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1دورية أكاديمية
المؤلفون: Harpaz, N, Goldblum, JR, Shepherd, NA, Riddell, RH, Rubio, CA, Vieth, M, Wang, HH, Odze, RD
المصدر: Human pathology. 138:49-61
مصطلحات موضوعية: Medicin och hälsovetenskap
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2دورية أكاديمية
المؤلفون: Quezada-Marín, JI, Lam, AK, Ochiai, A, Odze, RD, Washington, KM, Fukayama, M, Rugge, M, Klimstra, DS, Nagtegaal, ID, Tan, P-H, Arends, MJ, Goldblum, JR, Cree, IA, Salto-Tellez, M
المساهمون: Salto-Tellez, Manuel
الوصف: Molecular biomarkers have come to constitute one of the cornerstones of oncological pathology. The method of classification not only directly affects the manner in which patients are diagnosed and treated, but also guides the development of drugs and of artificial intelligence tools. The aim of this article is to organise and update gastrointestinal molecular biomarkers in order to produce an easy-to-use guide for routine diagnostics. For this purpose, we have extracted and reorganised the molecular information on epithelial neoplasms included in the 2019 World Health Organization classification of tumours. Digestive system tumours, 5th edn.
وصف الملف: Print-Electronic; 350; application/pdf
العلاقة: Histopathology, 2020, 77 (3), pp. 340 - 350; https://repository.icr.ac.uk/handle/internal/4041Test
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3دورية أكاديمية
المؤلفون: Kim, J, Bowlby, R, Mungall, AJ, Robertson, AG, Odze, RD, Cherniack, AD, Shih, J, Pedamallu, CS, Cibulskis, C, Dunford, A, Meier, SR, Dinjens, Winand, Van Nistelrooij, A, Wijnhoven, Bas, Sofia, HJ, Zhang, JS
المصدر: Kim , J , Bowlby , R , Mungall , AJ , Robertson , AG , Odze , RD , Cherniack , AD , Shih , J , Pedamallu , CS , Cibulskis , C , Dunford , A , Meier , SR , Dinjens , W , Van Nistelrooij , A , Wijnhoven , B , Sofia , HJ & Zhang , JS 2017 , ' Integrated genomic characterization of oesophageal carcinoma ' , Nature , vol. 541 , no. 7636 , pp. 169-+ . https://doi.org/10.1038/nature20805Test
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1038/nature20805Test
https://pure.eur.nl/en/publications/376b3287-6ab8-49c8-b507-0ec74171a62cTest
https://pure.eur.nl/ws/files/47929987/nature20805.pdfTest -
4دورية أكاديمية
المؤلفون: Washington, MK, Goldberg, RM, Chang, GJ, Limburg, P, Lam, AK, Salto-Tellez, M, Arends, MJ, Nagtegaal, ID, Klimstra, DS, Rugge, M, Schirmacher, P, Lazar, AJ, Odze, RD, Carneiro, F, Fukayama, M, Cree, IA, WHO Classification of Tumours Editorial Board
المساهمون: Salto-Tellez, Manuel
مصطلحات موضوعية: WHO Classification of Tumours Editorial Board, info, scipo
الوصف: The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as the WHO Blue Books. The first volume to be produced is on the classification of Digestive System tumours, replacing the successful 2010 version. It has been rewritten and updated accordingly. This article summarises the major diagnostic innovations that have occurred over the last decade and that have now been incorporated in the classification. As an example, it incorporates the recently proposed classification of neuroendocrine tumours, based on the recognition that neuroendocrine tumours and carcinomas differ substantially in the genetic abnormalities that drive their growth, findings relevant to treatment selection and outcome prediction. Several themes have emerged during the production process. One is the importance of the progression from hyperplasia to dysplasia to carcinoma in the evolution of the malignant process. Advances in imaging techniques and endoscopy have resulted in enhanced access to precancerous lesions in the gastrointestinal and biliary tract, necessitating both changes in classification schema and clinical practice. Diagnosis of tumours is no longer the sole purview of pathologists, and some patients now receive treatment before tissue is obtained, based on clinical, radiological and liquid biopsy results. This makes the classification relevant to many disciplines involved in the care of patients with tumours of the digestive system.
