المؤلفون: Rana Turkal, Cem Armağan Turan, Onur Elbasan, Serenay Aytan, Burcu Çakmak, Büşra Gözaydınoğlu, Duygu Ceyda Takır, Ozan Ünlü, Günel Bahramzada, Ahmet Faruk Tekin, Tülay Çevlik, Esra Esim Büyükbayrak, Önder Şirikçi, Hülya Gözü, Goncagül Haklar

المصدر: BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-14 (2022)

مصطلحات موضوعية: Thyroid dysfunction, Pregnancy, Gestation-specific, Reference interval, ATA, Gynecology and obstetrics, RG1-991

الوصف: Abstract Background Considering the changes in thyroid physiology associated with pregnancy and poor outcomes related to abnormal maternal thyroid function, international guidelines recommend using population-based trimester-specific reference intervals (RIs) for thyroid testing. If these RIs are not available in the laboratory, implementing recommended fixed cut-off values globally is still controversial. To address this issue, we aimed to establish appropriate RI of thyroid-stimulating hormone (TSH) in pregnant Turkish women for our laboratory and compare the prevalence of thyroid dysfunction based on the established and recommended criteria. Methods Of 2638 pregnant women, 1777 women followed in the obstetric outpatient were enrolled in the reference interval study after applying exclusion criteria related to medical and prenatal history. A retrospective study was conducted by collecting data from July 2016 to March 2019. Serum TSH was measured by UniCel DxI 800 Immunoassay System (Beckman Coulter Inc., Brea, CA, USA). The study design relied on two approaches in order to classify pregnant women: trimester-specific and subgroup-specific; the latter involved dividing each trimester into two subgroups: T1a, T1b, T2a, T2b, T3a, T3b. The lower and upper limits of the RIs were derived by the parametric method after normalizing the data distribution using the modified Box-Cox power transformation method. Results The lowest TSH value was detected at 8-12 weeks in early pregnancy, and the median value of TSH in the T1b subgroup was significantly lower than the T1a subgroup (P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2393Test

الوصول الحر: https://doaj.org/article/18c869dd68eb440ab003993eaaf9df4aTest

المؤلفون: Ceyda Dincer Yazan, Can Ilgin, Onur Elbasan, Tugce Apaydin, Saida Dashdamirova, Tayfun Yigit, Uluhan Sili, Aysegul Karahasan Yagci, Onder Sirikci, Goncagul Haklar, Hulya Gozu

المصدر: International Journal of Endocrinology, Vol 2021 (2021)

مصطلحات موضوعية: Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Background. COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study, we aimed to evaluate the thyroid function status and thyroid autoimmunity in COVID-19 patients. Material and Method. 205 patients were included. The medical history and laboratory parameters at admission were collected from medical records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and thyroglobulin antibody were measured, and patients were classified according to thyroid function status. Results. 34.1% of the patients were euthyroid. Length of hospitalization (p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1687-8337Test; https://doaj.org/toc/1687-8345Test

الوصول الحر: https://doaj.org/article/0ef47bc693304fbbafe25bed754d01d8Test

المؤلفون: Ayşegul Karahasan Yagci, Gamze Alci, Mehmet Mucahit Guncu, Omer Bugrahan Yilmaz, Eranalp Tekin, Safa Emre Cakir, Burak Cebe, Cem Ozturk, Onder Sirikci

المساهمون: Karahasan A.

