المؤلفون: Giaquinto, C, Rampon, O, D'Elia, R, De Rossi, A, Grosch-Worner, I, Feiterna-Sperling, C, Schmitz, T, Casteleyn, S, Mok, J, de Jose, I, Bates, I, Larru, B, Pena, JM, Garcia, JG, Lopez, JRA, Garcia-Rodriguez, MC, Asensi-Botet, F, Otero, MC, Perez-Tamarit, D, Suarez, G, Scherpbier, H, Kreyenbroek, M, Godfried, MH, Nellen, FJ, Boer, K, Bohlin, AB, Lindgren, S, Belfrage, E, Naver, L, Anzen, B, Lidman, K, Levy, J, Hainaut, M, Goetghebuer, T, Manigart, Y, Barlow, P, Ferrazin, A, Bassetti, D, De Maria, A, Bentivoglio, G, Ferrero, S, Gotta, C, Mur, A, Paya, A, Lopez-Vilchez, MA, Carreras, R, Valerius, NH, Jimenez, J, Coll, O, Suy, A, Perez, JM, Fortuny, C, Boguna, J, Caro, MC, Canet, Y, Pardi, G, Ravizza, M, Guerra, B, Lanari, M, Bianchi, S, Bovicelli, L, Prati, E, Duse, M, Scaravelli, G, Stegagno, M, De Santis, M, Savasi, V, Ferrazzi, E, Vigano, A, Giacomet, V, Probizer, FR, Maccabruni, A, Bucceri, A, Rancilio, L, Alberico, S, Rabusin, M, Bernardon, M, Taylor, GP, Lyall, EGH, Penn, Z, Buffolano, W, Tiseo, R, Martinelli, P, Sansone, M, Agangi, A, Tibaldi, C, Marini, S, Masuelli, G, Benedetto, C, Niemiec, T, Marczynska, M, Oldakowska, A, Kaflik, M, Posokhova, S, Kaleeva, T, Stelmah, A, Kiseleva, G

المصدر: AIDS (London, England). 20(10):1419-1427

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:112200804Test

المؤلفون: Steering D, Powderly B, Shortman N, Moecklinghoff C, Reilly G, Franquet X, Ryom L, Hatleberg CI, Sabin CA, Kamara D, Smith C, Phillips A, Mocroft A, Bojesen A, Grevsen A, Matthews C, Raben D, Lundgren JD, Brandt RS, Rickenbach M, Fanti I, Hillebreght M, Zaheri S, Gras L, Pernot E, Mourabi J, Sundström A, Delforge M, Fontas E, Torres F, McManus H, Wright S, Kristensen D, Sjøl A, Meidahl P, Helweg-Larsen J, Schmidt Iversen J, Kirk O, Reiss P, Smit C, Ross M, Fux CA, Morlat P, Moranne O, Kamara DA, Weber R, Pradier C, Friis-Møller N, Kowalska J, Sabin C, Law M, d'Arminio Monforte A, Dabis F, Bruyand M, Bonnet F, Bower M, Fätkenheuer G, Donald A, Grulich A, Prins JM, Kuijpers TW, Scherpbier HJ, van der Meer JT, Wit FW, Godfried MH, van der Poll T, Nellen FJ, Geerlings SE, van Vugt M, Pajkrt D, Bos JC, Wiersinga WJ, van der Valk M, Goorhuis A, Hovius JW, van Eden J, Henderiks A, van Hes AM, Mutschelknauss M, Nobel HE, Pijnappel FJ, Westerman AM, Jurriaans S, Back NK, Zaaijer HL, Berkhout B, Cornelissen MT, Schinkel CJ, Thomas XV, De Ruyter Ziekenhuis A, van den Berge M, Stegeman A, Baas S, de Looff L, Versteeg D, Pronk MJ, Ammerlaan HS, Korsten-Vorstermans EM, de Munnik ES, Jansz AR, Tjhie J, Wegdam MC, Deiman B, Scharnhorst V, Kinderziekenhuis E, van der Plas A, Weijsenfeld AM, van der Ende ME, de Vries-Sluijs TE, van Gorp EC, Schurink CA, Nouwen JL, Verbon A, Rijnders BJ, Bax HI, Hassing RJ, van der Feltz M, Bassant N, van Beek JE, Vriesde M, van Zonneveld LM, de Oude-Lubbers A, van den Berg-Cameron HJ, Bruinsma-Broekman FB, de Groot J, de Man de Z, Broekhoven-Kruijne MJ, Schutten M, Osterhaus AD, Boucher CA, Driessen GJ, van Rossum AM, van der Knaap LC, Visser E, Branger J, Duijf-van de Ven CJ, Haag D, Schippers EF, van Nieuwkoop C, Brimicombe RW, van IJperen M, van der Hut G, Franck PF, van Eeden A, Brokking W, Groot M, Damen M, Kwa IS, Groeneveld PH, Bouwhuis JW, van den Berg JF, van Hulzen AG, van der Bliek GL, Bor PC, Bloembergen P, Wolfhagen MJ, Ruijs GJ, Gasthuis K, van Lelyveld SF, Soetekouw R, Hulshoff N, van der Prijt LM, Schoemaker M, Bermon N, van der Reijden WA, Jansen R, Herpers BL, Veenendaal D, Kroon FP, Arend SM, de Boer MG, Bauer MP, Jolink H, Vollaard AM, Dorama W, Moons C, Claas EC, Kroes AC, den Hollander JG, Pogany K, Kastelijns M, Smit JV, Smit E, Bezemer M, van Niekerk T, Pontesilli O, Lowe SH, Oude Lashof A, Posthouwer D, Ackens RP, Schippers J, Vergoossen R, Weijenberg Maes B, Savelkoul PH, Loo IH, Zuiderzee MC, Weijer S, El Moussaoui R, Heitmuller M, Kortmann W, van Twillert G, Cohen Stuart JW, Diederen BM, Pronk D, van Truijen-Oud FA, van der Reijden W, Leyten EM, Gelinck LB, van Hartingsveld A, Meerkerk C, Wildenbeest GS, Mutsaers JA, Jansen CL, van Vonderen MG, van Houte DP, Dijkstra K, Faber S, Weel J, Kootstra GJ, Delsing CE, van der Burgvan de Plas M, Heins H, Lucas E, Brinkman K, Frissen PH, Blok WL, Schouten WE, Bosma AS, Brouwer CJ, Geerders GF, Hoeksema K, Kleene MJ, van der Meché IB, Toonen AJ, Wijnands S, van Ogtrop ML, Koopmans PP, Keuter M, van der Ven AJ, ter Hofstede HJ, Dofferhoff AS, van Crevel R, Albers M, Bosch ME, Grintjes-Huisman KJ, Zomer BJ, Stelma FF, Burger D, Richter C, van der Berg JP, Gisolf EH, Beest G, van Bentum PH, Langebeek N, Tiemessen R, Swanink CM, Veenstra J, Lettinga KD, Spelbrink M, Sulman H, Witte E, Peerbooms PG, Mulder JW, Vrouenraets SM, Lauw FN, van Broekhuizen MC, Paap H, Vlasblom DJ, Oudmaijer Sanders E, Smits PH, Rosingh AW, Verhagen DW, Geilings J, van Kasteren ME, Brouwer AE, de Kruijf-van de Wiel BA, Kuipers M, Santegoets RM, van der Ven B, Marcelis JH, Buiting AG, Kabel PJ, Bierman WF, Sprenger HG, Scholvinck EH, van Assen S, Wilting KR, Stienstra Y, de Groot-de Jonge H, van der Meulen PA, de Weerd DA, Niesters HG, Riezebos-Brilman A, van Leer-Buter CC, Hoepelman AI, Schneider MM, Mudrikova T, Ellerbroek PM, Oosterheert JJ, Arends JE, Barth RE, Wassenberg MW, van Elst-Laurijssen DH, Laan LM, van Oers-Hazelzet EE, Patist J, Vervoort S, Nieuwenhuis HE, Frauenfelder R, Schuurman R, Verduyn-Lunel F, Wensing AM, Peters EJ, van Agtmael MA, Perenboom RM, Bomers M, de Vocht J, Elsenburg LJ, Pettersson AM, Vandenbroucke-Grauls CM, Ang CW, Geelen SP, Wolfs TF, Bont LJ, Nauta N, Bezemer DO, van Sighem AI, Hillebregt M, Kimmel V, Tong Y, Lascaris B, van den Boogaard R, Hoekstra P, de Lang A, Berkhout M, Grivell S, Jansen A, de Groot L, van den Akker M, Bergsma D, Lodewijk C, Meijering R, Peeck B, Raethke M, Ree C, Regtop R, Ruijs Y, Schoorl M, Tuijn E, Veenenberg L, Woudstra T, Bakker Y, de Jong A, Broekhoven M, Claessen E, Rademaker MJ, Munjishvili L, Kruijne E, Tuk B, Bouchet S, Breilh D, Chêne G, Dupon M, Fleury H, Gaborieau V, Lacoste D, Malvy D, Mercié P, Neau D, Pellegrin I, Pellegrin JL, Tchamgoué S, Fagard C, Lawson-Ayayi S, Richert L, Thiébaut R, Wittkop L, André K, Bernard N, Caunègre L, Cazanave C, Ceccaldi J, Chossat I, Courtault C, Dauchy FA, De Witte S, Dondia D, Dupont A, Duffau P, Dutronc H, Farbos S, Faure I, Gerard Y, Greib C, Hessamfar-Joseph M, Imbert Y, Lataste P, Lazaro E, Marie J, Mechain M, Meraud JP, Monlun E, Ochoa A, Pillot-Debelleix M, Pistone T, Raymond I, Receveur MC, Rispal P, Sorin L, Valette C, Vandenhende MA, Vareil MO, Viallard JF, Wille H, Wirth G, Moreau JF, Lafon ME, Reigadas S, Trimoulet P, Haramburu F, Miremont-Salamé G, Blaizeau MJ, Crespel I, Decoin M, Delveaux S, Diarra F, D'Ivernois C, Hanappier C, Leleux O, Le Marec F, Lenaud E, Mourali J, Pougetoux A, Uwamaliya-Nziyumvira B, Tsaranazy A, Valdes A, Conte V, Louis I, Palmer G, Sapparrart V, Touchard D, Petoumenos K, Bendall C, Moore R, Edwards S, Hoy J, Watson K, Roth N, Nicholson J, Bloch M, Franic T, Baker D, Vale R, Carr A, Cooper D, Chuah J, Ngieng M, Nolan D, Skett J, Calvo G, Mateu S, Domingo P, Sambeat MA, Gatell J, Del Cacho E, Cadafalch J, Fuster M, Codina C, Sirera G, Vaqué A, De Wit S, Clumeck N, Necsoi C, Gennotte AF, Gerard M, Kabeya K, Konopnicki D, Libois A, Martin C, Payen MC, Semaille P, Van Y, Neaton J, Bartsch G, El-Sadr WM, Krum E, Thompson G, Wentworth D, Luskin-Hawk R, Telzak E, Abrams DI, Cohn D, Markowitz N, Arduino R, Mushatt D, Friedland G, Perez G, Tedaldi E, Fisher E, Gordin F, Crane LR, Sampson J, Baxter J, Losso M, Kundro M, Vetter N, Zangerle R, Karpov I, Vassilenko A, Mitsura VM, Paduto D, Florence E, Vandekerckhove L, Hadziosmanovic V, Kostov K, Begovac J, Machala L, Jilich D, Sedlacek D, Kronborg G, Benfield T, Gerstoft J, Katzenstein T, Hansen AB, Pedersen C, Møller NF, Ostergaard L, Dragsted UB, Nielsen LN, Zilmer K, Smidt J, Ristola M, Aho I, Katlama C, Viard JP, Girard PM, Cotte L, Duvivier C, Rockstroh J, Schmidt R, van Lunzen J, Degen O, Stellbrink HJ, Stefan C, Bogner J, Chkhartishvili N, Kosmidis J, Gargalianos P, Xylomenos G, Lourida P, Sambatakou H, Banhegyi D, Gottfredsson M, Mulcahy F, Yust I, Turner D, Burke M, Shahar E, Hassoun G, Elinav H, Haouzi M, Sthoeger ZM, D'Arminio Monforte A, Esposito R, Mazeu I, Mussini C, Mazzotta F, Gabbuti A, Vullo V, Lichtner M, Zaccarelli M, Antinori A, Acinapura R, D'Offizi G, Lazzarin A, Castagna A, Gianotti N, Galli M, Ridolfo A, Rozentale B, Uzdaviniene V, Matulionyte R, Staub T, Hemmer R, Ormaasen V, Maeland A, Bruun J, Knysz B, Gasiorowski J, Inglot M, Horban A, Bakowska E, Grzeszczuk A, Flisiak R, Parczewski M, Pynka M, Maciejewska K, Beniowski M, Mularska E, Smiatacz T, Gensing M, Jablonowska E, Malolepsza E, Wojcik K, Mozer-Lisewska I, Doroana M, Caldeira L, Mansinho K, Maltez F, Radoi R, Oprea C, Rakhmanova A, Trofimora T, Khromova I, Kuzovatova E, Jevtovic D, Shunnar A, Staneková D, Tomazic J, Moreno S, Rodriguez J, Clotet B, Jou A, Paredes R, Tural C, Puig J, Bravo I, Gatell JM, Miró JM, Gutierrez M, Mateo G, Laporte JM, Blaxhult A, Flamholc L, Falconer K, Thalme A, Sonnerborg A, Ledergerber B, Cavassini M, Calmy A, Furrer H, Battegay M, Elzi L, Schmid P, Kravchenko E, Chentsova N, Frolov V, Kutsyna G, Baskakov I, Servitskiy S, Kuznetsova A, Kyselyova G, Gazzard B, Johnson AM, Simons E, Johnson MA, Orkin C, Weber J, Scullard G, Fisher M, Leen C, Lundgren J, Grarup J, Cozzi-Lepri A, Thiebaut R, Peters L, Fischer AH, Grønborg Laut K, Larsen JF, Podlekareva D, Grint D, Shepherd L, Schultze A, Morfeldt L, Thulin G, Åkerlund B, Koppel K, Karlsson A, Håkangård C, Moroni M, Angarano G, Armignacco O, Castelli F, Cauda R, Di Perri G, Iardino R, Ippolito G, Perno CF, von Schloesser F, Viale P, Ceccherini-Silberstein F, Girardi E, Lo Caputo S, Puoti M, Andreoni M, Ammassari A, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi R, Cingolani A, Cinque P, De Luca A, Di Biagio A, Gori A, Guaraldi G, Lapadula G, Madeddu G, Maggiolo F, Marchetti G, Marcotullio S, Monno L, Quiros Roldan E, Rusconi S, Cicconi P, Formenti T, Galli L, Lorenzini P, Giacometti A, Costantini A, Santoro C, Suardi C, Vanino E, Verucchi G, Minardi C, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Sighinolfi L, Segala D, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Castelli A, Rizzardini G, Ridolfo AL, Piolini R, Salpietro S, Carenzi L, Moioli MC, Puzzolante C, Abrescia N, Chirianni A, Guida MG, Onofrio M, Baldelli F, Francisci D, Parruti G, Ursini T, Magnani G, Ursitti MA, d'Avino A, Gallo L, Nicastri E, Capozzi M, Libertone R, Tebano G, Cattelan A, Mura MS, Caramello P, Orofino GC, Sciandra M, Pellizzer G, Manfrin V, Castelli AP, Dollet K, Caissotti C, Dellamonica P, Bernard E, Cua E, De Salvador-Guillouet F, Durant J, Ferrando S, Dunais B, Mondain-Miton V, Naqvi A, Perbost I, Prouvost-Keller B, Pillet S, Pugliese P, Risso K, Roger PM, Aubert V, Bernasconi E, Böni J, Bucher HC, Burton-Jeangros C, Dollenmaier G, Egger M, Fehr J, Fellay J, Gorgievski M, Günthard H, Haerry D, Hasse B, Hirsch HH, Hoffmann M, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kouyos R, Kovari H, Martinetti G, Martinez de Tejada B, Metzner K, Müller N, Nadal D, Nicca D, Pantaleo G, Rauch A, Regenass S, Rudin C, Schöni-Affolter F, Schüpbach J, Speck R, Tarr P, Telenti A, Trkola A, Vernazza P, Yerly S.

