المؤلفون: Aktaa, Suleman, Gale, Chris P., Brida, Margarita, Giannakoulas, George, Kovacs, Gabor, Adir, Yochai, Benza, Raymond L., Böhm, Michael, Coats, Andrew, D'Alto, Michele, Escribano-Subias, Pilar, Ferrari, Pisana, Galiè, Nazzareno, Gibbs, J. Simon R., Gin-Sing, Wendy, Hoeper, Marius M., Humbert, Marc, Lang, Irene M., Maron, Bradley A., Meszaros, Gergely, Noordegraaf, Anton V., Price, Laura C., Pepke-Zaba, Joanna, Rådegran, Göran, Reis, Abilio, Sitbon, Olivier, Torbicki, Adam, Ulrich, Silvia, Rosenkranz, Stephan, Delcroix, Marion

المصدر: European Journal of Heart Failure. 25(4):469-477

مصطلحات موضوعية: Accountability, Clinical practice guidelines, Outcomes, Pulmonary arterial hypertension, Quality indicators, Treatment, Medicin och hälsovetenskap, Klinisk medicin, Kardiologi, Medical and Health Sciences, Clinical Medicine, Cardiac and Cardiovascular Systems

الوصف: Aims: To develop a suite of quality indicators (QIs) for the evaluation of the care and outcomes for adults with pulmonary arterial hypertension (PAH). Methods and results: We followed the European Society of Cardiology (ESC) methodology for the development of QIs. This included (i) the identification of key domains of care for the management of PAH, (ii) the proposal of candidate QIs following systematic review of the literature, and (iii) the selection of a set of QIs using a modified Delphi method. The process was undertaken in parallel with the writing of the 2022 ESC/European Respiratory Society (ERS) guidelines for the diagnosis and treatment of pulmonary hypertension and involved the Task Force chairs, experts in PAH, Heart Failure Association (HFA) members and patient representatives. We identified five domains of care for patients with PAH: structural framework, diagnosis and risk stratification, initial treatment, follow-up, and outcomes. In total, 23 main and one secondary QIs for PAH were selected. Conclusion: This document presents the ESC QIs for PAH, describes their development process and offers scientific rationale for their selection. The indicators may be used to quantify and improve adherence to guideline-recommended clinical practice and improve patient outcomes.

الوصول الحر: https://lup.lub.lu.se/record/c439f572-3672-45bb-9392-2f574a32494cTest
http://dx.doi.org/10.1002/ejhf.2830Test

المؤلفون: Botros, Liza, Jansen, Samara M. A., Ashek, Ali, Spruijt, Onno A., Tramper, Jelco, Noordegraaf, Anton V., Aman, Jurjan, Harms, Hans, de Man, Frances S., Huisman, Marc C., Zhao, Lan, Bogaard, Harm J.

المصدر: Botros , L , Jansen , S M A , Ashek , A , Spruijt , O A , Tramper , J , Noordegraaf , A V , Aman , J , Harms , H , de Man , F S , Huisman , M C , Zhao , L & Bogaard , H J 2021 , ' Application of [18F]FLT-PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type 2 mutation carriers ' , Pulmonary Circulation , vol. 11 , no. 3 . https://doi.org/10.1177/20458940211028017Test

الوصف: Pulmonary arterial hypertension is a heterogeneous group of diseases characterized by vascular cell proliferation leading to pulmonary vascular remodelling and ultimately right heart failure. Previous data indicated that 3′-deoxy-3′-[18F]-fluorothymidine (18FLT) positron emission tomography (PET) scanning was increased in pulmonary arterial hypertension patients, hence providing a possible biomarker for pulmonary arterial hypertension as it reflects vascular cell hyperproliferation in the lung. This study sought to validate 18FLT-PET in an expanded cohort of pulmonary arterial hypertension patients in comparison to matched healthy controls and unaffected bone morphogenetic protein receptor type 2 mutation carriers. 18FLT-PET scanning was performed in 21 pulmonary arterial hypertension patients (15 hereditary pulmonary arterial hypertension and 6 idiopathic pulmonary arterial hypertension), 11 unaffected mutation carriers and 9 healthy control subjects. In-depth kinetic analysis indicated that there were no differences in lung 18FLT k3 phosphorylation among pulmonary arterial hypertension patients, unaffected bone morphogenetic protein receptor type 2 mutation carriers and healthy controls. Lung 18FLT uptake did not correlate with haemodynamic or clinical parameters in pulmonary arterial hypertension patients. Sequential 18FLT-PET scanning in three patients demonstrated uneven regional distribution in 18FLT uptake by 3D parametric mapping of the lung, although this did not follow the clinical course of the patient. We did not detect significantly increased lung 18FLT uptake in pulmonary arterial hypertension patients, nor in the unaffected bone morphogenetic protein receptor type 2 mutation carriers, as compared to healthy subjects. The conflicting results with our preliminary human 18FLT report may be explained by a small sample size previously and we observed large variation of lung 18FLT signals between patients, challenging the application of 18FLT-PET as a biomarker in the pulmonary arterial hypertension ...

