المؤلفون: Khouloud Ferchichi, Imen Aouinti, Ahmed Zaiem, Ghozlane Lakhoua, Widd Kaabi, Ons Charfi, Sarrah Kastalli, Riadh Daghfous, Sihem El Aidli

المصدر: Clinical Immunology Communications, Vol 2, Iss , Pp 162-164 (2022)

مصطلحات موضوعية: Myocarditis, Coronavirus vaccine, mRNA vaccine, Adverse drug event, Immunologic diseases. Allergy, RC581-607

الوصف: Introduction: Myocarditis is an adverse reaction discovered after the marketing of SARS-CoV-2 mRNA vaccines. Nevertheless, this effect is not mentioned as an adverse reaction in the summary of product characteristics of other types of vaccines against this disease. Objective: In this work, we aim to present the cases of myocarditis after vaccination against COVID-19 reported to the national Tunisian centre of pharmacovigilance. Method: We present the cases of myocarditis reported after the COVID-19 vaccination. All cases are diagnosed according to Brighton's case definition of myocarditis. The vaccines causality assessment was estimated by the French imputability updated method of Bégaud et al. Results: We included five patients. The sex ratio (M/F) was 4. The mean age was 30 years. All patients had no notable cardiovascular history and did not report any significant past medical history. The onset of symptoms was two days post-vaccination in three patients. The predominant reported symptoms are chest pain and dyspnea in the five cases. Cardiac magnetic resonance imaging (MRI) confirmed the myocarditis diagnosis in four patients (not performed for one patient).All cases were classified as definitive cases according to the Brighton case definition of myocarditis. No patient required hospitalization in a cardiac intensive care unit. All the patients recovered from acute myocarditis within a few days. Conclusion: Reported cases of myocarditis post-COVID-19 vaccination in our population are rare, not severe, and have a quick favorable outcome.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2772613422000270Test; https://doaj.org/toc/2772-6134Test

الوصول الحر: https://doaj.org/article/e5666125a7fc4c689f5e3ce9bebb4122Test

المؤلفون: N. Litaiem, Ons Charfi, Sami Ouanes, S. Gara, Faten Zéglaoui

مصطلحات موضوعية: Melanin Pigmentation in Mammalian Skin, Cell Biology, Biochemistry, Genetics and Molecular Biology, Life Sciences, Olfactory Dysfunction in Health and Disease, Sensory Systems, Neuroscience, Role of Mast Cells in Immunoregulation and Disease, Immunology, FOS Clinical medicine, Immunology and Microbiology, Vitiligo, Temperament, Psychology, FOS Psychology, Stressor, Clinical psychology, Quality of life healthcare, Disease, Personality, Cross-sectional study, Psychiatry, Medicine, Internal medicine, Dermatology, Pathology, Psychotherapist, Social psychology

الوصف: Vitiligo is a skin disease associated with significant psychiatric comorbidities. Affective temperaments represent the inherited foundation of personality and represent the biologically stable part of emotional reactivity. Studies assessing the temperament profile of patients with vitiligo are still scarce.This was a cross-sectional study enrolling 34 patients with vitiligo and 34 age and sex-matched healthy controls. Affective temperament profile was investigated using the Temperament Evaluation of Memphis, Paris, and San Diego Auto-questionnaire. Dermatology life quality index was used to evaluate disease impact on patients' quality of life.We found significant differences with vitiligo patients scoring higher in anxious (11.5 ± 4.76 vs. 9.06 ± 6.22; p = 0.036) and lower in hyperthymic (5.79 ± 3.82 vs. 7.5 ± 3.64; p = 0.027) temperaments. Vitiligo worsening reported by patients was associated with recent psychological stressors in 18 cases (52.9%) and Koebner phenomenon in 20 cases (58.8%). Koebner ... : البهاق هو مرض جلدي مرتبط بأمراض نفسية مصاحبة كبيرة. تمثل المزاجات العاطفية الأساس الموروث للشخصية وتمثل الجزء المستقر بيولوجيًا من التفاعل العاطفي. لا تزال الدراسات التي تقيم الحالة المزاجية للمرضى المصابين بالبهاق نادرة. كانت هذه دراسة مستعرضة تسجل 34 مريضًا يعانون من البهاق و 34 ضوابط صحية متطابقة مع العمر والجنس. تم التحقيق في الحالة المزاجية العاطفية باستخدام تقييم الحالة المزاجية لسؤال ممفيس وباريس وسان دييغو التلقائي. تم استخدام مؤشر جودة حياة الأمراض الجلدية لتقييم تأثير المرض على نوعية حياة المرضى. وجدنا اختلافات كبيرة مع مرضى البهاق الذين سجلوا درجات أعلى في القلق (11.5 ± 4.76 مقابل 9.06 ± 6.22 ؛ p = 0.036) وأقل في فرط التوتر (5.79 ± 3.82 مقابل 7.5 ± 3.64 ؛ p = 0.027). ارتبط تفاقم البهاق الذي أبلغ عنه المرضى بالضغوط النفسية الأخيرة في 18 حالة (52.9 ٪) وظاهرة كوبنر في 20 حالة (58.8 ٪). ارتبطت ظاهرة كوبنر في كثير من الأحيان بمزاج فرط النشاط (p = 0.035). ارتبط المزاج الدوري بشكل إيجابي بمؤشر جودة حياة الأمراض الجلدية (rho = 0.417، p = 0.014). أظهرت هذه الدراسة أن المرضى الذين يعانون من البهاق لديهم ...

