المؤلفون: van de Vegte, YJ, Eppinga, RN, van der Ende, MY, Hagemeijer, YP, Mahendran, Y, Salfati, E, Smith, AV, Tan, VY, Arking, DE, Ntalla, I, Appel, EV, Schurmann, C, Brody, JA, Rueedi, R, Polasek, O, Sveinbjornsson, G, Lecoeur, C, Ladenvall, C, Zhao, JH, Isaacs, A, Wang, L, Luan, J, Hwang, S-J, Mononen, N, Auro, K, Jackson, AU, Bielak, LF, Zeng, L, Shah, N, Nethander, M, Campbell, A, Rankinen, T, Pechlivanis, S, Qi, L, Zhao, W, Rizzi, F, Tanaka, T, Robino, A, Cocca, M, Lange, L, Müller-Nurasyid, M, Roselli, C, Zhang, W, Kleber, ME, Guo, X, Lin, HJ, Pavani, F, Galesloot, TE, Noordam, R, Milaneschi, Y, Schraut, KE, den Hoed, M, Degenhardt, F, Trompet, S, van den Berg, ME, Pistis, G, Tham, Y-C, Weiss, S, Sim, XS, Li, HL, van der Most, PJ, Nolte, IM, Lyytikäinen, L-P, Said, MA, Witte, DR, Iribarren, C, Launer, L, Ring, SM, de Vries, PS, Sever, P, Linneberg, A, Bottinger, EP, Padmanabhan, S, Psaty, BM, Sotoodehnia, N, Kolcic, I, DCCT/EDIC Research Group, Arnar, DO, Gudbjartsson, DF, Holm, H, Balkau, B, Silva, CT, Newton-Cheh, CH, Nikus, K, Salo, P, Mohlke, KL, Peyser, PA, Schunkert, H, Lorentzon, M, Lahti, J, Rao, DC, Cornelis, MC, Faul, JD, Smith, JA, Stolarz-Skrzypek, K, Bandinelli, S, Concas, MP, Sinagra, G, Meitinger, T, Waldenberger, M, Sinner, MF, Strauch, K, Delgado, GE, Taylor, KD, Yao, J, Foco, L, Melander, O, de Graaf, J, de Mutsert, R, de Geus, EJC, Johansson, Å, Joshi, PK, Lind, L, Franke, A, Macfarlane, PW, Tarasov, KV, Tan, N, Felix, SB, Tai, E-S, Quek, DQ, Snieder, H, Ormel, J, Ingelsson, M, Lindgren, C, Morris, AP, Raitakari, OT, Hansen, T, Assimes, T, Gudnason, V, Timpson, NJ, Morrison, AC, Munroe, PB, Strachan, DP, Grarup, N, Loos, RJF, Heckbert, SR, Vollenweider, P, Hayward, C, Stefansson, K, Froguel, P, Groop, L, Wareham, NJ, van Duijn, CM, Feitosa, MF, O'Donnell, CJ, Kähönen, M, Perola, M, Boehnke, M, Kardia, SLR, Erdmann, J, Palmer, CNA, Ohlsson, C, Porteous, DJ, Eriksson, JG, Bouchard, C, Moebus, S, Kraft, P, Weir, DR, Cusi, D, Ferrucci, L, Ulivi, S, Girotto, G, Correa, A, Kääb, S, Peters, A, Chambers, JC, Kooner, JS, März, W, Rotter, JI, Hicks, AA, Smith, JG, Kiemeney, LALM, Mook-Kanamori, DO, Penninx, BWJH, Gyllensten, U, Wilson, JF, Burgess, S, Sundström, J, Lieb, W, Jukema, JW, Eijgelsheim, M, Lakatta, ELM, Cheng, C-Y, Dörr, M, Wong, T-Y, Sabanayagam, C, Oldehinkel, AJ, Riese, H, Lehtimäki, T, Verweij, N, van der Harst, P

الوصف: Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do not find evidence for a linear or non-linear genetic association between resting heart rate and all-cause mortality in contrast to our previous Mendelian randomization study. Systematic alteration of key differences between the current and previous Mendelian randomization study indicates that the most likely cause of the discrepancy between these studies arises from false positive findings in previous one-sample MR analyses caused by weak-instrument bias at lower P-value thresholds. The results extend our understanding of resting heart rate biology and give additional insights in its role in cardiovascular disease development.

