المؤلفون: Nuin, Paulo A.S., Otto, P.A.

المصدر: Genetics and Molecular Biology. March 2000 23(1)

الوصف: The paper describes a computer program for representing and simulating population genetic phenomena, such as the distribution of gene and genotype frequencies under different mating systems (panmixia, inbreeding and assortative mating systems) and under influence of evolution factors (mutation, selection, gene flow and genetic drift). The program was written in Visual Basic (Microsoft, Inc.) and is able to run in any IBM-PC compatible computer running Windows 3.1 or later versions.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572000000100009Test

المؤلفون: Davis, Paul, Zarowiecki, Magdalena, Arnaboldi, Valerio, Becerra, Andrés, Cain, Scott, Chan, Juancarlos, Chen, Wen J, Cho, Jaehyoung, da Veiga Beltrame, Eduardo, Diamantakis, Stavros, Gao, Sibyl, Grigoriadis, Dionysis, Grove, Christian A, Harris, Todd W, Kishore, Ranjana, Le, Tuan, Lee, Raymond YN, Luypaert, Manuel, Müller, Hans-Michael, Nakamura, Cecilia, Nuin, Paulo, Paulini, Michael, Quinton-Tulloch, Mark, Raciti, Daniela, Rodgers, Faye H, Russell, Matthew, Schindelman, Gary, Singh, Archana, Stickland, Tim, Van Auken, Kimberly, Wang, Qinghua, Williams, Gary, Wright, Adam J, Yook, Karen, Berriman, Matt, Howe, Kevin L, Schedl, Tim, Stein, Lincoln, Sternberg, Paul W

المصدر: Genetics. 220(4)

مصطلحات موضوعية: Biological Sciences, Genetics, Human Genome, Generic health relevance, Animals, Caenorhabditis, Caenorhabditis elegans, Databases, Genetic, Genome, Genomics, Humans, Nematoda, Caenorhabditis elegans, annotation, caenorhabditis, community, curation, data, database, gene, health, human, literature, mining, model, nematode, platform, research, resource, software, tools, Developmental Biology, Biochemistry and cell biology

الوصف: WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and many aspects of fundamental biology. Throughout our 22-year history, we have continued to evolve to reflect progress and innovation in the science and technologies involved in the study of C. elegans. We strive to incorporate new data types and richer data sets, and to provide integrated displays and services that avail the knowledge generated by the published nematode genetics literature. Here, we provide a broad overview of the current state of WormBase in terms of data type, curation workflows, analysis, and tools, including exciting new advances for analysis of single-cell data, text mining and visualization, and the new community collaboration forum. Concurrently, we continue the integration and harmonization of infrastructure, processes, and tools with the Alliance of Genome Resources, of which WormBase is a founding member.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2ch788zmTest

المؤلفون: Agapite, Julie, Albou, Laurent-Philippe, Aleksander, Suzanne A, Alexander, Micheal, Anagnostopoulos, Anna V, Antonazzo, Giulia, Argasinska, Joanna, Arnaboldi, Valerio, Attrill, Helen, Becerra, Andrés, Bello, Susan M, Blake, Judith A, Blodgett, Olin, Bradford, Yvonne M, Bult, Carol J, Cain, Scott, Calvi, Brian R, Carbon, Seth, Chan, Juancarlos, Chen, Wen J, Cherry, J Michael, Cho, Jaehyoung, Christie, Karen R, Crosby, Madeline A, Davis, Paul, da Veiga Beltrame, Eduardo, De Pons, Jeffrey L, D’Eustachio, Peter, Diamantakis, Stavros, Dolan, Mary E, dos Santos, Gilberto, Douglass, Eric, Dunn, Barbara, Eagle, Anne, Ebert, Dustin, Engel, Stacia R, Fashena, David, Foley, Saoirse, Frazer, Ken, Gao, Sibyl, Gibson, Adam C, Gondwe, Felix, Goodman, Josh, Gramates, L Sian, Grove, Christian A, Hale, Paul, Harris, Todd, Hayman, G Thomas, Hill, David P, Howe, Douglas G, Howe, Kevin L, Hu, Yanhui, Jha, Sagar, Kadin, James A, Kaufman, Thomas C, Kalita, Patrick, Karra, Kalpana, Kishore, Ranjana, Kwitek, Anne E, Laulederkind, Stanley JF, Lee, Raymond, Longden, Ian, Luypaert, Manuel, MacPherson, Kevin A, Martin, Ryan, Marygold, Steven J, Matthews, Beverley, McAndrews, Monica S, Millburn, Gillian, Miyasato, Stuart, Motenko, Howie, Moxon, Sierra, Muller, Hans-Michael, Mungall, Christopher J, Muruganujan, Anushya, Mushayahama, Tremayne, Nalabolu, Harika S, Nash, Robert S, Ng, Patrick, Nuin, Paulo, Paddock, Holly, Paulini, Michael, Perrimon, Norbert, Pich, Christian, Quinton-Tulloch, Mark, Raciti, Daniela, Ramachandran, Sridhar, Richardson, Joel E, Gelbart, Susan Russo, Ruzicka, Leyla, Schaper, Kevin, Schindelman, Gary, Shimoyama, Mary, Simison, Matt, Shaw, David R, Shrivatsav, Ajay, Singer, Amy, Skrzypek, Marek, Smith, Constance M, Smith, Cynthia L