المصدر: Infectious Diseases in Clinical Practice. 31:1-6

مصطلحات موضوعية: Microbiology (medical), Infectious Diseases, vaccine, Health Sciences, COVID-19, Klinik Tıp (MED), epidemiology, Sağlık Bilimleri, Clinical Medicine (MED)

الوصف: BackgroundThe number ofCOVID-19cases has been decreasing recently, and the restrictions are waived in many countries. The data aboutvaccineefficacy are essential to be prepared for the future even if the pandemic ends and the disease becomes endemic.AimsThe aim of this study was to define demographic and laboratory data for disease severity among vaccinatedCOVID-19cases who were hospitalized.Study DesignThis is a retrospective cohort study.MethodsSARS-CoV-2 polymerase chain reaction–positive patients who were fully vaccinated (2 doses of vaccines and 3 doses of vaccines) and had been hospitalized at least 15 days after the lastvaccinedose were enrolled in this study. Patients\" data including laboratory parameters were retrieved, and descriptive statistics and comparison of variables were calculated.ResultsBetween September 1, 2021, and February 28, 2022, 685 patients (mean age, 67.84 years; 50.8% female) were hospitalized. Inactivated whole-virion SARS-CoV-2vaccine(CoronaVac) had been administered to 467 of the patients (68.4%), BNT162b2 mRNAvaccine(Pfizer-Pfizer-BioNTech) had been administered to 107 of the patients (15.6%), and to 111 of the patients (16%), a combination of 2 vaccines had been administered. At least 1 comorbidity was present in 160 participants (23%) and more than 4 comorbidities in 46 patients (6.6%). The most common comorbidity was hypertension (349, 50.2%). The presence of comorbidities was significantly higher in patients having 3 doses ofvaccine. Increased ferritin levels were determined in 56.4% of the patients, increased D-dimer levels in 69.9% of the patients, increased C-reactive protein levels in 79.7% of the patients, and increased procalcitonin levels in 61.5% of the patients. A total of 36.4% of the patients had decreased lymphocyte counts, 20% had low lymphocyte/monocyte ratio, and 22% had decreased neutrophil/lymphocyte ratio. The only parameter that was significantly higher in patients having 3vaccinedoses was procalcitonin. Mean duration of hospitalization was 9.68 ± 7.29 days. In the CoronaVac and Pfizer-BioNTech groups, 68.5% and 21.4%, respectively, of the patients were older than 65 years. Seventeen (3.6%) patients in the CoronaVac group, 6 (5.4%) patients in the combination group, and 3 (2.8%) patients in Pfizer-BioNTech group had been admitted to the intensive care unit. Mortality rate was 0.3% (2 of 685 patients).ConclusionsThe incidence of severeCOVID-19disease among fully vaccinated patients is low even in the presence of comorbidities, older age, and presence of abnormal laboratory parameters, regardless of thevaccinetype.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60db91ed93f17366d0ffda54e12f7ccTest
https://doi.org/10.1097/ipc.0000000000001251Test

المؤلفون: Ceyda Dincer Yazan, Ali Yaman, Goncagul Haklar, Onder Sirikci, Oguzhan Deyneli

المساهمون: DİNÇER YAZAN C., Yaman A., HAKLAR G., ŞİRİKÇİ Ö., Deyneli O.

المصدر: J Diabetes Metab Disord

مصطلحات موضوعية: Internal Diseases, D-BINDING PROTEIN, ENDOCRINOLOGY & METABOLISM, Endocrinology, Diabetes and Metabolism, Endocrinology and Metabolic Diseases, Sağlık Bilimleri, İç Hastalıkları, Clinical Medicine (MED), SERUM, Endocrinology, FRACTURES, Health Sciences, Internal Medicine, Klinik Tıp (MED), Internal Medicine Sciences, Klinik Tıp, Endocrine and Autonomic Systems, Bioavailable vitamin D, Life Sciences, WOMEN, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Tıp, Free vitamin D, Type 1 DM, Endokrinoloji ve Metabolizma Hastalıkları, ENDOKRİNOLOJİ VE METABOLİZMA, Medicine, MINERAL DENSITY, TURNOVER, HEALTH, Research Article, VDBP

