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1دورية أكاديمية
المؤلفون: van Ginkel, Noor, Vis, André N., Boormans, Joost L., van der Poel, Henk G., van der Schoot, Deric K. E., Aben, Katja K. H., Hermans, Tom J. N., Meijer, Dennie, Voortman, Jens, Arends, Tom J. H., Ausems, Peter J., Baselmans, Dorine, Berger, Christian P. A. M., Berrens, Anne-Claire, Bickerstaffe, Henry, Bos, Siebe D., Braam, Marlene, Buddingh, K. Tim, Claus, Sebastiaan, Dekker, Karen, van Doeveren, Thomas, Einerhand, Sarah M. H., Fossion, Laurent M. C. Laurent, Hinsenveld, Florentien J., van Gennep, Erik J., Grondhuis Palacios, Lorena A., Hobijn, Mandy M., van Huystee, Suzanne H., Jaspers-Valentijn, Martinique, Klaver, O. Sjoerd, Koldewijn, Evert L., Korsten, Linn, Lenting, Anne, Lentjes, Koen J., Luiting, Henk B., van der Meer, Saskia, Mertens, Laura, Nieuwenhuijzen, Jakko A., Noordzij, M. Arjen, Nooter, Ronald I., Notenboom, Marije, Oomen, Robert J. A., van Roermund, Joep G. H., de Rooij, Judith, Roshani, Hossain, Schrier, Bart P., van der Slot, Michelle A., Somford, D. M. Rik, Stelwagen, Piter-Jan, Stroux, Aukje M. A., van der West, Alwine, Wijsman, Bart P., Windt, Willemijn A. K. M., van Zanten, Paul, van Beek, Sytse C.
المصدر: van Ginkel , N , Vis , A N , Boormans , J L , van der Poel , H G , van der Schoot , D K E , Aben , K K H , Hermans , T J N , Meijer , D , Voortman , J , Arends , T J H , Ausems , P J , Baselmans , D , Berger , C P A M , Berrens , A-C , Bickerstaffe , H , Bos , S D , Braam , M , Buddingh , K T , Claus , S , Dekker ....
الوصف: There is insufficient knowledge on intermediate-term survival of non-metastatic muscle-invasive bladder cancer (MIBC) after open (ORC) versus robot-assisted (RARC) cystectomy, with or without neo-adjuvant chemotherapy (NAC). This retrospective study was performed in 19 Dutch hospitals between 2012 and 2015 to assess the five-year survival after both interventions and the influence of NAC. Out of 1,534 cT1-4N0-1-patients, 1,086 patients were treated with ORC and 389 with RARC. The 5‑year survival rate after ORC was 51% (95% CI 47–53) versus 58% after RARC (95% CI 52–63), hazard ratio 1.00 (95% CI 0.84–1.20) after multivariable analysis. 226 of 965 cT2-4aN0 patients were treated with NAC. More patients had ypT0 after NAC than after no NAC (31% vs 15%; p < 0.01). The best five-year survival was in patients with ypT0 after NAC (89%; 95% CI 81–97). This study shows similar five-year survival of MIBC patients treated with ORC or RARC and shows that the best survival was after NAC.