المساهمون: Steering, D, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Ryom, L, Hatleberg, Ci, Sabin, Ca, Kamara, D, Smith, C, Phillips, A, Mocroft, A, Bojesen, A, Grevsen, A, Matthews, C, Raben, D, Lundgren, Jd, Brandt, R, Rickenbach, M, Fanti, I, Hillebreght, M, Zaheri, S, Gras, L, Pernot, E, Mourabi, J, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kristensen, D, Sjøl, A, Meidahl, P, Helweg-Larsen, J, Schmidt Iversen, J, Kirk, O, Reiss, P, Smit, C, Ross, M, Fux, Ca, Morlat, P, Moranne, O, Kamara, Da, Weber, R, Pradier, C, Friis-Møller, N, Kowalska, J, Sabin, C, Law, M, d'Arminio Monforte, A, Dabis, F, Bruyand, M, Bonnet, F, Bower, M, Fätkenheuer, G, Donald, A, Grulich, A, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, van der Meer, Jt, Wit, Fw, Godfried, Mh, van der Poll, T, Nellen, Fj, Geerlings, Se, van Vugt, M, Pajkrt, D, Bos, Jc, Wiersinga, Wj, van der Valk, M, Goorhuis, A, Hovius, Jw, van Eden, J, Henderiks, A, van Hes, Am, Mutschelknauss, M, Nobel, He, Pijnappel, Fj, Westerman, Am, Jurriaans, S, Back, Nk

مصطلحات موضوعية: Infectious Disease, Epidemiology, Immunology, Virology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26762990; info:eu-repo/semantics/altIdentifier/wos/WOS:000368264000006; volume:3; issue:1; firstpage:e23; lastpage:e32; journal:THE LANCET. HIV; http://hdl.handle.net/11379/478864Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84952990188; http://www.journals.elsevier.com/the-lancet-hivTest/

الإتاحة: https://doi.org/10.1016/S2352-3018Test(15)00211-8
http://hdl.handle.net/11379/478864Test
http://www.journals.elsevier.com/the-lancet-hivTest/

المؤلفون: Tariq, S, Townsend, Cl, Cortina Borja, M, Duong, T, Elford, J, Thorne, C, Tookey, Pa, Giaquinto, C, Rampon, O, Mazza, A, De Rossi, A, Grosch Wörner, I, Mok, J, de José MI, Larrú Martínez, B, Scherpbier, Hj, Kreyenbroek, M, Godfried, Mh, Nellen, Fj, Boer, K, Navér, L, Anzén, B, Lidman, K, Levy, J, Barlow, P, Manigart, Y, Hainaut, M, Goetghebuer, T, Brichard, B, De Camps, J, Thiry, N, Deboone, G, Waterloos, H, De Maria, A, Mûr, A, Payà, A, López Vilchez MA, Carreras, R, Valerius, Nh, Rosenfeldt, V, Coll, O, Suy, A, Perez, Jm, Fortuny, C, Boguña, J, Savasi, V, Viganò, A, Giacomet, V, Cerini, C, Raimondi, C, Zuccotti, G, Alberico, S, Rabusin, M, Bernardon, M, Buffolano, W, Tiseo, R, Martinelli, P, Sansone, M, Maruotti, G, Agangi, A, Tibaldi, C, Marini, S, Masuelli, G, Benedetto, Chiara, Niemieç, T, Marczynska, M, Dobosz, S, Popielska, J, Oldakowska, A, Masters, J, Haile Selassie, H, French, C, Shakes, I., National Study of HIV in Pregnancy Childhood

المساهمون: National Study of HIV in Pregnancy, Childhood, Martinelli, Pasquale, Amsterdam institute for Infection and Immunity, Paediatric Infectious Diseases / Rheumatology / Immunology, General Internal Medicine, Infectious diseases, Other Research, Obstetrics and Gynaecology, Tariq, S, Townsend, Cl, Cortina Borja, M, Duong, T, Elford, J, Thorne, C, Tookey, Pa, European Collaborative, Study, Giaquinto C, National Study of HIV in Pregnancy C. h. i. l. d. h. o. o. d., Rampon, O, Mazza, A, De Rossi, A, Grosch Wörner, I, Mok, J, de José, Mi, Larrú Martínez, B, Scherpbier, Hj, Kreyenbroek, M, Godfried, Mh, Nellen, Fj, Boer, K, Navér, L, Anzén, B, Lidman, K, Levy, J, Barlow, P, Manigart, Y, Hainaut, M, Goetghebuer, T, Brichard, B, De Camps, J, Thiry, N, Deboone, G, Waterloos, H, De Maria, A, Mûr, A, Payà, A, López Vilchez, Ma, Carreras, R, Valerius, Nh, Rosenfeldt, V, Coll, O, Suy, A, Perez, Jm, Fortuny, C, Boguña, J, Savasi, V, Viganò, A, Giacomet, V, Cerini, C, Raimondi, C, Zuccotti, G, Alberico, S, Rabusin, M, Bernardon, M, Buffolano, Wilma, Tiseo, R, Martinelli, P, Sansone, M, Maruotti, G, Agangi, A, Tibaldi, C, Marini, S, Masuelli, G, Benedetto, C, Niemieç, T, Marczynska, M, Dobosz, S, Popielska, J, Oldakowska, A, Masters, J, Haile Selassie, H, French, C, Shakes, I.

المصدر: Journal of acquired immune deficiency syndromes (1999), 57(4), 326-333. Lippincott Williams and Wilkins

مصطلحات موضوعية: Adult, Pediatrics, medicine.medical_specialty, Time Factors, HAART, Anti-HIV Agents, HIV Infections, antiretroviral agents, highly active antiretroviral therapy, HIV, pregnancy outcome, viral load, congenital abnormalities, Article, Zidovudine, ANTIRETROVIRAL AGENTS, immune system diseases, Hiv infected, Antiretroviral Therapy, Highly Active, Medicine, Humans, Pharmacology (medical), Pregnancy Complications, Infectious, antiretroviral agents, highly active antiretroviral therapy, HIV, pregnancy outcome, viral load, Pregnancy outcomes, Retrospective Studies, Pregnancy, integumentary system, business.industry, Infant, virus diseases, Retrospective cohort study, medicine.disease, Infectious Disease Transmission, Vertical, CD4 Lymphocyte Count, zidovudine, Europe, Infectious Diseases, In utero, Immunology, Female, pregnancy, business, Viral load, medicine.drug

الوصف: Increasing numbers of women in resource-rich settings are prescribed zidovudine (ZDV)-sparing highly active antiretroviral therapy (HAART) in pregnancy. We compare ZDV-sparing with ZDV-containing HAART in relation to maternal viral load at delivery, mother-to-child transmission (MTCT) of HIV, and congenital abnormality. This is an analysis of data from the National Study of HIV in Pregnancy and Childhood and the European Collaborative Study. Data on 7573 singleton births to diagnosed HIV-infected women between January 2000 and June 2009 were analyzed. Logistic regression models were fitted to estimate adjusted odds ratios (AORs). Overall, 15.8% (1199 of 7573) of women received ZDV-sparing HAART, with increasing use between 2000 and 2009 (P

وصف الملف: ELETTRONICO; STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94adb67d9c2efe6c343a2e43600d056Test
https://doi.org/10.1097/qai.0b013e31821d34d0Test

