regimen prior to ASCT obtained good response rates without the impairment of stem cells.

وصف الملف: electronic resource

العلاقة: https://www.mongoliajol.info/index.php/CAJMS/article/view/2716Test; https://doaj.org/toc/2413-8681Test; https://doaj.org/toc/2414-9772Test

الوصول الحر: https://doaj.org/article/3afbfcc504cb42fd8d34dc61fcd65349Test

المؤلفون: Narangerel Jigjidkhorol, Khishigjargal Batsukh, Oyundelger Norov, Myadagsuren Sukhbaatar, Nansalmaa Ayurzana, Mend-Amar Ravzanaadii, Saruul Tungalag, Altanshagai Boldbaatar, Khulan Purevdorj, Sarantuya Jav

المصدر: Central Asian Journal of Medical Sciences, Vol 1, Iss 1, Pp 81-84 (2015)

مصطلحات موضوعية: immunoglobulin m, plasma cells, plasmapheresis, Medicine, Medicine (General), R5-920

الوصف: Objectives: Waldenstrom Macroglobulinemia (WM) is a malignant disease of the B lymphocytes. We report on a patient in Mongolia having WM complicated with hyperviscosity syndrome. Methods: A 28 year-old Mongolian woman had symptoms due to hyperviscosity syndrome such as vision loss, headache, dizziness and, epistaxis. Upon examination, her morphology, biochemistry, histology, flow cytometry and serum protein electrophoresis indicated WM complicated with hyperviscosity syndrome. Results: The patient was was successfully treated with a combination chemotherapy and plasmapheresis. Conclusion: Hyperviscosity syndrome manifestations should be treated with plasmapheresis.

وصف الملف: electronic resource

العلاقة: https://www.mongoliajol.info/index.php/CAJMS/article/view/2618Test; https://doaj.org/toc/2413-8681Test; https://doaj.org/toc/2414-9772Test

الوصول الحر: https://doaj.org/article/7d9322f3d21f49ecb94913900a9acb5cTest

المؤلفون: Erdenetsogt Dungubat, Enkhtuya Sharkhuu, Bayarmaa Enkhba, Tsengelmaa Jamiyan, Oyundelger Norov, Galtsog Lodon

المصدر: Diagnostic Pathology, Vol 3, Iss 1 (2017)

مصطلحات موضوعية: Medicine (General), R5-920, Computer applications to medicine. Medical informatics, R858-859.7, Medical technology, R855-855.5

الوصف: Background: The prevalence of non-Hodgkin’s lymphoma (NHL) varies worldwide in association with demographic and environmental factors. The analysis of these associations in Asia, Africa, and less developed countries is limited by low absolute numbers and unknown etiologic factors such as in Mongolia. The geographic variations in NHL incidence and mortality rates may induce by differences in case ascertainment and registration, or disease diagnosis and classification. The interpretation of NHL patterns and trends remains difficult. Therefore, an attempt was made to test the correlation between Ki-67 expression and clinical parameters on one hand, and geographical or ethnic differences on the other. Research purpose: The objectives of this study are to examine the geographic distribution of non-Hodgkin's disease more in detail for high incidence Mongolian prefectures, and to evaluate the association between the distribution of NHL and Ki-67 expression. Methods: Expression of Ki-67 was examined using an immunohistochemical technique in archival paraffin-embedded sections taken from (n=35) both National pathology center of Mongolia and Etemo clinic previously. Geo-processing was conducted with the aide of the software R Studio [under the Mapping plots] (1.0.136 version). The analyzed geographic incidence rates of NHL include locations of the central and east provinces Orkhon, Uvurhangay, Khuvsgul, Ulaanbaatar and Dornod The age-specific incidence and mortality rates were compared to those for all regions in Mongolia and those for the combined high mortality localities within the high-risk prefectures. Results: Expression of Ki-67 protein was noted in 71.8% of the tumor cases. Average Ki-67 expression was associated with regions of high incidence. Conclusion: We found that provinces with a high incidence and mortality from non-Hodgkin's disease were aggregated in the eastern-central parts of Mongolia, particularly in the areas along Ulaanbaatar capital city.

