المؤلفون: Kawano, Noriaki, Kyohei, Yamada, Miyoshi, Hiroaki, Yoshida, Noriaki, Ohshima, Kouichi, Arakawa, Fumiko, Nakashima, Kazutaka, Kameda, Takuro, Kogure, Yasunori, Ito, Yuta, Yoshida, Shuro, Kuriyama, Takuro, Nakaike, Takashi, Tochigi, Taro, Takigawa, Ken, Yamashita, Kiyoshi, Toyofuku, Atsushi, Manabe, Tatsuya, Doi, Atsushi, Terasaka, Soushi, Marutsuka, Kouske, Ochiai, Hidenobu, Kikuchi, Ikuo, Mori, Yasuo, Kataoka, Keisuke, Yoshizumi, Tomoharu, Yamauchi, Junji, Yamano, Yoshihisa, Shimoda, Kazuya

المصدر: Renal Replacement Therapy ; volume 9, issue 1 ; ISSN 2059-1381

مصطلحات موضوعية: Transplantation, Urology, Nephrology

الوصف: Backgrounds Therefore, reports on the risk of HTLV-1-related diseases in organ transplantation have increased in recent years, and the management of HTLV in renal transplantation remains a challenge. Patients and methods We retrospectively analyzed four HTLV-1-positive recipients or donors among 89 renal transplantation cases from 2006 to 2021. Results Among the four HTLV-1-positive recipients, two patients developed adult T cell leukemia/lymphoma (ATL) derived from recipients at approximately 3 years (1016 days and 1195 days) after renal transplantation. Case 1 developed lymphoma-type ATL (an extranodal primary cutaneous variant), including skin and pulmonary lesions. The patient achieved CR with FK tapering and CHOP therapy following cord blood stem cell transplantation. However, the patient died 101 days after ATL development because of a severe fungal infection. Case 2 developed acute-type ATL with an unusual phenotype of CD4+8+30+. The patient was treated with FK tapering and palliative therapy because of poor PS. Notably, in case 1, histopathological findings showed high numbers of PD-1-positive TIL cells in ATL, suggesting exhausted T cells and a correlation with the early onset of ATL. Furthermore, in Case 2, histopathological findings revealed CD 30 expression in ATL cells, suggesting the importance of CD 30 in ATL development. Importantly, case 2 showed typical driver mutations, including CCR4 truncation mutations of the C-terminal, TBL1XR1 mutation, and TP53 mutation in the splice site. Notably, our present study and our previous study on renal transplantation strongly indicated that two out of two and one out of 59 “recipient” positive cases developed ATL, respectively. Furthermore, our previous nationwide study 4 out of 10 “donor” positive cases developed HAM. These findings showed that ATL may be derived from HTLV-I+ recipient cells and HAM may be derived from HTLV-1+ donor cells, although the precise mechanism remains unknown. Conclusions Thus, early onset and rapid progression of ATL ...

الإتاحة: https://doi.org/10.1186/s41100-023-00480-5Test

المؤلفون: Hiraki, Takamasa, Fukuoka, Kouhei, Tsumura, Yusuke, Inoue, Kyohei, Tomita, Osamu, Mitani, Yuichi, Ohshima, Kouichi, Mori, Makiko, Arakawa, Yuki, Tanami, Yutaka, Nakazawa, Atsuko, Kurihara, Jun, Koh, Katsuyoshi

المصدر: Neuro-Oncology Advances ; volume 1, issue Supplement_2, page ii17-ii17 ; ISSN 2632-2498

الوصف: Medulloblastoma is one of the most common malignant brain tumors in children. Despite multi-disciplinary treatment for medulloblastoma, including surgery, chemotherapy, and radiation, which have resulted in significant improvement of the prognosis, about 30% of patients still experience recurrence. Most recurrences occur within the first 15 months from diagnosis and late relapse of the tumor is quite rare. We report a case of a 15-year-old female patient with recurrent medulloblastoma 9 years after the primary tumor. At the age of 6, this patient developed a posterior fossa tumor without metastasis and underwent near-total resection. The pathological diagnosis was medulloblastoma with focal desmoplasia. After the surgery, she received multi-agent chemotherapy and radiation therapy consisting of 18 Gy craniospinal irradiation and 51.2 Gy local irradiation. She was in complete remission for 9 years after the treatment. However, gait disturbance began to gradually appear, and magnetic resonance imaging (MRI) showed an intradural lesion in her thoracic spine. The lesion was biopsied, and the pathological findings confirmed the recurrence of medulloblastoma. Currently, we plan to administer local radiation therapy concomitantly with temozolomide to the patient. The case reminds us of the importance of long-term careful follow-up of patients with medulloblastoma. Further studies are warranted for the treatment of relapsed medulloblastomas due to the limited information available at present.

