المؤلفون: Mongodi, Silvia, Ottonello, Gaia, Viggiano, Raffaelealdo, Borrelli, Paola, Orcesi, Simona, Pichiecchio, Anna, Balottin, Umberto, Mojoli, Francesco, Iotti, Giorgio Antonio

المصدر: BMC Anesthesiology ; volume 19, issue 1 ; ISSN 1471-2253

مصطلحات موضوعية: Anesthesiology and Pain Medicine

الوصف: Background Children require anesthesia for MRI to maintain immobility and reduce discomfort; clear indications about the best anesthesiologic management are lacking and each center developed its own protocol. Moreover, children with neuropsychiatric disorders more likely require sedation and are described in literature as more prone to general and respiratory complications. Aim of this study was to analyze the applicability of a sevoflurane-based approach, to describe general and respiratory complications and to identify risk factors in a pediatric neuropsychiatric population. Methods Retrospective cohort study, university Hospital (January 2007–December 2016). All the 1469 anesthesiologic records of children addressed from Neuropsychiatric Unit to undergo MRI under general anesthesia were analyzed; 12 patients equal or older than 18-year-old were excluded. We identified post-hoc nine macro-categories: static encephalopathies, metabolic/evolutive encephalopathies, epileptic encephalopathies, neuromuscular diseases, autistic spectrum disorders, migraine, psychiatric disorders, intellectual disabilities, others. A logistic regression model for events with low frequency (Firth’s penalized likelihood approach) was carried out to identify the mutually adjusted effect among endpoints (complications) and the independent variables chosen on the basis of statistical significance (univariate analysis, p ≤ 0.05) and clinical judgment. Results Of 1457 anesthesiologic records (age 4.0 (IQR 2.0 to 7.0) year-old, males 891 (61.2%), weight 17.0 (IQR 12.0 to 24.9) kg), 18 were cancelled for high anesthesiologic risk, 50 were cooperative, 1389 were anesthetized. A sevoflurane-based anesthesia was feasible in 92.3%; these patients required significantly less mechanical ventilation (8.6 vs. 16.2%; p = 0.012). Complications’ rate was low (6.2%; 3.1% respiratory). The risk for general complications increases with ASA score > 1 (OR 2.22, 95 CI% 1.30 to 3.77, p = 0.003), male sex (OR 1.73, 95% CI 1.07 to 2.81, p = 0.025), ...