وصف الملف: electronic resource

العلاقة: http://www.diagnosticpathology.eu/content/index.php/dpath/article/view/247Test; https://doaj.org/toc/2364-4893Test

الوصول الحر: https://doaj.org/article/f69d41b31ce24979a378c51cbb72906fTest

المؤلفون: Elbegjargal, Erdenebaatar, Oyundelger, Norov, Khishigjargal, Batsukh, Myadagsuren, Sukhbaatar, Nansalmaa, Ayurzana, Chinbat, Gonchigdash, Altanshagai, Boldbaatar, Bulgan, Davaasambuu, Baljinnyam, Purevsuren, Otgonbat, Altangerel

المصدر: Clinical Lymphoma Myeloma and Leukemia ; volume 23, page S170 ; ISSN 2152-2650

مصطلحات موضوعية: Cancer Research, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/s2152-2650Test(23)00508-6
https://api.elsevier.com/content/article/PII:S2152265023005086?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2152265023005086?httpAccept=text/plainTest

المؤلفون: Elbegjargal, Erdenebaatar, Oyundelger, Norov, Khishigjargal, Batsukh, Myadagsuren, Sukhbaatar, Nansalmaa, Ayurzana, Chinbat, Gonchigdash, Altanshagai, Boldbaatar, Bulgan, Davaasambuu, Baljinnyam, Purevsuren, Otgonbat, Altangerel

المصدر: Clinical Lymphoma Myeloma and Leukemia ; volume 23, page S286 ; ISSN 2152-2650

مصطلحات موضوعية: Cancer Research, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/s2152-2650Test(23)01031-5
https://api.elsevier.com/content/article/PII:S2152265023010315?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2152265023010315?httpAccept=text/plainTest

المؤلفون: Atsushi Kurata, Akihiko Gotoh, Masakatsu Takanashi, Masahiko Kuroda, Keiki Oikawa, Jun Matsubayashi, Kohsuke Kanekura, Toshitaka Nagao, Koji Fujita, Daigo Akahane, Narangerel Jigjidkhorloo, Oyundelger Norov, Hitoshi Endou

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, Prognostic factor, Amino Acid Transport Systems, Science, Gene Expression, Diseases, L-Type Amino Acid Transporter, Article, Large Neutral Amino Acid-Transporter 1, Malignant lymphoma, immune system diseases, Cell Line, Tumor, hemic and lymphatic diseases, Neutral amino acid transport, medicine, Humans, Aged, Cell Proliferation, Cancer, Aged, 80 and over, Multidisciplinary, biology, Drug discovery, Membrane transport protein, Cell growth, Gene Expression Profiling, Lymphoma, Non-Hodgkin, Middle Aged, Prognosis, medicine.disease, Lymphoma, Non-Hodgkin's lymphoma, Gene Expression Regulation, Neoplastic, Oncology, Amino Acid Transport System L, biology.protein, Cancer research, Medicine, Female, Transcriptome

الوصف: L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remains unknown. Here, we evaluated LAT1 expression level in tissues from 138 patients with Non-Hodgkin lymphoma (NHL). Overexpression of LAT1 was confirmed in all types of NHL and we found that there is a significant correlation between the level of LAT1 expression and lymphoma grade. The LAT1 expression was higher in aggressive types of lymphomas when compared with static types of lymphomas, suggesting that active tumor proliferation requires nutrient uptake via LAT1. The expression level of LAT1 was inversely correlated with patients’ survival span. Furthermore, pharmacological inhibition of LAT1 by a specific inhibitor JPH203 inhibits lymphoma cell growth. In conclusion, our study demonstrated that LAT1 expression can be used as a prognostic marker for patients with NHL and targeting LAT1 by JPH203 can be a novel therapeutic modality for NHL.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e310310b3994aaafec3f03fff4b4794dTest
https://doaj.org/article/254f7aaec22f4688a7954b03fd1e965bTest