المؤلفون: Dev, R., Raparelli, V., Bacon, S.L., Lavoie, K.L., Pilote, L., Norris, C.M.

الوصف: Objective Given the role of sociocultural gender in shaping human behaviours, the main objective of this study was to examine whether sex and gender-related factors were associated with the public’s adherence to COVID-19-recommended protective health behaviours. Design This was a retrospective analysis of the survey that captured data on people’s awareness, attitudes and behaviours as they relate to the COVID-19 policies. Setting Data from the International COVID-19 Awareness and Responses Evaluation survey collected between March 2020 and February 2021 from 175 countries. Participants Convenience sample around the world. Main outcome measures We examined the role of sex and gender-related factors in relation to non-adherence of protective health behaviours including: (1) hand washing; (2) mask wearing; and (3) physical distancing. Multivariable logistic regression was conducted to determine the factors associated with non-adherence to behaviours. Results Among 48 668 respondents (mean age: 43 years; 71% female), 98.3% adopted hand washing, 68.5% mask wearing and 76.9% physical distancing. Compared with males, females were more likely to adopt hand washing (OR=1.97, 95% CI: 1.71 to 2.28) and maintain physical distancing (OR=1.28, 95% CI: 1.22 to 1.34). However, in multivariable sex-stratified models, females in countries with higher Gender Inequality Indexes (GII) were less likely to report hand washing (adjusted OR (aOR)=0.47, 95% CI: 0.21 to 1.05). Females who reported being employed (aOR=0.22, 95% CI: 0.10 to 0.48) and in countries with low/medium GIIs (aOR=0.18, 95% CI 0.06 to 0.51) were less likely to report mask wearing. Females who reported being employed were less likely to report physical distancing (aOR=0.39, 95% CI: 0.32 to 0.49). Conclusion While females showed greater adherence to COVID-19 protective health behaviours, gender-related factors, including employment status and high country-wide gender inequality, were independently associated with non-adherence. These findings may inform public health ...

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/209081/7/e059673.full.pdfTest; Dev, R. orcid.org/0000-0003-1853-9728 , Raparelli, V., Bacon, S.L. orcid.org/0000-0001-7075-0358 et al. (3 more authors) (2022) Impact of biological sex and gender-related factors on public engagement in protective health behaviours during the COVID-19 pandemic: cross-sectional analyses from a global survey. BMJ Open, 12 (6). e059673. ISSN 2044-6055

الإتاحة: https://eprints.whiterose.ac.uk/209081Test/
https://eprints.whiterose.ac.uk/209081/7/e059673.full.pdfTest

المؤلفون: Rai, D., Waheed, S.H., Guerriero, M., III, Tahir, M.W., Pandey, R., Patel, H., Thakkar, S., Mulvagh, S.L., Bastiany, A., Zieroth, S., Norris, C.M., Van Spall, H.G.C., Michos, E.D., Gulati, M.

المساهمون: Division of Cardiology, University of Arizona

المصدر: CJC Open

الوصف: Background: The level of representation of women in cardiology remains low compared to that of men, particularly in leadership positions. We evaluated gender disparity in the authorship of Canadian Cardiovascular Society (CCS) guidelines. Methods: All CCS guidelines from 2001-2020 were identified. Gender was assessed based on pronoun use in the biographies and social media of the authors. Only primary panel authors were included in our analysis. Stratified analyses were performed based on subspecialties. Results: A total of 76 guidelines were identified, with 1172 authors (26% women, 74% men, P < 0.0001), with no significant change in percentage of women authors over 2 decades, (37.1% in 2001, 36.3% in 2020, P = 0.34). Inclusion of women as authors occurred less frequently than inclusion of men in general cardiology guidelines (20.1% vs 79.9%, P < 0.0001) and all subspecialties—heart failure (36.4% vs 63.6%, P < 0.0001), interventional cardiology (12.6% vs 87.4%, P < 0.0001), electrophysiology (20.2% vs 79.8%, P < 0.0001), and pediatric cardiology (41.7% vs 58.3%, P = 0.02). It was less likely for women to be a chair or cochair of a guideline writing committee, compared with men (20.1% vs 79.8%, P < 0.0001). There were 609 unique authors (25.6% women, 74.4% men, P < 0.0001), 542 unique medical doctorate (MD) authors (20.7% women, 79.3% men, P < 0.0001), and 67 unique non-MD authors (65.7% women, 34.3% men, P = 0.0003). Conclusions: There is a persistent shortfall in the inclusion of women authors for CCS guidelines, which has not changed over time. Further efforts are required to promote women's inclusion in leadership roles, which may lead to authorship of the guidelines. © 2021 ; Open access journal ; This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.