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.ms-excel

العلاقة: https://openaccess.sgul.ac.uk/id/eprint/115488/17/s41467-023-39521-2.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/22/41467_2023_39521_MOESM1_ESM.docxTest; https://openaccess.sgul.ac.uk/id/eprint/115488/24/41467_2023_39521_MOESM2_ESM.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/29/41467_2023_39521_MOESM3_ESM.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/34/41467_2023_39521_MOESM4_ESM.xlsxTest; https://openaccess.sgul.ac.uk/id/eprint/115488/35/41467_2023_39521_MOESM5_ESM.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/1/NCOMMS-22-22457C_Main_paper.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/6/NCOMMS-22-22457C_Figures.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/11/NCOMMS-22-22457C_Supplementary_Information.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/16/NCOMMS-22-22457C_Supplementary_Data.xlsxTest; van de Vegte, YJ; Eppinga, RN; van der Ende, MY; Hagemeijer, YP; Mahendran, Y; Salfati, E; Smith, AV; Tan, VY; Arking, DE; Ntalla, I; et al. van de Vegte, YJ; Eppinga, RN; van der Ende, MY; Hagemeijer, YP; Mahendran, Y; Salfati, E; Smith, AV; Tan, VY; Arking, DE; Ntalla, I; Appel, EV; Schurmann, C; Brody, JA; Rueedi, R; Polasek, O; Sveinbjornsson, G; Lecoeur, C; Ladenvall, C; Zhao, JH; Isaacs, A; Wang, L; Luan, J; Hwang, S-J; Mononen, N; Auro, K; Jackson, AU; Bielak, LF; Zeng, L; Shah, N; Nethander, M; Campbell, A; Rankinen, T; Pechlivanis, S; Qi, L; Zhao, W; Rizzi, F; Tanaka, T; Robino, A; Cocca, M; Lange, L; Müller-Nurasyid, M; Roselli, C; Zhang, W; Kleber, ME; Guo, X; Lin, HJ; Pavani, F; Galesloot, TE; Noordam, R; Milaneschi, Y; Schraut, KE; den Hoed, M; Degenhardt, F; Trompet, S; van den Berg, ME; Pistis, G; Tham, Y-C; Weiss, S; Sim, XS; Li, HL; van der Most, PJ; Nolte, IM; Lyytikäinen, L-P; Said, MA; Witte, DR; Iribarren, C; Launer, L; Ring, SM; de Vries, PS; Sever, P; Linneberg, A; Bottinger, EP; Padmanabhan, S; Psaty, BM; Sotoodehnia, N; Kolcic, I; DCCT/EDIC Research Group; Arnar, DO; Gudbjartsson, DF; Holm, H; Balkau, B; Silva, CT; Newton-Cheh, CH; Nikus, K; Salo, P; Mohlke, KL; Peyser, PA; Schunkert, H; Lorentzon, M; Lahti, J; Rao, DC; Cornelis, MC; Faul, JD; Smith, JA; Stolarz-Skrzypek, K; Bandinelli, S; Concas, MP; Sinagra, G; Meitinger, T; Waldenberger, M; Sinner, MF; Strauch, K; Delgado, GE; Taylor, KD; Yao, J; Foco, L; Melander, O; de Graaf, J; de Mutsert, R; de Geus, EJC; Johansson, Å; Joshi, PK; Lind, L; Franke, A; Macfarlane, PW; Tarasov, KV; Tan, N; Felix, SB; Tai, E-S; Quek, DQ; Snieder, H; Ormel, J; Ingelsson, M; Lindgren, C; Morris, AP; Raitakari, OT; Hansen, T; Assimes, T; Gudnason, V; Timpson, NJ; Morrison, AC; Munroe, PB; Strachan, DP; Grarup, N; Loos, RJF; Heckbert, SR; Vollenweider, P; Hayward, C; Stefansson, K; Froguel, P; Groop, L; Wareham, NJ; van Duijn, CM; Feitosa, MF; O'Donnell, CJ; Kähönen, M; Perola, M; Boehnke, M; Kardia, SLR; Erdmann, J; Palmer, CNA; Ohlsson, C; Porteous, DJ; Eriksson, JG; Bouchard, C; Moebus, S; Kraft, P; Weir, DR; Cusi, D; Ferrucci, L; Ulivi, S; Girotto, G; Correa, A; Kääb, S; Peters, A; Chambers, JC; Kooner, JS; März, W; Rotter, JI; Hicks, AA; Smith, JG; Kiemeney, LALM; Mook-Kanamori, DO; Penninx, BWJH; Gyllensten, U; Wilson, JF; Burgess, S; Sundström, J; Lieb, W; Jukema, JW; Eijgelsheim, M; Lakatta, ELM; Cheng, C-Y; Dörr, M; Wong, T-Y; Sabanayagam, C; Oldehinkel, AJ; Riese, H; Lehtimäki, T; Verweij, N; van der Harst, P (2023) Genetic insights into resting heart rate and its role in cardiovascular disease. Nat Commun, 14 (1). p. 4646. ISSN 2041-1723 https://doi.org/10.1038/s41467-023-39521-2Test SGUL Authors: Strachan, David Peter