العلاقة: https://dx.doi.org/10.60692/29t8n-k8647Test

الإتاحة: https://doi.org/10.60692/ypbzt-8fn3010.60692/29t8n-k8647Test

المؤلفون: Imen Aouinti, Widd Kaabi, Syrine Ben Hammamia, Riadh Daghfous, Ghozlane Lakhoua, Sihem El Aïdli, Ahmed Zaiem, Sarrah Kastalli, Ons Charfi

المصدر: Current Drug Safety. 18:264-266

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, business.industry, Antifungal drug, Toxicology, medicine.disease, Rash, Dermatology, Nephrotoxicity, Drug Hypersensitivity Syndrome, Amphotericin B, medicine, Eosinophilia, Pharmacology (medical), medicine.symptom, business, Adverse drug reaction, Kidney transplantation, medicine.drug

الوصف: Introduction: Liposomal amphotericin B is a widely used broad-spectrum antifungal drug. It was developed to reduce nephrotoxicity and maximize the therapeutic utility of amphotericin B in the treatment of invasive fungal infections. Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe drug-induced hypersensitivity syndrome commonly associated with aromatic antiepileptic drugs. Liposomal amphotericin-B was associated with DRESS syndrome in only one case. Case Report: We report an exceptional case of possible DRESS syndrome associated with liposomal amphotericin B in a 31-year-old male renal transplant recipient. Seventeen days after starting liposomal amphotericin B for visceral leishmaniosis, he developed a skin rash with elevated liver tests. Liposomal amphotericin B was then discontinued. A favourable outcome was slowly observed in one month. Results and Conclusion: This case scored two (possible case) based on the criteria adopted by the European group RegiSCAR. The Naranjo score for liposomal amphotericin B was four (possible).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fcd69058b5b51208afff5c1f9910def0Test
https://doi.org/10.2174/1574886316666210727145646Test

المؤلفون: Syrine Ben-Hammamia, Ons Charfi, Anis Belhadj, Amal Bouchrika, Faouzi Chebbi, Ghozlane Lakhoua, Sihem El Aidli

المصدر: Current Drug Safety. 18:267-269

مصطلحات موضوعية: Pharmacology, Pharmacology (medical), Toxicology

الوصف: Background: Acenocoumarol is an anticoagulant with numerous drug reactions. We report here, an unusual interaction between acenocoumarol and azathioprine. Case Presentation: A 35-year-old woman, treated with acenocoumarol for thrombosis of the superior mesenteric vein, was prescribed azathioprine for Crohn’s disease. Three days later, INR values decreased from 2.36 to 1.48. The dose of acenocoumarol had to almost be doubled to reach an INR value of 2.56. The interaction between azathioprine and acenocoumarol was then suspected. Few similar cases of interactions between azathioprine and another coumarin derivative, warfarin, have been reported. To our knowledge, this is the second case of such interaction reported with acenocoumarol in literature. Conclusion: Thus, despite the rarity of this interaction reporting, we draw attention to the importance of close monitoring of INR values in patients treated with acenocoumarol associated with azathioprine.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b481795ee34f0fde6f0873771ca1024cTest
https://doi.org/10.2174/1574886317666220425113613Test