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5دورية أكاديمية
المؤلفون: Rucker-Schmidt, RL, Sanchez, Carissa A, Blount, PL, Ayub, K, Li, Xiaohong, Rabinovitch, PS, Reid, BJ, Odze, RD
مصطلحات موضوعية: Digestive system cancer, Histology
الوصف: Rarely, dysplasia in Barrett's esophagus (BE) is composed of crypts lined by cuboidal-shaped cells that contain a centrally located nucleus, markedly increased nuclear/cytoplasmic ratio, but without nuclear stratification characteristic of conventional "adenomatous" dysplasia. The aim of this study was to evaluate the clinical and pathologic features, natural history, and DNA content flow cytometric abnormalities of BE patients with non-adenomatous dysplasia (NAD) in a cohort of BE patients enrolled in a prospective surveillance program. Eighteen patients with NAD identified over a 6 year period, in a cohort of 270 consecutive patients with BE and without esophageal adenocarcinoma (EA) at baseline, were evaluated for clinical and pathologic features, including association with conventional adenomatous dysplasia and EA, DNA content flow cytometric abnormalities (tetraploidy and aneuploidy) and outcome, over a mean follow-up period of 4.1 years. The findings in the 18 study patients were compared to those in the 252 remaining (control) patients without NAD. Control patients included 228 with metaplasia/indefinite for dysplasia, and 24 with conventional adenomatous dysplasia (13 low-grade, 11 high-grade). The prevalence rate of NAD in our BE cohort was 6.7% Of the 18 study patients, there were 17 were males and 1 female of mean age 66.7 years. The mean length of BE was 3.9 cm NAD foci were associated with goblet or non-goblet epithelium in 62% and 38% of cases, respectively. Ninety-four percent of patients with NAD (17/18) also had conventional adenomatous dysplasia (four with low-grade, 13 with high-grade) elsewhere in the esophagus at the same endoscopic procedure as the one that detected NAD. Patients with NAD had a significantly shorter length of BE compared to control patients with conventional adenomatous dysplasia (N=24) (p=0.03). Patients with NAD also showed a significantly higher rate of DNA content flow cytometric abnormalities compared to the entire cohort of control patients (38% vs. 11%, p=0.05). ...
وصف الملف: text
العلاقة: http://authors.fhcrc.org/283/1/SanchezRAmJSurgPathManuscript033009.pdfTest; Rucker-Schmidt, RL and Sanchez, Carissa A and Blount, PL and Ayub, K and Li, Xiaohong and Rabinovitch, PS and Reid, BJ and Odze, RD (2009) Nonadenomatous Dysplasia in Barrett Esophagus: A Clinical, Pathologic, and DNA Content Flow Cytometric Study. The American journal of surgical pathology, 33 (6). pp. 886-893. ISSN 1532-0979
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6
المؤلفون: Hamilton, MJ, Makrauer, FM, Golden, K, Wang, H, Friedman, S, Burakoff, B, Levine, JS, Joshi, P, Banks, PA, Odze, RD
مصطلحات موضوعية: Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::190f3bfd94f95f1ce007cddbf0dc78b4Test
https://europepmc.org/articles/PMC5023478Test/ -
7كتاب
المؤلفون: Odze RD, Riddell RH, Bosman FT, Carneiro F, F. Fléjou J, Geboes K, Genta RM, Hattori T, Hruban RH, van Krieken JH, Lauwers GY, Offerhaus GJA, Shimizu M, Shimoda T, Theise ND, Vieth M., RUGGE, MASSIMO
المساهمون: Bosman FT, Carneiro F, Hruban RH, Theise ND, Odze, Rd, Riddell, Rh, Bosman, Ft, Carneiro, F, F., Fléjou J, Geboes, K, Genta, Rm, Hattori, T, Hruban, Rh, van Krieken, Jh, Lauwers, Gy, Offerhaus, Gja, Rugge, Massimo, Shimizu, M, Shimoda, T, Theise, Nd, Vieth, M.