الإتاحة: https://doi.org/10.1093/noajnl/vdz039.075Test
http://academic.oup.com/noa/article-pdf/1/Supplement_2/ii17/33169716/vdz039.075.pdfTest

المؤلفون: Furuta, Takuya, Sugita, Yasuo, Komaki, Satoru, Ohshima, Kouichi, Morioka, Motohiro, Uchida, Yasuo, Tachikawa, Masanori, Otsuki, Sumio, Terasaki, Tetsuya, Nakada, Mitsutoshi

المصدر: Neuro-Oncology Advances ; volume 1, issue Supplement_2, page ii23-ii23 ; ISSN 2632-2498

الوصف: BACKGROUND AND AIM Leucine-rich α-2 glycoprotein 1 (LRG1) is one of the candidate proteins as a diagnostic marker for glioblastoma. Although association with angiogenesis has been reported, it has been suggested that the role as a biomarker differs depending on the tumor types. The role of LRG1 as a biomarker in glioblastoma was examined clinicopathologically. METHODS Tumor tissues of 156 cases diagnosed as diffuse glioma (27 astrocytomas, 15 oligodendrogliomas, 114 glioblastomas) according to WHO 2016 classification at Kurume University from January 2001 to April 2019 were used. The immunohistochemical intensity of LRG1 was scoring as 4 stages and classified into 2 groups; score 0–1 was defined as low expression and score 2–3 was defined as high expression. Mutations of IDH1/2 and TERT promoter were analyzed by Sanger method. In glioblastoma, the relationship between LRG1 expression and clinical parameters such as age, preoperative Karnofsky Performance Scale, tumor location, extent of resection, MGMT promoter, and prognosis were examined. RESULTS LRG1 high expression rate was 41.2% (47/114) in glioblastoma, 3.7% (1/27) in astrocytoma, 20% (3/15) in oligodendroglioma, and glioblastoma showed significant higher expression level of LRG1 compared with lower-grade glioma (p = 0.0003). High expression of LRG1 was an independent favorable prognostic factor (HR 0.41, 95% CI 0.18–0.86, p=0.019) in IDH-wildtype glioblastoma, and correlated with gross total resection (p = 0.002) and the tumor location of the non-subventricular zone (SVZ) (p = 0.00007). CONCLUSION LRG1 demonstrated multiple potential as diagnostic, prognostic, and regional biomarker for glioblastoma.

الإتاحة: https://doi.org/10.1093/noajnl/vdz039.103Test
http://academic.oup.com/noa/article-pdf/1/Supplement_2/ii23/33168331/vdz039.103.pdfTest

المؤلفون: Matsuoka, Atsuko, Fujii, Kazuyasu, Higashi, Yuko, Yoshimitsu, Makoto, Arakawa, Fumiko, Ohshima, Kouichi, Kanekura, Takuro

المصدر: The Journal of Dermatology ; volume 49, issue 12 ; ISSN 0385-2407 1346-8138

الإتاحة: https://doi.org/10.1111/1346-8138.16524Test

المؤلفون: Ohya, Kouichi, Okuyama, Shuhei, Ogata, Shin-ya, Maeda, Kunihiko, Yamada, Kyohei, Ohshima, Kouichi, Tajima, Katsushi

المصدر: Annals of Hematology ; volume 100, issue 11, page 2873-2875 ; ISSN 0939-5555 1432-0584

مصطلحات موضوعية: Hematology, General Medicine

الإتاحة: https://doi.org/10.1007/s00277-021-04633-6Test

المؤلفون: Tsurusawa, Masahito, Mori, Tetsuya, Kikuchi, Akira, Mitsui, Tetsuo, Sunami, Shosuke, Kobayashi, Ryoji, Takimoto, Tetsuya, Saito, Akiko, Watanabe, Tomoyuki, Fujimoto, Junichiro, Nakazawa, Atsuko, Ohshima, Kouichi, Horibe, Keizo

