المؤلفون: Norbert Kovacs, Janszky, J., Nagy, F.

المصدر: ResearcherID

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1b8b70d03e75be4c130047e93ff5707eTest
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=ISI&KeyUT=WOS:000269804100079&KeyUID=WOS:000269804100079Test

المؤلفون: Norbert Kovacs, Balas, I., Aschermann, Z., Varga, D., Komoly, S., Nagy, F.

المصدر: ResearcherID
Norbert Kovacs

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0e84bf0624b7721c51b5d0dfd178ae99Test
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000266618101237&KeyUID=WOS:000266618101237Test

المؤلفون: Norbert Kovacs, Balas, I., Kellenyi, L., Feldmann, A., Nagy, F.

المصدر: ResearcherID
Norbert Kovacs

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1410d82bc86245b4fb8325f41aa121f8Test
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240523200292&KeyUID=WOS:000240523200292Test

المؤلفون: Norbert Kovacs, Balas, I., Kellenyi, L., Nagy, F.

المصدر: ResearcherID
Norbert Kovacs

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22c2b57611d6f603677763bebfd3953fTest
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=ISI&KeyUT=WOS:000240523200293&KeyUID=WOS:000240523200293Test

المؤلفون: Daniel Robert Szabo, Norbert Kovács, Ádám Páthy, Péter Tóth

الوصف: In the construction industry, risk assessment and evaluation of actors vary by their size, market position and their roles in the production process. Actors detect exogenous and endogenous processes differently; dissimilarities can be found in the observation, response, speed, in the forethought and the degree and ability of having influence on the processes, in leader or follower behaviors. Even in this heterogeneity, certain regularities and correspondences can be observed, drawing new patterns. We suppose that the explanation and treatment of risks mainly differ by the size and market position of the actors. Based on this hypothesis, we were interested in risk explanations and risk management experience of Hungarian construction companies, in order to identify different patterns, typologies, risk management techniques and learning processes on this field. We used interviews as a method for qualitative research. We focused on contractors, but to get more precise consequences, we also made interviews with different actors of construction projects such as lenders, insurers and investors. The relations of theoretical knowledge and observed phenomena are also discussed in the study which investigates exclusively into the results of the survey. ; construction industry, risk management, risk assessment, risk typology

العلاقة: http://www.toknowpress.net/ISBN/978-961-6914-09-3/papers/ML14-601.pdfTest; http://www.toknowpress.net/ISBN/978-961-6914-09-3/MakeLearn2014.pdfTest

الإتاحة: http://www.toknowpress.net/ISBN/978-961-6914-09-3/papers/ML14-601.pdfTest
http://www.toknowpress.net/ISBN/978-961-6914-09-3/MakeLearn2014.pdfTest

المؤلفون: Corvol, Jean‐christophe, Azulay, Jean‐philippe, Bosse, Björn, Dauvilliers, Yves, Defebvre, Luc, Klostermann, Fabian, Kovacs, Norbert, Maltête, David, Ondo, William, G, Pahwa, Rajesh, Rein, Werner, Thobois, Stéphane, Valis, Martin, Videnovic, Aleksandar, Rascol, Olivier

المساهمون: Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), NS-Park/FCRIN Network, UMS 015, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Gui de Chauliac CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), CHU Montpellier, Université de Montpellier (UM), Département de neurologie Lille, Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Charité - UniversitätsMedizin = Charité - University Hospital Berlin, University of Pécs Medical School (UP MS), University of Pecs, Service de neurologie Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Center for neurogenetics Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, Weill Medical College of Cornell University New York, University of Kansas Medical Center Kansas City, KS, USA, Theranexus Lyon, Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (ISC-MJ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Hôpital neurologique et neurochirurgical Pierre Wertheimer CHU - HCL, Hospices Civils de Lyon (HCL), Univerzita Karlova Praha, Česká republika = Charles University Prague, Czech Republic (UK), Massachusetts General Hospital Boston, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), THN102-202 Study Investigators: Jean-Christophe Corvol, Jean-Philippe Azulay, Marek Baláž, Ralf Bodenschatz, Magdolna Bokor, Hana Brožová, Yves Dauvilliers, Luc Defebvre, Ondraj Fiala, Andràs Folyovich, Heinz Peter Herbst, Fabian Klostermann, Norbert Kovacs, Julianna Lajtos, Paul Lingor, David Maltête, Christian Oehlwein, Rajesh Pahwa, Jan Peregrin, Olivier Rascol, Daniela Rau, Ali Safavi, Joachim Springub, Jindra Svátová, Stéphane Thobois, Univ Lyon, Martin Valis, Làszlo Vécsei, Aleksandar Videnovic, Olga Waln, Katarina Zárubová

المصدر: ISSN: 0885-3185.