المصدر: Genetics. 220(4)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Genetics, Biotechnology, Human Genome, Underpinning research, 1.5 Resources and infrastructure (underpinning), Alleles, Animals, Caenorhabditis elegans, Databases, Genetic, Drosophila, Gene Ontology, Humans, Internet, Mice, Molecular Sequence Annotation, Rats, Saccharomycetales, Zebrafish, Alliance of Genome Resources Consortium, biocuration, data mining, gene expression, gene function, gene interaction, genome, knowledgebase, phenotype, variants, Developmental Biology, Biochemistry and cell biology

الوصف: The Alliance of Genome Resources (the Alliance) is a combined effort of 7 knowledgebase projects: Saccharomyces Genome Database, WormBase, FlyBase, Mouse Genome Database, the Zebrafish Information Network, Rat Genome Database, and the Gene Ontology Resource. The Alliance seeks to provide several benefits: better service to the various communities served by these projects; a harmonized view of data for all biomedical researchers, bioinformaticians, clinicians, and students; and a more sustainable infrastructure. The Alliance has harmonized cross-organism data to provide useful comparative views of gene function, gene expression, and human disease relevance. The basis of the comparative views is shared calls of orthology relationships and the use of common ontologies. The key types of data are alleles and variants, gene function based on gene ontology annotations, phenotypes, association to human disease, gene expression, protein-protein and genetic interactions, and participation in pathways. The information is presented on uniform gene pages that allow facile summarization of information about each gene in each of the 7 organisms covered (budding yeast, roundworm Caenorhabditis elegans, fruit fly, house mouse, zebrafish, brown rat, and human). The harmonized knowledge is freely available on the alliancegenome.org portal, as downloadable files, and by APIs. We expect other existing and emerging knowledge bases to join in the effort to provide the union of useful data and features that each knowledge base currently provides.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8xx9b11gTest