الإتاحة: https://doi.org/10.1038/s41467-023-39521-2Test
https://openaccess.sgul.ac.uk/id/eprint/115488Test/
https://openaccess.sgul.ac.uk/id/eprint/115488/17/s41467-023-39521-2.pdfTest
https://openaccess.sgul.ac.uk/id/eprint/115488/22/41467_2023_39521_MOESM1_ESM.docxTest
https://openaccess.sgul.ac.uk/id/eprint/115488/24/41467_2023_39521_MOESM2_ESM.pdfTest
https://openaccess.sgul.ac.uk/id/eprint/115488/29/41467_2023_39521_MOESM3_ESM.pdfTest
https://openaccess.sgul.ac.uk/id/eprint/115488/34/41467_2023_39521_MOESM4_ESM.xlsxTest
https://openaccess.sgul.ac.uk/id/eprint/115488/35/41467_2023_39521_MOESM5_ESM.pdfTest
https://openaccess.sgul.ac.uk/id/eprint/115488/1/NCOMMS-22-22457C_Main_paper.pdfTest
https://openaccess.sgul.ac.uk/id/eprint/115488/6/NCOMMS-22-22457C_Figures.pdfTest

المؤلفون: Ormel, J.

المصدر: Ormel , J 2023 , ' Meer behandeling, maar niet minder depressie; een ongemakkelijke paradox ' , Tijdschrift voor Psychiatrie , vol. 65 , no. 8 , pp. 484-490 . < https://www-tijdschriftvoorpsychiatrie-nl.proxy-ub.rug.nl/nl/artikelen/article/50-13210_Meer-behandeling-maar-niet-minder-depressie-een-ongemakkelijke-paradox#:~:text=Gegevens%20over%20de%20prevalentie%20en,behandeling,%20maar%20niet%20minder%20depressie.&text=Zowel%20de%20uitgaven%20voor,%20als,sterk%20gestegen%20in%20westerse%20landenTest. >

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/40d78f77-b60d-4cdf-bbba-373ae06509eeTest

الإتاحة: https://hdl.handle.net/11370/40d78f77-b60d-4cdf-bbba-373ae06509eeTest
https://research.rug.nl/en/publications/40d78f77-b60d-4cdf-bbba-373ae06509eeTest
https://pure.rug.nl/ws/files/918483794/65-2023-8-artikelTest-ormel.pdf
http://www.scopus.com/inward/record.url?scp=85172012408&partnerID=8YFLogxKTest
https://www-tijdschriftvoorpsychiatrie-nl.proxy-ub.rug.nl/nl/artikelen/article/50-13210_Meer-behandeling-maar-niet-minder-depressie-een-ongemakkelijke-paradox#:~:text=Gegevens%20over%20de%20prevalentie%20en,behandeling,%20maar%20niet%20minder%20depressie.&text=Zowel%20de%20uitgaven%20voor,%20als,sterk%20gestegen%20in%20westerse%20landenTest.

