المؤلفون: Natasha Baig, Muhammad Rafie Raza, Nida Zia, Sidra Maqsood, Nausheen Yaqoob, Muhammad Shamvil Ashraf

المصدر: Pediatric Hematology Oncology Journal, Vol 7, Iss 4, Pp 177-181 (2022)

مصطلحات موضوعية: Histiocytosis, Langerhans cells, Recurrence, Neoplasm, Paediatrics, Pediatrics, RJ1-570

الوصف: Introduction: Between 2 and 9 children per million per year are affected by Langerhans Cell Histiocytosis (LCH) globally. Despite aggressive treatment, mortality and reactivation rates for multisystem LCH remain above 20% and 30%, respectively. In low-middle income countries the problem is compounded by late presentation and diagnosis. Methods: A retrospective study was conducted by the Pediatric Hematology and Oncology Department at Indus Hospital and Health Network in Pakistan. Children 0 to 16 years with biopsy-proven LCH who presented between 2009 and 2019 were enrolled. Results: Forty-six patients were included, with a 59% male predominance. Thirty-two children had single system and 14 had multisystem LCH (64% with risk organ involvement). LCH-III protocol was administered to 17 and LCH-IV to 25. Relapse was observed in 12 patients; 8 were treated with modified salvage protocol, 3 with salvage protocol and 1 with LCH-III protocol. Two patients had progression of disease, 1 transformed to Hodgkin lymphoma and 1 developed non-Hodgkin lymphoma as a second malignancy. Over one-third of the patients expired. Conclusion: Further therapies must be developed to decrease LCH relapse rates and improve survival. Pakistan is subject to challenges, including malnutrition and treatment abandonment, that must be tackled to improve outcomes of children with cancer.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2468124522002613Test; https://doaj.org/toc/2468-1245Test

الوصول الحر: https://doaj.org/article/fe3daf0b34d742d5b61a0629ff2a9623Test

المؤلفون: Nausheen Yaqoob, Neelum Mansoor, Hania Naveed, Saba Jamal

المصدر: World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-5 (2022)

مصطلحات موضوعية: Primary myelofibrosis, Extramedullary hematopoiesis, Immunohistochemistry, Cytogenetics, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Extramedullary hematopoiesis (EMH) is a proliferation of hematopoietic tissue outside of the bone marrow medullary space. It is a pathophysiologic response, more often associated with either a benign reactive hematological disease or a myeloproliferative neoplasm (MPN). Identification of EMH in adults is always pathologic. It is highly unlikely for a myeloproliferative neoplasm to present with inguinal lymphadenopathy. An unusual and complex case can be precisely diagnosed via a multidisciplinary approach involving experts from various modalities of laboratory. In this regard, the present case highlights the importance of an integrated approach in establishing the diagnosis. Case presentation We report a case of a 61-year-old male patient of primary myelofibrosis who presented with extramedullary hematopoiesis in an inguinal lymph node. The patient initially presented with generalized symptoms including anemia, fatigue, abdominal pain, and weight loss. On examination, massive splenomegaly. Chest X-ray revealed consolidation which was secondary to right-sided pleural effusion. Therefore, he was suspected to have a lung carcinoma. However, lymph node biopsy revealed extensive fibrosis, consequently effacing the nodal architecture. An abnormal blood picture raised the possibility of bone marrow infiltration. Extensive panel of markers is tested on lymph node and bone trephine. Cytogenetic studies with G-banding analysis and fluorescence in situ hybridization (FISH) played a significant role in deriving clinical decision. Translocations identified in conventional cytogenetic workup led to the diagnosis of primary myelofibrosis. The case is being reported due to unusual presentation of PMF. Conclusion In conclusion, it is a distinctive case of myeloproliferative disorder initially presented with extramedullary hematopoiesis and through multidisciplinary workup successfully diagnosed as primary myelofibrosis. Awareness of unique clinical presentations and integrated approach towards diagnosis is the key to such challenging cases.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1477-7819Test

الوصول الحر: https://doaj.org/article/f0052c31717b4ca59939b8b814ecac03Test

المؤلفون: Zunaira Qayoom, Nausheen Yaqoob

المصدر: Journal of the Pakistan Medical Association, Vol 73, Iss 05 (2023)

مصطلحات موضوعية: Epidermoid cyst, Mucinous cystadenoma., Medicine

الوصف: Epidermoid cyst is a rare benign neoplasm of the ovary, lined by stratified squamous epithelium, lacking skin, adnexal structures, and other teratomatous elements. On the other hand, mucinous cystadenoma is one of the most common benign ovarian neoplasm that microscopically shows cystic areas lined by tall columnar mucinous epithelium. Although its coexistence with other tumours, such as mature cystic teratoma, squamous cell carcinoma, clear cell adenocarcinoma, Brenner’s tumour, serous cystadenoma, etc., have been reported, a combination of benign epidermoid cyst and mucinous cystadenoma has rarely been documented in literature. We report a case of coexistence of epidermoid cyst and mucinous cystadenoma in an ovarian cyst. Key Words: Epidermoid cyst, Mucinous cystadenoma.