الإتاحة: https://doi.org/10.1007/s13629-023-00409-xTest
https://research.vumc.nl/en/publications/229f7fc6-51f4-45df-a79d-667606c93839Test
http://www.scopus.com/inward/record.url?scp=85176406111&partnerID=8YFLogxKTest -
2دورية أكاديمية
المؤلفون: van Bergen, Saskia, Mahabier, Kiran, Van Lieshout, Esther M.M., van der Torre, Tim, Notenboom, Marije, Jawahier, PA, Verhofstad, Michiel, den Hartog, Dennis
المصدر: van Bergen , S , Mahabier , K , Van Lieshout , E M M , van der Torre , T , Notenboom , M , Jawahier , PA , Verhofstad , M & den Hartog , D 2023 , ' Humeral shaft fracture : systematic review of non-operative and operative treatment ' , Archives of Orthopaedic and Trauma Surgery , vol. 143 , no. 8 , pp. 5035-5054 . https://doi.org/10.1007/s00402-023-04836-8Test
الوصف: Introduction: Humeral shaft fractures can be treated non-operatively or operatively. The optimal management is subject to debate. The aim wasto compare non-operative and operative treatment of a humeral shaft fracture in terms of fracture healing, complications, and functional outcome. Methods: Databases of Embase, Medline ALL, Web-of-Science Core Collection, and the Cochrane Central Register of Controlled Trials (CENTRAL) were systematically searched for publications reporting clinical and functional outcomes of humeral shaft fractures after non-operative treatment with a functional brace or operative treatment by intramedullary nailing (IMN; antegrade or retrograde) or plate osteosynthesis (open plating or minimally invasive). A pooled analysis of the results was performed using MedCalc. Results: A total of 173 studies, describing 11,868 patients, were included. The fracture healing rate for the non-operative group was 89% (95% confidence interval (CI) 84–92%), 94% (95% CI 92–95%) for the IMN group and 96% (95% CI 95–97%) for the plating group. The rate of secondary radial nerve palsies was 1% in patients treated non-operatively, 3% in the IMN, and 6% in the plating group. Intraoperative complications and implant failures occurred more frequently in the IMN group than in the plating group. The DASH score was the lowest (7/100; 95% CI 1–13) in the minimally invasive plate osteosynthesis group. The Constant–Murley and UCLA shoulder score were the highest [93/100 (95% CI 92–95) and 33/35 (95% CI 32–33), respectively] in the plating group. Conclusion: This study suggests that even though all treatment modalities result in satisfactory outcomes, operative treatment is associated with the most favorable results. Disregarding secondary radial nerve palsy, specifically plate osteosynthesis seems to result in the highest fracture healing rates, least complications, and best functional outcomes compared with the other treatment modalities.
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1007/s00402-023-04836-8Test
https://pure.eur.nl/en/publications/92217d97-8343-400e-941f-7ed394b3394bTest
https://pure.eur.nl/ws/files/90898873/Systematic_review_Hummer_5_.pdfTest
http://www.scopus.com/inward/record.url?scp=85153476968&partnerID=8YFLogxKTest -
3دورية أكاديمية
المؤلفون: Notenboom, Marije, Praag, John, Miedema, Jelle
المصدر: Notenboom , M , Praag , J & Miedema , J 2023 , ' Unilateral Diaphragmatic Weakness After Stereotactic Radiotherapy of The Lung : A Case Report ' , Frontiers in Medical Case Reports , vol. 4 , no. 3 . https://doi.org/10.47746/FMCR.2023.4307Test
مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being
الوصف: Stereotactic body radiation therapy (SBRT) is the treatment of choice for patients with stage 1 non-small cell lung cancer (NSCLC) who are medically unfit or those refusing surgery. SBRT is a modality which is well tolerated with respect to limitations on surrounding organs and contra-indications. With improving techniques and cancer treatments, patients have a longer life span, but it is known that radiotherapy can cause late-onset complications. We are reporting the case of a 77-year-old woman who was treated with SBRT because of stage 1 NSCLC. She received a total dose of 51 Gy in three fractions, prescribed to the 78% isodose line. Eight months after SBRT she developed progressive dyspnea and the CT scan showed an elevated left hemi-diaphragm. Potential causes were ruled out. The SBRT treatment was performed without other complications. To our knowledge this complication has not previously been described after SBRT. With constant improving cancer treatments and radio-therapeutic techniques, and better longevity, we could see an increase in long term toxicity in the future.
