نتائج البحث - "Noci, Sara"

1

دورية أكاديمية

Colorectal carcinoma peritoneal metastases-derived organoids: results and perspective of a model for tailoring hyperthermic intraperitoneal chemotherapy from bench-to-bedside ...

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Cancer, Science Policy

الوصف: Background Peritoneal metastases from colorectal cancer (CRCPM) are related to poor prognosis. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been reported to improve survival, but peritoneal recurrence rates are still high and there is no consensus on the drug of choice for HIPEC. The aim of this study was to use patient derived organoids (PDO) to build a relevant CRCPM model to improve HIPEC efficacy in a comprehensive bench-to-bedside strategy. Methods Oxaliplatin (L-OHP), cisplatin (CDDP), mitomycin-c (MMC) and doxorubicin (DOX) were used to mimic HIPEC on twelve PDO lines derived from twelve CRCPM patients, using clinically relevant concentrations. After chemotherapeutic interventions, cell viability was assessed with a luminescent assay, and the obtained dose–response curves were used to determine the half-maximal inhibitory concentrations. Also, induction of apoptosis by different HIPEC interventions on PDOs was studied by evaluating CASPASE3 cleavage. ...

الإتاحة: https://doi.org/10.6084/m9.figshare.c.7215753Test
https://springernature.figshare.com/collections/Colorectal_carcinoma_peritoneal_metastases-derived_organoids_results_and_perspective_of_a_model_for_tailoring_hyperthermic_intraperitoneal_chemotherapy_from_bench-to-bedside/7215753Test

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2

دورية أكاديمية

Modulation of faecal miRNAs highlights the preventive effects of a Mediterranean low-inflammatory dietary intervention

المساهمون: European Union, European Cooperation in Science and Technology, MIUR

المصدر: Clinical Nutrition ; volume 43, issue 4, page 951-959 ; ISSN 0261-5614

مصطلحات موضوعية: Critical Care and Intensive Care Medicine, Nutrition and Dietetics

الإتاحة: https://doi.org/10.1016/j.clnu.2024.02.023Test
https://api.elsevier.com/content/article/PII:S0261561424000669?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0261561424000669?httpAccept=text/plainTest

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3

دورية أكاديمية

Additional file 1 of Colorectal carcinoma peritoneal metastases-derived organoids: results and perspective of a model for tailoring hyperthermic intraperitoneal chemotherapy from bench-to-bedside ...

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Cancer, Science Policy

الوصف: Supplementary Material 1. ...

الإتاحة: https://doi.org/10.6084/m9.figshare.25744371.v110.6084/m9.figshare.2574437110.1245/s10434-021-09587-710.1016/j.critrevonc.2016.01.01710.1016/j.annonc.2022.10.00310.1016/s1470-2045Test(20)30599-410.3390/cancers1507192610.1245/s10434-011-1631-510.1056/nejmoa170861810.1001/jamasurg.2023.066210.1016/j.ejso.2018.10.54210.1016/j.cell.2017.11.01010.1016/j.cell.2018.03.01710.1158/2159-8290.cd-18-047410.1158/2159-8290.cd-18-034910.1126/science.aao277410.1158/2159-8290.cd-16-115410.1126/science.aaw698510.1038/s41568-019-0209-610.1093/jmcb/mjac06410.1016/j.stem.2016.04.003
https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Colorectal_carcinoma_peritoneal_metastases-derived_organoids_results_and_perspective_of_a_model_for_tailoring_hyperthermic_intraperitoneal_chemotherapy_from_bench-to-bedside/25744371/1Test

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4

دورية أكاديمية

Genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue

المؤلفون: Minnai, Francesca, Noci, Sara, Chierici, Marco, Cotroneo, Chiara Elisabetta, Bartolini, Barbara, Incarbone, Matteo, Tosi, Davide, Mattioni, Giovanni, Jurman, Giuseppe, Dragani, Tommaso A., Colombo, Francesca

المساهمون: F. Minnai, S. Noci, M. Chierici, C.E. Cotroneo, B. Bartolini, M. Incarbone, D. Tosi, G. Mattioni, G. Jurman, T.A. Dragani, F. Colombo

مصطلحات موضوعية: gene expression, lung neoplasm, machine learning, prognosi, quantitative trait locus, Settore MED/03 - Genetica Medica