الإتاحة: https://doi.org/10.1186/s12871-019-0897-1Test

المؤلفون: Jaillette, Emmanuelle, Girault, Christophe, Brunin, Guillaume, Zerimech, Farid, Chiche, Arnaud, Broucqsault-Dedrie, Céline, Fayolle, Cyril, Minacori, Franck, Alves, Isabelle, Barrailler, Stephanie, Robriquet, Laurent, Delaporte, Emmanuel, Thellier, Damien, Delcourte, Claire, Duhamel, Alain, Nseir, Saad, Valette, Xavier, Desmeulles, Isabelle, Savary, Benoit, Masson, Romain, Seguin, Amélie, Daubin, Cédric, Sauneuf, Bertrand, Verrier, Pierre, Pottier, Véronique, Orabona, Marie, Samba, Désiré, Viquesnel, Gerald, Lermuzeaux, Mathilde, Hazera, Pascal, Hanouz, Jean-Luc, Parienti, Jean-Jacques, Du Cheyron, Damien, Demoule, Alexandre, Clavel, Marc, Rolland-Debord, Camille, Perbet, Sébastien, Terzi, Nicolas, Kouatchet, Achille, Wallet, Florent, Rozé, Hadrien, Vargas, Frédéric, Guerin, Claude, Dellamonica, Jean, Jaber, Samir, Similowski, Thomas, Quenot, Jean-Pierre, Binquet, Christine, Vinsonneau, Christophe, Barbar, Saber-Davide, Vinault, Sandrine, Deckert, Valérie, Lemaire, Stéphanie, Hssain, Ali Ait, BRUYERE, REMI, Souweine, Bertrand, Lagrost, Laurent, Adrie, Christophe, Jung, Boris, Daurat, Aurélien, De Jong, Audrey, Chanques, Gerald, Mahul, Martin, Monnin, Marion, Molinari, Nicolas, Lheureux, Olivier, Trépo, Eric, Hites, Maya, Cotton, Frederic, Wolff, Fleur, Surin, Rudy, Vincent, Jean-Louis, Gustot, Thierry, Jacobs, Frédérique, Taccone, Fabio Silvio, Neuville, Mathilde, Timsit, Jean-François, El-Helali, Najoua, Le Monnier, Alban, Magalhaes, Éric, Radjou, Aguila, Smonig, Roland, Soubirou, Jean-François, Voiriot, Guillaume, Sonneville, Romain, Bouadma, Lila, Mourvillier, Bruno, Gélisse, Elodie, Brasseur, Alexandre, Roisin, Sandrine, De Backer, Daniel, Van Ruychevelt, Valerie, Carlier, Eric, Piagnerelli, Michael, Vanhaeverbeek, Michel, Danguy, Christine, Biston, Patrick, Au, Siu-Ming, Bégot, Emmanuelle, Dalmay, François, Repessé, Xavier, Prat, Gwenael, Bouferrache, Koceila, Slama, Michel, Vieillard-Baron, Antoine, Marik, Paul, Teboul, Jean-Louis, Jozwiak, Mathieu, Richard, Christian, Chauvet, Jean-Louis, El-Dash, Shari, Delastre, Olivier, Bouffandeau, Bernard, Jusserand, Dominique, Michot, Jean-Baptiste, Bauer, Fabrice, Brazier, François, Mercado, Pablo, Kontar, Loay, Titeca, Dimitri, De Cagny, Bertand, Bacari-Risal, Gaelle, Rivière, Antoine, Guillot, Camille, Le Reun, Claire, Lampin, Marie, Sadik, Ahmed, Botte, Astrid, Collins, Aurélie, Kempeneers, Céline, Cajgfinger, Nathalie, Ohlmann, Camille, POUYAU, Robin, Subtil, Fabien, BAUDIN, Florent, MASSENAVETTE, Bruno, Javouhey, Etienne, Milési, Christophe, Essouri, Sandrine, Liet, Jean-Michel, Afanetti, Mickael, Durand, Sabine, Durand, Philippe, Rozé, Jean Christophe, Dupont, Didier, Cambonie, Gilles, Rusca, Marco, Lukaszewicz, Anne-Claire, Crassard, Isabelle, Guichard, Jean-Pierre, Bresson, Damien, de la Garanderie, Didier Payen, Cantier, Marie, Sabben, Candice, Louedec, Liliane, Delbosc, Sandrine, Journe, Clement, Ou, Phalla, Klein, Isabelle, Chau, Françoise, Lefort, Agnès, Desilles, Jean-Philippe, Michel, Jean-Baptiste, Mazighi, Mikael, Salem, Omar Ben Hadj, Demeret, Sophie, Bolgert, Francis, Sharshar, Tarek, Grabli, David, Arib, Safa, Crippa, Ilaria Alice, Soummer, Alexis, Engrand, Nicolas, Guedin, Pierre, ALDEA, Sorin, Cerf, Charles, Desailly, Victoire, Pasquier, Pierre, Brun, Patrick, Roux, Damien, Latournerie, Gwendoline, Kasprzyk, Laetitia, Grosjean, Vincent, Latreche, Amine, Habert, Pierre, Huot, Stephane, Jobin, Timon, Tesniere, Antoine, Dreyfuss, Didier, Ricard, Jean-Damien, Mignon, Alexandre, Laithier, François-Xavier, Chouihed, Tahar, Albizzati, Stéphane, Camenzind, Edoardo, Vanhuyse, Fabrice, Lévy, Bruno, Cour, Martin, Venet, Fabienne, Hernu, Romain, Demaret, Julie, Monneret, Guillaume, Dumas, Florence, Lamhaut, Lionel, Rosencher, Julien, Pène, Frédéric, Varenne, Olivier, Jouven, Xavier, Spaulding, Christian, Cariou, Alain, Bonnetain, Franck, Marijon, Eloi, Empana, Jean Philippe, Mirouse, Adrien, Resche-Rigon, Matthieu, Mayaux, Julien, Rabbat, Antoine, 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Perrigault, Pierre-François, Gangneux, Jean-Pierre, Mekontso-Dessap, Armand, Jansen, Chloe, Lecronier, Marie, Sandrine, Valade, Mira, Jean-Paul, Blein, Sophie, Marin, Nathalie, Rousseau, Christophe, Charpentier, Julien, Pachot, Alexandre, Hraiech, Sami, Bordes, Julien, De, Lamballerie Xavier, Mege, Jean-Louis, Forel, Jean-Marie, Guervilly, Christophe, Adda, Melanie, Raoult, Didier, Papazian, Laurent, Cohen-Solal, Zoé, Kentish-Barnes, Nancy, Souppart, Virginie, Kerhuel, Lionel, Haubertin, Carole, Exbrayat, Isabelle, Rozières, Elodie, Argain, Audrey, Suc, Agnès, Vignes, Michel, Cougot, Pierre, Fourcade, Olivier, Brunel, Elodie, Tubach, Florence, Dubief, Emeline, Pasquet, Blandine, Guillo, Sylvie, Pierron, Charlotte, Grimaud, Marion, Farnoux, Caroline, Maillard, Amélie, Prodanovic, Hélène, Idbaih, Ahmed, Alentorn, Agusti, Delattre, Jean-Yves, de Montmollin, Etienne, Brule, Noëlle, Conrad, Marie, Dailler, Frédéric, Navellou, Jean-Christophe, Alves, Mikael, Tonnelier, Jean-Marie, Ruckly, 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Laurent, Razazi, Keyvan, Surenaud, Mathieu, Bedet, Alexandre, Seemann, Aurélien, Hue, Sophie, Clere-Jehl, Raphaël, Charles, Anne-Laure, Geny, Bernard, Bilbault, Pascal, Lejour, Gabriel, Bourcier, Simon, Boêlle, Pierre