المؤلفون: Khouloud Berrim, Ghozlane Lakhoua, Ahmed Zaiem, Ons Charfi, Imen Aouinti, Sarrah Kastalli, Riadh Daghfous, Sihem El Aidli

المصدر: British Journal of Clinical Pharmacology. 89:574-578

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0e994b838a4d0d8684782bedfe811907Test
https://doi.org/10.1111/bcp.15601Test

المؤلفون: Ghozlane Lakhoua, Khouloud Berrim, Ons Charfi, Widd Kaabi, Ahmed Zaiem, Sarrah Kastalli, Riadh Daghfous, Sihem El Aidli

المصدر: Therapies. 77:627-630

مصطلحات موضوعية: Pharmacology (medical)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a3cf8c8212be60995207ece2b035b5bbTest
https://doi.org/10.1016/j.therap.2022.01.013Test

المؤلفون: Habiba Mizouni, Sarrah Kastalli, Sihem El Aïdli, Talel Badri, Fares Ben Salem, Imen Aouinti, Ahmed Zaiem, Ons Charfi, Syrine Ben Hammamia, Ghozlane Lakhoua

المصدر: Current Drug Safety. 17:169-175

مصطلحات موضوعية: medicine.medical_specialty, Allergy, Iodine Compounds, Contrast Media, Toxicology, In vivo tests, Drug Hypersensitivity, Iodinated contrast media, medicine, Humans, Pharmacology (medical), reproductive and urinary physiology, Retrospective Studies, Skin Tests, Pharmacology, business.industry, Iopromide, Retrospective cohort study, medicine.disease, Dermatology, Hypersensitivity reaction, embryonic structures, Intradermal test, Premedication, business, medicine.drug

الوصف: Background: Iodinated contrast media (ICM) are responsible for multiple side effects, especially hypersensitivity reactions. These reactions can either be authentic allergies or non-allergic hypersensitivity reactions. Skin tests (prick and intradermal tests) are simple to perform and can be of great help, especially if the ICM needs to be re-used. The aim of the study was to assess the characteristics of the patients in whom skin tests were performed and the results of these tests. Methods: This is a retrospective study from June 2014 to June 2019. All included patients had at least one episode of hypersensitivity reaction to ICM and underwent skin tests. Results: We included 35 patients aged 18 to 85 years. The iopromide was the most implicated ICM. The reactions were mainly cutaneous (n=30) and immediate (n=27). The skin tests were negative, except for two patients. The re-use of ICM occurred in 11 patients: 9 with an ICM other than the one suspected and two patients with the same ICM. Among these patients, 5 did not have any premedication. Two of them had a second hypersensitivity reaction, the first with another ICM and the second with the same ICM. Conclusion: One of the main pillars of allergic exploration is ICM skin testing, not only to prevent a recurrence, but also to allow patients to benefit from ICM re-use, which are sometimes essential.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b031c255d180a3f06a39755238b20ff1Test
https://doi.org/10.2174/1574886316666210923143012Test

المؤلفون: Ines Souilem, Imen Aouinti, Ahmed Zaiem, Ons Charfi, Widd Kaabi, Sarrah Kastalli, Riadh Daghfous, Ghozlane Lakhoua, Sihem El Aidli