المؤلفون: Bruyand, Mathias, Ryom, Lene, Shepherd, Leah, Fatkenheuer, Gerd, Grulich, Andrew, Reiss, Peter, De Wit, Stéphane, Darminio Monforte, Antonella, Furrer, Hansjakob, Pradier, Christian, Lundgren, Jens, Sabin, Caroline, Powderly B, Shortman N, Moecklinghoff C, Reilly G, Franquet X, Ryom L, Sabin CA, Kamara D, Smith C, Phillips A, Mocroft A, Tverland J, Mansfeld M, Nielsen J, Raben D, Lundgren JD, Salbøl Brandt R, Rickenbach M, Fanti I, Krum E, Hillebregt M, Geffard S, Sundström A, Delforge M, Fontas E, Torres F, McManus H, Wright S, Kjær J, Sjøl A, Meidahl P, Helweg Larsen J, Schmidt Iversen J, Kirk O, Reiss P, Ross M, Fux CA, Morlat P, Moranne O, Kesselring AM, Kamara DA, Weber R, Pradier C, Friis Møller N, Kowalska J, Sabin C, Law M, d'Arminio Monforte A, Dabis F, Bruyand M, Bower M, Fätkenheuer G, Donald A, Grulich A, Zaheri S, Gras L, Prins JM, Kuijpers TW, Scherpbier HJ, van der Meer JT, Wit FW, Godfried MH, van der Poll T, Nellen FJ, Lange JM, Geerlings SE, van Vugt M, Pajkrt D, Bos JC, van der Valk M, Grijsen ML, Wiersinga WJ, Goorhuis A, Hovius JW, Lowe S, Oude Lashof A, Posthouwer D, Pronk MJ, Ammerlaan HS, van der Ende ME, de Vries Sluijs TE, Schurink CA, Nouwen JL, Verbon A, Rijnders BJ, van Gorp EC, van der Feltz M, Driessen GJ, van Rossum AM, Branger J, Schippers EF, van Nieuwkoop C, van Elzakker EP, Groeneveld PH, Bouwhuis JW, Soetekouw R, ten Kate RW, Kroon FP, van Dissel JT, Arend SM, de Boer MG, Jolink H, ter Vollaard HJ, Bauer MP, den Hollander JG, Pogany K, van Twillert G, Kortmann W, Cohen Stuart JW, Diederen BM, Leyten EM, Gelinck LB, Kootstra GJ, Delsing CE, Brinkman K, Blok WL, Frissen PH, Schouten WE, van den Berk GE, van Kasteren ME, Brouwer AE, Veenstra J, Lettinga KD, Mulder JW, Vrouenraets SM, Lauw FN, van Eeden A, Verhagen DW, Sprenger HG, Doedens R, Scholvinck EH, van Assen S, Bierman WF, Koopmans PP, Keuter M, van der Ven AJ, ter Hofstede HJ, Dofferhoff AS, Warris A, van Crevel R, Hoepelman AI, Mudrikova T, Schneider MM, Ellerbroek PM, Oosterheert JJ, Arends JE, Wassenberg MW, Barth RE, van Agtmael MA, Perenboom RM, Claessen FA, Bomers M, Peters EJ, Geelen SP, Wolfs TF, Bont LJ, Richter C, van der Berg JP, Gisolf EH, van den Berge M, Stegeman A, van Vonderen MG, van Houte DP, Weijer S, el Moussaoui R, Winkel C, Muskiet F, Durand, Voigt R, Bonnet F, Breilh D, Dupon M, Chêne G, Fleury H, Malvy D, Mercié P, Pellegrin I, Neau D, Pellegrin JL, Thiébaut R, Bouchet S, Gaborieau V, Lacoste D, Tchamgoué S, Lawson Ayayi S, Wittkop L, Bernard N, Hessamfar M, Vandenhende MA, Dauchy FA, Dutronc H, Longy Boursier M, Duffau P, Schmeltz JR, Pistone T, Receveur MC, Cazanave C, Ochoa A, Vareil MO, Viallard JF, Greib C, Lazaro E, Lafon ME, Reigadas S, Trimoulet P, Molimard M, Titier K, Moreau JF, Haramburu F, Miremont Salamé G, Dupont A, Gerard Y, Caunègre L, André K, Bonnal F, Farbos S, Gemain MC, Ceccaldi J, De Witte S, Courtault C, Monlun E, Lataste P, Meraud JP, Chossat I, Blaizeau MJ, Conte V, Decoin M, Delaune J, Delveaux S, Diarra F, D'Ivernois C, Frosch A, Hanappier C, Lenaud E, Leleux U, Le Marec F, Leray J, Louis I, Palmer G, Pougetoux A, Sicard X, Touchard D, Uwamaliya Nziyumvira B, Petoumenos K, Bendall C, Moore R, Edwards S, Hoy J, Watson K, Roth N, Nicholson J, Bloch M, Franic T, Baker D, Vale R, Carr A, Cooper D, Chuah J, Ngieng A, Nolan D, Skett J, Calvo G, Mateu S, Domingo P, Sambeat MA, Gatell J, Del Cacho E, Cadafalch J, Fuster M, Codina C, Sirera G, Vaqué A, De Wit S, Clumeck N, Necsoi C, Gennotte AF, Gerard M, Kabeya K, Konopnicki D, Libois A, Martin C, Payen MC, Semaille P, Van Laethem Y, Neaton J, Bartsch G, El Sadr WM, Thompson G, Wentworth D, Luskin Hawk R, Telzak E, Abrams DI, Cohn D, Markowitz N, Arduino R, Mushatt D, Friedland G, Perez G, Tedaldi E, Fisher E, Gordin F, Crane LR, Sampson J, Baxter J, Cozzi Lepri A, Grint D, Podlekareva D, Peters L, Reekie J, Fischer AH, Losso M, Elias C, Vetter N, Zangerle R, Karpov I, Vassilenko A, Mitsura VM, Suetnov O, Colebunders R, Vandekerckhove L, Hadziosmanovic V, Kostov K, Begovac J, Machala L, Sedlacek D, Kronborg G, Benfield T, Larsen M, Gerstoft J, Katzenstein T, Hansen AB, Skinhøj P, Pedersen C, Ostergaard L, Zilmer K, Smidt J, Ristola M, Katlama C, Viard JP, Girard PM, Livrozet JM, Vanhems P, Rockstroh J, Schmidt R, van Lunzen J, Degen O, Stellbrink HJ, Staszewski S, Bickel M, Kosmidis J, Gargalianos P, Xylomenos G, Perdios J, Panos G, Filandras A, Karabatsaki E, Sambatakou H, Banhegyi D, Mulcahy F, Yust I, Turner D, Burke M, Pollack S, Hassoun G, Maayan S, Vella S, Esposito R, Mazeu I, Mussini C, Arici C, Pristera R, Mazzotta F, Gabbuti A, Vullo V, Lichtner M, Chirianni A, Montesarchio E, Gargiulo M, Antonucci G, Testa A, Narciso P, Vlassi C, Zaccarelli M, Lazzarin A, Castagna A, Gianotti N, Galli M, Ridolfo A, Rozentale B, Zeltina I, Chaplinskas S, Hemmer R, Staub T, Ormaasen V, Maeland A, Bruun J, Knysz B, Gasiorowski J, Horban A, Bakowska E, Grzeszczuk A, Flisiak R, Boron Kaczmarska A, Pynka M, Parczewski M, Beniowski M, Mularska E, Trocha H, Jablonowska E, Malolepsza E, Wojcik K, Antunes F, Doroana M, Caldeira L, Mansinho K, Maltez F, Duiculescu D, Rakhmanova A, Zakharova N, Buzunova S, Jevtovic D, Mokráš M, Tomazic J, González Lahoz J, Soriano V, Labarga P, Medrano J, Moreno S, Rodriguez JM, Clotet B, Jou A, Paredes R, Tural C, Puig J, Bravo I, Gatell JM, Miró JM, Gutierrez M, Mateo G, Karlsson A, Flamholc L, Ledergerber B, Francioli P, Cavassini M, Hirschel B, Boffi E, Furrer H, Battegay M, Elzi L, Kravchenko E, Chentsova N, Frolov V, Kutsyna G, Servitskiy S, Krasnov M, Barton S, Johnson AM, Mercey D, Johnson MA, Murphy M, Weber J, Scullard G, Fisher M, Leen C, Morfeldt L, Thulin G, Åkerlund B, Koppel K, Håkangård C, Moroni M, Angarano G, Antinori A, Armignacco O, Castelli F, Cauda R, Di Perri G, Iardino R, Ippolito G, Perno CF, von Schloesser F, Ceccherini Silberstein F, Girardi E, Lo Caputo S, Andreoni M, Ammassari A, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi R, Cingolani A, Cinque P, De Luca A, Di Biagio A, Gori A, Guaraldi G, Lapadula G, Madeddu G, Maggiolo F, Marchetti G, Marcotullio S, Monno L, Puoti M, Quiros Roldan E, Cicconi P, Formenti T, Galli L, Lorenzini P, Giacometti A, Costantini A, Santoro C, Suardi C, Viale P, Vanino E, Verucchi G, Minardi C, Quirino T, Abeli C, Manconi PE, Piano P, Sighinolfi L, Segala D, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Caramma I, Castelli AP, Rizzardini G, Ridolfo AL, Piolini R, Salpietro S, Carenzi L, Moioli MC, Puzzolante C, Abrescia N, Guida MG, Onofrio M, Baldelli F, Francisci D, Parruti G, Ursini T, Magnani G, Ursitti MA, d'Avino A, Gallo L, Nicastri E, Acinapura R, Capozzi M, Libertone R, Tebano G, Cattelan A, Mura MS, Caramello P, Orofino GC, Sciandra M, Pellizzer G, Manfrin V, Caissotti C, Dellamonica P, Bernard E, Cua E, De Salvador Guillouet F, Durant J, Ferrando S, Mondain Miton V, Naqvi A, Perbost I, Prouvost Keller B, Pillet S, Pugliese P, Rahelinirina V, Roger PM, Dollet K, Aubert V, Barth J, Bernasconi E, Böni J, Bucher HC, Burton Jeangros C, Calmy A, Egger M, Fehr J, Fellay J, Gorgievski M, Günthard H, Haerry D, Hasse B, Hirsch HH, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kovari H, Martinetti G, Martinez de Tejada B, Metzner K, Müller N, Nadal D, Pantaleo G, Rauch A, Regenass A, Rudin C, Schmid P, Schultze D, Schöni Affolter F, Schüpbach J, Speck R, Taffé P, Tarr P, Telenti A, Trkola A, Vernazza P, Yerly S., VECCHIET, Jacopo, FALASCA, KATIA

المساهمون: Bruyand, Mathia, Ryom, Lene, Shepherd, Leah, Fatkenheuer, Gerd, Grulich, Andrew, Reiss, Peter, De Wit, Stéphane, Darminio Monforte, Antonella, Furrer, Hansjakob, Pradier, Christian, Lundgren, Jen, Sabin, Caroline, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Ryom, L, Sabin, Ca, Kamara, D, Smith, C, Phillips, A, Mocroft, A, Tverland, J, Mansfeld, M, Nielsen, J, Raben, D, Lundgren, Jd, Salbøl Brandt, R, Rickenbach, M, Fanti, I, Krum, E, Hillebregt, M, Geffard, S, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kjær, J, Sjøl, A, Meidahl, P, Helweg Larsen, J, Schmidt Iversen, J, Kirk, O, Reiss, P, Ross, M, Fux, Ca, Morlat, P, Moranne, O, Kesselring, Am, Kamara, Da, Weber, R, Pradier, C, Friis Møller, N, Kowalska, J, Sabin, C, Law, M, d'Arminio Monforte, A, Dabis, F, Bruyand, M, Bower, M, Fätkenheuer, G, Donald, A, Grulich, A, Zaheri, S, Gras, L, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, van der Meer, Jt, Wit, Fw, Godfried, Mh, van der Poll, T, Nellen, Fj, Lange, Jm, Geerlings, Se, van Vugt, M, Pajkrt, D, Bos, Jc, van der Valk, M

مصطلحات موضوعية: antiretroviral therapy, cancer, HIV, risk, Adult, Highly Active, Female, Follow-Up Studie, HIV Infection, Human, Incidence, Male, Middle Aged, Neoplasm, Prospective Studie, Protease Inhibitor, Reverse Transcriptase Inhibitor, Risk Assessment, Infectious Disease, Pharmacology (medical), Medicine (all)

الوصف: BACKGROUND: The association between combination antiretroviral therapy (cART) and cancer risk, especially regimens containing protease inhibitors (PIs) or nonnucleoside reverse transcriptase inhibitors (NNRTIs), is unclear. METHODS: Participants were followed from the latest of D:A:D study entry or January 1, 2004, until the earliest of a first cancer diagnosis, February 1, 2012, death, or 6 months after the last visit. Multivariable Poisson regression models assessed associations between cumulative (per year) use of either any cART or PI/NNRTI, and the incidence of any cancer, non-AIDS-defining cancers (NADC), AIDS-defining cancers (ADC), and the most frequently occurring ADC (Kaposi sarcoma, non-Hodgkin lymphoma) and NADC (lung, invasive anal, head/neck cancers, and Hodgkin lymphoma). RESULTS: A total of 41,762 persons contributed 241,556 person-years (PY). A total of 1832 cancers were diagnosed [incidence rate: 0.76/100 PY (95% confidence interval: 0.72 to 0.79)], 718 ADC [0.30/100 PY (0.28-0.32)], and 1114 NADC [0.46/100 PY (0.43-0.49)]. Longer exposure to cART was associated with a lower ADC risk [adjusted rate ratio: 0.88/year (0.85-0.92)] but a higher NADC risk [1.02/year (1.00-1.03)]. Both PI and NNRTI use were associated with a lower ADC risk [PI: 0.96/year (0.92-1.00); NNRTI: 0.86/year (0.81-0.91)]. PI use was associated with a higher NADC risk [1.03/year (1.01-1.05)]. Although this was largely driven by an association with anal cancer [1.08/year (1.04-1.13)], the association remained after excluding anal cancers from the end point [1.02/year (1.01-1.04)]. No association was seen between NNRTI use and NADC [1.00/year (0.98-1.02)]. CONCLUSIONS: Cumulative use of PIs may be associated with a higher risk of anal cancer and possibly other NADC. Further investigation of biological mechanisms is warranted.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25763785; info:eu-repo/semantics/altIdentifier/wos/WOS:000351589500017; volume:68; issue:5; firstpage:568; lastpage:577; numberofpages:10; journal:JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES; http://hdl.handle.net/11564/644473Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925089152; http://journals.lww.com/jaids/pages/default.aspxTest

الإتاحة: https://doi.org/10.1097/QAI.0000000000000523Test
http://hdl.handle.net/11564/644473Test
http://journals.lww.com/jaids/pages/default.aspxTest