المؤلفون: Aleksander, Suzanne A., Anagnostopoulos, Anna V., Antonazzo, Giulia, Arnaboldi, Valerio, Attrill, Helen, Becerra, Andrés, Bello, Susan M., Blodgett, Olin, Bradford, Yvonne M., Bult, Carol J., Cain, Scott, Calvi, Brian R., Carbon, Seth, Chan, Juancarlos, Chen, Wen J., Cherry, J. Michael, Cho, Jaehyoung, Crosby, Madeline A., De Pons, Jeffrey L., D'Eustachio, Peter, Diamantakis, Stavros, Dolan, Mary E., dos Santos, Gilberto, Dyer, Sarah, Ebert, Dustin, Engel, Stacia R., Fashena, David, Fisher, Malcolm, Foley, Saoirse, Gibson, Adam C., Gollapally, Varun R., Gramates, L. Sian, Grove, Christian A., Hale, Paul, Harris, Todd, Hayman, G. Thomas, Hu, Yanhui, James-Zorn, Christina, Karimi, Kamran, Karra, Kalpana, Kishore, Ranjana, Kwitek, Anne E., Laulederkind, Stanley J. F., Lee, Raymond, Longden, Ian, Luypaert, Manuel, Markarian, Nicholas, Marygold, Steven J., Matthews, Beverley, McAndrews, Monica S., Millburn, Gillian, Miyasato, Stuart, Motenko, Howie, Moxon, Sierra, Muller, Hans-Michael, Mungall, Christopher J., Muruganujan, Anushya, Mushayahama, Tremayne, Nash, Robert S., Nuin, Paulo, Paddock, Holly, Pells, Troy, Perrimon, Norbert, Pich, Christian, Quinton-Tulloch, Mark, Raciti, Daniela, Ramachandran, Sridhar, Richardson, Joel E., Russo Gelbart, Susan, Ruzicka, Leyla, Schindelman, Gary, Shaw, David R., Sherlock, Gavin, Shrivatsav, Ajay, Singer, Amy, Smith, Constance M., Smith, Cynthia L., Smith, Jennifer R., Stein, Lincoln, Sternberg, Paul W, Tabone, Christopher J., Thomas, Paul D., Thorat, Ketaki, Thota, Jyothi, Tomczuk, Monika, Trovisco, Vitor, Tutaj, Marek A., Urbano, Jose-Maria, Van Auken, Kimberly, Van Slyke, Ceri E., Vize, Peter D., Wang, Qinghua, Weng, Shuai, Westerfield, Monte, Wilming, Laurens G., Wong, Edith D., Wright, Adam, Yook, Karen, Zhou, Pinglei, Zorn, Aaron, Zytkovicz, Mark, Alliance of Genome Resources Consortium

المصدر: Genetics, 227(1), iyae049, (2024-05)

الوصف: The Alliance of Genome Resources (Alliance) is an extensible coalition of knowledgebases focused on the genetics and genomics of intensively studied model organisms. The Alliance is organized as individual knowledge centers with strong connections to their research communities and a centralized software infrastructure, discussed here. Model organisms currently represented in the Alliance are budding yeast,Caenorhabditis elegans,Drosophila, zebrafish, frog, laboratory mouse, laboratory rat, and the Gene Ontology Consortium. The project is in a rapid development phase to harmonize knowledge, store it, analyze it, and present it to the community through a web portal, direct downloads, and application programming interfaces (APIs). Here, we focus on developments over the last 2 years. Specifically, we added and enhanced tools for browsing the genome (JBrowse), downloading sequences, mining complex data (AllianceMine), visualizing pathways, full-text searching of the literature (Textpresso), and sequence similarity searching (SequenceServer). We enhanced existing interactive data tables and added an interactive table of paralogs to complement our representation of orthology. To support individual model organism communities, we implemented species-specific “landing pages” and will add disease-specific portals soon; in addition, we support a common community forum implemented in Discourse software. We describe our progress toward a central persistent database to support curation, the data modeling that underpins harmonization, and progress toward a state-of-the-art literature curation system with integrated artificial intelligence and machine learning (AI/ML). ; © The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work ...

العلاقة: https://doi.org/10.1101/2023.11.20.567935Test; https://www.ncbi.nlm.nih.gov/pmc/PMC10690154Test; https://doi.org/10.1093/genetics/iyae049Test; oai:authors.library.caltech.edu:agb38-ew637; https://www.ncbi.nlm.nih.gov/pmc/PMC11075569Test

الإتاحة: https://doi.org/10.1093/genetics/iyae04910.1101/2023.11.20.567935Test
https://www.ncbi.nlm.nih.gov/pmc/PMC11075569Test

