المؤلفون: Randazzo, Gianmarco, Bovolenta, Eleonora, Ceccato, Tommaso, Reitano, Giuseppe, Betto, Giovanni, Novara, Giacomo, Iafrate, Massimo, Morlacco, Alessandro, Dal Moro, Fabrizio, Zattoni, Fabio

المصدر: Frontiers in Urology ; volume 4 ; ISSN 2673-9828

الوصف: Introduction The urinary microbiome (UMB) includes living bacteria, their genomes, and their products from interactions with the host environment. A “core” UMB could potentially exist, with variations between age and sex groups. Changes in UMB composition have been associated with benign urological disorders, but also with urologic cancers. Mechanisms through which UMB can trigger and maintain cancer can be local inflammation and interaction with immune system. Aim of the study To describe the association between UMB and development of urologic cancers. Methods A non-systematic literature review identified recently published studies (last 5 years), involving human patients, dealing with UMB. The database used for this review was PubMed, and the identified studies served as the base for a narrative analysis of the literature that explored the potential associations between UMB and urological cancers. Results In bladder cancer (BC), UMB may play a role in epithelial-mesenchymal transition (and thus to progression to metastasis), as well as in effectiveness of BCG response rate. BC is also associated with changes in UMB, with bacterial richness indices increased in cancer groups compared to non-neoplastic groups and being different between NMIBC vs MIBC patients. In prostate cancer (PCa), there is an abundance in proinflammatory bacteria and uropathogens. In regard to renal cell carcinoma (RCC), penile cancer and testicular cancer there are still too few studies to draw significant conclusions about its relationship with the UMB. Conclusions Gaining a deeper understanding of UMB role in urologic tumors could aid in the development of new therapies and improve classification of patients’ risk.

الإتاحة: https://doi.org/10.3389/fruro.2024.1367720Test

المؤلفون: Zattoni, Fabio, Dal Moro, Fabrizio, Bednarova, Iliana, Novara, Giacomo

المصدر: European Urology Open Science ; volume 61, page 52-53 ; ISSN 2666-1683

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.euros.2023.12.009Test
https://api.elsevier.com/content/article/PII:S2666168324002258?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666168324002258?httpAccept=text/plainTest

المؤلفون: Porpiglia, Francesco, Checcucci, Enrico, Autorino, Riccardo, Amparore, Daniele, Cooperberg, Matthew R, Ficarra, Vincenzo, Novara, Giacomo

المصدر: European Urology. 78(3)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Good Health and Well Being, Betacoronavirus, COVID-19, Communicable Disease Control, Congresses as Topic, Coronavirus Infections, Disease Transmission, Infectious, Forecasting, Humans, Inventions, Pandemics, Pneumonia, Viral, SARS-CoV-2, Telecommunications, Urology & Nephrology, Clinical sciences

الوصف: The speed and reach of the COVID-19 pandemic have forced rapid changes in how we conduct medical practice and research. The rapid evolution in how scientific meetings are conducted may have long-term benefits. A new reality in which technology and sociality are merged may offer a more engaging and adaptable scientific congress experience with more flexible and dynamic use of content modulated to the needs of each attendee.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5087f30hTest

المؤلفون: Marturano, Francesca, Guglielmo, Priscilla, Bettinelli, Andrea, Zattoni, Fabio, Novara, Giacomo, Zorz, Alessandra, Sepulcri, Matteo, Gregianin, Michele, Paiusco, Marta, Evangelista, Laura

المساهمون: Marturano, Francesca, Guglielmo, Priscilla, Bettinelli, Andrea, Zattoni, Fabio, Novara, Giacomo, Zorz, Alessandra, Sepulcri, Matteo, Gregianin, Michele, Paiusco, Marta, Evangelista, Laura

مصطلحات موضوعية: Artificial intelligence, Fluorocholine, Positron emission tomography computed tomography, Prostatic neoplasms