الوصف: Emerging evidence suggests that the prognosis of patients with lung adenocarcinoma can be determined from germline variants and transcript levels in nontumoral lung tissue. Gene expression data from noninvolved lung tissue of 483 lung adenocarcinoma patients were tested for correlation with overall survival using multivariable Cox proportional hazard and multivariate machine learning models. For genes whose transcript levels are associated with survival, we used genotype data from 414 patients to identify germline variants acting as cis-expression quantitative trait loci (eQTLs). Associations of eQTL variant genotypes with gene expression and survival were tested. Levels of four transcripts were inversely associated with survival by Cox analysis (CLCF1, hazard ratio [HR] = 1.53; CNTNAP1, HR = 2.17; DUSP14, HR = 1.78; and MT1F: HR = 1.40). Machine learning analysis identified a signature of transcripts associated with lung adenocarcinoma outcome that was largely overlapping with the transcripts identified by Cox analysis, including the three most significant genes (CLCF1, CNTNAP1, and DUSP14). Pathway analysis indicated that the signature is enriched for ECM components. We identified 32 cis-eQTLs for CNTNAP1, including 6 with an inverse correlation and 26 with a direct correlation between the number of minor alleles and transcript levels. Of these, all but one were prognostic: the six with an inverse correlation were associated with better prognosis (HR < 1) while the others were associated with worse prognosis. Our findings provide supportive evidence that genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36114746; info:eu-repo/semantics/altIdentifier/wos/WOS:000868621000001; volume:114; issue:1; firstpage:281; lastpage:294; numberofpages:14; journal:CANCER SCIENCE; https://hdl.handle.net/2434/1033228Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85139839346

الإتاحة: https://doi.org/10.1111/cas.15591Test
https://hdl.handle.net/2434/1033228Test

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5

دورية أكاديمية

Gut microbiota composition in colorectal cancer patients is genetically regulated

المؤلفون: Colombo, Francesca, Illescas, Oscar, Noci, Sara, Minnai, Francesca, Pintarelli, Giulia, Pettinicchio, Angela, Vannelli, Alberto, Sorrentino, Luca, Battaglia, Luigi, Cosimelli, Maurizio, Dragani, Tommaso A., Gariboldi, Manuela

المساهمون: Consejo Nacional de Ciencia y Tecnología, Fondazione Umberto Veronesi, H2020 European Research Council, 5 per mille donation program from the Italian Government

المصدر: Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: The risk of colorectal cancer (CRC) depends on environmental and genetic factors. Among environmental factors, an imbalance in the gut microbiota can increase CRC risk. Also, microbiota is influenced by host genetics. However, it is not known if germline variants influence CRC development by modulating microbiota composition. We investigated germline variants associated with the abundance of bacterial populations in the normal (non-involved) colorectal mucosa of 93 CRC patients and evaluated their possible role in disease. Using a multivariable linear regression, we assessed the association between germline variants identified by genome wide genotyping and bacteria abundances determined by 16S rRNA gene sequencing. We identified 37 germline variants associated with the abundance of the genera Bacteroides, Ruminococcus, Akkermansia, Faecalibacterium and Gemmiger and with alpha diversity. These variants are correlated with the expression of 58 genes involved in inflammatory responses, cell adhesion, apoptosis and barrier integrity. Genes and bacteria appear to be involved in the same processes. In fact, expression of the pro-inflammatory genes GAL , GSDMD and LY6H was correlated with the abundance of Bacteroides , which has pro-inflammatory properties; abundance of the anti-inflammatory genus Faecalibacterium correlated with expression of KAZN, with barrier-enhancing functions. Both the microbiota composition and local inflammation are regulated, at least partially, by the same germline variants. These variants may regulate the microenvironment in which bacteria grow and predispose to the development of cancer. Identification of these variants is the first step to identifying higher-risk individuals and proposing tailored preventive treatments that increase beneficial bacterial populations.