المؤلفون: Sternberg, Paul W., Van Auken, Kimberly, Wang, Qinghua, Wright, Adam, Yook, Karen, Zarowiecki, Magdalena, Arnaboldi, Valerio, Becerra, Andrés, Brown, Stephanie, Cain, Scott, Chan, Juancarlos, Chen, Wen J., Cho, Jaehyoung, Davis, Paul, Diamantakis, Stavros, Dyer, Sarah, Grigoriadis, Dionysis, Grove, Christian A., Harris, Todd, Howe, Kevin, Kishore, Ranjana, Lee, Raymond, Longden, Ian, Luypaert, Manuel, Müller, Hans-Michael, Nuin, Paulo, Quinton-Tulloch, Mark, Raciti, Daniela, Schedl, Tim, Schindelman, Gary, Stein, Lincoln

المصدر: Genetics, 227(1), iyae050, (2024-05)

الوصف: WormBase has been the major repository and knowledgebase of information about the genome and genetics ofCaenorhabditis elegansand other nematodes of experimental interest for over 2 decades. We have 3 goals: to keep current with the fast-pacedC. elegansresearch, to provide better integration with other resources, and to be sustainable. Here, we discuss the current state of WormBase as well as progress and plans for moving core WormBase infrastructure to the Alliance of Genome Resources (the Alliance). As an Alliance member, WormBase will continue to interact with theC. elegans community, develop new features as needed, and curate key information from the literature and large-scale projects. ; © The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. ; We thank our numerousC. elegans and other nematode colleagues for their continual feedback. We thank the National Human Genome Research Institute (NHGRI) Program Staff (Sandhya Xirasagar, Valentina di Francesco, Sarah Hutchison, and Helen Thompson) for guidance. ; The core funding for WormBase is from the National Human Genome Research Institute (NHGRI) U24HG002223 and Medical Research Council-UK grant MR/L001020/1; funding for the Alliance is from NHGRI and the National Heart, Lung and Blood Institute (U24HG010859). Curation tools are supported in part by the National Library of Medicine (NLM) R01LM013871. ; All WormBase and Alliance code and information are freely available. Specifically, WormBase code is freely available athttps://github.com/WormBase. WormBase data are available fordownloadand programmatically by API as described athttps://wormbase.org/about/userguide/for_developers/api-rest#10–10. Alliance data are ...

العلاقة: https://doi.org/10.1093/genetics/iyae050Test; oai:authors.library.caltech.edu:5sbp7-bgs69; https://www.ncbi.nlm.nih.gov/pmc/PMC11075546Test

الإتاحة: https://doi.org/10.1093/genetics/iyae050Test
https://www.ncbi.nlm.nih.gov/pmc/PMC11075546Test

المؤلفون: Goubran, Mariam (University of Alberta), Mason, Andrew L. (University of Alberta), Indik, Stanislav (University of Veterinary Medicine Vienna), Wang, Weiwei (University of Alberta), Wong, Gane K-S (University of Alberta), Macintyre, Georgina (University of Alberta), Nuin, Paulo (University of Alberta), Zhang, Guangzhi (University of Alberta), Carpenter, Eric J. (University of Alberta), Bintner, Jasper (University of Alberta), Wasilenko, Shawn T. (University of Alberta), Faschinger, Alexander (University of Veterinary Medicine Vienna)

المصدر: Viruses 14(5) (2022)

مصطلحات موضوعية: Mammary-Tumor Virus, Human Breast-Cancer, Env Gene-Sequences, Epithelial-Cells, Mouse, Integration, Cirrhosis, Dna, Identification, Autoimmune

الوصف: A human betaretrovirus (HBRV) has been linked with the autoimmune liver disease, primary biliary cholangitis (PBC), and various cancers, including breast cancer and lymphoma. HBRV is closely related to the mouse mammary tumor virus, and represents the only exogenous betaretrovirus characterized in humans to date. Evidence of infection in patients with PBC has been demonstrated through the identification of proviral integration sites in lymphoid tissue, the major reservoir of infection, as well as biliary epithelium, which is the site of the disease process. Accordingly, we tested the hypothesis that patients with PBC harbor a transmissible betaretrovirus by co-cultivation of PBC patients' lymph node homogenates with the HS578T breast cancer line. Because of the low level of HBRV replication, betaretrovirus producing cells were subcloned to optimize viral isolation and production. Evidence of infection was provided by electron microscopy, RT-PCR, in situ hybridization, cloning of the HBRV proviral genome and demonstration of more than 3400 integration sites. Further evidence of viral transmissibility was demonstrated by infection of biliary epithelial cells. While HBRV did not show a preference for integration proximal to specific genomic features, analyses of common insertion sites revealed evidence of integration proximal to cancer associated genes. These studies demonstrate the isolation of HBRV with features similar to mouse mammary tumor virus and confirm that patients with PBC display evidence of a transmissible viral infection.