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.47746/FMCR.2023.4307Test
https://pure.eur.nl/en/publications/a56c7cae-de47-433f-b835-0bd7972ec514Test
https://pure.eur.nl/ws/files/119092810/14644_pdf.pdfTest -
4دورية أكاديمية
المؤلفون: van Ginkel, Noor, Vis, André N., Boormans, Joost L., van der Poel, Henk G., van der Schoot, Deric K. E., Aben, Katja K. H., Hermans, Tom J. N., Meijer, Dennie, Voortman, Jens, Arends, Tom J. H., Ausems, Peter J., Baselmans, Dorine, Berger, Christian P. A. M., Berrens, Anne-Claire, Bickerstaffe, Henry, Bos, Siebe D., Braam, Marlene, Buddingh, K. Tim, Claus, Sebastiaan, Dekker, Karen, van Doeveren, Thomas, Einerhand, Sarah M. H., Fossion, Laurent M. C. Laurent, Hinsenveld, Florentien J., van Gennep, Erik J., Grondhuis Palacios, Lorena A., Hobijn, Mandy M., van Huystee, Suzanne H., Jaspers-Valentijn, Martinique, Klaver, O. Sjoerd, Koldewijn, Evert L., Korsten, Linn, Lenting, Anne, Lentjes, Koen J., Luiting, Henk B., van der Meer, Saskia, Mertens, Laura, Nieuwenhuijzen, Jakko A., Noordzij, M. Arjen, Nooter, Ronald I., Notenboom, Marije, Oomen, Robert J. A., van Roermund, Joep G. H., de Rooij, Judith, Roshani, Hossain, Schrier, Bart P., van der Slot, Michelle A., Somford, D. M. Rik, Stelwagen, Piter-Jan, Stroux, Aukje M. A.
المصدر: Tijdschrift voor Urologie ; volume 13, issue 8, page 164-175 ; ISSN 2211-3037 2211-4718
مصطلحات موضوعية: Urology
الوصف: Samenvatting Er is onvoldoende bekend over de middellangetermijnoverleving van niet-gemetastaseerd spierinvasieve blaaskanker (SIBC) na open (ORC) versus robotgeassisteerde (RARC) cystectomie, met of zonder neoadjuvante chemotherapie (NAC). Om de vijfjaarsoverleving na beide interventies en de invloed van NAC te onderzoeken, is een retrospectieve studie verricht in 19 Nederlandse ziekenhuizen tussen 2012 en 2015. Van de totaal 1.534 cT1-4N0-1-patiënten ondergingen 1.086 patiënten een ORC en 389 een RARC. De vijfjaarsoverleving was 51% na ORC (95%-BI 47–53) versus 58% na RARC (95%-BI 52–63); de hazard ratio na multivariabele correctie was 1,00 (95%-BI 0,84–1,20). 226 van de 965 cT2-4aN0-patiënten werden behandeld met NAC. Na case-control matching bleek (y)pT0 vaker voor te komen na NAC dan zonder NAC (31 vs. 15%; p < 0,01). De beste vijfjaarsoverleving trad op bij patiënten met ypT0 na NAC, namelijk 89% (95%-BI 81–97). Concluderend laat deze deze studie bij patiënten met SIBC vergelijkbare vijfjaarsoverleving zien na ORC of na RARC. De beste overleving was bij patiënten die waren behandeld met NAC voorafgaand aan cystectomie.