الإتاحة: https://doi.org/10.1038/s41598-022-15230-6Test
https://www.nature.com/articles/s41598-022-15230-6.pdfTest
https://www.nature.com/articles/s41598-022-15230-6Test

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6

دورية أكاديمية

Development and assessment of a method to determine the angle of attack on an operating wind turbine by matching onboard pressure measurements with panel method simulations

المؤلفون: Soto-Valle Rodrigo, Noci Sara, Papi Francesco, Bartholomay Sirko, Nayeri Christian Navid, Paschereit Christian Oliver, Bianchini Alessandro

المصدر: E3S Web of Conferences, Vol 312, p 08003 (2021)

مصطلحات موضوعية: Environmental sciences, GE1-350

الوصف: Wind Energy is substantially growing in recent years and is now one of the most competitive renewable energy sources on the market. To further foster the growth of this energy source, increasing effort is put into building accurate numerical models. Most models compute the loads acting on the turbine as a dependence of some sort to the angle of attack (AoA). Accurate AoA measurements would allow for comparison with experiments and would be of great benefit for the improvement of numerical models and the investigations of aerodynamic phenomena such as stall delay. However, the determination of the angle of attack during operation is troublesome to the present day. In addition to what was already mentioned, the AoA is key to evaluate loads acting on the wind turbine and assessing experiments, computational models, and aeroelastic models. This paper proposes a simple comparative method to estimate the AoA based on pressure distributions. The proposed method is tested using data from different numbers of pressure taps placed on the Berlin Research Turbine (BeRT) at the Hermann Föttinger Institut of the Technische Universität Berlin. The predicted results are in line with those from other methods while the operating conditions to which the model can be applied are improved.

العلاقة: https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/88/e3sconf_ati2021_08003.pdfTest; https://doaj.org/toc/2267-1242Test; https://doaj.org/article/b593c8e78471408ea3b845d1daafcf88Test

الإتاحة: https://doi.org/10.1051/e3sconf/202131208003Test
https://doaj.org/article/b593c8e78471408ea3b845d1daafcf88Test

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النص الكامل

7

دورية أكاديمية

Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients

المؤلفون: Colombo, Francesca, Pintarelli, Giulia, Galvan, Antonella, Noci, Sara, Corli, Oscar, Skorpen, Frank, Klepstad, Pål, Kaasa, Stein, Pigni, Alessandra, Brunelli, Cinzia, Roberto, Anna, Piazza, Rocco, Pirola, Alessandra, Gambacorti-Passerini, Carlo, Caraceni, Augusto Tomasso Giovanni

المصدر: 0 ; 10 ; Scientific Reports ; 1 ; 542

الوصف: Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is modulated by the genetic background of the patients. Whole exome sequencing of DNA pools from patients with either low (n = 937) or high (n = 557) nausea and vomiting intensity, recruited in the European Pharmacogenetic Opioid Study, revealed a preliminary association of 53 polymorphisms. PCR-based genotyping of 45 of these polymorphisms in the individual patients of the same series confirmed the association for six SNPs in AIM1L, CLCC1, MUC16, PDE3A, POM121L2, and ZNF165 genes. Genotyping of the same 45 polymorphisms in 264 patients of the Italian CERP study, also treated with opioids for cancer pain, instead confirmed the association for two SNPs in ZNF568 and PDE3A genes. Only one SNP, rs12305038 in PDE3A, was confirmed in both series, although with opposite effects of the minor allele on the investigated phenotype. Overall, our findings suggest that genetic factors are indeed associated with nausea and vomiting in opioid-treated cancer patients, but the role of individual polymorphisms may be weak. ; publishedVersion ; This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this ...

وصف الملف: application/pdf

العلاقة: Scientific Reports. 2020, 10 (1), .; urn:issn:2045-2322; https://hdl.handle.net/11250/2738242Test; https://doi.org/10.1038/s41598-019-57358-yTest; cristin:1834829

الإتاحة: https://doi.org/10.1038/s41598-019-57358-yTest
https://hdl.handle.net/11250/2738242Test

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النص الكامل

8

دورية أكاديمية

Read-through transcripts in lung: germline genetic regulation and correlation with the expression of other genes

المؤلفون: Maspero, Davide, Dassano, Alice, Pintarelli, Giulia, Noci, Sara, De Cecco, Loris, Incarbone, Matteo, Tosi, Davide, Santambrogio, Luigi, Dragani, Tommaso A, Colombo, Francesca

المساهمون: Associazione Italiana Ricerca Cancro (AIRC), Italy

المصدر: Carcinogenesis ; volume 41, issue 7, page 918-926 ; ISSN 0143-3334 1460-2180

