المؤلفون: Butt, Noreen, Bache-Mathiesen, L K, Ushakova, A, Nordrehaug, J E, Jensen, S E, Munk, P S, Danchin, N, Dubois-Rande, J L, Hansen, H S, Paganelli, F, Corvoisier, P Le, Firat, H, Erlinge, D, Atar, D, Larsen, A I

المصدر: Butt , N , Bache-Mathiesen , L K , Ushakova , A , Nordrehaug , J E , Jensen , S E , Munk , P S , Danchin , N , Dubois-Rande , J L , Hansen , H S , Paganelli , F , Corvoisier , P L , Firat , H , Erlinge , D , Atar , D & Larsen , A I 2020 , ' Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage : Kinetic profile, relationship to interleukin 6 and infarct size ....

مصطلحات موضوعية: STEMI, high-sensitive C-reactive protein, inflammation, interleukin 6, pentraxin 3, primary percutaneous coronary intervention

الوصف: BACKGROUND: The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein (hs-CRP) and infarct size. METHODS: PTX3, IL-6 and hs-CRP were measured at predefined time points, at baseline (before percutaneous coronary intervention (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation myocardial infarction (STEMI). RESULTS: PTX3 and IL-6 levels increased in the early phase, followed by a gradual decrease between 12 and 72 hours. There were statistically significant correlations between PTX3 and IL-6 in general, for all time points and for changes over time (0-72 hours). In a linear mixed model, PTX3 predicted IL-6 (p < 0.001). PTX3 is also correlated with hs-CRP in general, and at each time point post PCI, except at baseline. PTX3, IL-6 and hs-CRP were all significantly correlated with infarct size in general, and at the peak time point for maximum troponin I. In addition, there was a modest correlation between IL-6 levels at baseline and infarct size at 72 hours after PCI (ρ = 0.23, p = 0.006). CONCLUSIONS: PTX3 had a similar kinetic profile to IL-6, with an early increase and decline, and was statistically significantly correlated with markers of infarct size in STEMI patients post primary PCI. Baseline levels of IL-6 only predicted infarct size at 72 hours post PCI.

وصف الملف: application/pdf

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/7b9d636b-b7b0-4135-9e35-8ea30a2ea6fdTest

الإتاحة: https://doi.org/10.1177/2048872620923641Test
https://portal.findresearcher.sdu.dk/da/publications/7b9d636b-b7b0-4135-9e35-8ea30a2ea6fdTest
https://findresearcher.sdu.dk/ws/files/173841385/2048872620923641.pdfTest

المؤلفون: Pettersen, T, Schjott, J, Allore, H, Bendz, B, Borregaard, B, Fridlund, B, Hadjistavropoulos, H D, Larsen, A I, Nordrehaug, J E, Rasmussen, T B, Rotevatn, S, Valaker, I, Wentzel-Larsen, T, Norekval, T M

المصدر: European Heart Journal ; volume 44, issue Supplement_2 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Despite experiencing adverse drug reactions (ADRs) more often than men, the proportion of women participating in clinical drug trials is low. Thus, evidence for sex differences in the incidence of ADRs is limited. Aim To determine sex differences in incidence of self-reported ADRs after percutaneous coronary intervention (PCI). Further, to determine whether receiving information about ADRs is associated with sex. Methods CONCARDPCI is a prospective multicentre cohort study (N=3417) conducted at seven referral PCI centres in two Nordic countries. Clinical data were collected from patients’ medical records. Socio-demographic characteristics were obtained by self-report after PCI. Two questions from the Heart Continuity of Care Questionnaire (HCCQ) were used to determine if information about potential ADRs was received before hospital discharge. De novo created questions were used to determine if patients reported ADRs from prescribed therapy. Questionnaires were distributed two- (T1), six- (T2), and twelve months (T3) after hospital discharge to assess the incidence of self-reported ADRs in a longitudinal perspective. Logistic regression was utilised to scrutinize the aims, reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results Patients were predominantly male (78%), with a mean age of 65 years (SD 11). Female patients were older (68, SD 10). Acute coronary syndrome was the most frequent cause of admission for PCI (62%). At T1, 2656 of the included patients responded to the questions from the HCCQ. Of these, 1019 patients (39%) reported being informed of potential ADRs from prescribed therapy, 1075 patients (42%) reported not having been informed, 511 patients (20%) reported ‘Hard to decide’, and 51 (2%) reported ‘Not applicable’. Patients reporting ‘Hard to decide’ or ‘Not applicable’ were excluded from further analysis. Women were less likely to receive information than men (OR 0.58, CI 0.45 – 0.75, p<0.001). For the total study population, 42%, 49% and 40% reported ...