المؤلفون: Kamara DA1, Ryom L, Ross M, Kirk O, Reiss P, Morlat P, Moranne O, Fux CA, Mocroft A, Sabin C, Lundgren JD, Smith CJ, D:A:D study Group, Powderly B, Shortman N, Moecklinghoff C, Reilly G, Franquet X, Sabin CA, Kamara D, Smith C, Phillips A, Tverland J, Mansfeld M, Nielsen J, Raben D, Brandt R, Rickenbach M, Fanti I, Krum E, Hillebregt M, Geffard S, Sundström A, Delforge M, Fontas E, Torres F, McManus H, Wright S, Kjær J, Sjøl A, Meidahl P, Helweg Larsen J, Iversen J, Kesselring AM, Kamara DA, Weber R, Pradier C, Friis Møller N, Kowalska J, Law M, d'Arminio Monforte A, Dabis F, Bruyand M, Bower M, Fätkenheuer G, Donald A, Grulich A, Zaheri S, Gras L, Prins JM, Kuijpers TW, Scherpbier HJ, van der Meer JT, Wit FW, Godfried MH, van der Poll d, Nellen FJ, Lange JM, Geerlings SE, van Vugt M, Pajkrt D, Bos D, van der Valk D, Grijsen ML, Wiersinga WJ, Goorhuis A, Hovius JW, Lowe S, Lashof A, Posthouwer D, Ammerlaan HS, Pronk MJ, van der Ende ME, de Vries Sluijs TE, Schurink CA, Nouwen JL, Verbon A, Rijnders BJ, van Gorp EC, van der Feltz M, Driessen GJ, van Rossum AM, Branger J, Schippers F, van Nieuwkoop C, van Elzakker EP, Groeneveld PH, Bouwhuis JW, Soetekouw R, ten Kate RW, Kroon FP, van Dissel JT, Arend SM, de Boer MG, Jolink H, ter Vollaard HJ, Bauer MP, den Hollander JG, Pogany K, van Twillert D, Kortmann W, Stuart JW, Diederen BM, Leyten MS, Gelinck LB, Kootstra GJ, Delsing CE, Brinkman K, Blok WL, Frissen PH, Schouten WE, van den Berk GE, van Kasteren ME, Brouwer AE, Veenstra J, Lettinga KD, Mulder JW, Vrouenraets SM, Lauw FN, van Eeden A, Verhagen DW, Sprenger HG, Doedens R, Scholvinck EH, van Assen S, Bierman WF, Koopmans PP, Keuter M, van der Ven AJ, ter Hofstede HJ, Dofferhoff AS, Warris A, van Crevel R, Hoepelman AI, Mudrikova T, Schneider MM, Ellerbroek PM, Oosterheert JJ, Arends JE, Wassenberg MW, Barth RE, van Agtmael M, Perenboom RM, Claessen FA, Bomers M, Peters EJ, Geelen SP, Wolfs TF, Bont LJ, Richter C, van der Berg JP, Gisolf EH, van den Berge M, Stegeman A, van Vonderen MG, van Houte DP, Weijer S, el Moussaoui R, Winkel C, Muskiet F, Durand, Voigt R, Chêne G, Lawson Ayayi S, Thiébaut R, Bonnal F, Bonnet F, Bernard N, Caunègre L, Cazanave C, Ceccaldi J, Chambon D, Chossat I, Dauchy FA, De Witte S, Dupon M, Duffau P, Dutronc H, Farbos S, Gaborieau V, Gemain MC, Gerard Y, Greib C, Hessamfar M, Lacoste D, Lataste P, Lafarie S, Lazaro E, Malvy D, Meraud JP, Mercié P, Monlun E, Neau D, Ochoa A, Pellegrin JL, Pistone T, Ragnaud JM, Receveur MC, Tchamgoué S, Vandenhende MA, Viallard JF, Moreau JF, Pellegrin I, Fleury H, Lafon ME, Masquelier B, Trimoulet P, Breilh D, Haramburu F, Miremont Salamé G, Blaizeau MJ, Decoin M, Delaune J, Delveaux S, D'Ivernois C, Hanapier C, Leleux O, Uwamaliya Nziyumvira B, Sicard X, Palmer G, Touchard D, Petoumenos K, Bendall C, Moore R, Edwards S, Hoy J, Watson K, Roth N, Nicholson J, Bloch M, Franic T, Baker D, Vale R, Carr A, Cooper D, Chuah J, Ngieng M, Nolan D, Skett J, Calvo G, Mateu S, Domingo P, Sambeat MA, Gatell J, Del Cacho E, Cadafalch J, Fuster M, Codina C, Sirera G, Vaqué A, De Wit S, Clumeck N, Necsoi C, Gennotte AF, Gerard M, Kabeya K, Konopnicki D, Libois A, Martin C, Payen MC, Semaille P, Van Laethem Y, Neaton J, Bartsch G, El Sadr WM, Thompson G, Wentworth D, Luskin Hawk R, Telzak E, Abrams DI, Cohn D, Markowitz N, Arduino R, Mushatt D, Friedland G, Perez G, Tedaldi E, Fisher E, Gordin F, Crane LR, Sampson J, Baxter J, Lundgren J, Cozzi Lepri A, Grint D, Podlekareva D, Peters L, Reekie J, Fischer AH, Losso M, Elias C, Vetter N, Zangerle R, Karpov I, Vassilenko A, Mitsura VM, Suetnov O, Colebunders R, Vandekerckhove L, Hadziosmanovic V, Kostov K, Machala L, Begovac J, Jilich D, Sedlacek D, Kronborg G, Gerstoft J, Benfield T, Larsen M, Katzenstein T, Hansen AB, Skinhøj P, Pedersen C, Ostergaard L, Zilmer K, Smidt J, Ristola M, Katlama C, Viard J, Girard P, Livrozet JM, Vanhems P, Rockstroh J, Schmidt R, van Lunzen J, Degen O, Stellbrink HJ, Staszewski S, Bickel M, Kosmidis J, Gargalianos P, Xylomenos G, Perdios J, Panos G, Filandras A, Karabatsaki E, Sambatakou H, Banhegyi D, Mulcahy F, Yust I, Turner D, Burke M, Pollack S, Hassoun G, Maayan S, Vella S, Esposito R, Mazeu I, Mussini C, Arici C, Pristera R, Mazzotta F, Gabbuti A, Vullo V, Lichtner M, Chirianni A, Montesarchio E, Gargiulo M, Antonucci G, Testa A, Narciso P, Vlassi C, Zaccarelli M, Lazzarin A, Castagna A, Gianotti N, Galli M, Ridolfo A, Rozentale B, Zeltina I, Chaplinskas S, Hemmer R, Staub T, Ormaasen V, Maeland A, Bruun J, Knysz B, Gasiorowski J, Horban A, Bakowska E, Grzeszczuk A, Flisiak R, Boron Kaczmarska A, Pynka M, Parczewski M, Beniowski M, Mularska E, Trocha H, Jablonowska E, Malolepsza E, Wojcik K, Antunes F, Doroana M, Caldeira L, Mansinho K, Maltez F, Duiculescu D, Rakhmanova A, Babes V, Zakharova N, Jevtovic D, Mokráš M, Staneková D, Tomazic J, González Lahoz J, Soriano V, Labarga P, Medrano J, Moreno S, Rodriguez JM, Clotet B, Jou A, Paredes R, Tural C, Puig J, Bravo I, Gatell JM, Miró JM, Gutierrez M, Karlsson A, Mateo G, Flamholc L, Ledergerber B, Francioli P, Cavassini M, Hirschel B, Boffi E, Kravchenko E, Furrer H, Battegay M, Elzi L, Chentsova N, Frolov V, Kutsyna G, Servitskiy S, Krasnov M, Barton S, Johnson AM, Mercey D, Johnson MA, Murphy M, Weber J, Scullard G, Fisher M, Leen C, Morfeldt L, Thulin G, Åkerlund B, Koppel K, Håkangård C, Moroni M, Angarano G, Antinori A, Armignacco O, Castelli F, Cauda R, Di Perri G, Iardino R, Ippolito G, Perno CF, von Schloesser F, Viale P, Ceccherini Silberstein F, Girardi E, Lo Caputo S, Puoti M, Andreoni M, Ammassari A, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi MR, Cingolani A, Cinque P, De Luca A, Di Biagio A, Gori A, Guaraldi G, Lapadula G, Madeddu G, Maggiolo F, Marchetti G, Marcotullio S, Monno L, Quiros E, Rusconi S, Cicconi P, Formenti T, Galli L, Lorenzini P, Giacometti A, Costantini A, Santoro C, Suardi C, Vanino E, Verucchi G, Quiros Roldan E, Minardi C, Quirino T, Abeli C, Manconi PE, Piano P, Sighinolfi L, Segala D, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Caramma I, Castelli AP, Rizzardini G, Ridolfo AL, Piolini R, Salpietro S, Carenzi L, Moioli MC, Puzzolante C, Onofrio M, Abrescia N, Guida MG, Baldelli F, Francisci D, Parruti G, Ursini T, Magnani G, Ursitti MA, d' Avino A, Gallo L, Nicastri E, Acinapura R, Capozzi M, Libertone R, Tebano G, Cattelan A, Mura MS, Caramello P, Orofino GC, Sciandra M, Pellizzer G, Manfrin V, Caissotti C, Dellamonica P, Bernard E, Cua E, De Salvador Guillouet F, Durant J, Ferrando S, Mondain Miton V, Naqvi A, Perbost I, Prouvost Keller B, Pillet S, Pugliese P, Rahelinirina V, Roger PM, Dollet K, Aubert V, Barth J, Bernasconi E, Böni J, Bucher HC, Burton Jeangros C, Calmy A, Egger M, Fehr J, Fellay J, Gorgievski M, Günthard H, Haerry D, Hasse B, Hirsch HH, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kovari H, Martinetti G, de Tejada BM, Metzner K, Müller N, Nadal D, Pantaleo G, Rauch A, Regenass A, Rudin C, Schmid P, Schultze D, Schöni Affolter F, Schüpbach J, Speck R, Taffé P, Tarr P, Telenti A, Trkola A, Vernazza P, Yerly S., VECCHIET, Jacopo, FALASCA, KATIA

المساهمون: Kamara, Da1, Ryom, L, Ross, M, Kirk, O, Reiss, P, Morlat, P, Moranne, O, Fux, Ca, Mocroft, A, Sabin, C, Lundgren, Jd, Smith, Cj, D:A:D study, Group, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Sabin, Ca, Kamara, D, Smith, C, Phillips, A, Tverland, J, Mansfeld, M, Nielsen, J, Raben, D, Brandt, R, Rickenbach, M, Fanti, I, Krum, E, Hillebregt, M, Geffard, S, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kjær, J, Sjøl, A, Meidahl, P, Helweg Larsen, J, Iversen, J, Kesselring, Am, Kamara, Da, Weber, R, Pradier, C, Friis Møller, N, Kowalska, J, Law, M, d'Arminio Monforte, A, Dabis, F, Bruyand, M, Bower, M, Fätkenheuer, G, Donald, A, Grulich, A, Zaheri, S, Gras, L, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, van der Meer, Jt, Wit, Fw, Godfried, Mh, van der Poll, D, Nellen, Fj, Lange, Jm, Geerlings, Se, van Vugt, M, Pajkrt, D, Bos, D

الوصف: BACKGROUND: No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glomerular filtration rate (eGFR) >90 ml/min/1.73 m2 (using Cockcroft Gault) in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study from 2004 to 2011. METHODS: Two definitions were evaluated; RP definition A: An average eGFR decline (slope) ≥5 ml/min/1.73 m2/year over four years of follow-up with ≥3 eGFR measurements/year, last eGFR <90 ml/min/1.73 m2 and an absolute decline ≥5 ml/min/1.73 m2/year in two consecutive years. RP definition B: An absolute annual decline ≥5 ml/min/1.73 m2/year in each year and last eGFR <90 ml/min/1.73 m2. Sensitivity analyses were performed considering two and three years' follow-up. The percentage with and without RP who went on to subsequently develop incident chronic kidney disease (CKD; 2 consecutive eGFRs <60 ml/min/1.73 m2 and 3 months apart) was calculated. RESULTS: 22,603 individuals had baseline eGFR ≥90 ml/min/1.73 m2. 108/3655 (3.0%) individuals with ≥4 years' follow-up and ≥3 measurements/year experienced RP under definition A; similar proportions were observed when considering follow-up periods of three (n=195/6375; 3.1%) and two years (n=355/10756; 3.3%). In contrast under RP definition B, greater proportions experienced RP when considering two years (n=476/10756; 4.4%) instead of three (n=48/6375; 0.8%) or four (n=15/3655; 0.4%) years' follow-up. For RP definition A, 13 (12%) individuals who experienced RP progressed to CKD, and only (21) 0.6% of those without RP progressed to CKD (sensitivity 38.2% and specificity 97.4%); whereas for RP definition B, fewer RP individuals progressed to CKD. CONCLUSIONS: Our results suggest using three years' follow-up and at least two eGFR measurements per year is most appropriate for a RP definition, as it allows inclusion of a reasonable number of individuals and is associated with the known ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000335066800001; volume:25; issue:15; firstpage:51; lastpage:63; numberofpages:13; journal:BMC NEPHROLOGY; http://hdl.handle.net/11564/520702Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84898407890