مصطلحات موضوعية: Cancer Research, General Medicine

الوصف: Transcripts originating from the transcriptional read through of two adjacent, similarly oriented genes have been identified in normal and neoplastic tissues, but their functional role and the mechanisms that regulate their expression are mostly unknown. Here, we investigated whether the expression of read-through transcripts previously identified in the non-involved lung tissue of lung adenocarcinoma patients was genetically regulated. Data on genome-wide single nucleotide variant genotypes and expression levels of 10 read-through transcripts in 201 samples of lung tissue were combined to identify expression quantitative trait loci (eQTLs). Then, to identify genes whose expression levels correlated with the 10 read-through transcripts, we used whole transcriptome profiles available for 154 patients. For 8 read-though transcripts, we identified 60 eQTLs (false discovery rate <0.05), including 17 cis-eQTLs and 43 trans-eQTLs. These eQTLs did not maintain their behavior on the ‘parental’ genes involved in the read-through transcriptional event. The expression levels of 7 read-through transcripts were found to correlate with the expression of other genes: CHIA–PIFO and CTSC–RAB38 correlated with CHIA and RAB38, respectively, while 5 other read-through transcripts correlated with 43 unique non-parental transcripts; thus offering indications about the molecular processes in which these chimeric transcripts may be involved. We confirmed 9 eQTLs (for 4 transcripts) in the non-involved lung tissue from an independent series of 188 lung adenocarcinoma patients. Therefore, this study indicates that the expression of four read-through transcripts in normal lung tissue is under germline genetic regulation, and that this regulation is independent of that of the genes involved in the read-through event.

الإتاحة: https://doi.org/10.1093/carcin/bgaa020Test
http://academic.oup.com/carcin/article-pdf/41/7/918/33494522/bgaa020.pdfTest

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9

دورية أكاديمية

A pilot exome sequencing study suggests that germline variants influence methotrexate‐induced toxicities in pediatric patients with localized osteosarcoma.

المؤلفون: Minnai, Francesca, Noci, Sara, Mangano, Nunzia, De Cecco, Loris, Meazza, Cristina, Terenziani, Monica, Massimino, Maura, Colombo, Francesca

المصدر: Pediatric Blood & Cancer; Sep2023, Vol. 70 Issue 9, p1-7, 7p

10

دورية أكاديمية

Lung Adenocarcinoma Diagnosed at a Younger Age Is Associated with Advanced Stage, Female Sex, and Ever-Smoker Status, in Patients Treated with Lung Resection.

المؤلفون: Dragani, Tommaso A, Muley, Thomas, Schneider, Marc A, Kobinger, Sonja, Eichhorn, Martin, Winter, Hauke, Hoffmann, Hans, Kriegsmann, Mark, Noci, Sara, Incarbone, Matteo, Tosi, Davide, Franzi, Sara, Colombo, Francesca

المساهمون: Klinik und Poliklinik für Chirurgie (Prof. Friess)

مصطلحات موضوعية: info:eu-repo/classification/ddc

الوصف: To date, the factors which affect the age at diagnosis of lung adenocarcinoma are not fully understood. In our study, we examined the relationships of age at diagnosis with smoking, pathological stage, sex, and year of diagnosis in a discovery (n = 1694) and validation (n = 1384) series of lung adenocarcinoma patients who had undergone pulmonary resection at hospitals in the Milan area and at Thoraxklinik (Heidelberg), respectively. In the discovery series, younger age at diagnosis was associated with ever-smoker status (OR = 1.5, p = 0.0035) and advanced stage (taking stage I as reference: stage III OR = 1.4, p = 0.0067; stage IV OR = 1.7, p = 0.0080), whereas older age at diagnosis was associated with male sex (OR = 0.57, p < 0.001). Analysis in the validation series confirmed the ever versus never smokers' association (OR = 2.9, p < 0.001), the association with highest stages (stage III versus stage I OR = 1.4, p = 0.0066; stage IV versus stage I OR = 2.0, p = 0.0022), and the male versus female sex association (OR = 0.78, p = 0.032). These data suggest the role of smoking in affecting the natural history of the disease. Moreover, aggressive tumours seem to have shorter latency from initiation to clinical detection. Finally, younger age at diagnosis is associated with the female sex, suggesting that hormonal status of young women confers risk to develop lung adenocarcinoma. Overall, this study provided novel findings on the mechanisms underlying age at diagnosis of lung adenocarcinoma.

العلاقة: https://mediatum.ub.tum.de/1740020Test

الإتاحة: https://doi.org/10.3390/cancers15082395Test
https://mediatum.ub.tum.de/1740020Test

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