الوصف: Acenocoumarol is the most widely prescribed vitamin K antagonist (VKA) to prevent and treat thromboembolic disorders. It keeps a major place in many indications despite the introduction of new direct oral anticoagulants (DOACs). However, a narrow therapeutic range, an intra-individual variability and drug interactions may lead to serious adverse drug reactions. Sometimes, a genetic or acquired resistance to this drug may lead to a risky situation. Hopefully, resistance to acenocoumarol is a very rare phenomen. Here in we present an unsusual case of a suspected resistance to acenocoumarol. This case was notified to the Tunisian National Center of Pharmacovigilance on October 2017 and registered under the number 2449/2017. A 67-year-old patient with hypertension, diabetes, and coronary disease was treated with captopril, atenolol, atorvastatin, and salicylic acid. In 2017, acenocoumarol treatment was introduced. At biological control, the prothrombin time (PT) was 100%. The doses of acenocoumarol were raised progressively with iterative controls of PT. PT was always 100% even when acenocoumarol reached the dose of 2 g/day. A resistance to acenocoumarol was suspected. The patient was referred to pharmacovigilance department for case analysis. During the patient interview, we discover that the patient was confusing acenocoumarol with atenolol. In fact, when his doctor was increasing the doses of acenocoumarol, the patient increased her intake of atenolol believing that it was acenocoumarol. A resistance to acenocoumarol was eliminated in this patient since she had never taken the drug. We highlight through this case the importance of patient’s interview. Explaining the indications and the potential adverse events of the drug to patients taking VKA is crucial to ensure a better efficiency of treatment without increasing the risk of bleeding complication.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::98f193533328f27a28f0b9cdaf44e09aTest
https://doi.org/10.22541/au.168062646.60217403/v1Test

المؤلفون: Ines Souilem, Ghozlane Lakhoua, Ons Charfi, Ahmed Zaiem, Riadh Daghfous, Sihem El Aidli

الوصف: Iopromide is one of the latest generations of non-ionic monomers (NIM) iodinated contrast media (CM). Its use is generally considered to be safe but can occasionally results in adverse events. The frequency of late adverse reactions to non-ionic monomers is between 0.52 and 23%. Delayed adverse reactions mainly manifest as skin reactions such as erythema, maculopapular exanthema and exceptionally as fixed drug eruption (FDE). To the best of our knowledge this is an exceptional case of bullous FDE diagnosed after administration of iopromide. This case was notified to the Tunisian Center of Pharmacovigilance on December 2020 and registered under the number 1925/2020. A 75-year-old woman, with a history of breast carcinoma underwent a chest CT scan with injection of contrast product (ultravist® iopromide) in November 2020. The same day, she developed four, 2 cm in diameter, well limited and oval shaped slightly erythematous itchy plaques on the trunk and right lower limb with a burning sensation. The next day, some of these lesions developed to bullae and erosions. There was not any pathological finding in the physical examination. Biopsy findings were in line with the clinical diagnosis of FDE. The skin lesions were treated with topical corticoids and showed complete resolution one month later with residual hyperpigmentation. Although very uncommon, bullous FDE induced by CM does exist and should be known by radiologists. In this case, we emphasize the importance of a thorough pharmacovigilance investigation with a detailed history and a careful examination of physical and histopathological findings, since patch tests expose the patient to the risk of reactivation and more severe reactions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::54578384388d0737490a44624ee9ae76Test
https://doi.org/10.22541/au.168001733.35955108/v1Test

المؤلفون: Ines Souilem, Ons Charfi, Imen Hamza, Fatma Zgolli, Sarrah Kastalli, Ghozlane Lakhoua, Sihem El Aidli

الوصف: Background: Sofosbuvir, a very effective new direct-acting antiviral agent (DAA), has revolutionized the therapeutic management of people infected with hepatitis C virus. It has a low reported rate of side effects. Leukocytoclastic vasculitis can be associated with hepatitis C but can also be induced by many drugs. We describe a case of leucocytoclasic vasculitis induced by Sofosbuvir that resolved 3 days after drug withdrawal. We observed a temporal relationship between the treatment and the onset of vasculitis. We emphasize the multidisciplinary approach to patients with hepatitis C to make the difference between drug-induced skin damage and damage caused by the virus itself. Case presentation: A 61-year-old woman, with a history of hepatitis C virus infection started treatment with the combination ledipasvir sofosbuvir in June 2020, 400 mg per day. Five weeks later, she developed a slightly itchy erythematous and symmetrical rash on lower members. The patient initially suspected the treatment and she stopped it. Histological finding revealed a diffuse neutrophile infiltration of vessel walls confirming leukocytoclastic vasculitis. These lesions disappeared completely three days after drug withdrawal without any symptomatic treatment. Conclusions: Sofosbuvir is one of the several recent drugs that should be prone to further attention.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::dcefd71f332cbd463e3a8840218e0973Test
https://doi.org/10.22541/au.167786486.61251656/v1Test