الوصف: AIM: Vitamin D deficiency is known to be associated with metabolic bone diseases. The aim of this study is to evaluate vitamin D and calculated free and bioactive vitamin D levels of type 1 diabetic patients and to evaluate the association with bone turnover markers. METHOD: This cross-sectional study includes 60 patients admitted to endocrinology outpatient clinic with diagnosis of type 1 diabetes mellitus and 60 controls. Weight, height and waist circumference were recorded and blood samples were taken for measurement of 25-hydroxyvitamin D (25(OH)D), vitamin D binding protein (VDBP), osteocalcin, bone alkaline phosphatase (bone-ALP), c-telopeptide. Free and bioavailable vitamin D levels were calculated with formula. RESULTS: Vitamin D levels of type 1 diabetic patients were significantly higher (p = 0.01). Parathormone levels of the group with vitamin D level under 20 ng/ml was significantly higher (p = 0.029). VDBP levels were similar in both groups. Correlation analysis of free and bioavailable vitamin D level with osteocalcin, c-telopeptide, bone alkaline phosphatase revealed only a weak significant correlation between free vitamin D and osteocalcin (r = -0.201; p = 0.028). A negative correlation was determined between 25(OH)D and parathormone levels (r = -0.294; p

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e8fc8fe1bfeabdc6f137bf27275978Test
https://hdl.handle.net/11424/288694Test

المؤلفون: Huseyin Bilgin, Marisa Marku, Sultan Seval Yilmaz, Aysegul Karahasan Yagci, Uluhan Sili, Baris Can, Rabia Can Sarinoglu, Lutfiye Mulazimoglu Durmusoglu, Goncagul Haklar, Onder Sirikci, Emel Eksioglu Demiralp

المساهمون: Bilgin H., Marku M., Yilmaz S. S., Karahasan Yagci A., Sili U., Can B., Can Sarinoglu R., Mulazimoglu Durmusoglu L., Haklar G., Sirikci O., et al.

مصطلحات موضوعية: COVID-19 Vaccines, Plasma Cells, Immunology, Life Sciences (LIFE), Antibodies, Viral, Sağlık Bilimleri, Medical Ecology and Hydroclimatology, Clinical Medicine (MED), Genel İmmünoloji ve Mikrobiyoloji, IFN-gamma, Interferon-gamma, Tıbbi Ekoloji ve Hidroklimatoloji, Araştırma ve Teori, Yaşam Bilimleri, Health Sciences, İncelemeler ve Referanslar (tıbbi), Humans, Klinik Tıp (MED), TIP, ARAŞTIRMA VE DENEYSEL, Internal Medicine Sciences, General Veterinary, İmmünoloji, Klinik Tıp, Research and Theory, General Immunology and Microbiology, SARS-CoV-2, Temel Bilimler, SARS-CoV-2 infection, Vaccination, Public Health, Environmental and Occupational Health, Anti-spike antibody, Life Sciences, COVID-19, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Tıp, Killer Cells, Natural, Infectious Diseases, Yaşam Bilimleri (LIFE), MEDICINE, RESEARCH & EXPERIMENTAL, Reviews and References (medical), Molecular Medicine, Medicine, CoronaVac, Whole virion inactivated vaccine, Natural Sciences