وصف الملف: application/pdf

العلاقة: isPartOf:https://phaidra.vetmeduni.ac.at/o:605Test[Publications / University of Veterinary Medicine Vienna]; https://phaidra.vetmeduni.ac.at/o:1909Test

الإتاحة: https://doi.org/10.3390/v14050886Test
https://phaidra.vetmeduni.ac.at/o:1909Test

المؤلفون: Davis, Paul, Zarowiecki, Magdalena, Arnaboldi, Valerio, Becerra, Andrés, Cain, Scott, Chan, Juancarlos, Chen, Wen J., Cho, Jaehyoung, da Veiga Beltrame, Eduardo, Diamantakis, Stavros, Gao, Sibyl, Grigoriadis, Dionysis, Grove, Christian A., Harris, Todd W., Kishore, Ranjana, Le, Tuan, Lee, Raymond Y. N., Luypaert, Manuel, Müller, Hans-Michael, Nakamura, Cecilia, Nuin, Paulo, Paulini, Michael, Quinton-Tulloch, Mark, Raciti, Daniela, Rodgers, Faye H., Russell, Matthew, Schindelman, Gary, Singh, Archana, Stickland, Tim, Van Auken, Kimberly, Wang, Qinghua, Williams, Gary, Wright, Adam J., Yook, Karen, Berriman, Matt, Howe, Kevin L., Schedl, Tim, Stein, Lincoln, Sternberg, Paul W.

المصدر: Genetics, 220(4), Art. No. iyac003, (2022-04)

مصطلحات موضوعية: Caenorhabditis elegans, caenorhabditis, nematode, resource, model, database, data, community, software, gene, curation, annotation, research, literature, mining, tools, health, human, platform, Genetics

الوصف: WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and many aspects of fundamental biology. Throughout our 22-year history, we have continued to evolve to reflect progress and innovation in the science and technologies involved in the study of C. elegans. We strive to incorporate new data types and richer data sets, and to provide integrated displays and services that avail the knowledge generated by the published nematode genetics literature. Here, we provide a broad overview of the current state of WormBase in terms of data type, curation workflows, analysis, and tools, including exciting new advances for analysis of single-cell data, text mining and visualization, and the new community collaboration forum. Concurrently, we continue the integration and harmonization of infrastructure, processes, and tools with the Alliance of Genome Resources, of which WormBase is a founding member. ; © The Author(s) 2022. Published by Oxford University Press on behalf of Genetics Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. The authors wish to thank the US National Human Genome Research Institute; UK Medical Research Council funding agencies for their ongoing support of WormBase and members of the C. elegans research community whose insights and explorations form the purpose of WormBase, all those contributing data through AFP or data submission forms, and all the WormBase users, for all your feedback, input and requests which inspire and guide us. Funding for WormBase is from US National Human Genome Research Institute [U24 HG002223]; UK ...

العلاقة: https://doi.org/10.1093/genetics/iyac003Test; oai:authors.library.caltech.edu:ax9qa-w5481; https://www.ncbi.nlm.nih.gov/pmc/PMC8982018Test; eprintid:113875; resolverid:CaltechAUTHORS:20220310-752284000

الإتاحة: https://doi.org/10.1093/genetics/iyac003Test
https://www.ncbi.nlm.nih.gov/pmc/PMC8982018Test

المؤلفون: Elian,Fahed, Are,Ubah, Ghosh,Sunita, Nuin,Paulo, Footz,Tim, McMullen,Todd, Brindley,David, Walter,Michael A