الإتاحة: https://doi.org/10.1093/eurheartj/ehad655.2879Test
https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.2879/53609781/ehad655.2879.pdfTest

المؤلفون: Schartum-Hansen, H, Seifert, R, Svingen, G F T, Ueland, P M, Pedersen, E R, Nordrehaug, J E, Nilsen, D W T, Dahr, I, Nygaard, O N

المصدر: European Heart Journal ; volume 39, issue suppl_1 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1093/eurheartj/ehy564.p627Test
http://academic.oup.com/eurheartj/article-pdf/39/suppl_1/ehy564.P627/25573939/ehy564.p627.pdfTest

المؤلفون: Butt, N., Bache-Mathiesen, L., Nordrehaug, J. E., Tuseth, V., Munk, P. S., Hall, T. S., Danchin, N., Jensen, Svend Eggert, Dubois Rande, J. L., Bonnet, J. L., Halvorsen, S., Firat, H., Erlinge, D., Atar, D., Larsen, A. I.

المصدر: Butt , N , Bache-Mathiesen , L , Nordrehaug , J E , Tuseth , V , Munk , P S , Hall , T S , Danchin , N , Jensen , S E , Dubois Rande , J L , Bonnet , J L , Halvorsen , S , Firat , H , Erlinge , D , Atar , D & Larsen , A I 2016 , ' Infusion of TRO40303 in patients with ST-elevation myocardial infarction prior to primary percutaneous coronary intervention did not alter levels of inflammatory biomarkers in the MITOCARE study ' , European ....

العلاقة: https://vbn.aau.dk/da/publications/e1ab8a93-addd-462a-8f16-38680a91688fTest

الإتاحة: https://doi.org/10.1093/eurheartj/ehw434Test
https://vbn.aau.dk/da/publications/e1ab8a93-addd-462a-8f16-38680a91688fTest

المؤلفون: Nordlund, D., Heiberg, E., Carlsson, Marcus, Frund, E. T., Hoffmann, P., Nordrehaug, J. E., Koul, S., Atar, D., Erlinge, D., Engblom, H., Arheden, H.

المصدر: Nordlund , D , Heiberg , E , Carlsson , M , Frund , E T , Hoffmann , P , Nordrehaug , J E , Koul , S , Atar , D , Erlinge , D , Engblom , H & Arheden , H 2015 , ' The extent of myocardium at Risk for LAD, RCA and LCx using contrast enhanced SSFP and T2-weighted imaging ' , Journal of Cardiovascular Magnetic Resonance , vol. 17 , no. S1 . https://doi.org/10.1186/1532-429X-17-S1-P139Test

مصطلحات موضوعية: heart muscle *risk *imaging human patient astronomy coronary artery blood flow infarction heart infarction cardiovascular magnetic resonance image quality acute heart infarction multicenter study standard heart muscle ischemia angiography heart muscle perfusion core laboratory heart left ventricle statistical significance perfusion coronary artery single photon emission computer tomography gadolinium