العلاقة: https://research.vumc.nl/en/publications/08681773-ccf3-4195-876b-2c2b016fd1a8Test

الإتاحة: https://doi.org/10.1177/20458940211028017Test
https://research.vumc.nl/en/publications/08681773-ccf3-4195-876b-2c2b016fd1a8Test
http://www.scopus.com/inward/record.url?scp=85109046329&partnerID=8YFLogxKTest

المؤلفون: Botros, Liza, Jansen, Samara M.A., Ashek, Ali, Spruijt, Onno A., Tramper, Jelco, Noordegraaf, Anton V., Aman, Jurjan, Harms, Hans, de Man, Frances S., Huisman, Marc C., Zhao, Lan, Bogaard, Harm J.

مصطلحات موضوعية: 110203 Respiratory Diseases, FOS: Clinical medicine, Cardiology

الوصف: Supplemental material, sj-pdf-2-pul-10.1177_20458940211028017 for Application of [18F]FLT-PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type 2 mutation carriers by Liza Botros, Samara M.A. Jansen, Ali Ashek, Onno A. Spruijt, Jelco Tramper, Anton V. Noordegraaf, Jurjan Aman, Hans Harms, Frances S. de Man, Marc C. Huisman, Lan Zhao and Harm J. Bogaard in Pulmonary Circulation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234ef8ec344f0bfe942d74c8554224d9Test

المؤلفون: Botros, Liza, Jansen, Samara M.A., Ashek, Ali, Spruijt, Onno A., Tramper, Jelco, Noordegraaf, Anton V., Aman, Jurjan, Harms, Hans, de Man, Frances S., Huisman, Marc C., Zhao, Lan, Bogaard, Harm J.

مصطلحات موضوعية: 110203 Respiratory Diseases, FOS: Clinical medicine, Cardiology

الوصف: Supplemental material, sj-pdf-1-pul-10.1177_20458940211028017 for Application of [18F]FLT-PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type 2 mutation carriers by Liza Botros, Samara M.A. Jansen, Ali Ashek, Onno A. Spruijt, Jelco Tramper, Anton V. Noordegraaf, Jurjan Aman, Hans Harms, Frances S. de Man, Marc C. Huisman, Lan Zhao and Harm J. Bogaard in Pulmonary Circulation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aefeff64d8d0b06cec4a711552c6b30Test

المؤلفون: Marcus, J. Tim, Noordegraaf, Anton V., Roeleveld, Roald J., Postmus, Pieter E., Heethaar, Rob M., Van Rossum, Albert C., Boonstra, Anco

المصدر: Marcus , J T , Noordegraaf , A V , Roeleveld , R J , Postmus , P E , Heethaar , R M , Van Rossum , A C & Boonstra , A 2001 , ' Impaired left ventricular filling due to right ventricular pressure overload in primary pulmonary hypertension : Noninvasive monitoring using MRI ' , Chest , vol. 119 , no. 6 , pp. 1761-1765 . https://doi.org/10.1378/chest.119.6.1761Test