الإتاحة: http://hdl.handle.net/11564/520702Test

المؤلفون: Kamara, David A., Ryom, Lene, Ross, Michael, Kirk, Ole, Reiss, Peter, Morlat, Philippe, Moranne, Olivier, Fux, Christoph A., Mocroft, Amanda, Sabin, Caroline, Lundgren, Jens D., Smith, Colette J, D:A:D study Group., Quiros Roldan, M. E. Powderly B, Shortman N, Moecklinghoff C, Reilly G, Franquet X, Ryom L, Sabin CA, Kamara D, Smith C, Phillips A, Mocroft A, Tverland J, Mansfeld M, Nielsen J, Raben D, Lundgren JD, Brandt R, Rickenbach M, Fanti I, Krum E, Hillebregt M, Geffard S, Sundström A, Delforge M, Fontas E, Torres F, McManus H, Wright S, Kjær J, Sjøl A, Meidahl P, Helweg-Larsen J, Iversen J, Kirk O, Reiss P, Ross M, Fux CA, Morlat P, Moranne O, Kesselring AM, Kamara DA, Weber R, Pradier C, Friis-Møller N, Kowalska J, Sabin C, Law M, d'Arminio Monforte A, Dabis F, Bruyand M, Bower M, Fätkenheuer G, Donald A, Grulich A, Zaheri S, Gras L, Prins JM, Kuijpers TW, Scherpbier HJ, van der Meer JT, Wit FW, Godfried MH, van der Poll d, Nellen FJ, Lange JM, Geerlings SE, van Vugt M, Pajkrt D, Bos D, van der Valk D, Grijsen ML, Wiersinga WJ, Goorhuis A, Hovius JW, Lowe S, Lashof A, Posthouwer D, Ammerlaan HS, Pronk MJ, van der Ende ME, de Vries-Sluijs TE, Schurink CA, Nouwen JL, Verbon A, Rijnders BJ, van Gorp EC, van der Feltz M, Driessen GJ, van Rossum AM, Branger J, Schippers F, van Nieuwkoop C, van Elzakker EP, Groeneveld PH, Bouwhuis JW, Soetekouw R, ten Kate RW, Kroon FP, van Dissel JT, Arend SM, de Boer MG, Jolink H, ter Vollaard HJ, Bauer MP, den Hollander JG, Pogany K, van Twillert D, Kortmann W, Stuart JW, Diederen BM, Leyten MS, Gelinck LB, Kootstra GJ, Delsing CE, Brinkman K, Blok WL, Frissen PH, Schouten WE, van den Berk GE, van Kasteren ME, Brouwer AE, Veenstra J, Lettinga KD, Mulder JW, Vrouenraets SM, Lauw FN, van Eeden A, Verhagen DW, Sprenger HG, Doedens R, Scholvinck EH, van Assen S, Bierman WF, Koopmans PP, Keuter M, van der Ven AJ, ter Hofstede HJ, Dofferhoff AS, Warris A, van Crevel R, Hoepelman AI, Mudrikova T, Schneider MM, Ellerbroek PM, Oosterheert JJ, Arends JE, Wassenberg MW, Barth RE, van Agtmael M, Perenboom RM, Claessen FA, Bomers M, Peters EJ, Geelen SP, Wolfs TF, Bont LJ, Richter C, van der Berg JP, Gisolf EH, van den Berge M, Stegeman A, van Vonderen MG, van Houte DP, Weijer S, el Moussaoui R, Winkel C, Muskiet F, Durand, Voigt R, Chêne G, Lawson-Ayayi S, Thiébaut R, Bonnal F, Bonnet F, Bernard N, Caunègre L, Cazanave C, Ceccaldi J, Chambon D, Chossat I, Dauchy FA, De Witte S, Dupon M, Duffau P, Dutronc H, Farbos S, Gaborieau V, Gemain MC, Gerard Y, Greib C, Hessamfar M, Lacoste D, Lataste P, Lafarie S, Lazaro E, Malvy D, Meraud JP, Mercié P, Monlun E, Neau D, Ochoa A, Pellegrin JL, Pistone T, Ragnaud JM, Receveur MC, Tchamgoué S, Vandenhende MA, Viallard JF, Moreau JF, Pellegrin I, Fleury H, Lafon ME, Masquelier B, Trimoulet P, Breilh D, Haramburu F, Miremont-Salamé G, Blaizeau MJ, Decoin M, Delaune J, Delveaux S, D'Ivernois C, Hanapier C, Leleux O, Uwamaliya-Nziyumvira B, Sicard X, Palmer G, Touchard D, Petoumenos K, Bendall C, Moore R, Edwards S, Hoy J, Watson K, Roth N, Nicholson J, Bloch M, Franic T, Baker D, Vale R, Carr A, Cooper D, Chuah J, Ngieng M, Nolan D, Skett J, Calvo G, Mateu S, Domingo P, Sambeat MA, Gatell J, Del Cacho E, Cadafalch J, Fuster M, Codina C, Sirera G, Vaqué A, De Wit S, Clumeck N, Necsoi C, Gennotte AF, Gerard M, Kabeya K, Konopnicki D, Libois A, Martin C, Payen MC, Semaille P, Van Laethem Y, Neaton J, Bartsch G, El-Sadr WM, Thompson G, Wentworth D, Luskin-Hawk R, Telzak E, Abrams DI, Cohn D, Markowitz N, Arduino R, Mushatt D, Friedland G, Perez G, Tedaldi E, Fisher E, Gordin F, Crane LR, Sampson J, Baxter J, Lundgren J, Cozzi-Lepri A, Grint D, Podlekareva D, Peters L, Reekie J, Fischer AH, Losso M, Elias C, Vetter N, Zangerle R, Karpov I, Vassilenko A, Mitsura VM, Suetnov O, Colebunders R, Vandekerckhove L, Hadziosmanovic V, Kostov K, Machala L, Begovac J, Jilich D, Sedlacek D, Kronborg G, Gerstoft J, Benfield T, Larsen M, Katzenstein T, Hansen AB, Skinhøj P, Pedersen C, Ostergaard L, Zilmer K, Smidt J, Ristola M, Katlama C, Viard J, Girard P, Livrozet JM, Vanhems P, Rockstroh J, Schmidt R, van Lunzen J, Degen O, Stellbrink HJ, Staszewski S, Bickel M, Kosmidis J, Gargalianos P, Xylomenos G, Perdios J, Panos G, Filandras A, Karabatsaki E, Sambatakou H, Banhegyi D, Mulcahy F, Yust I, Turner D, Burke M, Pollack S, Hassoun G, Maayan S, Vella S, Esposito R, Mazeu I, Mussini C, Arici C, Pristera R, Mazzotta F, Gabbuti A, Vullo V, Lichtner M, Chirianni A, Montesarchio E, Gargiulo M, Antonucci G, Testa A, Narciso P, Vlassi C, Zaccarelli M, Lazzarin A, Castagna A, Gianotti N, Galli M, Ridolfo A, Rozentale B, Zeltina I, Chaplinskas S, Hemmer R, Staub T, Ormaasen V, Maeland A, Bruun J, Knysz B, Gasiorowski J, Horban A, Bakowska E, Grzeszczuk A, Flisiak R, Boron-Kaczmarska A, Pynka M, Parczewski M, Beniowski M, Mularska E, Trocha H, Jablonowska E, Malolepsza E, Wojcik K, Antunes F, Doroana M, Caldeira L, Mansinho K, Maltez F, Duiculescu D, Rakhmanova A, Babes V, Zakharova N, Jevtovic D, Mokráš M, Staneková D, Tomazic J, González-Lahoz J, Soriano V, Labarga P, Medrano J, Moreno S, Rodriguez JM, Clotet B, Jou A, Paredes R, Tural C, Puig J, Bravo I, Gatell JM, Miró JM, Gutierrez M, Karlsson A, Mateo G, Flamholc L, Ledergerber B, Francioli P, Cavassini M, Hirschel B, Boffi E, Kravchenko E, Furrer H, Battegay M, Elzi L, Chentsova N, Frolov V, Kutsyna G, Servitskiy S, Krasnov M, Barton S, Johnson AM, Mercey D, Johnson MA, Murphy M, Weber J, Scullard G, Fisher M, Leen C, Morfeldt L, Thulin G, Åkerlund B, Koppel K, Håkangård C, Moroni M, Angarano G, Antinori A, Armignacco O, Castelli F, Cauda R, Di Perri G, Iardino R, Ippolito G, Perno CF, von Schloesser F, Viale P, Ceccherini-Silberstein F, Girardi E, Lo Caputo S, Puoti M, Andreoni M, Ammassari A, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi MR, Cingolani A, Cinque P, De Luca A, Di Biagio A, Gori A, Guaraldi G, Lapadula G, Madeddu G, Maggiolo F, Marchetti G, Marcotullio S, Monno L, Quiros E, Rusconi S, Cicconi P, Formenti T, Galli L, Lorenzini P, Giacometti A, Costantini A, Santoro C, Suardi C, Vanino E, Verucchi G, Quiros Roldan E, Minardi C, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Sighinolfi L, Segala D, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Caramma I, Castelli AP, Rizzardini G, Ridolfo AL, Piolini R, Salpietro S, Carenzi L, Moioli MC, Puzzolante C, Onofrio M, Abrescia N, Guida MG, Baldelli F, Francisci D, Parruti G, Ursini T, Magnani G, Ursitti MA, d' Avino A, Gallo L, Nicastri E, Acinapura R, Capozzi M, Libertone R, Tebano G, Cattelan A, Mura MS, Caramello P, Orofino GC, Sciandra M, Pellizzer G, Manfrin V, Caissotti C, Dellamonica P, Bernard E, Cua E, De Salvador- Guillouet F, Durant J, Ferrando S, Mondain-Miton V, Naqvi A, Perbost I, Prouvost-Keller B, Pillet S, Pugliese P, Rahelinirina V, Roger PM, Dollet K, Aubert V, Barth J, Bernasconi E, Böni J, Bucher HC, Burton- Jeangros C, Calmy A, Egger M, Fehr J, Fellay J, Gorgievski M, Günthard H, Haerry D, Hasse B, Hirsch HH, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kovari H, Martinetti G, de Tejada BM, Metzner K, Müller N, Nadal D, Pantaleo G, Rauch A, Regenass A, Rudin C, Schmid P, Schultze D, Schöni-Affolter F, Schüpbach J, Speck R, Taffé P, Tarr P, Telenti A, Trkola A, Vernazza P, Yerly S.

المساهمون: Kamara, David A., Ryom, Lene, Ross, Michael, Kirk, Ole, Reiss, Peter, Morlat, Philippe, Moranne, Olivier, Fux, Christoph A., Mocroft, Amanda, Sabin, Caroline, Lundgren, Jens D., Smith, Colette J, D:A:D study, Group., Quiros, Roldan, M. E., Powderly B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Ryom, L, Sabin, Ca, Kamara, D, Smith, C, Phillips, A, Mocroft, A, Tverland, J, Mansfeld, M, Nielsen, J, Raben, D, Lundgren, Jd, Brandt, R, Rickenbach, M, Fanti, I, Krum, E, Hillebregt, M, Geffard, S, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kjær, J, Sjøl, A, Meidahl, P, Helweg-Larsen, J, Iversen, J, Kirk, O, Reiss, P, Ross, M, Fux, Ca, Morlat, P, Moranne, O, Kesselring, Am, Kamara, Da, Weber, R, Pradier, C, Friis-Møller, N, Kowalska, J, Sabin, C, Law, M, d'Arminio Monforte, A, Dabis, F, Bruyand, M, Bower, M, Fätkenheuer, G, Donald, A, Grulich, A, Zaheri, S, Gras, L, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, van der Meer, Jt, Wit, Fw, Godfried, Mh, van der Poll, D, Nellen, Fj, Lange, Jm, Geerlings, Se, van Vugt, M, Pajkrt, D

مصطلحات موضوعية: Chronic kidney disease, Estimated glomerular filtration rate, HIV, Kidney disease, Rapid progression

الوصف: Background: No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glomerular filtration rate (eGFR) >90 ml/min/1.73 m2 (using Cockcroft Gault) in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study from 2004 to 2011. Methods. Two definitions were evaluated; RP definition A: An average eGFR decline (slope) ≥5 ml/min/1.73 m 2/year over four years of follow-up with ≥3 eGFR measurements/year, last eGFR <90 ml/min/1.73 m2 and an absolute decline ≥5 ml/min/1.73 m2/year in two consecutive years. RP definition B: An absolute annual decline ≥5 ml/min/1.73 m2/year in each year and last eGFR <90 ml/min/1.73 m2. Sensitivity analyses were performed considering two and three years' follow-up. The percentage with and without RP who went on to subsequently develop incident chronic kidney disease (CKD; 2 consecutive eGFRs <60 ml/min/1.73 m2 and 3 months apart) was calculated. Results: 22,603 individuals had baseline eGFR ≥90 ml/min/1.73 m2. 108/3655 (3.0%) individuals with ≥4 years' follow-up and ≥3 measurements/year experienced RP under definition A; similar proportions were observed when considering follow-up periods of three (n=195/6375; 3.1%) and two years (n=355/10756; 3.3%). In contrast under RP definition B, greater proportions experienced RP when considering two years (n=476/10756; 4.4%) instead of three (n=48/6375; 0.8%) or four (n=15/3655; 0.4%) years' follow-up. For RP definition A, 13 (12%) individuals who experienced RP progressed to CKD, and only (21) 0.6% of those without RP progressed to CKD (sensitivity 38.2% and specificity 97.4%); whereas for RP definition B, fewer RP individuals progressed to CKD. Conclusions: Our results suggest using three years' follow-up and at least two eGFR measurements per year is most appropriate for a RP definition, as it allows inclusion of a reasonable number of individuals and is associated with the ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/24666792; info:eu-repo/semantics/altIdentifier/wos/WOS:000335066800001; volume:15; issue:1; firstpage:51; journal:BMC NEPHROLOGY; http://hdl.handle.net/11379/479047Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84898407890

الإتاحة: https://doi.org/10.1186/1471-2369-15-51Test
http://hdl.handle.net/11379/479047Test