الوصف: Background: Contrast enhanced SSFP (CE-SSFP) and T2-weighted triple inversion recovery imaging (T2w) have both been clinically validated for determining myocardium at risk (MaR) by cardiovascular magnetic resonance (CMR), using myocardial perfusion SPECT (MPS) as reference standard. Previously, MPS has been used to describe the coronary perfusion territories during myocardial ischemia. Compared to MPS, CMR offers superior image quality and logistical advantages. The aim of this study was to describe the coronary perfusion territories of LAD, RCA and LCx based on CMR data using CE-SSFP and T2w in patients after STelevation myocardial infarction. Methods: CE-SSFP and T2w data from the recently published international multi-center trials CHILL-MI and MITOCARE, was used to assess MaR. CESSFP images from 206/212 patients (6 excluded due to inability to detect MaR) and T2w images from 147/212 patients (12 excluded due to missing data, 53 due to inability to detect MaR) were included. Late gadolinium enhancement (LGE) imaging was used to assess infarct size. Imaging was performed on systems from three different vendors (Siemens, Philips, GE) and data was analyzed by a core laboratory. Culprit vessel was determined using angiography. Results: Average size of MaR was greater for LAD (CE-SSFP: 44+/-10%, T2w: 44+/-9% of the left ventricle [LV], p-value <0.0001) than for both LCx (CE-SSFP: 30+/-9%, T2w: 30+/-12% of the LV) and RCA (CE-SSFP: 31+/-7%, T2w: 30+/-8% of the LV). A comparison of coronary perfusion territories between CMR and previously published MPS data is shown in 1. All patients had a smaller infarct by LGE compared to MaR by CE-SSFP and all patients but one by T2w (2). Conclusions: The perfusion territories of the three main coronary arteries were described using CE-SSFP and T2w in patients with acute myocardial infarction and resemble previous territories by MPS, with expected overlap between RCA and LCx. (Figure presented) .

الإتاحة: https://doi.org/10.1186/1532-429X-17-S1-P139Test
https://portal.findresearcher.sdu.dk/da/publications/0e38a6b4-c99b-4d43-b722-22b99e6f628cTest

المؤلفون: Morken, I, Ponitz, V, Brugger-Andersen, T, Aareskjold, O, Aadnanes, L, Melberg, T, Bru, E, Nordrehaug, J E

المصدر: European Heart Journal ; volume 43, issue Supplement_2 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Electrical cardioversion (ECV) of atrial fibrillation (AF) is known to be effective in restoring sinus rhythm. However, limited and contradictory data exist on the impact of ECV on short- and long-term quality of life outcomes. Purpose To examine the impact of ECV on short- and long-term quality of life in patients with AF. Methods This was a prospective cohort study of consecutive patients with AF referred for outpatient electrical cardioversion at a university hospital in Norway. Recruitment started March 2017, and ended December 2019. Baseline demographics, clinical characteristics, and procedure details were obtained from medical records. Quality of life was measured with the Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire before electrical cardioversion (baseline), and at three and 12 months after ECV. Results Two hundred and ninety-five patients underwent ECV and completed follow-up questionnaires at three months (n-259) and at 12 months (n=258). The median age was 68 years (range 37–86 years) and 79% were men. The mean left ventricular ejection fraction obtained by echocardiography was 51% (±9.2). The mean body mass index score was 28±4.8. Immediate success of electric cardioversion was 91%. Recurrence of AF after successful ECV was 36% within three months. Twenty-two percent of the patient underwent new ECV before three months, and 25% of the patients had persistent AF at three months. The overall mean AFEQT score at baseline was 62.9±21.4, and the domain-specific scores were as follows: symptoms, 72.3±23.1; daily activities, 52±26.6; treatment concerns, 71.1±22.4; and treatment satisfaction, 59.9±25.2. There were significant improvements in the overall mean AFEQT score at three months, 70.8±20.8, (p<0.01) and at 12 months, 72.3±20.8 (p<0.01) compared with baseline values. There were also significant improvement (p<0.01) in all AFQET subscales at three and 12 months. Daily activity scores and treatment satisfactions scores demonstrated highest ...