المؤلفون: Hopwood, Christopher J, Kotov, Roman, Krueger, Robert F, Watson, David, Widiger, Thomas A, Althoff, Robert R, Ansell, Emily B, Bach, Bo, Bagby, R Michael, Blais, Mark A, Bornovalova, Marina A, Chmielewski, Michael, Cicero, David C, Conway, Christopher, De Clercq, Barbara, De Fruyt, Filip, Docherty, Anna R, Eaton, Nicholas R, Edens, John F, Forbes, Miriam K, Forbush, Kelsie T, Hengartner, Michael P, Ivanova, Masha Y, Leising, Daniel, Livesley, W John, Lukowitsky, Mark R, Lynam, Donald R, Markon, Kristian E, Miller, Joshua D, Morey, Leslie C, Mullins‐Sweatt, Stephanie N, Ormel, J Hans, Patrick, Christopher J, Pincus, Aaron L, Ruggero, Camilo, Samuel, Douglas B, Sellbom, Martin, Slade, Tim, Tackett, Jennifer L, Thomas, Katherine M, Trull, Timothy J, Vachon, David D, Waldman, Irwin D, Waszczuk, Monika A, Waugh, Mark H, Wright, Aidan GC, Yalch, Mathew M, Zald, David H, Zimmermann, Johannes

المصدر: Personality and Mental Health. 12(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical and Health Psychology, Social and Personality Psychology, Clinical Sciences, Psychology, Humans, International Classification of Diseases, Personality Disorders, Public Health and Health Services, Clinical sciences, Clinical and health psychology, Social and personality psychology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4gn754q6Test

المؤلفون: Demontis, D, Walters, RK, Martin, J, Mattheisen, M, Als, TD, Agerbo, E, Baldursson, G, Belliveau, R, Bybjerg-Grauholm, J, Baekvad-Hansen, M, Cerrato, F, Chambert, K, Churchhouse, C, Dumont, A, Eriksson, N, Gandal, M, Goldstein, JI, Grasby, KL, Grove, J, Gudmundsson, OO, Hansen, CS, Hauberg, ME, Hollegaard, MV, Howrigan, DP, Huang, H, Maller, JB, Martin, AR, Martin, NG, Moran, J, Pallesen, J, Palmer, DS, Pedersen, CB, Pedersen, MG, Poterba, T, Poulsen, JB, Ripke, S, Robinson, EB, Satterstrom, FK, Stefansson, H, Stevens, C, Turley, P, Walters, GB, Won, H, Wright, MJ, Andreassen, OA, Asherson, P, Burton, CL, Boomsma, DI, Cormand, B, Dalsgaard, S, Franke, B, Gelernter, J, Geschwind, D, Hakonarson, H, Haavik, J, Kranzler, HR, Kuntsi, J, Langley, K, Lesch, KP, Middeldorp, C, Reif, A, Rohde, LA, Roussos, P, Schachar, R, Sklar, P, Sonuga-Barke, EJS, Sullivan, PF, Thapar, A, Tung, JY, Waldman, ID, Medland, SE, Stefansson, K, Nordentoft, M, Hougaard, DM, Werge, T, Mors, O, Mortensen, PB, Daly, MJ, Faraone, SV, Borglum, AD, Neale, BM, Albayrak, O, Anney, RJL, Arranz, MJ, Banaschewski, TJ, Bau, C, Biederman, J, Buitelaar, JK, Casas, M, Charach, A, Crosbie, J, Dempfle, A, Doyle, AE, Ebstein, RP, Elia, J, Freitag, C, Focker, M, Gill, M, Grevet, E, Hawi, Z, Hebebrand, J, Herpertz-Dahlmann, B, Hervas, A, Hinney, A, Hohmann, S, Holmans, P, Hutz, M, Ickowitz, A, Johansson, S, Kent, L, Kittel-Schneider, S, Lambregts-Rommelse, N, Lehmkuhl, G, Loo, SK, McGough, JJ, Meyer, J, Mick, E, Middletion, F, Miranda, A, Mota, NR, Mulas, F, Mulligan, A, Nelson, F, Nguyen, TT, Oades, RD, O'Donovan, MC, Owen, MJ, Palmason, H, Ramos-Quiroga, JA, Renner, TJ, Ribases, M, Rietschel, M, Rivero, O, Romanos, J, Romanos, M, Rothenberger, A, Royers, H, Sanchez-Mora, C, Scherag, A, Schimmelmann, BG, Schafer, H, Sergeant, J, Sinzig, J, Smalley, SL, Steinhausen, HC, Thompson, M, Todorov, A, Vasquez, AA, Walitza, S, Wang, YF, Warnke, A, Williams, N, Witt, SH, Yang, L, Zayats, T, Zhang-James, Y, Smith, GD, Davies, GE, Ehli, EA, Evans, DM, Fedko, IO, Greven, CU, Groen-Blokhuis, MM, Guxens, M, Hammerschlag, AR, Hartman, CA, Heinrich, J, Hottenga, JJ, Hudziak, J, Jugessur, A, Kemp, JP, Krapohl, E, Murcia, M, Myhre, R, Nolte, IM, Nyholt, DR, Ormel, J, Ouwens, KG, Pappa, I, Pennell, CE, Plomin, R, Ring, S, Standl, M, Stergiakouli, E, St Pourcain, B, Stoltenberg, C, Sunyer, J, Thiering, E, Tiemeier, H, Tiesler, CMT, Timpson, NJ, Trzaskowski, M, van der Most, PJ, Vilor-Tejedor, N, Wang, CA, Whitehouse, AJO, Zhao, HY, Agee, M, Alipanahi, B, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Furlotte, NA, Hinds, DA, Hromatka, BS, Huber, KE, Kleinman, A, Litterman, NK, McIntyre, MH, Mountain, JL, Northover, CAM, Pitts, SJ, Sathirapongsasuti, JF, Sazonova, OV, Shelton, JF, Shringarpure, S, Tian, C, Vacic, V, Wilson, CH