المؤلفون: Steering, D, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Ryom, L, Hatleberg, Ci, Sabin, Ca, Kamara, D, Smith, C, Phillips, A, Mocroft, A, Bojesen, A, Grevsen, A, Matthews, C, Raben, D, Lundgren, Jd, Brandt, Rs, Rickenbach, M, Fanti, I, Hillebreght, M, Zaheri, S, Gras, L, Pernot, E, Mourabi, J, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kristensen, D, Sjøl, A, Meidahl, P, Helweg-Larsen, J, Schmidt Iversen, J, Kirk, O, Reiss, P, Smit, C, Ross, M, Fux, Ca, Morlat, P, Moranne, O, Kamara, Da, Weber, R, Pradier, C, Friis-Møller, N, Kowalska, J, Sabin, C, Law, M, d'Arminio Monforte, A, Dabis, F, Bruyand, M, Bonnet, F, Bower, M, Fätkenheuer, G, Donald, A, Grulich, A, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, van der Meer JT, Wit, Fw, Godfried, Mh, van der Poll, T, Nellen, Fj, Geerlings, Se, van Vugt, M, Pajkrt, D, Bos, Jc, Wiersinga, Wj, van der Valk, M, Goorhuis, A, Hovius, Jw, van Eden, J, Henderiks, A, van Hes AM, Mutschelknauss, M, Nobel, He, Pijnappel, Fj, Westerman, Am, Jurriaans, S, Back, Nk, Zaaijer, Hl, Berkhout, B, Cornelissen, Mt, Schinkel, Cj, Thomas, Xv, De Ruyter Ziekenhuis, A, van den Berge, M, Stegeman, A, Baas, S, de Looff, L, Versteeg, D, Pronk, Mj, Ammerlaan, Hs, Korsten-Vorstermans, Em, de Munnik ES, Jansz, Ar, Tjhie, J, Wegdam, Mc, Deiman, B, Scharnhorst, V, Kinderziekenhuis, E, van der Plas, A, Weijsenfeld, Am, van der Ende ME, de Vries-Sluijs TE, van Gorp EC, Schurink, Ca, Nouwen, Jl, Verbon, A, Rijnders, Bj, Bax, Hi, Hassing, Rj, van der Feltz, M, Bassant, N, van Beek JE, Vriesde, M, van Zonneveld LM, de Oude-Lubbers, A, van den Berg-Cameron HJ, Bruinsma-Broekman, Fb, de Groot, J, de Man de, Z, Broekhoven-Kruijne, Mj, Schutten, M, Osterhaus, Ad, Boucher, Ca, Driessen, Gj, van Rossum AM, van der Knaap LC, Visser, E, Branger, J, Duijf-van de Ven CJ, Haag, D, Schippers, Ef, van Nieuwkoop, C, Brimicombe, Rw, van IJperen, M, van der Hut, G, Franck, Pf, van Eeden, A, Brokking, W, Groot, M, Damen, M, Kwa, Is, Groeneveld, Ph, Bouwhuis, Jw, van den Berg JF, van Hulzen AG, van der Bliek GL, Bor, Pc, Bloembergen, P, Wolfhagen, Mj, Ruijs, Gj, Gasthuis, K, van Lelyveld SF, Soetekouw, R, Hulshoff, N, van der Prijt LM, Schoemaker, M, Bermon, N, van der Reijden WA, Jansen, R, Herpers, Bl, Veenendaal, D, Kroon, Fp, Arend, Sm, de Boer MG, Bauer, Mp, Jolink, H, Vollaard, Am, Dorama, W, Moons, C, Claas, Ec, Kroes, Ac, den Hollander JG, Pogany, K, Kastelijns, M, Smit, Jv, Smit, E, Bezemer, M, van Niekerk, T, Pontesilli, O, Lowe, Sh, Oude Lashof, A, Posthouwer, D, Ackens, Rp, Schippers, J, Vergoossen, R, Weijenberg Maes, B, Savelkoul, Ph, Loo, Ih, Zuiderzee, Mc, Weijer, S, El Moussaoui, R, Heitmuller, M, Kortmann, W, van Twillert, G, Cohen Stuart JW, Diederen, Bm, Pronk, D, van Truijen-Oud FA, van der Reijden, W, Leyten, Em, Gelinck, Lb, van Hartingsveld, A, Meerkerk, C, Wildenbeest, Gs, Mutsaers, Ja, Jansen, Cl, van Vonderen MG, van Houte DP, Dijkstra, K, Faber, S, Weel, J, Kootstra, Gj, Delsing, Ce, van der Burgvan de Plas, M, Heins, H, Lucas, E, Brinkman, K, Frissen, Ph, Blok, Wl, Schouten, We, Bosma, As, Brouwer, Cj, Geerders, Gf, Hoeksema, K, Kleene, Mj, van der Meché IB, Toonen, Aj, Wijnands, S, van Ogtrop ML, Koopmans, Pp, Keuter, M, van der Ven AJ, ter Hofstede HJ, Dofferhoff, As, van Crevel, R, Albers, M, Bosch, Me, Grintjes-Huisman, Kj, Zomer, Bj, Stelma, Ff, Burger, D, Richter, C, van der Berg JP, Gisolf, Eh, Beest, G, van Bentum PH, Langebeek, N, Tiemessen, R, Swanink, Cm, Veenstra, J, Lettinga, Kd, Spelbrink, M, Sulman, H, Witte, E, Peerbooms, Pg, Mulder, Jw, Vrouenraets, Sm, Lauw, Fn, van Broekhuizen MC, Paap, H, Vlasblom, Dj, Oudmaijer Sanders, E, Smits, Ph, Rosingh, Aw, Verhagen, Dw, Geilings, J, van Kasteren ME, Brouwer, Ae, de Kruijf-van de Wiel BA, Kuipers, M, Santegoets, Rm, van der Ven, B, Marcelis, Jh, Buiting, Ag, Kabel, Pj, Bierman, Wf, Sprenger, Hg, Scholvinck, Eh, van Assen, S, Wilting, Kr, Stienstra, Y, de Groot-de Jonge, H, van der Meulen PA, de Weerd DA, Niesters, Hg, Riezebos-Brilman, A, van Leer-Buter CC, Hoepelman, Ai, Schneider, Mm, Mudrikova, T, Ellerbroek, Pm, Oosterheert, Jj, Arends, Je, Barth, Re, Wassenberg, Mw, van Elst-Laurijssen DH, Laan, Lm, van Oers-Hazelzet EE, Patist, J, Vervoort, S, Nieuwenhuis, He, Frauenfelder, R, Schuurman, R, Verduyn-Lunel, F, Wensing, Am, Peters, Ej, van Agtmael MA, Perenboom, Rm, Bomers, M, de Vocht, J, Elsenburg, Lj, Pettersson, Am, Vandenbroucke-Grauls, Cm, Ang, Cw, Geelen, Sp, Wolfs, Tf, Bont, Lj, Nauta, N, Bezemer, Do, van Sighem AI, Hillebregt, M, Kimmel, V, Tong, Y, Lascaris, B, van den Boogaard, R, Hoekstra, P, de Lang, A, Berkhout, M, Grivell, S, Jansen, A, de Groot, L, van den Akker, M, Bergsma, D, Lodewijk, C, Meijering, R, Peeck, B, Raethke, M, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Tuijn, E, Veenenberg, L, Woudstra, T, Bakker, Y, de Jong, A, Broekhoven, M, Claessen, E, Rademaker, Mj, Munjishvili, L, Kruijne, E, Tuk, B, Bouchet, S, Breilh, D, Chêne, G, Dupon, M, Fleury, H, Gaborieau, V, Lacoste, D, Malvy, D, Mercié, P, Neau, D, Pellegrin, I, Pellegrin, Jl, Tchamgoué, S, Fagard, C, Lawson-Ayayi, S, Richert, L, Thiébaut, R, Wittkop, L, André, K, Bernard, N, Caunègre, L, Cazanave, C, Ceccaldi, J, Chossat, I, Courtault, C, Dauchy, Fa, De Witte, S, Dondia, D, Dupont, A, Duffau, P, Dutronc, H, Farbos, S, Faure, I, Gerard, Y, Greib, C, Hessamfar-Joseph, M, Imbert, Y, Lataste, P, Lazaro, E, Marie, J, Mechain, M, Meraud, Jp, Monlun, E, Ochoa, A, Pillot-Debelleix, M, Pistone, T, Raymond, I, Receveur, Mc, Rispal, P, Sorin, L, Valette, C, Vandenhende, Ma, Vareil, Mo, Viallard, Jf, Wille, H, Wirth, G, Moreau, Jf, Lafon, Me, Reigadas, S, Trimoulet, P, Haramburu, F, Miremont-Salamé, G, Blaizeau, Mj, Crespel, I, Decoin, M, Delveaux, S, Diarra, F, D'Ivernois, C, Hanappier, C, Leleux, O, Le Marec, F, Lenaud, E, Mourali, J, Pougetoux, A, Uwamaliya-Nziyumvira, B, Tsaranazy, A, Valdes, A, Conte, V, Louis, I, Palmer, G, Sapparrart, V, Touchard, D, Petoumenos, K, Bendall, C, Moore, R, Edwards, S, Hoy, J, Watson, K, Roth, N, Nicholson, J, Bloch, M, Franic, T, Baker, D, Vale, R, Carr, A, Cooper, D, Chuah, J, Ngieng, M, Nolan, D, Skett, J, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, De Wit, S, Clumeck, N, Necsoi, C, Gennotte, Af, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Martin, C, Payen, Mc, Semaille, P, Van, Y, Neaton, J, Bartsch, G, El-Sadr, Wm, Krum, E, Thompson, G, Wentworth, D, Luskin-Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Losso, M, Kundro, M, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, Vm, Paduto, D, Florence, E, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, J, Machala, L, Jilich, D, Sedlacek, D, Kronborg, G, Benfield, T, Gerstoft, J, Katzenstein, T, Hansen, Ab, Pedersen, C, Møller, Nf, Ostergaard, L, Dragsted, Ub, Nielsen, Ln, Zilmer, K, Smidt, J, Ristola, M, Aho, I, Katlama, C, Viard, Jp, Girard, Pm, Cotte, L, Duvivier, C, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Stefan, C, Bogner, J, Chkhartishvili, N, Kosmidis, J, Gargalianos, P, Xylomenos, G, Lourida, P, Sambatakou, H, Banhegyi, D, Gottfredsson, M, Mulcahy, F, Yust, I, Turner, D, Burke, M, Shahar, E, Hassoun, G, Elinav, H, Haouzi, M, Sthoeger, Zm, D'Arminio Monforte, A, Esposito, R, Mazeu, I, Mussini, C, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Zaccarelli, M, Antinori, A, Acinapura, R, D'Offizi, G, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, Rozentale, B, Uzdaviniene, V, Matulionyte, R, Staub, T, Hemmer, R, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Inglot, M, Horban, A, Bakowska, E, Grzeszczuk, A, Flisiak, R, Parczewski, M, Pynka, M, Maciejewska, K, Beniowski, M, Mularska, E, Smiatacz, T, Gensing, M, Jablonowska, E, Malolepsza, E, Wojcik, K, Mozer-Lisewska, I, Doroana, M, Caldeira, L, Mansinho, K, Maltez, F, Radoi, R, Oprea, C, Rakhmanova, A, Trofimora, T, Khromova, I, Kuzovatova, E, Jevtovic, D, Shunnar, A, Staneková, D, Tomazic, J, Moreno, S, Rodriguez, J, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, Jm, Miró, Jm, Gutierrez, M, Mateo, G, Laporte, Jm, Blaxhult, A, Flamholc, L, Falconer, K, Thalme, A, Sonnerborg, A, Ledergerber, B, Cavassini, M, Calmy, A, Furrer, H, Battegay, M, Elzi, L, Schmid, P, Kravchenko, E, Chentsova, N, Frolov, V, Kutsyna, G, Baskakov, I, Servitskiy, S, Kuznetsova, A, Kyselyova, G, Gazzard, B, Johnson, Am, Simons, E, Johnson, Ma, Orkin, C, Weber, J, Scullard, G, Fisher, M, Leen, C, Lundgren, J, Grarup, J, Cozzi-Lepri, A, Thiebaut, R, Peters, L, Fischer, Ah, Grønborg Laut, K, Larsen, Jf, Podlekareva, D, Grint, D, Shepherd, L, Schultze, A, Morfeldt, L, Thulin, G, Åkerlund, B, Koppel, K, Karlsson, A, Håkangård, C, Moroni, M, Angarano, G, Armignacco, O, Castelli, F, Cauda, R, Di Perri, G, Iardino, R, Ippolito, G, Perno, Cf, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Girardi, E, Lo Caputo, S, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, R, Cingolani, A, Cinque, P, De Luca, A, Di Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marchetti, G, Marcotullio, S, Monno, L, Quiros Roldan, E, Rusconi, S, Cicconi, P, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Santoro, C, Suardi, C, Vanino, E, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Castelli, A, Rizzardini, G, Ridolfo, Al, Piolini, R, Salpietro, S, Carenzi, L, Moioli, Mc, Puzzolante, C, Abrescia, N, Chirianni, A, Guida, Mg, Onofrio, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, Ma, D'Avino, A, Gallo, L, Nicastri, E, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Mura, Ms, Caramello, P, Orofino, Gc, Sciandra, M, Pellizzer, G, Manfrin, V, Castelli, Ap, Dollet, K, Caissotti, C, Dellamonica, P, Bernard, E, Cua, E, De Salvador-Guillouet, F, Durant, J, Ferrando, S, Dunais, B, Mondain-Miton, V, Naqvi, A, Perbost, I, Prouvost-Keller, B, Pillet, S, Pugliese, P, Risso, K, Roger, Pm, Aubert, V, Bernasconi, E, Böni, J, Bucher, Hc, Burton-Jeangros, C, Dollenmaier, G, Egger, M, Fehr, J, Fellay, J, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, Hh, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Martinetti, G, Martinez de Tejada, B, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schüpbach, J, Speck, R, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Yerly, S.

المساهمون: University College of London [London] (UCL), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Chemical Biology, Internal Medicine, Medical Microbiology & Infectious Diseases, Pediatrics, Virology, Mocroft, A:, Lundgren, Jd, Ross, M, Fux, Ca, Reiss, P, Moranne, O, Morlat., P, Monforte, Ad, Kirk, O, Ryom, L, for the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D), Study, Lazzarin, A, Castagna, A, Other departments, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Global Health, Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, General Internal Medicine, Center of Experimental and Molecular Medicine, Graduate School, Medical Microbiology and Infection Prevention, Gastroenterology and Hepatology, APH - Health Behaviors & Chronic Diseases, Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA MMI Staf (9), MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: DA MMI Infectieserologie (9), MUMC+: DA MMI AIOS (9), RS: FHML non-thematic output, Mocroft, A, Lundgren, J, Fux, C, Morlat, P, Monforte, A, Gori, A

المصدر: Lancet HIV
Lancet HIV, Elsevier, 2016, 3 (1), pp.e23-e32. ⟨10.1016/S2352-3018(15)00211-8⟩
LANCET HIV
The Lancet HIV, 3(1). Elsevier
Europe PubMed Central
The Lancet HIV, 3(1), e23-32. Elsevier Ltd.
Mocroft, A, Lundgren, J D, Ross, M, Fux, C A, Reiss, P, Moranne, O, Morlat, P, Monforte, A DA, Kirk, O, Ryom, L, Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) Study & Pedersen, C 2016, ' Cumulative and current exposure to potentially nephrotoxic antiretrovirals and development of chronic kidney disease in HIV-positive individuals with a normal baseline estimated glomerular filtration rate : a prospective international cohort study ', The Lancet HIV, vol. 3, no. 1, pp. e23-e32 . https://doi.org/10.1016/S2352-3018Test(15)00211-8
Lancet HIV, 3(1), e23-e32. Elsevier Limited
The lancet HIV, 3(1), E23-E32. Elsevier Limited
The Lancet HIV, 3, 1, pp. e23-32
The Lancet HIV, 3(1), E23-E32. ELSEVIER INC
The Lancet HIV, 3, e23-32

مصطلحات موضوعية: 0301 basic medicine, Male, PROTEASE INHIBITOR, Epidemiology, Infectious Diseases, Immunology, Virology, Research Support, U.S. Gov't, P.H.S, HIV Infections, SDG 3 – Goede gezondheid en welzijn, Rate ratio, THERAPY, chemistry.chemical_compound, 0302 clinical medicine, HIV, antiretroviral, kidney disease, immune system diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, HIV Infection, 030212 general & internal medicine, Prospective Studies, Renal Insufficiency, Chronic, Prospective cohort study, Research Support, Non-U.S. Gov't, Antiretrovirals, virus diseases, Lopinavir, ASSOCIATION, Middle Aged, 3. Good health, Europe, Antiretrovirals, HIV, chronic kidney disease, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, NAIVE PATIENTS, CREATININE, Human, Cohort study, medicine.drug, Glomerular Filtration Rate, United State, Adult, medicine.medical_specialty, TENOFOVIR DISOPROXIL FUMARATE, RENAL-FUNCTION, Adolescent, Anti-HIV Agents, Atazanavir Sulfate, Renal function, Infectious Disease, Australia, Humans, Renal Insufficiency, Chronic, Tenofovir, United States, Young Adult, NO, 03 medical and health sciences, EFAVIRENZ, SDG 3 - Good Health and Well-being, Internal medicine, Journal Article, medicine, Creatinine, business.industry, Anti-HIV Agent, medicine.disease, 030112 virology, Atazanavir, INFECTED INDIVIDUALS, Prospective Studie, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], chemistry, RISK-FACTORS, business, chronic kidney disease, Kidney disease