الوصف: AimTo study the feasibility of radiomic analysis of baseline [F-18]fluoromethylcholine positron emission tomography/computed tomography (PET/CT) for the prediction of biochemical recurrence (BCR) in a cohort of intermediate and high-risk prostate cancer (PCa) patients.Material and methodsSeventy-four patients were prospectively collected. We analyzed three prostate gland (PG) segmentations (i.e., PG(whole): whole PG; PG(41%): prostate having standardized uptake value - SUV > 0.41*SUVmax; PG(2.5): prostate having SUV > 2.5) together with three SUV discretization steps (i.e., 0.2, 0.4, and 0.6). For each segmentation/discretization step, we trained a logistic regression model to predict BCR using radiomic and/or clinical features.ResultsThe median baseline prostate-specific antigen was 11 ng/mL, the Gleason score was > 7 for 54% of patients, and the clinical stage was T1/T2 for 89% and T3 for 9% of patients. The baseline clinical model achieved an area under the receiver operating characteristic curve (AUC) of 0.73. Performances improved when clinical data were combined with radiomic features, in particular for PG(2.5) and 0.4 discretization, for which the median test AUC was 0.78.ConclusionRadiomics reinforces clinical parameters in predicting BCR in intermediate and high-risk PCa patients. These first data strongly encourage further investigations on the use of radiomic analysis to identify patients at risk of BCR.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37079030; info:eu-repo/semantics/altIdentifier/wos/WOS:000972783100002; journal:EUROPEAN RADIOLOGY; https://hdl.handle.net/11577/3481026Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85153055763

الإتاحة: https://doi.org/10.1007/s00330-023-09642-9Test
https://hdl.handle.net/11577/3481026Test

المؤلفون: Zattoni, Fabio, Pereira, Leonor J. Paulino, Marra, Giancarlo, Valerio, Massimo, Olivier, Jonathan, Puche-Sanz, Ignacio, Rajwa, Pawel, Maggi, Martina, Campi, Riccardo, Amparore, Daniele, De Cillis, Sabrina, Junlong, Zhuang, Guo, Hongqian, La Bombarda, Giulia, Fuschi, Andrea, Veccia, Alessandro, Ditonno, Francesco, Marquis, Alessandro, Barletta, Francesco, Leni, Riccardo, Serni, Sergio, Kasivisvanathan, Veeru, Antonelli, Alessandro, Dal Moro, Fabrizio, Rivas, Juan Gomez, van den Bergh, Roderick C. N., Briganti, Alberto, Gandaglia, Giorgio, Novara, Giacomo

المساهمون: Università degli Studi di Padova

المصدر: World Journal of Urology ; volume 41, issue 11, page 3357-3366 ; ISSN 1433-8726

مصطلحات موضوعية: Urology

الوصف: Objective To evaluate the proportions of detected prostate cancer (PCa) and clinically significant PCa (csPCa), as well as identify clinical predictors of PCa, in patients with PI-RADS > = 3 lesion at mpMRI and initial negative targeted and systematic biopsy (initial biopsy) who underwent a second MRI and a re-biopsy. Methods A total of 290 patients from 10 tertiary referral centers were included. The primary outcome measures were the presence of PCa and csPCa at re-biopsy. Logistic regression analyses were performed to evaluate predictors of PCa and csPCa, adjusting for relevant covariates. Results Forty-two percentage of patients exhibited the presence of a new lesion. Furthermore, at the second MRI, patients showed stable, upgrading, and downgrading PI-RADS lesions in 42%, 39%, and 19%, respectively. The interval from the initial to repeated mpMRI and from the initial to repeated biopsy was 16 mo (IQR 12–20) and 18 mo (IQR 12–21), respectively. One hundred and eight patients (37.2%) were diagnosed with PCa and 74 (25.5%) with csPCa at re-biopsy. The presence of ASAP on the initial biopsy strongly predicted the presence of PCa and csPCa at re-biopsy. Furthermore, PI-RADS scores at the first and second MRI and a higher number of systematic biopsy cores at first and second biopsy were independent predictors of the presence of PCa and csPCa. Selection bias cannot be ruled out. Conclusions Persistent PI-RADS ≥ 3 at the second MRI is suggestive of the presence of a not negligible proportion of csPca. These findings contribute to the refinement of risk stratification for men with initial negative MRI-TBx.