وصف الملف: STAMPA
العلاقة: ispartofseries:WHO 4Th Edition; ispartofbook:WHO Classification of Tumours of the Digestive System; firstpage:10; lastpage:12; numberofpages:3; http://hdl.handle.net/11577/2518758Test
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8دورية أكاديمية
المؤلفون: FASSAN, MATTEO, REALDON, STEFANO, BATTAGLIA, GIORGIO, ZANINOTTO, GIOVANNI, RUGGE, MASSIMO, Volinia S, Palatini J, Pizzi M, Fernandez Cymering C, Balistreri M, Souza R, Odze RD, Croce CM
المساهمون: Fassan, Matteo, Volinia, S, Palatini, J, Pizzi, M, Fernandez Cymering, C, Balistreri, M, Realdon, Stefano, Battaglia, Giorgio, Souza, R, Odze, Rd, Zaninotto, Giovanni, Croce, Cm, Rugge, Massimo
الوصف: OBJECTIVES: The histological definition of Barrett's esophagus (BE) is debated, particularly regarding the phenotype of its metaplastic columnar epithelium. Histologically proven intestinal metaplasia (IM) was the sine qua non condition for a diagnosis of BE but, more recently, non-intestinalized (i.e., cardiac gastric-type; GM) columnar metaplasia has been re-included in the spectrum of Barrett's histology. MicroRNAs modulate cell commitment, and are also reportedly dysregulated in Barrett's carcinogenesis. This study investigates miRNA expression in the histological spectrum of esophageal columnar metaplastic changes, specifically addressing the biological profile of GM vs. IM. METHODS: A study was performed to discover microRNA microarray in 30 matching mucosa samples obtained from 10 consecutive BE patients; for each patient, biopsy tissue samples were obtained from squamous, GM and intestinalized epithelium. Microarray findings were further validated by qRT-PCR analysis in another bioptic series of 75 mucosa samples. RESULTS: MicroRNA profiling consistently disclosed metaplasia-specific microRNA signatures. Six microRNAs were significantly dysregulated across the histological phenotypes considered; five of them (two overexpressed (hsa-miR-192; -miR-215) and three under-expressed (hsa-miR-18a*; -miR-203, and -miR-205)) were progressively dysregulated in the phenotypic sequence from squamous to gastric-type, to intestinal-type mucosa samples. CONCLUSIONS: A consistent microRNA expression signature underlies both gastric- and intestinal-type esophageal metaplasia. The pattern of microRNA dysregulation suggests that GM may further progress to IM. The clinico-pathological implications of these molecular profiles prompt further study on the "personalized" cancer risk associated with each of these metaplastic transformations.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23677165; info:eu-repo/semantics/altIdentifier/wos/WOS:000209394600001; volume:4; firstpage:e34; numberofpages:7; journal:CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY; http://hdl.handle.net/11577/2683891Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84886998817
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9مؤتمر
المؤلفون: Harpaz, N, Goldblum, JR, Shepherd, N, Riddell, RH, Rubio, CA, Vieth, M, Odze, RD
المصدر: LABORATORY INVESTIGATION. 97:174A-174A
مصطلحات موضوعية: Medicin och hälsovetenskap
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10
المؤلفون: Odze, Rd, Riddell, Rh, Bosman, Ft, Carneiro, F, Fléjou J, F., Geboes, K, Genta, Rm, Hattori, T, Hruban, Rh, van Krieken JH, Lauwers, Gy, Offerhaus, Gja, Rugge, Massimo, Shimizu, M, Shimoda, T, Theise, Nd, Vieth, M.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______3657::244af2ac5080e51f3ee6cb28db8e753fTest
http://hdl.handle.net/11577/2518758Test
النص الكامل