المصدر: Nature genetics. 51(1):63

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:139854823Test

المؤلفون: Meeus, Wim, Vollebergh, Wilma, Branje, Susan, Crocetti, Elisabetta, Ormel, J., van de Schoot, R., Crone, Eveline A, Becht, Andrik

المساهمون: Adolescent development: Characteristics and determinants, Leerstoel Branje, Youth in Changing Cultural Contexts, Leerstoel Vollebergh, Leerstoel Schoot, Methodology and statistics for the behavioural and social sciences

مصطلحات موضوعية: Adolescent risk, Developmental trajectories, Dual systems models, Imbalance hypothesis, Substance use, Social Psychology, Education, Developmental and Educational Psychology, Social Sciences (miscellaneous)

الوصف: Heterogeneity in development of imbalance between impulse control and sensation seeking has not been studied until now. The present study scrutinized this heterogeneity and the link between imbalance and adolescent risk. Seven-wave data of 7,558 youth (50.71% males; age range from 12/13 until 24/25) were used. Three developmental trajectories were identified. The first trajectory, “sensation seeking to balanced sensation seeking”, included participants with a higher level of sensation seeking than impulse control across all ages. The second trajectory, “moderate dominant control”, included participants showing moderate and increasing impulse control relative to sensation seeking across all ages. The third trajectory, “strong late dominant control”, included participants showing the highest level of impulse control which was about as strong as sensation seeking from early to middle adolescence and became substantially stronger from late adolescence to early adulthood. Although the systematic increase of impulse control in all subgroups is in line with both models, neither of these combined trajectories of control and sensation seeking was predicted by the Dual Systems Model or the Maturational Imbalance Model. Consistent with both models the “sensation seeking to balanced sensation seeking” trajectory showed the highest level of substance use. It can be concluded that, even though both theories adequately predict the link between imbalance and risk, neither the Dual Systems Model nor the Maturational Imbalance Model correctly predict the heterogeneity in development of imbalance between impulse control and sensation seeking.