الوصف: Objectives: We evaluated the antibody response, natural killer cell response and B cell phenotypes in healthcare workers (HCW) who are vaccinated with two doses of CoronaVac with or without documented SARS-CoV-2 infection and unvaccinated HCWs with SARS-CoV-2 infection. Methods: HCWs were divided into four groups: vaccine only (VO), vaccine after SARS-CoV-2 infection (VAI), SARS-CoV-2 infection only (IO), and SARS-CoV-2 infection after vaccine (IAV). Anti-SARS-CoV-2 spike protein (Anti-S) antibodies were measured by Elecsys Anti–SARS–CoV–2 S ELISA kit. Memory B cells (CD19+ CD27+ ), plasmablast B cells (CD19+ CD138+ ) and long-lived plasma cells (LLPC; CD138+ CD19- ) were measured by flow cytometry in 74 patients. Interferon gamma (IFN-c) release by natural killer (NK) cells were measured by NKVue Test (NKMAX, Republic of Korea) in 76 patients. RT-PCR was performed with Bio-speedy COVID-19 qPCR detection kit, Version 2 (Bioexen LTD, Istanbul, Turkey). Results: The Anti-S antibodies were detectable in all HCWs (n: 224). The median Anti-S titers (BAU/mL) was significantly higher in VAI (620 25–75% 373–1341) compared to VO (136, 25–75% 85–283) and IO (111, 25–75% 54–413, p < 0.01). VAI group had significantly lower percentage of plasmablasts (2.9; 0– 8.7) compared to VO (6.8; 3.5–12.0) and IO (9.9; 4.7–47.5, p < 0.01) (n:74). Percentage of LLPCs in groups VO, VAI and IO was similar. There was no difference of IFN-c levels between the study groups (n: 76). Conclusion: The antibody response was similar between uninfected vaccinated HCWs and unvaccinated HCWs who had natural infection. HCWs who had two doses of CoronaVac either before or after the natural SARS-CoV-2 infection elicited significantly higher antibody responses compared to uninfected vaccinated HCWs. The lower percentages of plasmablasts in the VAI group may indicate their migration to lymph nodes and initiation of the germinal center reaction phase. IFN-c response did not differ among the groups.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a6c506fd7c4d87a7bee31231dc0a5bTest
https://hdl.handle.net/11424/288178Test

المؤلفون: Tuğçe Apaydin, Ahu Telli, Dilek Gogas Yavuz, Onder Sirikci, Palmet Atak, Özlem Üstay

المساهمون: Yavuz, Dilek Gogas, Ustay, Ozlem, Atak, Palmet Gun, Telli, Ahu, Apaydin, Tugce, Sirikci, Onder

مصطلحات موضوعية: medicine.medical_specialty, PREDICTOR, paraoxonase Q192R gene, Endocrinology, Diabetes and Metabolism, PHENOTYPE, INTIMA-MEDIA THICKNESS, VARIABLES, LIPOPROTEINS, Internal medicine, Internal Medicine, medicine, gender, OXIDATIVE STRESS, Serum paraoxonase, Paraoxonase-1, PON1, RISK, biology, business.industry, arylesterase, Healthy population, Paraoxonase, ASSOCIATION, Endocrinology, biology.protein, CORONARY-ARTERY-DISEASE, Gene polymorphism, high-HDL cholesterol, business

الوصف: Objective: Paraoxonase-1 (PON1) enzyme and PON Q192R gene polymorphism are associated with atherosclerosis in many middle-aged individuals and high populations at risk of cardiovascular disease. This study aimed to determine serum PON-1 and arylesterase (ARE) activities, PON Q192R polymorphism, and their association with gender, lipoprotein levels, and carotid intima-media thickness (CIMT) among young healthy individuals. Material and Methods: Four hundred fifteen healthy volunteers (F/M: 213/202, 19-25 years) were included in the study. Serum lipoprotein levels and PON1, ARE activities were measured using spectrophotometric methods. PON 192Q polymorphism was evaluated by polymerase chain reaction, and CIMT was measured using Doppler ultrasonography. Results: Serum PON1 activity and PON Q192R polymorphism frequencies were similar between men and women, while ARE activity was significantly higher in women. PON1 activity was considerably higher in RR carriers than in QQ and QR carriers among both men and women. Serum high-density lipoprotein level was lower, and CIMT was higher in men compared to women. Conclusion: PON1 enzyme activities did not differ according to gender, and ARE activity was higher in women. High PON1 activity is associated with PONQ192 RR polymorphism carriers. PON Q192 gene polymorphism could be a determinant of PON activity.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376def06fed27fd7caee9333e29d6d27Test
https://hdl.handle.net/11424/243412Test