الوصف: BACKGROUND: Whether or not the association between some antiretrovirals used in HIV infection and chronic kidney disease is cumulative is a controversial topic, especially in patients with initially normal renal function. In this study, we aimed to investigate the association between duration of exposure to antiretrovirals and the development of chronic kidney disease in people with initially normal renal function, as measured by estimated glomerular filtration rate (eGFR).METHODS: In this prospective international cohort study, HIV-positive adult participants (aged ≥16 years) from the D:A:D study (based in Europe, the USA, and Australia) with first eGFR greater than 90 mL/min per 1·73 m(2) were followed from baseline (first eGFR measurement after Jan 1, 2004) until the occurrence of one of the following: chronic kidney disease; last eGFR measurement; Feb 1, 2014; or final visit plus 6 months (whichever occurred first). Chronic kidney disease was defined as confirmed (>3 months apart) eGFR lower than 60 mL/min per 1·73 m(2). The primary outcome was the occurrence of chronic kidney disease. Poisson regression was used to estimate the incidence rate of chronic kidney disease associated with cumulative exposure to tenofovir disoproxil fumarate, ritonavir-boosted atazanavir, ritonavir-boosted lopinavir, other ritonavir-boosted protease inhibitors, or abacavir.FINDINGS: Between Jan 1, 2004, and July 26, 2013, 23,905 eligible individuals from the D:A:D study were included. Participants had a median baseline eGFR of 110 mL/min per 1·73 m(2) (IQR 100-125), a median age of 39 years (33-45), and median CD4 cell count of 441 cells per mm(3) (294-628). During a median follow-up of 7·2 years (IQR 5·1-8·9), 285 (1%) of 23,905 people developed chronic kidney disease (incidence 1·76 per 1000 person-years of follow-up [95% CI 1·56-1·97]). After adjustment, we recorded a significant increase in chronic kidney disease associated with each additional year of exposure to tenofovir disoproxil fumarate (adjusted incidence rate ratio 1·14 [95% CI 1·10-1·19], pINTERPRETATION: In people with normal renal function, the annual incidence of chronic kidney disease increased for up to 6 years of exposure to tenofovir disoproxil fumarate, ritonavir-boosted atazanavir, or ritonavir-boosted lopinavir therapy. Although the absolute number of new cases of chronic kidney disease was modest, treatment with these antiretrovirals might result in an increasing and cumulative risk of chronic kidney disease. Patients on potentially nephrotoxic antiretrovirals or at high risk of chronic kidney disease should be closely monitored.FUNDING: The Highly Active Antiretroviral Therapy Oversight Committee.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00dd794aaed9592a093ceee85596b86cTest
https://hal.archives-ouvertes.fr/hal-01908643Test

المؤلفون: Aebi Popp K, Mulcahy F, Glass TR, Rudin C, Martinez de Tejada B, Bertisch B, Fehr J, Grawe C, Scheibner K, Rickenbach M, Hoesli I, Thorne C, European Collaborative Study in EuroCoord, Swiss Mother, Child HIV Cohort Study Collaborators: Thorne C, Bailey H, Giaquinto C, Rampon O, Mazza A, De Rossi A, Wörner I, Mok J, de José MI, Martínez B, Peña J, Garcia J, Lopez JR, Rodriguez MC, Asensi Botet F, Otero MC, Pérez Tamarit D, Scherpbier HJ, Kreyenbroek M, Godfried MH, Nellen FJ, Boer K, Navér L, Bohlin AB, Lindgren S, Kaldma A, Belfrage E, Levy J, Barlow P, Manigart Y, Hainaut M, Goetghebuer T, Brichard B, De Camps J, Thiry N, Deboone G, Waterloos H, Viscoli C, De Maria A, Bentivoglio G, Ferrero S, Gotta C, Mûr A, Payà A, López Vilchez MA, Carreras R, Valerius NH, Rosenfeldt V, Coll O, Suy A, Perez J, Fortuny C, Boguña J, Savasi V, Fiore S, Crivelli M, Viganò A, Giacomet V, Cerini C, Raimondi C, Zuccotti G, Alberico S, Maso G, Tropea M, Barresi V, Taylor G, Lyall EG, Penn Z, Buffolano W, Tiseo R, Martinelli P, Sansone M, Maruotti G, Agangi A, Tibaldi C, Marini S, Masuelli G, Niemieç T, Marczynska M, Dobosz S, Popielska J, Oldakowska A, Aubert V, Barth J, Battegay M, Bernasconi E, Böni J, Brazzola P, Bucher HC, Burton Jeangros C, Calmy A, Cavassini M, Cheseaux JJ, Drack G, Duppenthaler A, Egger M, Elzi L, Fellay J, Francini K, Furrer H, Fux CA, Gorgievski M, Günthard H, Haerry D, Hasse B, Hirsch HH, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kovari H, Ledergerber B, Martinetti G, de Tejada B, Metzner K, Müller N, Nadal D, Pantaleo G, Polli Ch, Posfay Barbe K, Rauch A, Regenass S, Schmid P, Schultze D, Schöni Affolter F, Schüpbach J, Speck R, Taffé P, Tarr P, Telenti A, Trkola A, Vernazza P, Weber R, Wyler CA, Yerly S., BENEDETTO, Chiara

المساهمون: Aebi-Popp K, Mulcahy F, Glass TR, Rudin C, Martinez de Tejada B, Bertisch B, Fehr J, Grawe C, Scheibner K, Rickenbach M, Hoesli I, Thorne C, European Collaborative Study in EuroCoord, Swiss Mother & Child HIV Cohort Study Collaborators: Thorne C, Bailey H, Giaquinto C, Rampon O, Mazza A, De Rossi A, Wörner I, Mok J, de José MI, Martínez B, Peña J, Garcia J, Lopez JR, Rodriguez MC, Asensi-Botet F, Otero MC, Pérez-Tamarit D, Scherpbier HJ, Kreyenbroek M, Godfried MH, Nellen FJ, Boer K, Navér L, Bohlin AB, Lindgren S, Kaldma A, Belfrage E, Levy J, Barlow P, Manigart Y, Hainaut M, Goetghebuer T, Brichard B, De Camps J, Thiry N, Deboone G, Waterloos H, Viscoli C, De Maria A, Bentivoglio G, Ferrero S, Gotta C, Mûr A, Payà A, López-Vilchez MA, Carreras R, Valerius NH, Rosenfeldt V, Coll O, Suy A, Perez J, Fortuny C, Boguña J, Savasi V, Fiore S, Crivelli M, Viganò A, Giacomet V, Cerini C, Raimondi C, Zuccotti G, Alberico S, Maso G, Tropea M, Barresi V, Taylor G, Lyall EG, Penn Z, Buffolano W, Tiseo R, Martinelli P, Sansone M, Maruotti G, Agangi A, Tibaldi C, Marini S, Masuelli G, Benedetto C, Niemieç T, Marczynska M, Dobosz S, Popielska J, Oldakowska A, Aubert V, Barth J, Battegay M, Bernasconi E

مصطلحات موضوعية: HIV, Pregnancy, mode of delivery, provvedimento amministrativo - nullità - domanda riconvenzionale

الوصف: Introduction: Most national guidelines for the prevention of mother-to-child transmission of HIV in Europe updated between 2001 and 2010 recommend vaginal deliveries for women with undetectable or very low viral load (VL). Our aim was to explore the impact of these new guidelines on the rates of vaginal deliveries among HIV-positive women in Europe. Methods: In a pooled analysis of data on HIV-positive pregnant women enrolled in the Swiss Mother & Child HIV Cohort Study and the European Collaborative Study 2000 to 2010, deliveries were classified as occurring pre- or postpublication of national guidelines recommending vaginal delivery. Results: Overall, 2663 women with 3013 deliveries were included from 10 countries; 28% women were diagnosed with HIV during pregnancy. Combination antiretroviral therapy was used in most pregnancies (2020, 73%), starting during the first or second trimester in 78% and during the third trimester in 22%; in 25% pregnancies, the woman conceived on combination antiretroviral therapy. Overall, in 86% pregnancies, a VL < 400 copies per milliliter was achieved before delivery. The proportion of vaginal deliveries increased from 17% (414/2377) before the change in guidelines to 52% (313/600) after; elective Caesarean section rates decreased from 65% to 27%. The proportion of women with undetectable VL having a Caesarean section was 55% after implementation of new guidelines. We observed a decrease of late preterm deliveries from 16% (377/2354) before to 7% (42/599) after the change in guidelines (P < 0.001). Conclusion: There are still missed opportunities for women with HIV to fully suppress their VL and to deliver vaginally in Europe.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23842074; info:eu-repo/semantics/altIdentifier/wos/WOS:000330451600012; volume:64; issue:1; firstpage:58; lastpage:65; numberofpages:8; journal:JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES; http://hdl.handle.net/2318/145044Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84883451777

الإتاحة: https://doi.org/10.1097/QAI.0b013e3182a334e3Test
http://hdl.handle.net/2318/145044Test

المؤلفون: Bailey, Heather, Townsend, Claire L., Cortina-Borja, Mario, Thorne, Claire Collaborators (80): Giaquinto C, Rampon O, Mazza A, De Rossi A, Grosch Wörner I, Mok J, de José MI, Larrú Martínez B, Peña JM, Gonzalez Garcia J, Arribas Lopez JR, Garcia Rodriguez MC, Asensi-Botet F, Otero MC, Pérez-Tamarit D, Scherpbier HJ, Kreyenbroek M, Godfried MH, Nellen FJ, Boer K, Navér L, Bohlin AB, Lindgren S, Kaldma A, Belfrage E, Levy J, Barlow P, Manigart Y, Hainaut M, Goetghebuer T, Brichard B, De Camps J, Thiry N, Deboone G, Waterloos H, Viscoli C, De Maria A, Bentivoglio G, Ferrero S, Gotta C, Mûr A, Payà A, López-Vilchez MA, Carreras R, Valerius H, Rosenfeldt V, Coll C, Suy A, Perez JM, Fortuny C, Boguña J, Savasi V, Fiore S, Crivelli M, Viganò A, Giacomet V, Cerini C, Raimondi C, Zuccotti G, Alberico S, DAL MASO, GIULIA, Airoud N, Taylor GP, Lyall EG, Penn Z, Buffolano W, Tiseo R, MARTINELLI, Pasquale, Sansone M, Maruotti G, AGANGI, ANNA, Tibaldi C, Marini S, Masuelli G, Benedetto C, Niemieç T, Marczynska M, Dobosz S, Popielska J, Oldakowska A.

المساهمون: Bailey, Heather*, Townsend, Claire L., Cortina-Borja, Mario, Thorne, Claire Collaborators (80): Giaquinto C, Rampon O, Mazza A, De Rossi A, Grosch Wörner I, Mok J, de José MI, Larrú Martínez B, Peña JM, Gonzalez Garcia J, Arribas Lopez JR, Garcia Rodriguez MC, Asensi-Botet F, Otero MC, Pérez-Tamarit D, Scherpbier HJ, Kreyenbroek M, Godfried MH, Nellen FJ, Boer K, Navér L, Bohlin AB, Lindgren S, Kaldma A, Belfrage E, Levy J, Barlow P, Manigart Y, Hainaut M, Goetghebuer T, Brichard B, De Camps J, Thiry N, Deboone G, Waterloos H, Viscoli C, De Maria A, Bentivoglio G, Ferrero S, Gotta C, Mûr A, Payà A, López-Vilchez MA, Carreras R, Valerius H, Rosenfeldt V, Coll C, Suy A, Perez JM, Fortuny C, Boguña J, Savasi V, Fiore S, Crivelli M, Viganò A, Giacomet V, Cerini C, Raimondi C, Zuccotti G, Alberico S, Maso G, Airoud N, Taylor GP, Lyall EG, Penn Z, Buffolano W, Tiseo R, Martinelli P, Sansone M, Maruotti G, Agangi A, Tibaldi C, Marini S, Masuelli G, Benedetto C, Niemieç T, Marczynska M, Dobosz S, Popielska J, Oldakowska A.