Yves, Safaa, Nemlaghi, Paulus, Sylvie, Flamens, Claire, Neidecker, Jean, Allioux, Cecile, Guedj, Romain, Guellec, Isabelle, Guilbert, Julia, Leger, Pierre-Louis, Demoulin, Maryne, Durandy, Amélie, Jean, Sandrine, Carbajal, Ricardo, Morand, Aurelie, Zieleskiewicz, Laurent, Brissaud, Olivier, Le Bel, Stéphane, Meresse, Zoe, Panuel, Michel, Thomachot, Laurent, Leone, Marc, Michel, Fabrice, Deho’, Anna, Sadozai, Laïly, Dauger, Stéphane, Prot-Labarthe, Sonia, GENUINI, Mathieu, Florence, Moulin, Tréluyer, Jean-Marc, Renolleau, Sylvain, Chalavon, Emmanuelle, Dessein, Rodrigue, Grandbastien, Bruno, Pesin, Sarah, Dubos, Francois, Leteurtre, Stephane, Puel, Marie-Aude, Szulc, Marie, Philippe, Anais, Severac, Francois, Astruc, Dominique, Kuhn, Pierre, Desprez, Philippe, Colomb, Benoît, Petion, Anne Marie, Queudet, Laurent, Remy, Solenn, Youssef, Mouaffak, Roumeliotis, Nadia, Dong, Christian, Pettersen, Geraldine, Crevier, Louis, Emeriaud, Guillaume, Naudin, Jérôme, Abdallah, Laetitia, Ganier, Marion, Frannais, Karine, Douglas, Dylia, Flusin, Cecile, Brossier, David, Eltaani, Redha, Sauthier, Michaël, Guillois, Bernard, Rambaud, Jérôme, Larroquet, Michelle, Amblard, Alain, Lode, Noella, Casadevall, Isabelle, Kessous, Katia, Walti, Hervé, Poiré, Christophe, Chen, Huixiong, Habacha, Sahar, Chatbri, Bassem, Masniere, Cyril, Megarbane, Bruno, Souissi, Samar, Ghord, Hatem El, Kouraichi, N., Brahmi, Nozha, Marhbène, Takoua, Mejri, Islam, Lakhdar, Douha, Merhabane, Takoua, la Maamouri, Hé, Charlotte, Oestreicher, Wegelius, Helena, Landelle, Caroline, Schrenzel, Jacques, Kaiser, Laurent, Belhadj, Hind, Chanareille, Paul, Ladureau, Adélie, Sanna, Alice, Rolle, Amélie, Pons, Bertrand, Piednoir, Pascale, Ardisson, Fanny, Martino, Frédéric, Bernos, Thomas, Elkoun, Khalid, Elain, Elie, Lawson, Roland, Resh-Rigon, Matthieu, Belorgey, Sophie, Thiery, Guillaume, Berlemont, Caroline Hauw, Pricopi, Cyprian, Barthes, Françoise, Doddie, Thansya, Nsiala, Mj, Situakibanza, Nh, Amisi, Be, Kazadi, Mj, Kilembe, Ma, Clément, Christophe, Lamontagne, François, Boyer, Valérie Nocquet, Naimo, Sébastien, Raulais, Ronan, Genevois, Emilie, Bouchoud, Lucie, Boroli, Filippo, Abidi, Nour, Abbas, Mohamed, Harbarth, Stefan, Pugin, Jerôme, Charles, Pierre-Emmanuel, Dereux, Caroline, De Guillebon, Stanislas, Morisse, Eloise, France, Julie, Gasser, Deborah, Badia, Philippe, Picard, Walter, Corne, P., De Boulastel, I., Seguin, S., BLASCO, A., Ledur, V., Jonquet, Olivier, Sophie, Paktoris-Papine, artiguenave, margaux, Sayed, Faten El, Espinasse, Florence, Dinh, Aurélien, Charron, Cyril, Lebas, Benjamin, Hatsch, Sophie, Maestraggi, Quentin, Dureau, Anne-Florence, Faitot, François, Margetis, Dimitri, Bouvet, Odile, Chevret, Didier, Denamur, Erick, Simonet, Justine, Vest, Philippe, Peigne, Vincent, Couffin, Séverine, Cheikh Bouhlel, M., Khedher, Ahmed, Meddeb, Kaoula, Azouzi, A., Hamdaoui, Y., Ayachi, Jihene, Brahim, W., Bouneb, Rania, Florens, Nans, Varéon, Julie, Malatray, Arnaud, Argaud, Laurent, Dupland, Pierre, Vergier, Romain, Issaurat, Pauline, Estagnasie, Philippe, Squara, Pierre, Brusset, Alain, Génin, Vincent, Jendoubi, Ali, Jlassi, Rifka, Hamrouni, Bassem, Marzougui, Yahia, Kouka, Jihen, Ghedira, Salma, Houissa, Mohamed, Dhifaoui, Kaouther, Oziel, Johanna, Dinh, Alexy Tran, Neulier, Caroline, Amara, Marlène, Nebot, Nicaise, Troché, Gilles, Breton, Nelly, Cavelot, Sébastien, Pangon, Béatrice, Merrer, Jacques, Labaste, Francois, Conil, Jean-Marie, Grossac, Julia, Ruiz, Stéphanie, Grare, Marion, Minville, Vincent, Georges, Bernard, Van Der Meersch, Guillaume, Karoubi, Philippe, Huang, Christophe, Carbonne, Helene, Amarsy, Rishma, Mateo, Joaquim, Von Edelsberg, Sophie Leloup, Vercheval, Christelle, Damas, Pierre, Bouguerra, Chaker, Naas, Noura, Muller, Joris, Schaeffer, Mickaël, Loc, Pierre Tran Ba, Deboscker, Stephanie, Harley, Marie-Line, Lavigne, Thierry, Brunet, Jennifer, Canoville, Bertrand, Lellouche, François, L’Her, Erwan, Bouchard, Pierre Alexandre, Elfaramawy, Tamer, Gosselin, Benoit, Guégan, Sarah, Michotte, Jean-Bernard, Staderini, Enrico, Dugernier, Jonathan, Rusu, Rares, Liistro, Giuseppe, Reychler, Grégory, Simon, Mathieu, Essoukaki, Elmaati, Michotte, Jean Bernard, Contal, Olivier, Trabelsi, Becem, Garsallah, Hedi, Harira, Khaoula, Rafat, Cédric, Mariotte, Eric, Le Jeune, Caroline, Roy, Pascal, Michallet, Mauricette, Zerbib, Yoann, Baudin, François, Blot, François, Bornstain, Caroline, Gelinotte, Stéphanie, Rigaud, Jean-Philippe, Tamion, Fabienne, Bouteloup, Marie, Darmon, Michael, Nouira, H., Degirmenci, Su, Kummerlen, Christine, Delile, Eugénie, Thiébaut, Pierre-Alain, Do Rego, Jean-Claude, Coquerel, David, Nevière, Rémi, Ichou, Laure, Carbonell, Nicolas, Rautou, Pierre-Emmanuel, Nousbaum, Jean-Baptiste, RENOU, Christophe, Anty, Rodolphe, Landraud, Luce, Ait-Oufella, Hafid, Coudroy, Rémi, Lecron, Jean-Claude, Helary, Michael, Paillot, Jonathan, Pili-Floury, Sébastien, Ezzamouri, Asma, Salem, Mohamed, Kerdjana, Lamia, Dumitrescu, Mihaela, Mimoz, Olivier, Debaene, Bertrand, Migeot, Virginie, Dahyot-Fizelier, Claire, Khedher, Sana, Maoui, Amira, Champigneulle, Benoit, Zafrani, Lara, Lascarrou, Jean-Baptiste, Lissonde, Floriane, Le Thuaut, Aurélie, Reignier, Jean, Platon, Laura, Lambert, Jérôme, Lagier, David, Brun, Jeanpaul, Sannini, Antoine, Chow-Chine, Laurent, Bisbal, Magali, Faucher, Marion, Mokart, Djamel, la Mourtada, Leï, Virgnie, Lemiale, Gaudet, Alexandre, Parmentier-Decrucq, Erika, De Freitas