المؤلفون: Bon Chu Chung, Goncagül Haklar, Serap Turan, Cengiz Kara, Jamala Mamadova, Tulay Guran, Melek Yildiz, Ahmet Anık, Eda Celebi Bitkin, Jen-Chieh Lin, Zeynep Atay, Teoman Akcay, Gönül Çatlı, Birgül Kirel, Hasan Önal, Azad Akbarzade, Onder Sirikci, Abdullah Bereket, Mehmet Keskin, Karl-Heinz Storbeck, Ayla Guven, Gülay Can Yılmaz, Tugba Baris, Filiz Tutunculer, Lise Barnard

المساهمون: İstinye Üniversitesi, Hastane, Akcay, Teoman, Ondokuz Mayıs Üniversitesi

المصدر: The Journal of clinical endocrinology and metabolism. 105(3)

مصطلحات موضوعية: Male, Turkey, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Physiology, Puberty, Precocious, Biochemistry, Endocrinology, HSD3B2, Chlorocebus aethiops, Missense mutation, 3 beta HSD2 deficiency, Child, Children, Sanger sequencing, Hsd3b2, CAH, Cah, Homozygote, Polycystic ovary, Child, Preschool, COS Cells, symbols, Metabolome, Female, adrenal insufficiency, medicine.medical_specialty, Adolescent, medicine.drug_class, Pediatric endocrinology, Mutation, Missense, Context (language use), symbols.namesake, children, Internal medicine, medicine, Adrenal insufficiency, Animals, Humans, Genetic Testing, Genetic Association Studies, Adrenal Hyperplasia, Congenital, business.industry, Progesterone Reductase, Biochemistry (medical), Infant, medicine.disease, 3 Beta Hsd2 Deficiency, Cross-Sectional Studies, Mineralocorticoid, business, Adrenal Insufficiency

الوصف: Context The clinical effects of classical 3β-hydroxysteroid dehydrogenase 2 (3βHSD2) deficiency are insufficiently defined due to a limited number of published cases. Objective To evaluate an integrated steroid metabolome and the short- and long-term clinical features of 3βHSD2 deficiency. Design Multicenter, cross-sectional study. Setting Nine tertiary pediatric endocrinology clinics across Turkey. Patients Children with clinical diagnosis of 3βHSD2 deficiency. Main Outcome Measures Clinical manifestations, genotype-phenotype-metabolomic relations. A structured questionnaire was used to evaluate the data of patients with clinical 3βHSD2 deficiency. Genetic analysis of HSD3B2 was performed using Sanger sequencing. Novel HSD3B2 mutations were studied in vitro. Nineteen plasma adrenal steroids were measured using LC-MS/MS. Results Eleven homozygous HSD3B2 mutations (6 novel) were identified in 31 children (19 male/12 female; mean age: 6.6 ± 5.1 yrs). The patients with homozygous pathogenic HSD3B2 missense variants of > 5% of wild type 3βHSD2 activity in vitro had a non-salt–losing clinical phenotype. Ambiguous genitalia was an invariable feature of all genetic males, whereas only 1 of 12 female patients presented with virilized genitalia. Premature pubarche was observed in 78% of patients. In adolescence, menstrual irregularities and polycystic ovaries in females and adrenal rest tumors and gonadal failure in males were observed. Conclusions Genetically-documented 3βHSD2 deficiency includes salt-losing and non-salt–losing clinical phenotypes. Spared mineralocorticoid function and unvirilized genitalia in females may lead to misdiagnosis and underestimation of the frequency of 3βHSD2 deficiency. High baseline 17OHPreg to cortisol ratio and low 11-oxyandrogen concentrations by LC-MS/MS unequivocally identifies patients with 3βHSD2 deficiency.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfb0ff143eb66a4edc2f84c869cebcbTest
https://pubmed.ncbi.nlm.nih.gov/31950145Test