الإتاحة: https://doi.org/10.1007/s00345-023-04578-7Test

المؤلفون: Randazzo, Gianmarco, Reitano, Giuseppe, Carletti, Filippo, Iafrate, Massimo, Betto, Giovanni, Novara, Giacomo, Dal Moro, Fabrizio, Zattoni, Fabio

المساهمون: Università degli Studi di Padova

المصدر: World Journal of Urology ; volume 41, issue 10, page 2647-2657 ; ISSN 1433-8726

مصطلحات موضوعية: Urology

الوصف: Purpose Metaverse is becoming an alternative world in which technology and virtual experiences are mixed with real life, and it holds the promise of changing our way of living. Healthcare is already changing thanks to Metaverse and its numerous applications. In particular, Urology and urologic patients can benefit in many ways from Metaverse. Methods A non-systematic literature review identified recently published studies dealing with Metaverse. The database used for this review was PubMed, and the identified studies served as the base for a narrative analysis of the literature that explored the use of Metaverse in Urology. Results Virtual consultations can enhance access to care and reduce distance and costs, and pain management and rehabilitation can find an incredible support in virtual reality, reducing anxiety and stress and improving adherence to therapy. Metaverse has the biggest potential in urologic surgery, where it can revolutionize both surgery planning, with 3D modeling and virtual surgeries, and intraoperatively, with augmented reality and artificial intelligence. Med Schools can implement Metaverse in anatomy and surgery lectures, providing an immersive environment for learning, and residents can use this platform for learning in a safe space at their own pace. However, there are also potential challenges and ethical concerns associated with the use of the metaverse in healthcare. Conclusions This paper provides an overview of the concept of the metaverse, its potential applications, challenges, and opportunities, and discusses the implications of its development in Urology.

الإتاحة: https://doi.org/10.1007/s00345-023-04560-3Test

المؤلفون: Zattoni, Fabio, Carletti, Filippo, Randazzo, Gianmarco, Tuminello, Arianna, Betto, Giovanni, Novara, Giacomo, Dal Moro, Fabrizio

المصدر: European Urology Focus ; ISSN 2405-4569

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.euf.2023.12.003Test
https://api.elsevier.com/content/article/PII:S240545692300295X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S240545692300295X?httpAccept=text/plainTest

المؤلفون: Dal Moro, Fabrizio, Zattoni, Fabio, Tonet, Elisa, Morlacco, Alessandro, Betto, Giovanni, Novara, Giacomo

المصدر: European Urology Open Science ; volume 57, page 8-15 ; ISSN 2666-1683

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.euros.2023.09.001Test
https://api.elsevier.com/content/article/PII:S2666168323009199?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666168323009199?httpAccept=text/plainTest

المؤلفون: Zattoni, Fabio, Marra, Giancarlo, Martini, Alberto, Kasivisvanathan, Veeru, Grummet, Jeremy, Harkin, Timothy, Ploussard, Guillaume, Olivier, Jonathan, Chiu, Peter K., Valerio, Massimo, Marquis, Alessandro, Gontero, Paolo, Guo, Hongqian, Zhuang, Junlong, Frydenberg, Mark, Moon, Daniel, Morlacco, Alessandro, Kretschmer, Alexander, Barletta, Francesco, Heidegger, Isabel, Tilki, Derya, van den Bergh, Roderick, Dal Moro, Fabrizio, Briganti, Alberto, Montorsi, Francesco, Novara, Giacomo, Gandaglia, Giorgio

المساهمون: University of Padua

المصدر: European Urology Focus ; volume 9, issue 4, page 621-628 ; ISSN 2405-4569

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.euf.2023.01.016Test
https://api.elsevier.com/content/article/PII:S2405456923000329?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2405456923000329?httpAccept=text/plainTest

المؤلفون: Novara, Giacomo, Lami, Valeria, Evangelista, Laura, Bartoletti, Paola, De Conti, Giorgio, Carletti, Filippo, Martino, Francesca Katiana, Betto, Giovanni, Zattoni, Fabio, Dal Moro, Fabrizio

المساهمون: Novara, Giacomo, Lami, Valeria, Evangelista, Laura, Bartoletti, Paola, De Conti, Giorgio, Carletti, Filippo, Martino, Francesca Katiana, Betto, Giovanni, Zattoni, Fabio, Dal Moro, Fabrizio

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37607303; info:eu-repo/semantics/altIdentifier/wos/WOS:001062768100001; volume:133; issue:1; firstpage:46; lastpage:48; numberofpages:3; journal:BJU INTERNATIONAL; https://hdl.handle.net/11577/3502962Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85169789484

الإتاحة: https://doi.org/10.1111/bju.16164Test
https://hdl.handle.net/11577/3502962Test