Caires, Nathalie, Dubucquoi, Sylvain, Lassalle, Philippe, Mathieu, Daniel, Richard, Jean-Christophe, Tapponnier, Romain, Quintin, Luc, Pichot, C., Petitjeans, F., Guillon, Antoine, Jouan, Youenn, Breah, Daborah, Gueugnon, Fabien, Dalloneau, Emilie, Baranek, Thomas, Henry, Clémence, Morello, Eric, Renauld, Jc, Pichavant, M., Gosset, Philippe, Courty, Y., Diot, Patrice, Si-Tahar, Mustapha, Vuillard, Constance, La Combe, Béatrice, Ponsin, Pauline, BODDAERT, Guillaume, Grand, Bertrand, Baudoin, Yohan, Bonnet, Stéphane, Snouda, Salah, Abbes, Mohamed Fehmi, Benchiekh, Imen, Sedghiani, Ines, Belayachi, Jihane, Debono, Leila, Auvet, Adrien, Nadal-Desbarats, Lydie, Tankovic, Jacques, Dahoumane, Redouane, Oufella, Hafid Ait, Offenstadt, Georges, Filali, Amel, Faure, Emmanuel, Nigeon, Olivier, Bazus, H., Mallat, Jihad, Thevenin, Didier, Lempereur-Legros, Sophie, Ledoux, Didier, Nys, Monique, Hajjej, Zied, Messika, Jonathan, Clermont, Olivier, Aubry, Alexandra, Fernandes, Romain, Garnaud, Cécile, Cornet, Muriel, Pavèse, Patricia, Foroni, Luc, Boisset, Sandrine, le Maubon, Daniè, Abid, Maha, Ezzouine, Hanane, Edith, Constant Aniolo, Sztrymf, Benjamin, Serre, Jean-Emmanuel, Landreau, L., Jean-Michel, Vanessa, Couturaud, Francis, Moore, Elizabeth, Egreteau, Pierre-Yves, Boles, Jean-Michel, Herbrecht, Jean-Etienne, Kaeuffer, Charlotte, Meyer, Anne, Arfi, Khaouther Ben, Lesage, Fabrice, Séguret, Sylvie, DUPIC, Laurent, De Saint Blanquat, Laure, Baptiste, Anne-Sophie, Georges, Hugues, Delannoy, Pierre-Yves, Devos, Patrick, Albarracín, Dolores, Ducousso-Lacaze, A., Dufour, Julien, Cabasson, Séverin, Veinstein, Anne, Chatellier, Delphine, Ha, Vivien Hong Tuan, Lau, Nicolas, Mimoun, Lucie, Forceville, Xavier, Maamar, Adel, Chevalier, Stéphanie, Botoc, Vlad, Rouleau, Stephane, Desachy, Arnaud, Calvat, Sylvie, Lafon, Charles, Cracco, Christophe, Van Grunderbeeck, Nicolas, Temime, J., Molmy, Perrine, Gasan, G., Béranger, Agathe, Chappuy, Hélène, Bertrand, Pierre-Marie, Beurton, Alexandra, Bodet-Contentin, Laëtitia, Danin, Pierre-Eric, Dubois, Elsa, Karaca, Yasemin, Mora, Pierre, Vodovar, Dominique, Desbrosses, Yohan, Chauchet, Adrien, Daguindau, Etienne, Deconinck, Eric, Chermak, Akli, Baron, Marinne, Calvet, Laure, Sapin, Anne Françoise, Pereira, Bruno, Vettoretti, Lucie, Lacroix, Jacques, Clayton, Lucy, Sabri, Elham, Bardiaux, Laurent, Tiberghien, Pierre, Hebert, Paul, Lengline, Etienne, Socié, Gérard, Borcoman, Edith, Rusinová, Katerina, Del Galy, Aurélien Sutra, Mercier, Mélanie, Hamel, Jean-François, Raveau, Tommy, Moles, Marie-Pierre, Clavert, Aline, Hunault-Berger, Mathilde, Ifrah, Norbert, Schmidt-Tanguy, Aline, Carreira, Serge, Lavault, Sophie, Pallanca, Olivier, Morawiec, Elise, Arnulf, Isabelle, D’humières, Thomas, Carrié, Cédric, Gisbert-Mora, Chloé, Bonnardel, Éline, Biais, Matthieu, Hilbert, Gilles, Bureau, Côme, Joannon, Thomas, Marincamp, Aude, Chiche, Jean-Daniel, Ferré, Alexis, Lichtenstein, Daniel, Meziere, Gilbert, Dres, Martin, Gonzalez, Céline, Hamzaoui, Olfa, Geffriaud, Thomas, Leleu, François, Boissier, Florence, Cuquemelle, Elise, Lim, Pascal, Amara, R., Boussarsar, Mohamed, Léger, Julie, Jacob, Christophe, Bouferache, Koceila, Vignon, Philippe, Ragot, Claire, Corradi, Laure, Maurice, Laure, Julliand, S., DEHO, Anna, Le Bourgeois, Fleur, Jacquot, Aurélien, Valla, Frédéric, Letois, Flavie, Salvadori, Alexandre, Ottonello, Gaia, Blanot, Stéphane, Montmayeur, Juliette, Orliaguet, Gilles, Habas, Flora, Baleine, Julien, Lebouhellec, Julia, Combes, Clémentine, CHOMTON, Maryline, Jouvet, Philippe, Ranchin, Bruno, Macher, Marie Alice, Gaillot, Theophile, Bahloul, Mabrouk, Moine, Murielle, Ageron, François Xavier, Jannel, Claire, Debillon, Thierry, Wroblewski, Isabelle, Duprey, Matthieu, Jarlier, Vincent, Luyt, Charles-Edouard, Bailly, Sébastien, Longval, Thomas, Schnell, David, Padoin, Christophe, Cohen, Yves, Mokline, Amel, Gaies, Emna, Triki, Sameh, Klouz, Anis, Moussa, Mouhamed, Desrumaux, Flavie, May, Faten, Perrin, Marion, Nguyen, Jean-Claude, Tiercelet, Kelly, Fournier, Julien, Cherin, Mélanie, Kitzis, Marie Dominique, Misset, Benoît, Mathien, Cyrille, Poidevin, Antoine, Donatti, Luis, Mootien, Joy, Pinto, Luís, Egard, Mathieu, Bodur, Gokhan, Barberet, Guillaume, Ionescu, Carmen, Ganster, Frédérique, Guiot, Philippe, Kuteifan, Khaldoun, Mpela, Alain, Chelly, Jonathan, Guérin, Laurent, Persichini, Romain, Hullin, Thomas, Deye, Nicolas, Aubertein, Pierre, Paul, Marine, Sandroni, Claudio, Passouant, Olivier, Geri, Guillaume, Chenevier-Gobeaux, Camille, Batteux, Frédéric, Llitjos, Jean-François, Drouet, Ludovic, Voicu, Sébastian, Henry, Patrick, Dillinger, Jean-Guillaume, Bougouin, Wulfran, Resiere, Dabor, Dessoy, A., Faivre, Valérie, Damoisel, Charles, Soyer, Benjamin, Galoisy, Anne-Cécile, Mauvieux, Laurent, Zobairi, Fatiha, Anglès-Cano, Eduardo, Stiel, Laure, Piau, Caroline, Tadié, Jean-Marc, Daix, Thomas, Jeannet, Robin, Feuillard, Jean, Jolly, Lucie, Boufenzer, Amir, Carrasco, Kevin, Derive, Marc, Gibot, Sébastien, Merdji, Hamid, Belaidouni, Nadia, Toubiana, Julie, L’Hermitte, Yann, Woimant, France, Oppenheim, Catherine, Couvreur, Christophe, Dolveck, François, Devriese, Magali, Dupeyrat, Sophie, Ray, Patrick, Lefèvre, Guillaume, Roothaer, Nicolas, Carpentier, Amélie, Vaniet, Fabien, Maisonneuve, Antoine, WIEL, Eric, Canu, Sébastien, Hammad, Emmanuelle, Antonini, Francois, Poirier, Marion, Vigne, Coralie, Haddam, Malik, Alingrin, Julie, Dangers, Laurence, Mangiapan, Gilles, Huet, Isabelle, Dhalluin, Xavier, Bautin, Nathalie, Quiot, Jean