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/411665Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/411665Test

المؤلفون: Meeus, W. (Wim), Vollebergh, W.A.M. (Wilma), Branje, S.J.T. (Susan), Crocetti, E. (Elisabetta), Ormel, J. (Johan), Schoot, R. (Rens) van de, Crone, E.A. (Eveline), Becht, A.I. (Andrik)

المصدر: Journal of Youth and Adolescence

مصطلحات موضوعية: Dual systems models ● Imbalance hypothesis ● Developmental trajectories ● Substance use ● Adolescent risk

الوصف: Heterogeneity in development of imbalance between impulse control and sensation seeking has not been studied until now. The present study scrutinized this heterogeneity and the link between imbalance and adolescent risk. Seven-wave data of 7,558 youth (50.71% males; age range from 12/13 until 24/25) were used. Three developmental trajectories were identified. The first trajectory, “sensation seeking to balanced sensation seeking”, included participants with a higher level of sensation seeking than impulse control across all ages. The second trajectory, “moderate dominant control”, included participants showing moderate and increasing impulse control relative to sensation seeking across all ages. The third trajectory, “strong late dominant control”, included participants showing the highest level of impulse control which was about as strong as sensation seeking from early to middle adolescence and became substantially stronger from late adolescence to early adulthood. Although the systematic increase of impulse control in all subgroups is in line with both models, neither of these combined trajectories of control and sensation seeking was predicted by the Dual Systems Model or the Maturational Imbalance Model. Consistent with both models the “sensation seeking to balanced sensation seeking” trajectory showed the highest level of substance use. It can be concluded that, even though both theories adequately predict the link between imbalance and risk, n

وصف الملف: application/pdf

العلاقة: http://repub.eur.nl/pub/135333Test; urn:hdl:1765/135333

الإتاحة: https://doi.org/10.1007/s10964-021-01419-xTest
http://repub.eur.nl/pub/135333Test

المؤلفون: Krueger, RF, Kotov, R, Watson, D, Forbes, MK, Eaton, NR, Ruggero, CJ, Simms, LJ, Widiger, TA, Achenbach, TM, Bach, B, Bagby, RM, Bornovalova, MA, Carpenter, WT, Chmielewski, M, Cicero, DC, Clark, LA, Conway, C, DeClercqq, B, DeYoung, CG, Docherty, AR, Drislane, LE, First, MB, Forbush, KT, Hallquist, M, Haltigan, JD, Hopwood, CJ, Ivanova, MY, Jonas, KG, Latzman, RD, Markon, KE, Miller, JD, Morey, LC, Mullins-Sweatt, SN, Ormel, J, Patalay, P, Patrick, CJ, Pincus, AL, Regier, DA, Reininghaus, U, Rescorla, LA, Samuel, DB, Sellbom, M, Shackman, AJ, Skodol, A, Slade, T, South, SC, Sunderland, M, Tackett, JL, Venables, NC, Waldman, ID, Waszczuk, MA, Waugh, MH, Wright, AGC, Zald, DH, Zimmermann, J

المصدر: Annales Médico-psychologiques, revue psychiatrique , 179 (1) pp. 95-106. (2021)

مصطلحات موضوعية: Science & Technology, Social Sciences, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Psychiatry, Psychology, Multidisciplinary, Classification, Clinical utility, Dimensions, DSM, Hierarchical taxonomy of psychopathology, ICD, Mental disorder, Nosology, Personality, Psychopathology, RDoC, PERSONALITY-DISORDER, EMOTIONAL DISORDERS, EXTERNALIZING PSYCHOPATHOLOGY, HIERARCHICAL STRUCTURE, TAXOMETRIC EVIDENCE, META-STRUCTURE, SUBSTANCE USE, MODEL, VALIDITY, SYMPTOMS