الوصف: Objective: To analyze the effect of primary pulmonary hypertension (PPH) on cardiac function using MRI. Methods: In 12 patients (9 women; age range, 30 to 56 years), the diagnosis of PPH had been established by catheterization (mean ± SD pulmonary artery pressure [PAP] was 56 ± 8 mm Hg). With breath-hold cine MRI, a series of short-axis images was acquired covering the whole left ventricle (LV) and right ventricle (RV). The curvature, defined as 1 divided by the radius of curvature in centimeters, was calculated for the septum and the LV free wall in early diastole. Leftward ventricular septal bowing (LVSB) is denoted by a negative curvature. For the LV and the RV, the end-diastolic volume (EDV), stroke volume (SV), and volumetric filling rate were calculated. The control subjects were all healthy (n = 14; 11 women; age range, 20 to 57 years). Results: In the patients, LVSB was quantified in early diastole by the septal curvature of - 0.14 ± 0.07 cm -1 , and the septal to free-wall curvature ratio of - 0.42 ± 0.21. LV EDV and LV SV correlated negatively with diastolic PAP (p = 0.004 and p = 0.04, respectively). In patients vs control subjects, RV SV was reduced (52 ± 12 mL vs 82 ± 11 mL, p < 0.0001); LV peak filling rate was smaller (2.2 ± 0.7 EDV/s vs 3.3 ± 0.5 EDV/s, p < 0.001); LV EDV was smaller (81 ± 23 mL vs 117 ± 19 mL, p = 0.001); and LV SV was smaller (49 ± 18 mL vs 83 ± 13 mL, p < 0.0001). Conclusion: In PPH, RV pressure overload leads to LVSB and reduced RV output. By decreased blood delivery, LV filling is reduced, which results in decreased LV SV by the Frank-Starling mechanism.

العلاقة: https://research.vumc.nl/en/publications/660b3d7b-2001-444e-9873-91303086bcbdTest

الإتاحة: https://doi.org/10.1378/chest.119.6.1761Test
https://research.vumc.nl/en/publications/660b3d7b-2001-444e-9873-91303086bcbdTest
http://www.scopus.com/inward/record.url?scp=0034885430&partnerID=8YFLogxKTest

المؤلفون: Marcus, J. Tim, Noordegraaf, Anton V., Roeleveld, Roald J., Postmus, Pieter E., Heethaar, Rob M., Van Rossum, Albert C., Boonstra, Anco

المساهمون: Radiology and nuclear medicine, ACS - Pulmonary hypertension & thrombosis, CCA - Imaging and biomarkers, Pulmonary medicine, APH - Quality of Care, Physics and medical technology, Cardiology, ACS - Heart failure & arrhythmias

المصدر: Chest, 119(6), 1761-1765. American College of Chest Physicians
Marcus, J T, Noordegraaf, A V, Roeleveld, R J, Postmus, P E, Heethaar, R M, Van Rossum, A C & Boonstra, A 2001, ' Impaired left ventricular filling due to right ventricular pressure overload in primary pulmonary hypertension : Noninvasive monitoring using MRI ', Chest, vol. 119, no. 6, pp. 1761-1765 . https://doi.org/10.1378/chest.119.6.1761Test

الوصف: Objective: To analyze the effect of primary pulmonary hypertension (PPH) on cardiac function using MRI. Methods: In 12 patients (9 women; age range, 30 to 56 years), the diagnosis of PPH had been established by catheterization (mean ± SD pulmonary artery pressure [PAP] was 56 ± 8 mm Hg). With breath-hold cine MRI, a series of short-axis images was acquired covering the whole left ventricle (LV) and right ventricle (RV). The curvature, defined as 1 divided by the radius of curvature in centimeters, was calculated for the septum and the LV free wall in early diastole. Leftward ventricular septal bowing (LVSB) is denoted by a negative curvature. For the LV and the RV, the end-diastolic volume (EDV), stroke volume (SV), and volumetric filling rate were calculated. The control subjects were all healthy (n = 14; 11 women; age range, 20 to 57 years). Results: In the patients, LVSB was quantified in early diastole by the septal curvature of - 0.14 ± 0.07 cm-1, and the septal to free-wall curvature ratio of - 0.42 ± 0.21. LV EDV and LV SV correlated negatively with diastolic PAP (p = 0.004 and p = 0.04, respectively). In patients vs control subjects, RV SV was reduced (52 ± 12 mL vs 82 ± 11 mL, p < 0.0001); LV peak filling rate was smaller (2.2 ± 0.7 EDV/s vs 3.3 ± 0.5 EDV/s, p < 0.001); LV EDV was smaller (81 ± 23 mL vs 117 ± 19 mL, p = 0.001); and LV SV was smaller (49 ± 18 mL vs 83 ± 13 mL, p < 0.0001). Conclusion: In PPH, RV pressure overload leads to LVSB and reduced RV output. By decreased blood delivery, LV filling is reduced, which results in decreased LV SV by the Frank-Starling mechanism.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fc9acbf23c9f49723348bbab3d282e99Test
https://research.vumc.nl/en/publications/660b3d7b-2001-444e-9873-91303086bcbdTest