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5دورية أكاديمية
المؤلفون: van Ginkel, Noor, Hermans, Tom J. N., Meijer, Dennie, Boormans, Joost L., Voortman, Jens, Mertens, Laura, van Beek, Sytse C., Vis, Andre N., Notenboom, Marije
المصدر: van Ginkel , N , Hermans , T J N , the Dutch Cystectomy Snapshot Group , Meijer , D , Boormans , J L , Voortman , J , Mertens , L , van Beek , S C , Vis , A N & Notenboom , M 2022 , ' Survival outcomes of patients with muscle-invasive bladder cancer according to pathological response at radical cystectomy with or without neo-adjuvant chemotherapy : a case-control matching study ' , International Urology and Nephrology , vol. 54 , no. 12 , pp. 3145-3152 . https://doi.org/10.1007/s11255-022-03339-6Test
مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being
الوصف: Objectives: To assess survival of patients with muscle-invasive bladder cancer (MIBC) who underwent radical cystectomy (RC) with or without neo-adjuvant chemotherapy (NAC) according to the pathological response at RC. Methods: 965 patients with MIBC (cT2-4aN0M0) who underwent RC with or without NAC were analyzed. Among the collected data were comorbidity, clinical and pathological tumor stage, tumor grade, nodal status (y)pN, and OS. Case–control matching of 412 patients was performed to compare oncological outcomes. Kaplan–Meier curves were created to estimate OS for patients who underwent RC with or without NAC, and for those with complete response (pCR), partial response (pPR), or residual or progressive disease (PD). Results: Patients with a pCR or pPR at RC, with or without NAC, had better OS than patients who had PD (both p values < 0.001). Moreover, the incidence of pCR was significantly higher in patients receiving NAC prior to RC than in patients undergoing RC only (31% versus 15%, respectively; p < 0.001). Case–control matching displayed better OS of patients who underwent RC with NAC, median survival not reached, than of those who underwent RC only, median 4.5 years (p = 0.023). Conclusions: This study showed that patients with MIBC who underwent NAC with RC had a significant better OS than those who underwent RC only. The proportion of patients with a pCR was higher in those who received NAC and RC than in those who were treated by RC only. The favorable OS rate in the NAC and RC cohort was probably attributed to the higher observed pCR rate.
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1007/s11255-022-03339-6Test
https://pure.eur.nl/en/publications/bc92a65d-3fba-4ea9-a6ad-7f028252da5cTest
https://pure.eur.nl/ws/files/64118492/s11255_022_03339_6.pdfTest
http://www.scopus.com/inward/record.url?scp=85136548658&partnerID=8YFLogxKTest -
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المؤلفون: Van Bergen, Saskia H., Van Lieshout, Esther M.M., Mahabier, Kiran C., Geraerds, Alexandra J.L.M., Polinder, Suzanne, Den Hartog, Dennis, Verhofstad, Michael H.J., Notenboom, Marije
المساهمون: Surgery, AMS - Musculoskeletal Health, Graduate School, APH - Methodology, CCA - Imaging and biomarkers, Other Research, Public Health, Erasmus MC other, Anesthesiology, General Practice, Radiotherapy, APH - Quality of Care
المصدر: European journal of trauma. Urban und Vogel
European Journal of Trauma and Emergency Surgery, 49(2), 929-938. Springer International Publishing AG
European Journal of Trauma and Emergency Surgery. Urban und Vogel
the HUMMER Investigators 2022, ' Economic evaluation of operative versus nonoperative treatment of a humeral shaft fracture : economic analyses alongside a multicenter prospective cohort study (HUMMER) ', European Journal of Trauma and Emergency Surgery . https://doi.org/10.1007/s00068-022-02160-1Testمصطلحات موضوعية: Cost-utility, Shaft, Fracture, SDG 3 - Good Health and Well-being, Health care consumption, Nonoperative, Emergency Medicine, Orthopedics and Sports Medicine, Surgery, Cost-effectiveness, Humerus, Critical Care and Intensive Care Medicine, Operative