مصطلحات موضوعية: Adult, Anti-Retroviral Agent, Antiretroviral Therapy, Highly Active, Europe, Female, HIV Infection, Human, Medication Adherence, Pregnancy, Treatment Failure, Viral Load, Immunology and Allergy, Immunology, Infectious Diseases

الوصف: Among 396 HIV-infected women conceiving on combination antiretroviral therapy and enrolled in the European Collaborative Study in 2000-2011, the proportion with virological failure (>200 copies/ml after ≥24 weeks of treatment) declined substantially from 34% in 2000-2001 to 3% in 2010-2011. In adjusted analyses, younger women and those with at least two children were at increased risk of virological failure, highlighting the importance of close monitoring and adherence support.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23736151; info:eu-repo/semantics/altIdentifier/wos/WOS:000326702700020; volume:27; issue:14; firstpage:2312; lastpage:2315; numberofpages:4; journal:AIDS; http://hdl.handle.net/2318/1677198Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84884499957

الإتاحة: https://doi.org/10.1097/QAD.0b013e32836378e4Test
http://hdl.handle.net/2318/1677198Test

المؤلفون: Ryom L, Mocroft A, Kirk O, Worm SW, Kamara DA, Reiss P, Ross M, Fux CA, Morlat P, Moranne O, Smith C, Lundgren JD, D:A:D Study Group, Dabis F, El Sadr W, Pradier C, Weber R, Law M, Morfeldt L, de Wit S, Calvo G, d'Arminio Monforte A, Shortman N, Butcher D, Rode R, Franquet X, Powderly W, Sabin C, Phillips A, Lundgren J, Kamara D, Tverland J, Nielsen J, Salbøl Brandt R, Rickenbach M, Fanti I, Krum E, Hillebregt M, Geffard S, Sundström A, Delforge M, Fontas E, Torres F, McManus H, Wright S, Kjær J, Sjøl A, Meidahl P, Helweg Larsen J, Schmidt Iversen J, Worm S, Fux C, de Wolf F, Zaheri S, Gras L, Prins JM, Kuijpers TW, Scherpbier HJ, Boer K, van der Meer JT, Wit FW, Godfried MH, van der Poll T, Nellen FJ, Lange JM, Geerlings SE, van Vugt M, Vrouenraets SM, Pajkrt D, van der Valk M, Schreij G, Lowe S, Oude Lashof A, Pronk MJ, Bravenboer B, van der Ende ME, de Vries Sluijs TE, Schurink CA, van der Feltz M, Nouwen JL, Gelinck LB, Verbon A, Rijnders BJ, Slobbe L, Hartwig NG, Driessen GJ, Branger J, Kauffmann RH, Schippers EF, Groeneveld PH, Alleman MA, Bouwhuis JW, ten Kate RW, Soetekouw R, Kroon FP, van den Broek PJ, van Dissel JT, Arend SM, van Nieuwkoop C, de Boer MG, Jolink H, den Hollander JG, Pogany K, van Twillert G, Kortmann W, Vriesendorp R, Leyten EM, ten Napel CH, Kootstra GJ, Brinkman K, Blok WL, Frissen PH, Schouten WE, van den Berk GE, Juttmann JR, van Kasteren ME, Brouwer AE, Veenstra J, Lettinga KD, Mulder JW, van Gorp EC, Smit PM, Weijer S, van Eeden A, Verhagen DW, Sprenger HG, Doedens R, Scholvinck EH, van Assen S, Stek CJ, Koopmans PP, de Groot R, Keuter M, van der Ven AJ, ter Hofstede HJ, van der Flier M, Brouwer AM, Dofferhoff AS, Hoepelman AI, Mudrikova T, Schneider MM, Jaspers CA, Ellerbroek PM, Peters EJ, Maarschalk Ellerbroek LJ, Oosterheert JJ, Arends JE, Wassenberg MW, van der Hilst JC, Danner SA, van Agtmael MA, de Vocht J, Perenboom RM, Claessen FA, Bierman WF, de Jong EV, bij de Vaate EA, Geelen SP, Wolfs TF, Richter C, van der Berg JP, Gisolf EH, van den Berge M, Stegeman A, van Houte DP, Polée MB, van Vonderen MG, Winkel C, Duits AJ, Bruyand M, Chêne G, Lawson Ayayi S, Thiébaut R, Bonnal F, Bonnet F, Bernard N, Caunègre L, Cazanave C, Ceccaldi J, Chambon D, Chossat I, Dauchy FA, De Witte S, Dupon M, Duffau P, Dutronc H, Farbos S, Gaborieau V, Gemain MC, Gerard Y, Greib C, Hessamfar M, Lacoste D, Lataste P, Lafarie S, Lazaro E, Malvy D, Meraud JP, Mercié P, Monlun E, Neau D, Ochoa A, Pellegrin JL, Pistone T, Ragnaud JM, Receveur MC, Tchamgoué S, Vandenhende MA, Viallard JF, Moreau JF, Pellegrin I, Fleury H, Lafon ME, Masquelier B, Trimoulet P, Breilh D, Haramburu F, Miremont Salamé G, Blaizeau MJ, Decoin M, Delaune J, Delveaux S, D'Ivernois C, Hanapier C, Leleux O, Uwamaliya Nziyumvira B, Sicard X, Palmer G, Touchard D, Petoumenos K, Bendall C, Moore R, Edwards S, Hoy J, Watson K, Roth N, Nicholson J, Bloch M, Franic T, Baker D, Vale R, Carr A, Cooper D, Chuah J, Chuah M, Nolan D, Skett J, Mateu S, Domingo P, Sambeat MA, Gatell J, Del Cacho E, Cadafalch J, Fuster M, Codina C, Sirera G, Vaqué A, De Wit S, Clumeck N, Necsoi C, Gennotte AF, Gerard M, Kabeya K, Konopnicki D, Libois A, Martin C, Payen MC, Semaille P, Van Laethem Y, Neaton J, Bartsch G, Thompson G, Wentworth D, Luskin Hawk R, Telzak E, El Sadr WM, Abrams DI, Cohn D, Markowitz N, Arduino R, Mushatt D, Friedland G, Perez G, Tedaldi E, Fisher E, Gordin F, Crane LR, Sampson J, Baxter J, Cozzi Lepri A, Grint D, Podlekareva D, Peters L, Fischer AH, Losso M, Elias C, Ramos Mejia JM, Vetter N, Zangerle R, Karpov I, Vassilenko A, Mitsura VM, Suetnov O, Colebunders R, Vandekerckhove L, Hadziosmanovic V, Kostov K, Begovac J, Machala L, Jilich D, Sedlacek D, Kronborg G, Benfield T, Larsen M, Gerstoft J, Katzenstein T, Hansen AB, Skinhøj P, Pedersen C, Ostergaard L, Zilmer K, Smidt J, Ristola M, Katlama C, Viard JP, Girard PM, Livrozet JM, Vanhems P, Rockstroh J, Schmidt R, van Lunzen J, Degen O, Stellbrink HJ, Bickel M, Goethe JW, Bogner J, Fätkenheuer G, Kosmidis J, Gargalianos P, Xylomenos G, Perdios J, Panos G, Filandras A, Karabatsaki E, Sambatakou H, Banhegyi D, Mulcahy F, Yust I, Turner D, Burke M, Pollack S, Hassoun G, Maayan S, Vella S, Esposito R, Mazeu I, Mussini C, Arici C, Pristera R, Mazzotta F, Gabbuti A, Vullo V, Lichtner M, Chirianni A, Montesarchio E, Gargiulo M, Cotugno AD, Antonucci G, Testa A, Narciso P, Vlassi C, Zaccarelli M, Lazzarin A, Castagna A, Gianotti N, Galli M, Ridolfo A, Sacco L, Rozentale B, Zeltina I, Chaplinskas S, Hemmer R, Staub T, Ormaasen V, Maeland A, Bruun J, Knysz B, Gasiorowski J, Horban A, Bakowska E, Grzeszczuk A, Flisiak R, Boron Kaczmarska A, Pynka M, Parczewski M, Beniowski M, Mularska E, Trocha H, Jablonowska E, Malolepsza E, Wojcik K, Antunes F, Doroana M, Caldeira L, Mansinho K, Maltez F, Duiculescu D, Babes V, Rakhmanova A, Zakharova n, Jevtovic D, Mokráš M, Staneková D, Tomazic J, González Lahoz J, Soriano V, Labarga P, Medrano J, Moreno S, Rodriguez JM, Clotet B, Jou A, Paredes R, Tural C, Puig J, Bravo I, Gatell JM, Miró JM, Gutierrez M, Mateo G, Karlsson A, Flamholc L, Ledergerber B, Francioli P, Cavassini M, Hirschel B, Boffi E, Furrer H, Battegay M, Elzi L, Kravchenko E, Chentsova N, Frolov V, Kutsyna G, Servitskiy S, Krasnov M, Barton S, Johnson AM, Mercey D, Johnson MA, Murphy M, Weber J, Scullard G, Fisher M, Leen C, Thulin G, Åkerlund B, Koppel K, Håkangård C, Moroni M, Angarano G, Antinori A, Castelli F, Cauda R, Di Perri G, Iardino R, Ippolito G, Perno CF, Armignacco O, Viale PL, Von Schlosser F, Andreoni M, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi MR, Ceccherini Silberstein F, Cinque P, De Luca A, Gervasoni C, Girardi E, Gori A, Guaraldi G, Lo Caputo S, Madeddu G, Maggiolo F, Marchetti G, Marcotullio S, Monno L, Murri R, Puoti M, Torti C, Cicconi P, Formenti T, Galli L, Lorenzini P, Giacometti A, Costantini A, Riva A, Carrisa C, Lazzari G, Verucchi G, Minardi C, Quirino T, Abeli C, Manconi PE, Piano P, Sighinolfi L, Segala D, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Caramma I, Chiodera A, Castelli P, Rizzardini G, Ridolfo AL, Piolini R, Salpietro S, Galli A, Bigoloni A, Spagnuolo V, Carenzi L, Zucchi P, Moioli MC, Rossotti R, Bisio L, Lapadula G, Abrescia N, Guida MG, Baldelli F, Belfiori B, Parruti G, Ursini T, Magnani G, Ursitti MA, Tozzi V, d'Avino A, Gallo L, Nicastro E, Acinapura R, Capozzi M, Libertone R, Tebano G, Mura MS, Caramello P, Sciandra M, Orofino GC, Pellizzer G, Manfrin V, Caissotti C, Dellamonica P, Bernard E, Cua E, De Salvador Guillouet F, Durant J, Ferrando S, Mondain Miton V, Naqvi A, Perbost I, Prouvost Keller B, Pillet S, Pugliese P, Rahelinirina V, Roger PM, Dollet K, Barth J, Bernasconi E, Böni J, Bucher HC, Burton Jeangros C, Calmy A, Cellerai C, Dubs R, Egger M, Fehr J, Flepp M, Gorgievski M, Günthard H, Hasse B, Hirsch HH, Hösli I, Kahlert C, Kaiser L, Keiser O, Kind C, Klimkait T, Kovari H, Martinetti G, Martinez de Tejada B, Müller N, Nadal D, Pantaleo G, Rauch A, Regenass S, Rudin C, Schmid P, Schultze D, Schöni Affolter F, Schüpbach J, Speck R, Taffé P, Telenti A, Trkola A, Vernazza P, von Wyl V, Yerly S., VECCHIET, Jacopo, FALASCA, KATIA

المساهمون: Ryom, L, Mocroft, A, Kirk, O, Worm, Sw, Kamara, Da, Reiss, P, Ross, M, Fux, Ca, Morlat, P, Moranne, O, Smith, C, Lundgren, Jd, D:A:D Study, Group, Dabis, F, El Sadr, W, Pradier, C, Weber, R, Law, M, Morfeldt, L, de Wit, S, Calvo, G, d'Arminio Monforte, A, Shortman, N, Butcher, D, Rode, R, Franquet, X, Powderly, W, Sabin, C, Phillips, A, Lundgren, J, Kamara, D, Tverland, J, Nielsen, J, Salbøl Brandt, R, Rickenbach, M, Fanti, I, Krum, E, Hillebregt, M, Geffard, S, Sundström, A, Delforge, M, Fontas, E, Torres, F, Mcmanus, H, Wright, S, Kjær, J, Sjøl, A, Meidahl, P, Helweg Larsen, J, Schmidt Iversen, J, Worm, S, Fux, C, de Wolf, F, Zaheri, S, Gras, L, Prins, Jm, Kuijpers, Tw, Scherpbier, Hj, Boer, K, van der Meer, Jt, Wit, Fw, Godfried, Mh, van der Poll, T, Nellen, Fj, Lange, Jm, Geerlings, Se, van Vugt, M, Vrouenraets, Sm, Pajkrt, D, van der Valk, M, Schreij, G

الوصف: BACKGROUND: Several antiretroviral agents (ARVs) are associated with chronic renal impairment, but the extent of such adverse events among human immunodeficiency virus (HIV)-positive persons with initially normal renal function is unknown. METHODS: D:A:D study participants with an estimated glomerular filtration rate (eGFR) of ≥ 90 mL/min after 1 January 2004 were followed until they had a confirmed eGFR of ≤ 70 mL/min (the threshold below which we hypothesized that renal interventions may begin to occur) or ≤ 60 mL/min (a value indicative of moderately severe chronic kidney disease [CKD]) or until the last eGFR measurement during follow-up. An eGFR was considered confirmed if it was detected at 2 consecutive measurements ≥ 3 months apart. Predictors and eGFR-related ARV discontinuations were identified using Poisson regression. RESULTS: Of 22 603 persons, 468 (2.1%) experienced a confirmed eGFR of ≤ 70 mL/min (incidence rate, 4.78 cases/1000 person-years of follow-up [95% confidence interval {CI}, 4.35-5.22]) and 131 (0.6%) experienced CKD (incidence rate, 1.33 cases/1000 person-years of follow-up [95% CI, 1.10-1.56]) during a median follow-up duration of 4.5 years (interquartile range [IQR], 2.7-6.1 years). A current eGFR of 60-70 mL/min caused significantly higher rates of discontinuation of tenofovir (adjusted incidence rate ratio [aIRR], 1.72 [95% CI, 1.38-2.14]) but not other ARVs compared with a current eGFR of ≥ 90 mL/min. Cumulative tenofovir use (aIRR, 1.18/year [95% CI, 1.12-1.25]) and ritonavir-boosted atazanavir use (aIRR, 1.19/year [95% CI, 1.09-1.32]) were independent predictors of a confirmed eGFR of ≤ 70 but were not significant predictors of CKD whereas ritonavir-boosted lopinavir use was a significant predictor for both end points (aIRR, 1.11/year [95% CI, 1.05-1.17] and 1.22/year [95% CI, 1.16-1.28], respectively). Associations were unaffected by censoring for concomitant ARV use but diminished after discontinuation of these ARVs. CONCLUSIONS: Tenofovir, ritonavir-boosted atazanavir, and ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000317434600003; volume:207; issue:9; firstpage:1359; lastpage:1369; numberofpages:11; journal:THE JOURNAL OF INFECTIOUS DISEASES; http://hdl.handle.net/11564/440960Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84875971855

الإتاحة: http://hdl.handle.net/11564/440960Test