العلاقة: Rai, D., Waheed, S. H., Guerriero, M., III, Tahir, M. W., Pandey, R., Patel, H., Thakkar, S., Mulvagh, S. L., Bastiany, A., Zieroth, S., Norris, C. M., Van Spall, H. G. C., Michos, E. D., & Gulati, M. (2021). National Trends of Gender Disparity in Canadian Cardiovascular Society Guideline Authors, 2001-2020. CJC Open.; http://hdl.handle.net/10150/661364Test; CJC Open

الإتاحة: https://doi.org/10.1016/j.cjco.2021.04.003Test
http://hdl.handle.net/10150/661364Test

المؤلفون: Escartin, C, Galea, Elena, Lakatos, A., O’Callaghan, J.P., Petzold, G.C., Serrano-Pozo, Alberto, Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N.J, Araque, Alfonso, Barbeito, Luis, Barzilai, Ari, Bergles, D. E., Bonvento, Gilles, Butt, A.M., Chen, W.T., Cohen-Salmon, M., Cunningham, C., Deneen, B., De Strooper, B., Díaz-Castro, Blanca, Farina, C., Freeman, Mark, Gallo, V., Goldman, J.E., Goldman, S.A., Götz, Magdalena, Gutiérrez, A., Haydon, P. G., Heiland, D.H., Hol, E.M., Holt, M.G., Lino, M., Kastanenka, K.V., Kettenmann, H., Khakh, B.S., Koizumi, S., Lee, C.J., Liddelow, S.A., MacVicar, B.A., Magistretti, P., Messing, A., Mishra, A., Molofsky, A.V., Murai, K.K., Norris, C.M., Okada, S.

الوصف: Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters—preferably in vivo—plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions. ; Funding: CNRS, CEA, ANR, and France Alzheimer to CE.; MCINN (PID2019-107633RB-I00) and Generalitat de Catalunya (2017-SGR547, Grup de demències Sant Pau) to E.G. US Centers for Disease Control and Prevention to J. P.O. Alzheimer’s Association (AACF-17-524184) and NIH-NIA (K08AG064039) to A.S.-P. DFG (SPP1757, STE 552/5, STE 552/4), EU (H2020-MSCA-ITN project 722053 EU-GliaPhD) and BMBF (16GW0182 CONNEXIN) to C.S. Swiss National Science Foundation grant 31003A 173124/1; SNSF NCCR ‘Transcure’ (51NF40-160620); Synapsis Foundation Heidi Seiler-Stiftung 2018-PI01 to A.Volterra. NIH-NINDS (NS084030), Dr. Miriam and Sheldon G. Adelson Medical Foundation and Wings for Life to M.V.S. The authors thank T. Yohannan of Alpha Language Services, Barcelona, for expert copy editing.

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107633RB-I00/ES/DESARROLLO DE FARMACOS NEUROPROTECTORES CONTRA DIANAS ASTROCITARIAS MEDIANTE INTELIGENCIA ARTIFICIAL/; Publisher's version; http://dx.doi.org/10.1038/s41593-020-00783-4Test; Sí; Nature Neuroscience 24: 312- 325 (2021); http://hdl.handle.net/10261/259929Test

الإتاحة: https://doi.org/10.1038/s41593-020-00783-4Test
http://hdl.handle.net/10261/259929Test

المؤلفون: Houle, J., Proietti, M., Raparelli, V., Atzema, C., Norris, C.M., Abrahamowicz, M., Lip, G.Y.H., Boriani, G., Pilote, L.

المصدر: Canadian Journal of Cardiology ; volume 39, issue 5, page S8 ; ISSN 0828-282X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.cjca.2023.02.043Test
https://api.elsevier.com/content/article/PII:S0828282X23001757?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0828282X23001757?httpAccept=text/plainTest

المؤلفون: Tegg, N.L., Ahmed, S., Shlakhter, O., Norris, C.M.