الوصف: Purpose Operative treatment of a humeral shaft fracture results in faster recovery than nonoperative treatment. The cost-effectiveness, in terms of costs per Quality-Adjusted Life Year (QALY) gained (Dutch threshold €20,000-€80,000) or minimal important change (MIC) in disability reduced (DASH 6.7), is unknown. The aim of this study was to determine cost-utility and cost-effectiveness of operative versus nonoperative treatment in adults with a humeral shaft fracture type 12A or 12B. Methods This study was performed alongside a multicenter prospective cohort study. Costs for health care and lost productivity until one year after trauma were calculated. The incremental cost-utility ratio (ICUR) was reported in costs per QALY (based on the EuroQoL-5D-3L (EQ-5D)) gained. The incremental cost-effectiveness ratio (ICER) was reported in costs per MIC (based on the DASH score at three months) reduced. Results Overall, 245 patients were treated operatively and 145 nonoperatively. In the operative group, the mean total costs per patient (€11,925 versus €8793; p p i.e., €3132/0.028). The DASH was 7.3 points (p i.e., €3132/7.3*6.7). Conclusion Due to the limited effect of treatment on quality of life measured with the EQ-5D, the ICUR of operative treatment (€111,860 per QALY gained) exceeds the threshold. However, the incremental costs of €2880 per clinically meaningful difference in DASH are much lower and suggest that operative treatment for a humeral shaft fracture is cost-effective.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50b42e5a7efdc0031d29a24218b339bTest
https://pure.amc.nl/en/publications/economic-evaluation-of-operative-versus-nonoperative-treatment-of-a-humeral-shaft-fractureTest(1a1a6a00-f234-476e-9903-5801fab08693).html -
7دورية
المؤلفون: van Ginkel, Noor, Vis, André N., Boormans, Joost L., van der Poel, Henk G., van der Schoot, Deric K. E., Aben, Katja K. H., Hermans, Tom J. N., Meijer, Dennie, Voortman, Jens, Arends, Tom J. H., Ausems, Peter J., Baselmans, Dorine, Berger, Christian P. A. M., Berrens, Anne-Claire, Bickerstaffe, Henry, Bos, Siebe D., Braam, Marlene, Buddingh, K. Tim, Claus, Sebastiaan, Dekker, Karen, van Doeveren, Thomas, Einerhand, Sarah M. H., Fossion, Laurent M. C. Laurent, Hinsenveld, Florentien J., van Gennep, Erik J., Grondhuis Palacios, Lorena A., Hobijn, Mandy M., van Huystee, Suzanne H., Jaspers-Valentijn, Martinique, Klaver, O. Sjoerd, Koldewijn, Evert L., Korsten, Linn, Lenting, Anne, Lentjes, Koen J., Luiting, Henk B., van der Meer, Saskia, Mertens, Laura, Nieuwenhuijzen, Jakko A., Noordzij, M. Arjen, Nooter, Ronald I., Notenboom, Marije, Oomen, Robert J. A., van Roermund, Joep G. H., de Rooij, Judith, Roshani, Hossain, Schrier, Bart P., van der Slot, Michelle A., Somford, D. M. Rik, Stelwagen, Piter-Jan, Stroux, Aukje M. A., van der West, Alwine, Wijsman, Bart P., Windt, Willemijn A. K. M., van Zanten, Paul, van Beek, Sytse C.
المصدر: Tijdschrift voor Urologie; 20230101, Issue: Preprints p1-10, 10p
مستخلص: Er is onvoldoende bekend over de middellangetermijnoverleving van niet-gemetastaseerd spierinvasieve blaaskanker (SIBC) na open (ORC) versus robotgeassisteerde (RARC) cystectomie, met of zonder neoadjuvante chemotherapie (NAC). Om de vijfjaarsoverleving na beide interventies en de invloed van NAC te onderzoeken, is een retrospectieve studie verricht in 19 Nederlandse ziekenhuizen tussen 2012 en 2015. Van de totaal 1.534 cT1-4N0-1-patiënten ondergingen 1.086 patiënten een ORC en 389 een RARC. De vijfjaarsoverleving was 51% na ORC (95%-BI 47–53) versus 58% na RARC (95%-BI 52–63); de hazard ratio na multivariabele correctie was 1,00 (95%-BI 0,84–1,20). 226 van de 965 cT2-4aN0-patiënten werden behandeld met NAC. Na case-control matching bleek (y)pT0 vaker voor te komen na NAC dan zonder NAC (31 vs. 15%; p< 0,01). De beste vijfjaarsoverleving trad op bij patiënten met ypT0 na NAC, namelijk 89% (95%-BI 81–97). Concluderend laat deze deze studie bij patiënten met SIBC vergelijkbare vijfjaarsoverleving zien na ORC of na RARC. De beste overleving was bij patiënten die waren behandeld met NAC voorafgaand aan cystectomie.
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