الوصف: Résumé: Les lacunes des classifications de la psychopathologie fondées sur des consensus d’experts ont conduit à de nombreuses tentatives actuelles pour classer la psychopathologie de manière quantitative. Dans cet article, nous passons en revue les progrès accomplis dans la réalisation d’une classification quantitative et empirique de la psychopathologie. Une littérature empirique substantielle montre que la psychopathologie est généralement plus dimensionnelle que catégorielle. Et lorsque la distinction entre une psychopathologie discrète et une psychopathologie continue est traitée comme une question de recherche, par opposition à une distinction basée sur un argument d’autorité, alors les preuves scientifiques soutiennent clairement l’hypothèse d’une psychopathologie continue. En outre, un corpus de littérature connexe montre comment les dimensions de la psychopathologie peuvent être organisées selon une hiérarchie qui va de dimensions très larges d’un niveau de type « spectre » à des groupes spécifiques et étroits de symptômes. De cette manière, une approche quantitative résout le « problème de la comorbidité » en modélisant explicitement la cooccurrence entre les signes et les symptômes au sein d’une hiérarchie détaillée et variée, maniant des concepts dimensionnels qui ont une utilité clinique directe. De nombreuses preuves concernant la structure dimensionnelle et hiérarchique de la psychopathologie ont conduit à la formation du consortium Hierarchical Taxonomy of Psychopathology (HiTOP, taxonomie hiérarchique de la psychopathologie). Il s’agit d’un groupe de 70 chercheurs travaillant ensemble pour étudier la classification empirique de la psychopathologie. Dans cet article, nous décrivons les objectifs et les axes de recherches actuels du consortium HiTOP. Ces objectifs concernent la poursuite des recherches sur l’organisation empirique de la psychopathologie ; le lien entre la personnalité et la psychopathologie ; l’utilité des construits empiriques de la psychopathologie, à la fois pour la recherche ...

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10142303/1/nihms-1721484.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10142303Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10142303/1/nihms-1721484.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10142303Test/

المؤلفون: Ormel, J., Oerlemans, A.M., Raven, D., Oldehinkel, A.J., Laceulle, O.M.

المساهمون: Leerstoel Thomaes, Social and personality development: A transactional approach

مصطلحات موضوعية: adolescence, mental disorder, neuroticism, personality development, personality-psychopathology models, psychopathology, self-control, Taverne, Clinical Psychology

الوصف: The experience of a mental disorder may affect the development of personality in multiple ways, but empirical evidence regarding psychopathology effects on personality development that persist after remission of the disorder is limited and inconsistent. In the longitudinal cohort TRacking Adolescents’ Individual Lives Survey (TRAILS), mental disorders during adolescence were assessed using the Composite International Diagnostic Interview and parent-reported effortful control, fearfulness, and frustration at age 11 and age 19 through the Early Adolescent Temperament Questionnaire. We found that adolescent mental disorders had small effects on personality change. Internalizing disorders predicted increases of fearfulness and frustration but hardly affected effortful control; externalizing disorders were unrelated to frustration and fearfulness but predicted a decrease of effortful control. Whereas fearfulness and frustration partially caught up after disorder remission, virtually all delay in effortful control was still present 2.9 years later, suggesting scarring effects.

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/409476Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/409476Test

المؤلفون: Waszczuk, M.A., Eaton, N.R., Krueger, R.F., Shackman, A.J., Waldman, I.D., Zald, D.H., Lahey, B.B., Patrick, C.J., Conway, C.C., Ormel, J., Hyman, S.E., Fried, E.I., Forbes, M.K., Docherty, A.R., Althoff, R.R., Bach, B., Chmielewski, M., DeYoung, C.G., Forbush, K.T., Hallquist, M., Hopwood, C.J., Ivanova, M.Y., Jonas, K.G., Latzman, R.D., Markon, K.E., Mullins-Sweatt, S.N., Pincus, A.L., Reininghaus, U., South, S.C., Tackett, J.L., Watson, D., Wright, A.G.C., Kotov, R.

المصدر: Waszczuk , M A , Eaton , N R , Krueger , R F , Shackman , A J , Waldman , I D , Zald , D H , Lahey , B B , Patrick , C J , Conway , C C , Ormel , J , Hyman , S E , Fried , E I , Forbes , M K , Docherty , A R , Althoff , R R , Bach , B , Chmielewski , M , DeYoung , C G , Forbush , K T , Hallquist , M , Hopwood , C ....