المؤلفون: Ali Yaman, Gülşen Altınkanat Gelmez, Ismail Cinel, Melis Sirinoglu, Serap Turan, Nilufer Yalindag-Ozturk, Mustafa Bakir, Goncagül Haklar, Ayşe Karaaslan, Eda Kepenekli Kadayifci, Güner Söyletir, Ahmet Soysal, Onder Sirikci

المصدر: Journal of Infection and Chemotherapy. 23:17-22

مصطلحات موضوعية: Calcitonin, Male, Microbiology (medical), medicine.medical_specialty, Sensitivity and Specificity, Gastroenterology, Procalcitonin, Receptors, Urokinase Plasminogen Activator, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, Protein Precursors, Child, Receptor, Prospective cohort study, biology, business.industry, C-reactive protein, Case-control study, 030208 emergency & critical care medicine, Prognosis, medicine.disease, Systemic Inflammatory Response Syndrome, Systemic inflammatory response syndrome, C-Reactive Protein, Infectious Diseases, ROC Curve, SuPAR, Case-Control Studies, Child, Preschool, biology.protein, Female, business

الوصف: The aim of the present study was to determine the diagnostic and prognostic values of suPAR and to compare them to CRP and PCT in pediatric patients with systemic inflammatory response syndrome (SIRS).A prospective case-control study was performed.The study was performed in a tertiary university hospital which has a 649-bed capacity. Patients included 27 children with SIRS and 27 control subjects without any infection or immunosuppressive condition. Blood samples were obtained on the day of admission and on the 4-7th days of the hospital stay.The median (min-max) serum levels of suPAR obtained on the first day of the admission were 10.06 (2.7-57.46) and 2.22 (1.08-5.13) ng/Ml for the SIRS group and control group, respectively. The median serum levels of suPAR in the SIRS group was significantly higher than that in the control group (p 0.05). The serum suPAR levels was significantly higher in nonsurvivors than in survivors in SIRS group (p 0.05). In the SIRS group, the area under the receiver operating characteristics curve (AUCWe conclude that suPAR does have diagnostic value in children with SIRS. Additionally, persistent high serum suPAR level predicts mortality in SIRS in children.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac2954d916dcac0de31d99b35ef7daaTest
https://doi.org/10.1016/j.jiac.2016.08.015Test

المؤلفون: Serap Turan, Goncagül Haklar, Mustafa Bakir, Ali Yaman, Gülşen Altınkanat Gelmez, Ahmet Soysal, Güner Söyletir, Onder Sirikci, Gülnur Tokuç, Ismail Cinel, Ahmet Koç, Ayşe Karaaslan, Eda Kepenekli Kadayifci, Melis Sirinoglu

المصدر: Pediatric Hematology and Oncology. 33:200-208

مصطلحات موضوعية: Calcitonin, Male, medicine.medical_specialty, Adolescent, Gastroenterology, Procalcitonin, Receptors, Urokinase Plasminogen Activator, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Child, Receptor, Febrile Neutropenia, Hematology, biology, Receiver operating characteristic, business.industry, Urokinase Plasminogen Activator, C-reactive protein, Infant, medicine.disease, C-Reactive Protein, Oncology, SuPAR, Case-Control Studies, Child, Preschool, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Immunology, biology.protein, Female, business, Febrile neutropenia

الوصف: The aim of the present study was to determine the diagnostic value of soluble urokinase plasminogen activator receptor (suPAR) in pediatric patients with febrile neutropenia. A prospective case-control study was performed. Patients included 29 children with febrile neutropenia (FN) and 27 control subjects without any infection or immunosuppressive condition. Blood samples were obtained on the day of admission and on the 4th to 7th days of the hospital stay. The median (minimum-maximum) serum levels of suPAR obtained on the first day of the admission were 2.08 (0.93-9.42) and 2.22 (1.08-5.13) ng/mL for the FN group and the control group, respectively. The median serum levels of suPAR in the FN and control groups were not significantly different (P = .053). The mean serum suPAR level was significantly higher in nonsurvivors than in survivors in the FN group (P < .05). In the FN group, the area under the receiver operating characteristics curve (AUCROC) for suPAR was 0.546, but no optimum cutoff value, sensitivity, specificity, negative predictive value (NPV), or positive predictive value (PPV) was obtained. We conclude that suPAR is not useful as a diagnostic biomarker in children with febrile neutropenia; however, persistent high serum suPAR level may predict mortality in FN in children.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74ddfe5c270f988d7cb145ac34535d0Test
https://doi.org/10.3109/08880018.2016.1155100Test