الإتاحة: https://doi.org/10.1093/eurheartj/ehac544.2754Test
https://academic.oup.com/eurheartj/article-pdf/43/Supplement_2/ehac544.2754/46367103/ehac544.2754.pdfTest

المؤلفون: Pettersen, T, Schjott, J, Allore, H, Bendz, B, Borregaard, B, Fridlund, B, Hadjistavropoulos, H D, Larsen, A I, Nordrehaug, J E, Rasmussen, T B, Rotevatn, S, Valaker, I, Wentzel-Larsen, T, Norekval, T M

المصدر: European Heart Journal ; volume 43, issue Supplement_2 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Healthcare providers are commonly reluctant to inform patients about potential adverse drug reactions (ADRs) from prescribed therapy to avoid increasing the incidence of ADRs through the nocebo effect. However, patients need information on all aspects of prescribed therapy to facilitate informed decision-making and take ownership of their care. Purpose To describe wether patients received information about potential ADRs from prescribed therapy before hospital discharge after percutaneous coronary intervention (PCI). Furthermore, to determine whether receiving information about ADRs is associated with incidence of self-reported ADRs. Methods CONCARDPCI is a prospective multicentre cohort study including 3417 patients after PCI. The study was conducted between June 2017 and May 2020 at seven large referral PCI centres in Norway and Denmark. Clinical data were collected from patients' medical records. Socio-demographic characteristics were obtained by self-report during index hospitalization after PCI. Two questions from the Heart Continuity of Care Questionnaire were used to determine if information about potential ADRs was received before hospital discharge. De novo created questions were used to determine if patients reported ADRs from prescribed therapy. Questionnaires were distributed two (T1), six (T2), and twelve months (T3) after hospital discharge to assess the incidence of self-reported ADRs in a longitudinal perspective. Logistic regression was utilised to scrutinize the aims, reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results Patients were predominantly men (78%), with a mean age of 66 years (SD 11, range 20–96 years), and married or living with a partner (75%). Stable coronary artery disease was the most frequent cause of admission for PCI (30%). Before hospital discharge, 59% were informed of potential ADRs from prescribed therapy and 50% were informed what to do if ADRs occurred. The incidence of self-reported ADRs were significantly lower for those who ...

الإتاحة: https://doi.org/10.1093/eurheartj/ehac544.2736Test
https://academic.oup.com/eurheartj/article-pdf/43/Supplement_2/ehac544.2736/46364230/ehac544.2736.pdfTest

المؤلفون: Pettersen, T., Schjott, J., Allore, H., Bendz, B., Borregaard, B., Fridlund, B., Larsen, A. I., Nordrehaug, J. E., Rotevatn, S., Wentzel-Larsen, T., Norekvaal, T. M.

المصدر: Pettersen , T , Schjott , J , Allore , H , Bendz , B , Borregaard , B , Fridlund , B , Larsen , A I , Nordrehaug , J E , Rotevatn , S , Wentzel-Larsen , T & Norekvaal , T M 2021 , ' Perceptions of efficacy and safety of generic medicines in patients after percutaneous coronary intervention ' , European Heart Journal , vol. 42 , no. Suppl. 1 , pp. 3020 . https://doi.org/10.1093/eurheartj/ehab724.3020Test

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/19704451-fc16-43d7-ad98-edcc49c545f5Test

الإتاحة: https://doi.org/10.1093/eurheartj/ehab724.3020Test
https://portal.findresearcher.sdu.dk/da/publications/19704451-fc16-43d7-ad98-edcc49c545f5Test

المؤلفون: Aase, M., Nordrehaug, J. E., Malterud, K.

المصدر: Journal of Medical Ethics, 2008 Nov 01. 34(11), 767-771.

الوصول الحر: https://www.jstor.org/stable/27720204Test

المؤلفون: Degerud, E, Hoff, R, Nygård, O, Strand, E, Nilsen, D W, Nordrehaug, J E, Midttun, Ø, Ueland, P M, de Vogel, S, Dierkes, J

المصدر: European Journal of Clinical Nutrition ; volume 70, issue 4, page 517-522 ; ISSN 0954-3007 1476-5640

مصطلحات موضوعية: Nutrition and Dietetics, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1038/ejcn.2015.200Test
http://www.nature.com/articles/ejcn2015200Test
http://www.nature.com/articles/ejcn2015200.pdfTest