مصطلحات موضوعية: Parkinson's disease, sleepiness, clinical trial, modafinil, flecainide, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; BackgroundExcessive daytime sleepiness (EDS) is a frequent and disabling symptom of Parkinson's disease (PD) without approved treatment. THN102 is a novel combination drug of modafinil and low-dose flecainide.ObjectiveThe aim of this study is to evaluate the safety and efficacy of THN102 in PD patients with EDS.MethodsThe method involved a randomized, double-blind, placebo-controlled, crossover trial testing two doses of THN102 (200 mg/d modafinil with 2 mg/d [200/2] or 18 mg/d flecainide [200/18]) versus placebo; 75 patients were exposed to treatment. The primary endpoint was safety. The primary efficacy outcome was the change in Epworth Sleepiness Scale (ESS) score.ResultsBoth doses of THN102 were well tolerated. ESS significantly improved with THN102 200/2 (least square means vs. placebo [95% confidence interval, CI]: −1.4 [−2.49; −0.31], P = 0.012) but did not change significantly with the 200/18 dosage.ConclusionsTHN102 was well tolerated and showed a signal of efficacy at the 200/2 dose, supporting further development for the treatment of EDS in PD. © 2021 International Parkinson and Movement Disorder Society

العلاقة: hal-03416717; https://hal.sorbonne-universite.fr/hal-03416717Test; https://hal.sorbonne-universite.fr/hal-03416717/documentTest; https://hal.sorbonne-universite.fr/hal-03416717/file/Corvol%20et%20al.%20-%20THN%20102%20for%20Excessive%20Daytime%20Sleepiness%20Associate.pdfTest

الإتاحة: https://doi.org/10.1002/mds.28840Test
https://hal.sorbonne-universite.fr/hal-03416717Test
https://hal.sorbonne-universite.fr/hal-03416717/documentTest
https://hal.sorbonne-universite.fr/hal-03416717/file/Corvol%20et%20al.%20-%20THN%20102%20for%20Excessive%20Daytime%20Sleepiness%20Associate.pdfTest

المساهمون: Dr. Norbert Kovacs, Associate professor, specialist in neurology and movement disorders, Department of Neurology

المصدر: Kovács N, Pál E, Késmárky Komoly S, Nagy F, Herceg M. Pramexole for treatg essentl tremor. Eur J Neurol 2011;18(Suppl 2):482.
Efficacy of Pramipexole Extended Release in the Treatment of Essential Tremor: a Double-blind, Cross-over, Placebo-controlled Multicenter Study

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT01441284Test

المساهمون: Dr. Norbert Kovacs, Associate professor, specialist in neurology and movement disorders, Department of Neurology

المصدر: Kupsch A, Benecke R, Muller J, Trottenberg T, Schneer GH, Poewe W, Ener W, Wolters A, Muller JU, Deuschl G, Psker MO, Skogse , Roeste GK, Vollmer-Haase J, Brentrup A, Krause M, Tronnr V, Schnzler A, Voges J, Nkhah G, Vesper J, Naumann M, Volkmann J; Deep-Bra Stulatn for Dyston Study Group. Pallal deep-bra stulatn prary generaled or segmental dyston. N Engl J Med. 2006 Nov 9;355(19):1978-90. do 10.1056/NEJMoa063618.
Vahet M, Vercue L, Houeto JL, Krystkowk P, Benab AL, Cornu P, Lagrange C, Tezenas du Montcel S, Dormont D, Grand S, Blond S, Detante O, Plon B, Ardou C, Ag Y, Destee A, Pollak P; French Stulatn du Pallum terne dans la Dyston (SPY) Study Group. Bateral deep-bra stulatn of the globus pallus prary generaled dyston. N Engl J Med. 2005 Feb 3;352(5):459-67. do 10.1056/NEJMoa042187.
Valldeorla F, Regor Mguez-Castellanos A, Lezcano E, Garc-Ru P, Rojo A, Salvador A, Castro A, Grandas F, Kulevsky J, MartMJ, Martez-Mart P, Relova L, Rum J, Camara A, Burguera JA, Lazasoro G, de Val JL, Obeso J, Rodruez-Oroz MC, Tolosa E; Grupo ESpanol para el EStud de la EStulacn PALal en la Dton. Effacy and safety of pallal stulatn prary dyston: results of the Spanh multentr study. J Neurol Neurosurg Psychtry. 2010 Jan;81(1):65-9. do 10.1136/jnnp.2009.174342. Epub 2009 Sep 10.
Vahet M, Vercue L, Houeto JL, Krystkowk P, Lagrange C, Yeln J, Bardet E, Benab AL, Navarro S, Dormont D, Grand S, Blond S, Ardou C, Plon B, Dujard K, Hahn-Barma V, Ag Y, Destee A, Pollak P; French SPY Study Group. Bateral, pallal, deep-bra stulatn prary generaled dyston: a prospecte 3 year follow-up study. Lancet Neurol. 2007 Mar;6(3):223-9. do 10.1016/S1474-4422(07)70035-2.
Kupsch A, TagltM, Vahet M, Az T, Krack P, Moro E, Krauss JK. Early postoperate management of DBS dyston: programmg, response to stulatn, adverse events, medatn changes, evaluatns, and troubleshootg. Mov Dord. 2011 Jun;26 Suppl 1:S37-53. do 10.1002/mds.23624.
Kovacs N, Janszky J, Nagy F, Balas Changg to terleavg stulatn mht prove dyston cases not respondg to pallal stulatn. Mov Dord. 2012 Jan;27(1):163-5. do 10.1002/mds.23962. Epub 2011 Sep 28. No abstract avaable.
TagltM, Krack P, Volkmann J, Az T, Krauss JK, Kupsch A, Vahet AM. Long-Term management of DBS dyston: response to stulatn, adverse events, battery changes, and specl conseratns. Mov Dord. 2011 Jun;26 Suppl 1:S54-62. do 10.1002/mds.23535.
Comparison of the Efficacy of Double Monopolar Versus Interleaving Stimulation Modes for the Deep Brain Stimulation Treatment of Primary Generalized or Segmental Dystonia

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT01497639Test