المؤلفون: Dilek Gogas Yavuz, Goncagül Haklar, Sule Temizkan, Medeni Arpa, Onder Sirikci, Mehmet Yasar, Dilek Yazici, Mutlu Gunes, Oguzhan Deyneli, Nese Imeryuz

المساهمون: Temizkan, S., Deyneli, O., Yasar, M., Arpa, M., Gunes, M., Yazici, D., Sirikci, O., Haklar, G., Imeryuz, N., Yavuz, D. G.

المصدر: European Journal of Clinical Nutrition. 69:162-166

مصطلحات موضوعية: Adult, Blood Glucose, Male, EXPRESSION, Sucrose, Sucralose, medicine.medical_specialty, TASTE RECEPTORS, Medicine (miscellaneous), Type 2 diabetes, GUSTDUCIN, Carbohydrate metabolism, chemistry.chemical_compound, Glucagon-Like Peptide 1, Diabetes mellitus, Internal medicine, Dietary Carbohydrates, ABSORPTION, medicine, Insulin, In patient, Aspartame, ORAL GLUCOSE, Glucose tolerance test, Nutrition and Dietetics, C-Peptide, medicine.diagnostic_test, business.industry, Healthy subjects, HUMANS, Glucose Tolerance Test, Middle Aged, ARTIFICIAL SWEETENER, Carbohydrate, Glucagon, medicine.disease, Healthy Volunteers, Glucose, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Area Under Curve, Sweetening Agents, CELLS, Female, HORMONES, business

الوصف: BACKGROUND/OBJECTIVE: Artificial sweeteners were thought to be metabolically inactive, but after demonstrating that the gustatory mechanism was also localized in the small intestine, suspicions about the metabolic effects of artificial sweeteners have emerged. The objective of this study was to determine the effect of artificial sweeteners (aspartame and sucralose) on blood glucose, insulin, c-peptide and glucagon-like peptide-1 (GLP-1) levels. SUBJECTS/METHODS: Eight newly diagnosed drug-naive type 2 diabetic patients (mean age 51.5 +/- 9.2 years; F/M: 4/4) and eight healthy subjects (mean age 45.0 +/- 4.1 years; F/M: 4/4) underwent 75 g oral glucose tolerance test (OGTT). During OGTT, glucose, insulin, c-peptide and GLP-1 were measured at 15-min intervals for 120 min. The OGTTs were performed at three settings on different days, where subjects were given 72 mg of aspartame and 24 mg of sucralose in 200 ml of water or 200 ml of water alone 15 min before OGTT in a single-blinded randomized order. RESULTS: In healthy subjects, the total area under the curve (AUC) of glucose was statistically significantly lower in the sucralose setting than in the water setting (P = 0.002). There was no difference between the aspartame setting and the water setting (P = 0.53). Total AUC of insulin and c-peptide was similar in aspartame, sucralose and water settings. Total AUC of GLP-1 was significantly higher in the sucralose setting than in the water setting (P = 0.04). Total AUC values of glucose, insulin, c-peptide and GLP-1 were not statistically different in three settings in type 2 diabetic patients. CONCLUSIONS: Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in newly diagnosed type 2 diabetic patients.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c4362e4a8450508fa0503a352d04a6Test
https://doi.org/10.1038/ejcn.2014.208Test