Jacques, De Vecchi, Corinne Appere, Chenivesse, Cecile, Tarmiz, Khalil, Medhioub, Fatma Kaaniche, Smaoui, Mariem, Cheikh, Chaigar Mohammed, El Alami, E., Mochel, Fanny, Galanaud, Damien, Puybasset, Louis, Lodey, Marion, Guiller, Elsa, Weiss, Nicolas, Silva, Stein, Vuillaume, Corine, De Pasquale, Francesco, Démonet, Jean François, Sinnah, Fabrice, Dalloz, Marie Amelie, d’Ortho, Marie Pia, Rouvel-Tallec, Anny, Couret, David, Catan, Aurélie, Nativel, Brice, Planesse, Cynthia, Diotel, Nicolas, Meilhac, Olivier, Roy-Gash, Fabian, Lebard, Christophe, Larbi, Anne-Gaelle Si, Gaudin, Virginie, Bonnin, France, Sultan, Oceane, Hoc, Cecile, Mathieu, Emmanuel, Lapergue, Bertrand, Bourdain, Frédéric, Caron, Margot, Parrot, Antoine, Labbé, Vincent, Hafiani, El Mahdi, Quesnel, Christophe, GENAY, Stéphanie, Decaudin, Bertrand, Ethgen, Sabine, Odou, Pascal, Lebuffe, Gilles, Gaudry, Stéphane, Aubron, Cecile, Mcquilte, Zoe, Garrouste-Orgeas, Maïté, Soufir, Lilia, Allaouchiche, Bernard, Verdière, Bruno, Nyunga, Martine, Banaias, Noémie, Colling, Delphine, Kauv, Marie, Blondeau, Erik, Ouanes, Islem, Auclin, Édouard, Haw-Berlemont, Caroline, Taieb, Julien, Oudard, Stéphane, Morissette, Genevieve, Kechaou, Wassim, Litalien, Catherine, Merouani, Aïcha, Phan, Véronique, Bouchard, Josée, Starck, Julie, Briand, Nelly, Sachs, Philippe, Angoulvant, François, Sommet, Julie, Holvoet, L., Benkerrou, M., DREYFUS, Lélia, Bordet, Fabienne, Touzet, Sandrine, Denis, Angélique, Le Coz, Julien, Chéron, Gérard, Nabbout, Rima, Patteau, Geraldine, Heilbronner, Claire, HUBERT, Philippe, Oualha, Mehdi, Aoul, Nabil Tabet, Crulli, Benjamin, Toledano, Baruch, Poirier, Nancy, Vobecky, Suzanne, Khouadja, Hosni, Robert, René, Vinet, M., Vinclair, Camille, Boisramé-Helms, Julie, Beloncle, François, Radermacher, Peter, Asfar, Pierre, Coupez, Elisabeth, Bohe, Julien, Shinotsuka, Cláudia Righy, Caironi, Pietro, Villois, Paola, Fontana, Vito, Creteur, Jacques, Pourcine, Franck, Vong, Ly, Weyer, Claire Marie, Akando, Benoit, Abdallah, Razach, Wetzstein, Morgane, Maizel, Julien, Antier, Nadiejda, Serroukh, Yasmina, Boudjeltia, Karim Zouaoui, Joosten, Anne, Rousseau, Alexandre, Grunebaum, Lélia, Delabranche, Xavier, Mootien, Yoganaden, Gaci, Rostane, Garric, Jean-Romain, Delbove, Agathe, Darreau, Cédric, Dargent, Auguste, Soudry-Faure, Agnès, de Chambrun, Marc Pineton, Demondion, Pierre, Blanchard, Jean-Christophe, Chocron, Sydney, Meneveau, Nicolas, Corsi, Filippo, Meynieu, Pierre-Emmanuel, Repusseau, Benjamin, Germain, Arnaud, Baudry, Guillaume, Hierle, Lucie, Besch, Guillaume, Thomas, Guillemette, Cassir, Nadim, Dizier, Stéphanie, Roch, Antoine, Trebbia, Grégoire, Govindaradjou, Kiruba, Devaquet, Jérôme, Picard, Clement, Parquin, François, Leguen, Morgan, Felten, Marie-Louise, Sage, Edouard, Chapelier, Alain, Decavele, Maxens, Duruisseaux, Michaël, Fleury, Jocelyne, Antoine, Martine, Carette, Marie-France, Wislez, Marie, Givel, Claire, De Margerie-Mellon, Constance, De Kerviler, Eric, Tandjaoui-Lambiotte, Yacine, Freynet, Olivia, Kimmoun, Antoine, Baux, Elisabeth, Das, Vincent, Talec, Patrice, Anguel, Nadia, Louis, Guillaume, Girerd, Nicolas, Tallon, Pauline, Hadchouel-Duvergé, Alice, Salvi, Nadège, Cairet, Pascale, Delacourt, Christophe, Blandine, Blandine Lefebvre, Beraud, Laurence, Coppere, Zoé, Lamazière, Antonin, Lionnet, François, Fartoukh, Muriel, Lehingue, Samuel, D’Journo, Xavier, Jean-Marie, Forel, Thibault, Ronan, Makhlouf, Anne-Marie, Mulliez, Aurélien, Gonzalez, Cristina, Dadet, Sylvain, Kekstas, Gintautas, Preiser, Jean-Charles, Rotovnik, Kozjek Nada, Rozalen, Isabel Ceniceros, Kupczyk, Kinga, Krznaric, Zeljko, Cano, Noël, Pichard, Claude, Le Roux, Bénédicte Gaillard-, Jotterand, Corinne, ROOZE, Shancy, Moullet, Clemence, Henin, Aurélia, Ettori, Florence, Zemmour, Christophe, Boher, Jean Marie, Arnaout, Michel, Feltry, Audrey, Ben, Salah Adel, Audibert, Juliette, Conia, Alexandre, Gontier, Olivier, Hamrouni, Mouldi, Lherm, Thierry, Ouchenir, Abdelkader, Rétif, Jérôme, Proudhom, Alain, Lagardere, Chantal, Tissot, Stéphane, Kalfon, Pierre, Sacre, Lynn, Villa, Antoine, Khadija, Alaywa, Garnier, Robert, Vasset, Brigitte, Heinzelman, Annette, Jouffroy, Romain, Durand, Elsa Démarest, Compagnon, Patricia, Maaroufi, Neila, M’rad, A., Jebri, Alia, Ghezala, Hassen Ben, Legout, Céline, Baud, Frédéric, Castot-Villepelet, Anne, Valade, Sandrine, Lesieur, Olivier, Delmas, Benjamin, Visseaux, Benoit, Cohen, Johana, Nguyen, Liem Binh Luong, Morbieu, Caroline, Burdet, Charles, Lescure, François-Xavier, Armand-Lefevre, Laurence, Yazdanpanah, Yazdan, Houhou-Fidouh, Nadira, Cazaux, Marine, Goff Jérôme, Le, Meignin, Véronique, Boutboul, David, Rispail, Philippe, Brunot, Vincent, Besnard, N., Céballos, Patrice, Stoclin, Annabelle, Rotolo, Federico, Wartelle, Muriel, Hicheri, Yosr, Maillet, Sylvia, Chachaty, Elisabeth, Pignon, Jean-Pierre, Venot, Marion, Delorme, Mathieu, Bialais, Emilie, Julie, Dupuis, Paoloni, Laura, Wittebolle, Xavier, Hickmann, Cheryl, Castanares-Zapatero, Diego, Tordeur, Antoine, Colmant, Lise, Wittebole, Xavier, Tirone, Giuseppe, Laterre, Pierre-Francois, Ducroux, Lorraine, Kemlin, Claire, Moulton, Eric, Rosso, Charlotte, Le Neindre, Aymeric, Mongodi, Silvia, Bouhemad, Béaïd, Rodrigues, Joana, Botteau, Caroline, Waroquier, François, Christiaens, Karel, Vantrimpont, Frank, Duprez, Frédéric, Elkhawand, Charbel, Vermeesh, Frank