مصطلحات موضوعية: Breast Cancer: Targets and Therapy

الوصف: Fahed A Elian,1 Ubah Are,1 Sunita Ghosh,2,3 Paulo Nuin,1 Tim Footz,1 Todd PW McMullen,4 David N Brindley,5,6 Michael A Walter1 1Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; 2Department of Medical Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; 3Department of Mathematical and Statistical Sciences, Faculty of Science, University of Alberta, Edmonton, AB, Canada; 4Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; 5Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; 6Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB, CanadaCorrespondence: Michael A WalterDepartment of Medical Genetics, Faculty of Medicine & Dentistry, University of Alberta, 8-32 Medical Sciences Building, Edmonton, AB, T6G 2H7, CanadaTel +1 (780) 492-3028Email mwalter@ualberta.caPurpose: Forkhead box Q1 (FOXQ1) has been shown to contribute to the development and progression of cancers, including ovarian and breast cancer (BC). However, research exploring FOXQ1 expression, copy number variation (CNV), and prognostic value across different BC subtypes is limited. Our purpose was to evaluate FOXQ1 mRNA expression, CNV, and prognostic value across BC subtypes.Materials and Methods: We determined FOXQ1 expression and CNV in BC patient tumors using RT-qPCR and qPCR, respectively. We also analyzed FOXQ1 expression and CNV in BC cell lines in the CCLE database using K-means clustering. The prognostic value of FOXQ1 expression in the TCGA-BRCA database was assessed using univariate and multivariate Cox’s regression analysis as well as using the online tools OncoLnc, GEPIA, and UALCAN.Results: Our analyses reveal that FOXQ1 mRNA is differentially expressed between different subtypes of BC and is significantly decreased in luminal BC and HER2 patients when compared to normal breast tissue samples. Furthermore, ...

وصف الملف: text/html

العلاقة: https://www.dovepress.com/foxq1-is-differentially-expressed-across-breast-cancer-subtypes-with-l-peer-reviewed-fulltext-article-BCTTTest

الإتاحة: https://doi.org/10.2147/BCTT.S282860Test
https://www.dovepress.com/foxq1-is-differentially-expressed-across-breast-cancer-subtypes-with-l-peer-reviewed-fulltext-article-BCTTTest

المؤلفون: Elian, Fahed, Are, Ubah, Ghosh, Sunita, Nuin, Paulo, Footz, Tim, McMullen, Todd, Brindley, David, Walter, Michael A

المصدر: Breast Cancer: Targets and Therapy ; volume Volume 13, page 171-188 ; ISSN 1179-1314

الإتاحة: https://doi.org/10.2147/bctt.s282860Test
https://www.dovepress.com/getfile.php?fileID=67173Test

المؤلفون: Harris, Todd W, Arnaboldi, Valerio, Cain, Scott, Chan, Juancarlos, Chen, Wen J, Cho, Jaehyoung, Davis, Paul, Gao, Sibyl, Grove, Christian A, Kishore, Ranjana, Lee, Raymond Y N, Muller, Hans-Michael, Nakamura, Cecilia, Nuin, Paulo, Paulini, Michael, Raciti, Daniela, Rodgers, Faye H, Russell, Matthew, Schindelman, Gary, Auken, Kimberly V, Wang, Qinghua, Williams, Gary, Wright, Adam J, Yook, Karen, Howe, Kevin L, Schedl, Tim, Stein, Lincoln, Sternberg, Paul W

المساهمون: National Human Genome Research Institute, Medical Research Council, Biotechnology and Biological Sciences Research Council

المصدر: Nucleic Acids Research ; ISSN 0305-1048 1362-4962

الوصف: WormBase (https://wormbase.orgTest/) is a mature Model Organism Information Resource supporting researchers using the nematode Caenorhabditis elegans as a model system for studies across a broad range of basic biological processes. Toward this mission, WormBase efforts are arranged in three primary facets: curation, user interface and architecture. In this update, we describe progress in each of these three areas. In particular, we discuss the status of literature curation and recently added data, detail new features of the web interface and options for users wishing to conduct data mining workflows, and discuss our efforts to build a robust and scalable architecture by leveraging commercial cloud offerings. We conclude with a description of WormBase's role as a founding member of the nascent Alliance of Genome Resources.

الإتاحة: https://doi.org/10.1093/nar/gkz920Test