مصطلحات موضوعية: behavior genetics, comorbidity, deficit hyperactivity disorder, dsm-iv criteria, eating-disorders, environmental risk-factors, general factor, genome-wide association, major depression, molecular genetics, nosology, personality-disorder, polygenic risk, population-based sample, substance use disorders

الوصف: Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven classification system proposed by the Hierarchical Taxonomy of Psychopathology (HiTOP) consortium provides a more effective approach to identifying genes that underlie mental disorders, and to studying psychiatric etiology, than current diagnostic categories. Specifically, genes are expected to operate at different levels of the HiTOP hierarchy, with some highly pleiotropic genes influencing higher order psychopathology (e.g., the general factor), whereas other genes conferring more specific risk for individual spectra (e.g., internalizing), subfactors (e.g., fear disorders), or narrow symptoms (e.g., mood instability). We propose that the HiTOP model aligns well with the current understanding of the higher order genetic structure of psychopathology that has emerged from a large body of family and twin studies. We also discuss the convergence between the HiTOP model and findings from recent molecular studies of psychopathology indicating broad genetic pleiotropy, such as cross-disorder SNP-based shared genetic covariance and polygenic risk scores, and we highlight molecular genetic studies that have successfully redefined phenotypes to enhance precision and statistical power. Finally, we suggest how to integrate a HiTOP approach into future molecular genetic research, including quantitative and hierarchical assessment tools for future data-collection and recommendations concerning phenotypic analyses.

الإتاحة: https://doi.org/10.1037/abn0000486Test
https://cris.maastrichtuniversity.nl/en/publications/cd9e2d12-f2cd-4aa8-90f5-a63c8cc32fdfTest

المؤلفون: Ormel, J, Ruhé, H G, Bockting, C L H, Nolen, W, Schene, A H, Spijker, J, Ten Doesschate, M, Cramer, A O J, Verhaak, P, Spinhoven, P

المصدر: Ormel , J , Ruhé , H G , Bockting , C L H , Nolen , W , Schene , A H , Spijker , J , Ten Doesschate , M , Cramer , A O J , Verhaak , P & Spinhoven , P 2020 , ' Antidepressiva : al decennia voor­geschreven én toch nog steeds bekritiseerd; een perspectief op oorzaken en oplossingen ' , Tijdschrift voor Psychiatrie , vol. 62 , no. 3 , pp. 213-222 . < https://www.tijdschriftvoorpsychiatrie.nl/issues/550/articles/12140Test >

الوصف: BACKGROUND: From around 1980, antidepressants (ad) have increasingly been prescribed, for longer periods of time, especially selective serotonin reuptake inhibitors (ssris). Paradoxically, their effectiveness is still doubted, especially outside the psychiatric profession. AIM: To explain increase and offer a perspective on causes and solutions, and to indicate how to reach consensus. METHOD: Position paper with critical analysis and synthesis of relevant literature. RESULTS: The rise in AD prescriptions results from: 1. increased safety and ease of prescribing, 2. increased presentation and recognition of depression in primary care, 3. extension of indication criteria, 4. effective marketing strategies, and 5. effectiveness in acute phase (aad) and of relapse/recurrence prevention in continuation/maintenance phases (coad).Critics point to: 1. low added value of aad relative to placebo, 2. many drop-outs and non-responders, 3. relapse/recurrence prevention with coad works only for responders to aad, 4. relapse/recurrence after AD discontinuation often involves withdrawal symptoms, and 5. publication bias, selective reporting, selective patient selection, and suboptimal blinding, resulting in overestimated effectiveness and underestimated disadvantages.Factors that keep fueling the controversy are: 1. critics stress the net effectiveness of AD whereas proponents point at gross effectiveness which includes spontaneous recovery and placebo effect; 2. persistence of distrust in industry-funded rcts; 3. ideological positions, reinforced by conflicts of interest and selective citations; 4. lack of rcts with relevant long-term outcome measurements. CONCLUSION: Although consensus is difficult to achieve given the ideological component, there are options. Three factors are critically important: confer to establish which data convince the opposition, response prediction (what works for whom), and rcts with long-term functional outcomes.

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/c4c70653-6153-4d7e-9d9a-8f31d6fb16fbTest

الإتاحة: https://hdl.handle.net/11370/c4c70653-6153-4d7e-9d9a-8f31d6fb16fbTest
https://research.rug.nl/en/publications/c4c70653-6153-4d7e-9d9a-8f31d6fb16fbTest
https://pure.rug.nl/ws/files/128945364/62_2020_3_artikel_ormel.pdfTest
https://www.tijdschriftvoorpsychiatrie.nl/issues/550/articles/12140Test