المصدر: Pediatric Blood & Cancer ; volume 61, issue 11, page 2144-2144 ; ISSN 1545-5009 1545-5017

الإتاحة: https://doi.org/10.1002/pbc.25293Test

المؤلفون: Ohshima Kouichi, Sakaguchi Shimon, Yamaguchi Tomoyuki, Satou Yorifumi, Miyazato Paola, Matsuoka Masao

المصدر: Retrovirology, Vol 8, Iss Suppl 1, p A111 (2011)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1742-4690Test

الوصول الحر: https://doaj.org/article/b051fd9535124218b51ecaccd853f75dTest

المؤلفون: Miyazato, Paola, Satou, Yorifumi, Yamaguchi, Tomoyuki, Sakaguchi, Shimon, Ohshima, Kouichi, Matsuoka, Masao

المصدر: Retrovirology ; volume 8, issue S1 ; ISSN 1742-4690

مصطلحات موضوعية: Infectious Diseases, Virology

الإتاحة: https://doi.org/10.1186/1742-4690-8-s1-a111Test

المؤلفون: Koga, Noriko, Noguchi, Masanori, Moriya, Fukuko, Ohshima, Kouichi, Yoshitake, Nobuyuki, Matsuoka, Kei

المصدر: Rare Tumors ; volume 1, issue 2, page 169-170 ; ISSN 2036-3613 2036-3613

مصطلحات موضوعية: Oncology, Histology

الوصف: We report a case of primary mucosa-associated lymphoid tissue (MALT) lymphoma of the prostate. A 67-year-old man presented with urinary obstruction and an elevated prostate-specific antigen (PSA) level. A physical examination revealed mild prostate enlargement and no lymphadenopathy. A needle biopsy and immunohistochemical studies of the prostate were performed, which revealed marginal zone B-cell MALT-type lymphoma. A bone marrow aspiration and biopsy did not show involvement by lymphoma. Magnetic resonance imaging (MRI) of the abdomen and the pelvis revealed no lymphadenopathy or ascites. There was no involvement of other sites by lymphoma. The patient was diagnosed and staged as extranodal marginal zone B-cell MALT-type lymphoma of the prostate, low grade and stage I. The patient received external beam radiation therapy to the prostate with a total dose of 3600cGy in 22 fractions, and became free of disease within the following 15 months.

الإتاحة: https://doi.org/10.4081/rt.2009.e55Test

المؤلفون: Tomoyose, Takeaki, Nagasaki, Akitoshi, Uchihara, Jun‐Nosuke, Kinjo, Shigeko, Sugaya, Kimio, Onaga, Tomohiro, Ohshima, Kouichi, Masuda, Masato, Takasu, Nobuyuki

المصدر: American Journal of Hematology ; volume 82, issue 8, page 748-752 ; ISSN 0361-8609 1096-8652

الوصف: Primary adrenal lymphoma (PAL) is very rare; the majority of cases reported previously were of B‐cell origin. We report a rare case of primary adrenal adult T‐cell leukemia/lymphoma (primary adrenal ATLL). ATLL is a highly aggressive T‐cell type non‐Hodgkin's lymphoma and etiologically associated with human T‐cell lymphotropic virus 1 (HTLV‐1). Most ATLL patients present with leukemia and widespread lymphadenopathy. A 37‐year‐old Japanese woman presented with back pain in January 2004. Examination showed no peripheral lymphadenopathy, circulating lymphoma cells, hepatosplenomegaly, and skin lesions. Imaging studies demonstrated large adrenal masses bilaterally. Subsequently, she underwent open adrenal biopsy and pathological diagnosis was confirmed as T‐cell lymphoma. The serum antibody to HTLV‐1 was positive. Southern blot analysis detected monoclonal integration of proviral DNA of HTLV‐1 into host genome in the biopsy specimen. The diagnosis of ATLL arising in adrenal glands was established. Despite repeated systemic chemotherapy, the patient died of progressive disease in December 2004. ATLL could primarily involve the adrenal gland and this disease entity should be included in the differential diagnosis of adrenal mass lesions. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.

الإتاحة: https://doi.org/10.1002/ajh.20856Test