المساهمون: CHU Rouen, Laboratoire de Physico-Chimie des Polymères et des Milieux Dispersés PPMD, Biologie et physiologie des états septiques, Santé publique : épidémiologie et qualité des soins-EA 2694 CERIM, Centre Hospitalier Régional Universitaire Lille CHRU Lille, Service de réanimation médicale CHU Caen, Laboratoire des Matériaux, Surfaces et Procédés pour la Catalyse LMSPC, Service de Soins Intensifs CHU Caen, CHU Caen, Service d'Anesthésie - Réanimation Chirurgicale CHU Caen, CHU Pitié-Salpêtrière APHP, CHU Limoges, Hôpital Charles Foix - Jean Rostand, CHU Clermont-Ferrand, Centre Hospitalier Universitaire d'Angers CHU Angers, Adaptation cardiovasculaire à l'ischémie, CHU Bordeaux Bordeaux, Institut Mondor de recherche biomédicale IMRB, Neurophysiologie Respiratoire Expérimentale et Clinique, Service de Réanimation Médicale (CHU de Dijon), Epidémiologie, santé publique et développement, Agroécologie Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand CHU Dijon, Lipides - Nutrition - Cancer (U866) LNC, Laboratoire Microorganismes : Génome et Environnement LMGE, Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 PhyMedExp, Département d'anesthésie-réanimation Montpellier, Institut Montpelliérain Alexander Grothendieck IMAG, Groupe hospitalier Paris Saint-Joseph - Hôpital, Service de réanimation médicale et infectieuse, Service des maladies infectieuses et réanimation médicale, AP-HP - Hôpital Bichat - Claude Bernard Paris, Service de cardiologie CHU Limoges, Neuroépidémiologie Tropicale et Comparée NETEC, Hôpital Ambroise Paré AP-HP, CHRU Brest - Service de Réanimation Médicale CHU - BREST - Réa Med, Service de réanimation medico-chirurgicale CHU Raymond-Poincaré, Hôpital Bicêtre, Institut Mondor de Recherche Biomédicale IMRB, Hôpital Charles Nicolle Rouen, Pharmacologie des Dysfonctionnements Endotheliaux et Myocardiques, CHU Amiens-Picardie, Centre interdisciplinaire de recherche, culture, éducation, formation, travail CIRCEFT, Hôpital Femme Mère Enfant CHU - HCL HFME, Biostatistiques santé, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement UMRESTTE UMR T9405, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement UMRESTTE UMR_T9405, Centre hospitalier universitaire de Nantes CHU Nantes, Centre Hospitalier Universitaire de Nice CHU Nice, Modélisation mathématique et numérique M2N, Science et Technologie du Lait et de l'Oeuf STLO, Hôpital Lariboisière, Service de Neuroradiologie CHU Lariboisière, Biomécanique et Bioingénierie BMBI, Laboratoire de Recherche Vasculaire Translationnelle LVTS (UMR_S_1148 / U1148), Hémostase, bio-ingénierie et remodelage cardiovasculaires LBPC, Infection, Anti-microbiens, Modélisation, Evolution IAME (UMR_S_1137 / U1137), Service de médecine interne, Histopathologie humaine et Modèles animaux, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière CRICM, Hôpital Foch Suresnes, Fondation Ophtalmologique Adolphe de Rotschild, Centre d'études supérieures de la Renaissance UMR 7323 CESR, Laboratoire Univers et Particules de Montpellier LUPM, Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) INRS ( Vandoeuvre lès Nancy), Computing tools to empower users MJOLNIR, Laboratoire Universitaire Médical d’Enseignement basé sur les technologies Numériques et de Simulation iLumens - site Paris 5, Service de Réanimation Médico-Chirurgicale Avicenne, Université de Lorraine UL, Centre d'investigation clinique plurithématique Pierre Drouin Nancy CIC-P, Défaillance Cardiovasculaire Aiguë et Chronique DCAC, Geometry and Lighting ALICE, Continental Automotive France Toulouse, Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques - EA 7426 PI3, Hôpital Edouard Herriot CHU - HCL, Paris-Centre de Recherche Cardiovasculaire PARCC - UMR-S U970, CHU Necker - Enfants Malades AP-HP, CHU Cochin AP-HP, CHU Saint Louis APHP, Service de Pneumologie et Réanimation Médicale CHU Pitié-Salpêtrière Département " R3S ", Centre Hospitalier de Versailles André Mignot CHV, Service de réanimation médicale, Service de Réanimation Médicale Grenoble, Hôpital Saint-Louis, Université de Bordeaux UB, Service d'Immunopathologie Hôpital Saint-Louis, Paris, Institut Cochin IC UM3 (UMR 8104 / U1016), Groupe Henri Mondor-Albert Chenevier, Centre hospitalier universitaire de Poitiers CHU Poitiers, Service de physiologie, explorations fonctionnelles Mondor, CIC - Poitiers, Centre de Physique Théorique - UMR 6207 CPT, Service de Réanimation polyvalente Toulouse, Service de neurologie Poitiers, CHU Tenon APHP, ATOMycA CRCINA-ÉQUIPE 6, Centre de Physique des Particules de Marseille CPPM, Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations

الوصف: 6 ; S1

وصف الملف: application/octet-stream

العلاقة: Annals of Intensive Care; http://hdl.handle.net/20.500.12210/29633Test

الإتاحة: https://doi.org/20.500.12210/29633Test
https://hdl.handle.net/20.500.12210/29633Test

المؤلفون: Burzio, Valentina, Guerini, Paola, Leoni, Maria Chiara, Ottonello, Gaia, Raschetti, Roberto, Zavras, Niki, Giorgiani, Giovanna, Zecca, Marco

الوصف: Rhabdomyosarcomas (RMSs) represent more than 50% of soft tissue sarcomas occurring in childhood and adolescence. Although RMS is a rare tumor, it is one of the typical pediatric cancers. RMS is a highly malignant tumor that is characterized by local aggressiveness and a propensity to metastasize. Like other soft tissue sarcomas, an enlarging soft tissue mass is the usual expression of the primary tumor, but in deep sites (the pelvis, or trunk) the clinical evidence of the mass could appear relatively late. Ultrasonography is often the first diagnostic modality used in diagnosis. Computed tomography (CT) scans or magnetic resonance imaging (MRI) of the primary site improve the first local evaluation of the site and are mandatory for assessing local tumor extension before any treatment is given. After evidence of a suspected soft part lesion is obtained, pathological assessment is necessary to identify the histological nature of the tumor. In the past 30 years, the cure rate for RMS has dramatically improved from 25–30% (before the modern chemotherapy era) to approximately 70% This success is due to the development of multidisciplinary and risk-adapted treatment approaches developed by international cooperative groups. RMS is a rare tumor, and its treatment is necessarily multidisciplinary and complex. We analyse a clinical report of a child hospitalised in the ward of Pediatric Oncohematology of Policlinico San Matteo.
Bollettino della Società Medico Chirurgica di Pavia, Vol 124, N° 1 (2011)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b05f8a676a4e11fd16380abeea8fe419Test

المؤلفون: Benazzo, Francesco, Burzio, Valentina, Caretti, Valentina, Costa, Pietro, Guerini, Paola, Indino, Cristian, Leoni, Maria Chiara, Marullo, Matteo, Mosconi, Mario, Occhini, Antonio, Ottonello, Gaia, Peschiera, Valeria, Raschetti, Roberto, Rossi, Stefano Marco Paolo, Zecca, Marco

مصطلحات موضوعية: musculoskeletal diseases, musculoskeletal system

الوصف: Osteosarcoma is the most common of all primary malignancies of bone. In most cases it occurs in young pa-tients under 20 years of age. Almost 60% of cases involves proximal tibia or distal femur. A 6-years-old child received in July 2010 diagnosis of osteosarocma of proximal left tibia without primary metastases. She received neoadjuvant chemiotherapy followed in October 2010 by resection of the tumor, vascularised fibular autograft and adjuvant chemiotherapy. Now she’s free of disease and she can walk but there’s the need of longer surgical follow-up to verify long-term efficacy of this treatment.
Bollettino della Società Medico Chirurgica di Pavia, Vol 124, N° 1 (2011)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::63930edb0a454027856bd434b3ecee90Test

المؤلفون: Raschetti, Roberto, Burzio, Valentina, Burzio, Paola, Leoni, Maria Chiara, Ottonello, Gaia, Giorgiani, Giovanna, Zecca, Marco, Locatelli, Franco

الوصف: Il trapianto allogenico di cellule staminali emopoietiche rappresenta il trattamento di scelta per molte patologie oncoematologiche dell’infanzia e dell’età adulta. Tuttavia, un donatore familiare HLA-identico è disponibile solo in circa il 25% dei casi e spesso non è possibile identificare in tempo utile un donatore volontario non con-sanguineo nei registri internazionali dei donatori volontari di midollo osseo. Proprio per questo motivo, sono state sviluppate nel corso degli anni strategie trapiantologiche alternative, basate sull’impiego di fonti di cellule staminali emopoietiche differenti (come ad esempio il sangue placentare) o sull’impiego di donatori familiari HLA-parzialmente compatibili. In particolare, questo secondo approccio appare di rilevante interesse, in quanto permette virtualmente di poter identificare un donatore di cellule staminali emopoietiche per tutti i pazienti can-didati ad un trapianto. Questo lavoro dimostra come il trapianto di cellule staminali emopoietiche da sangue periferico da donatore familiare HLA-parzialmente compatibile, dopo procedura di T-deplezione, rappresenti una valida opzione terapeutica per pazienti che necessitano di un trapianto allogenico di cellule staminali emopoietiche ma che sono sprovvisti di un donatore familiare o non consanguineo HLA-compatibile.
Bollettino della Società Medico Chirurgica di Pavia, Vol 123, N° 3 (2010)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7780e7a12c34cf7d554d352c681fa86dTest

المؤلفون: Burzio, Valentina, Guerini, Paola, Leoni, Maria Chiara, Ottonello, Gaia, Raschetti, Roberto, Zecca, Marco, Locatelli, Franco