المصدر: Canadian Journal of Cardiology ; volume 39, issue 5, page S11 ; ISSN 0828-282X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.cjca.2023.02.050Test
https://api.elsevier.com/content/article/PII:S0828282X23001824?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0828282X23001824?httpAccept=text/plainTest

المؤلفون: Gisinger, T., Dev, R., Kautzky, A., Harreiter, J., Raparelli, V., Kublickiene, K., Trinidad Herrero, M., Norris, C.M., Lavoie, K.L., Pilote, L., Kautzky-Willer, A.

الوصف: Objective: The COVID-19 pandemic influences mental health drastically. Therefore, our aim was to investigate whether biological sex and gender-related factors are associated with mental health during the COVID-19 pandemic. Materials and Methods: The International COVID-19 Awareness and Responses Evaluation Study is an international multiwave cross-sectional observational cohort study of public awareness, attitudes, and responses to public health policies (www.mbmc-cmcm.ca/covid19). The study is led by the Montreal Behavioural Medicine Centre in collaboration with 200 international collaborators from 42 countries. It has received research ethics board approval from the Comité d'éthique de recherche du CIUSSS-NIM (Centre intégré universitaire de santé et de services sociaux du Nord- de-l'île-de-Montréal), approval no.: 2020-2099/25-03-2020. Recruitment began on March 27, 2020, and the survey is available in 34 languages. The associations between biological sex, sociocultural gender, and mental health were assessed in multivariate logistic regression models only for the European population (n = 12,300). Results: Positive correlations were found between female sex and “feeling nervous, anxious or worried” (OR = 3.2, p < 0.001, 95% CI 1.87–5.63) and “feeling sad, depressed or hopeless” (OR 1.8, p = 0.031, CI 1.05–3.05). Male sex was related to more frequently “feeling irritable, frustrated, and angry” (OR = 1.8, p = 0.04, 95% CI 1.03–2.99). Concerning gender, a negative correlation between being employed and “feeling lonely or isolated” (OR = 0.26, p < 0.001, 95% CI 0.11–0.59) was observed in the female cohort. Conclusion: Sex and gender differences exist in the emotional responses during the COVID-19 pandemic. Especially, within the female cohort, unemployment is negatively associated with mental health. Therefore, this study suggests more targeted psychological and social support for females during the pandemic.

العلاقة: Gisinger, T., Dev, R., Kautzky, A. et al. (8 more authors) (2022) Sex and Gender Impact Mental and Emotional Well-Being During COVID-19 Pandemic: A European Countries Experience. Journal of Women's Health, 31 (11). pp. 1529-1539. ISSN 1540-9996

الإتاحة: https://eprints.whiterose.ac.uk/209079Test/

المؤلفون: Norris, C.M., Clark, M., McGannon, K.R., Berry, T.R., Rodgers, W.C., Spence, J.C.

المصدر: Canadian Journal of Cardiology ; volume 32, issue 4, page S4 ; ISSN 0828-282X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.cjca.2016.02.014Test
https://api.elsevier.com/content/article/PII:S0828282X16001124?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0828282X16001124?httpAccept=text/plainTest

المؤلفون: Bainey, K.R., Norris, C.M., Welsh, R.C.

المصدر: Canadian Journal of Cardiology ; volume 31, issue 10, page S85-S86 ; ISSN 0828-282X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.cjca.2015.07.193Test
https://api.elsevier.com/content/article/PII:S0828282X15007394?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0828282X15007394?httpAccept=text/plainTest

المؤلفون: McGrath, B., Norris, C.M., Welsh, R.C., Bainey, K.R.

المصدر: Canadian Journal of Cardiology ; volume 31, issue 10, page S63 ; ISSN 0828-282X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.cjca.2015.07.145Test
https://api.elsevier.com/content/article/PII:S0828282X15006911?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0828282X15006911?httpAccept=text/plainTest

المؤلفون: Tucci, C., Tosti, G., Basili, S., Herrero Ezquerro, M.T., Johnson, E.O., Kautzky-Willer, A., Norris, C.M., Pilote, L., Kublickiene, K., Raparelli, V.

المصدر: Canadian Journal of Cardiology ; volume 37, issue 2, page e9 ; ISSN 0828-282X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.cjca.2020.02.026Test
https://api.elsevier.com/content/article/PII:S0828282X20300994?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0828282X20300994?httpAccept=text/plainTest