الوصف: Più dell’80% dei bambini affetti da leucemia mieloide acuta (LAM) insorta de novo raggiunge la remissione completa con una terapia di induzione basata sulla combinazione di farmaci chemioterapici attivi sui blasti mieloidi. Tuttavia, è il trattamento post- remissione a giocare un ruolo cruciale nell’outcome finale di questi pazienti. Negli ultimi anni numerosi gruppi di ricerca hanno dimostrato che, nei bambini affetti da LAM ad alto rischio (ovvero, non connotata da citogenetica favorevole), il trapianto allogenico di cellule staminali emopoietiche, seppur gravato da un maggiore rischio di complicanze terapia-correlate, offre risultati migliori in termini di sopravvivenza libera da malattia rispetto alle altre forme di trattamento post-remissionale. Il nostro studio dimostra come il trapianto allogenico di cellule staminali emopoietiche, effettuato dopo un regime mieloablativo basato sulla combinazione di 3 farmaci alchilanti, busulfano (BU), ciclofosfamide (CY) e melphalan (MEL), sia una modalità di trattamento post-remissionale caratterizzata da un buon profilo di tolleranza farmacologica, accettabile tossicità e buon effetto antileucemico e possa garantire elevate probabilità di cura per pazienti pediatrici affetti da LAM in prima RC di malattia.
Bollettino della Società Medico Chirurgica di Pavia, Vol 123, N° 3 (2010)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c9b3af17f264e4fda011cf244ff34d8fTest

المؤلفون: Ottonello, Gaia, Guerini, Paola, Leoni, Maria Chiara, Raschetti, Roberto, Burzio, Valentina, Zecca, Marco

الوصف: La malattia veno-occlusiva (VOD) epatica è una delle più gravi e frequenti complicanze acute del trapianto di cellule staminali emopoietiche, con un’incidenza stimata tra il 10% ed il 60%, in relazione alle caratteristiche dei soggetti, al regime di condizionamento, alla tipologia di trapianto ed ai criteri diagnostici impiegati. Clinicamen-te, è una sindrome caratterizzata da epatomegalia dolente, ittero, ascite, ritenzione idrica ed incremento ponderale. La patogenesi è complessa e coinvolge rilascio di citochine, danno endoteliale ed attivazione dell’emostasi, che portano ad un’obliterazione fibrotica delle venule epatiche terminali e delle vene sublobulari, dilatazione e fibrosi dei sinusoidi centrolobulari e necrosi degli epatociti della zona 3. Si distinguono diversi livelli di gravità, da forme lievi e reversibili, alla VOD severa, correlata ad un elevato tasso di mortalità per insufficienza multiorgano. Il trattamento si avvale di una terapia di prima linea specifica, che comprende Defibrotide ed attivatore tissutale del plasminogeno, associata a terapia di supporto, come diuretici, trasfusioni, plasma expander ed analgesia.
Bollettino della Società Medico Chirurgica di Pavia, Vol 123, N° 3 (2010)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::acb90450611f1fd3dae343c1d4f0c62cTest

المؤلفون: Burzio, Valentina, Guerini, Paola, Leoni, Maria Chiara, Ottonello, Gaia, Raschetti, Roberto, Zecca, Marco

الوصف: Poche altre terapie hanno così profondamente inciso sulla storia naturale di molte patologie come il trapianto di cellule staminali emopoietiche (TCSE). In relazione alle implicazioni immunologiche che subentrano al trapian-to di cellule staminali emopoietiche e alle terapie utilizzate nel suo condizionamento, si possono sviluppare una serie di complicanze, distinte in precoci o tardive in relazione al periodo di insorgenza; si definiscono compli-canze precoci quelle che intervengono nei primi 100 giorni post-trapianto. Il nostro lavoro vuole rappresentare una review della letteratura riguardante le complicanze acute che possono insorgere in un bambino sottoposto a TCSE. Tra le principali condizioni che possono insorgere nel periodo post-TCSE si possono annoverare: la graft versus host disease acuta, le complicanze gastrointestinali, la malattia veno-occlusiva, la microangiopatia trom-botica, la cistite emorragica e le complicanze polmonari.
Bollettino della Società Medico Chirurgica di Pavia, Vol 123, N° 3 (2010)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b10ecc2622b06679c8567e592058a311Test

المؤلفون: Burzio, Valentina, Guerini, Paola, Leoni, Maria Chiara, Ottonello, Gaia, Raschetti, Roberto, Zecca, Marco

الوصف: Le masse parotidee nella popolazione pediatrica non sono comuni e possono rappresentare varie entità patologi-che. Questa combinazione rende la diagnosi e il trattamento suscettibili di continue trasformazioni e revisioni, soprattutto nei bambini. Una massa asintomatica rappresenta la presentazione clinica più comune. I segni e i sintomi associati all’anamnesi sono fondamentali per poter porre una diagnosi presuntiva, tuttavia appare diffici-le, in relazione alla clinica, determinare la natura della massa parotidea; la biopsia ad ago sottile è utile nel valu-tare le lesioni selle ghiandole salivari e si è dimostrata avere una specificità del 91% e una sensibilità del 96% quando un numero di cellule sufficiente è presente. La patologie infiammatorie e infettive sono le cause più co-muni di ingrandimento della ghiandola parotidea nella popolazione pediatrica. Le neoplasie parotidee nei bam-bini sono meno comuni rispetto agli adulti, tuttavia l’emangioma infantile è la neoplasia più comune dell’età pediatrica. La diagnosi precoce permette di iniziare il trattamento appropriato e evitare le principali complicanze.
Bollettino della Società Medico Chirurgica di Pavia, Vol 123, N° 2 (2010)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5b049f57ed51301f832d6c2c0c92ef6cTest

المؤلفون: Burzio, Valentina, Guerini, Paola, Leoni, Maria Chiara, Ottonello, Gaia, Raschetti, Roberto, Zecca, Marco

الوصف: Con il termine Leucemia Mieloide Acuta (LAM) si intende un gruppo eterogeneo di leucemie che origina a par-tire dalla cellula staminale emopoietica orientata in senso mieloide o da progenitori mieloidi. Queste neoplasie derivano dalla trasformazione clonale dei precursori emopoietici indotta dall’acquisizione di riarrangiamenti cromosomici e mutazioni geniche multiple. Le nuove tecnologie hanno permesso di ottenere una comprensione approfondita di queste alterazioni molecolari, un miglioramento della classificazione della LAM in relazione alla prognosi e lo sviluppo di terapie molecolari. Come risultato di una ricerca clinica altamente collaborativa tra i vari gruppi di studio in tutto il mondo, la sopravvivenza libera da malattia di tale patologia è migliorata significa-tivamente nelle ultime tre decadi. Il trapianto di cellule staminali emopoietiche, in combinazione con i farmaci chemio-terapici convenzionali, è il trattamento curativo di maggior successo nella LAM.
Bollettino della Società Medico Chirurgica di Pavia, Vol 123, N° 2 (2010)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bf81150f759fb6bfc17c00c4ad7bf923Test