وصف الملف: electronic resource

العلاقة: https://www.ojs.jpma.org.pk/index.php/public_html/article/view/5635Test; https://doaj.org/toc/0030-9982Test

الوصول الحر: https://doaj.org/article/da8b2512fc114851a0846cf85bcff889Test

المؤلفون: Nausheen Yaqoob, Salima Mansoor, Kanwal Aftab, Riyasat Ahmed Memon, Saba Jamal

المصدر: Journal of the Pakistan Medical Association, Vol 72, Iss 10 (2022)

مصطلحات موضوعية: Medicine

الوصف: Carcinoma ex pleomorphic adenoma is a neoplasm of the salivary gland that causes 3.6% of salivary gland tumours and 12% of salivary gland malignancies. It is a myoepithelial or epithelial neoplasm that arises from pleomorphic adenoma, whether primary or recurrent. Historically carcinoma ex pleomorphic adenoma is considered a high-grade malignancy. Salivary duct carcinoma and high-grade adenocarcinoma are the histologic types that most commonly arise in the background of Pleomorphic adenoma. However, 15% of tumours arising in Pleomorphic adenoma are considered low grade and have sluggish growth. Low-grade carcinoma ex pleomorphic adenoma can be difficult to differentiate from cellular pleomorphic adenoma. The case of a 56-year-old female patient who had neck swelling is being presented. The biopsy showed spindle cell component with mild atypia, invasion into surrounding tissue, and increased mitotic activity on the basis ---Continue

وصف الملف: electronic resource

العلاقة: https://www.ojs.jpma.org.pk/index.php/public_html/article/view/3528Test; https://doaj.org/toc/0030-9982Test

الوصول الحر: https://doaj.org/article/3d8e114e204f470e84d3447449cd1ea9Test

المؤلفون: Yousuf Abd Mallick, Nausheen Yaqoob

المصدر: Anais Brasileiros de Dermatologia, Vol 96, Iss 5, Pp 617-619 (2021)

مصطلحات موضوعية: Dermatology, RL1-803

وصف الملف: electronic resource

العلاقة: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962021000500617&tlng=enTest; https://doaj.org/toc/0365-0596Test

الوصول الحر: https://doaj.org/article/a18828b15e5340afa0a2612e4e2b7a09Test

المؤلفون: Yousuf Abd Mallick, Nausheen Yaqoob

المصدر: Journal of the Dow University of Health Sciences, Vol 14, Iss 1, Pp 42-44 (2020)

مصطلحات موضوعية: mycetoma, eumycetoma, aspergillus niger, voriconazole, dot-in-circle sign, Medicine

الوصف: Mycetoma is a chronic granulomatous infection of skin and subcutaneous tissues. It is a neglected disease with severe physical and psychological comorbidity burden as many cases end up with amputations. Proper diagnosis with tissue culture is lacking because of unavailability of facilities in remote areas. Eumycetoma by different Aspergillus species has already been reported in the literature for decades. But here, we are reporting a case of eumycetoma caused by Aspergillus niger, which is the first ever case-report to the best of our knowledge and search. Treatment with voriconazole 400 mg/day was successful without any major side-effects, and saved patient from amputation.

وصف الملف: electronic resource

العلاقة: http://www.jduhs.com/index.php/jduhs/article/view/809Test; https://doaj.org/toc/1995-2198Test; https://doaj.org/toc/2410-2180Test

الوصول الحر: https://doaj.org/article/a41b41ca852244ebbd7e80bf5c6275dcTest

المؤلفون: Yousuf Abd Mallick, Nausheen Yaqoob

المصدر: Journal of the Dow University of Health Sciences, Vol 14, Iss 3 (2020)

مصطلحات موضوعية: histopathology, mosaicism, Inflammatory linear verrucous epidermal nevus, Medicine

الوصف: Inflammatory linear verrucous epidermal nevus (ILVEN) is rare, mosaicism-induced linear inflammatory dermatoses with early childhood presentation and persistence for whole life in majority of cases. No definite gene or genetic locus has been nominated yet. Treatment is mostly aimed for relief of symptoms and for cosmetic concerns.Here, authors are reporting a case of 6-year-old girl presented with history of extremely pruritic, erythematous, linear plaques following the lines of Blaschko over all 4 limbs, trunk and flexures since infancy.Clinical impression of bilateral ILVEN was confirmed by histopathology. No systemic abnormality was detected.Bilateral ILVEN is extremely rare entity and it should be documented whenever encounter.

وصف الملف: electronic resource

العلاقة: https://jduhs.com/index.php/jduhs/article/view/963Test; https://doaj.org/toc/1995-2198Test; https://doaj.org/toc/2410-2180Test

الوصول الحر: https://doaj.org/article/71e971f561634924a55083901c0ccba3Test

المؤلفون: Daniel C. Moreira, Revathi Rajagopal, Regina M. Navarro-Martin del Campo, Ana C. Polanco, Ana Patricia Alcasabas, Luis A. Arredondo-Navarro, Danny Campos, Sandro Casavilca-Zambrano, Rosdali Yesenia Diaz Coronado, Nor Faizal, Dharmendra Ganesan, Syed Ahmer Hamid, Rafeah Khan, Kathleen Khu, Jasmin Loh, Marissa Lukban, Tatiana Negreiros, Estuardo Pineda, Nausheen Yaqoob, Nida Zia, Amar Gajjar, Carlos Rodriguez-Galindo, Ibrahim Qaddoumi

المصدر: JCO Global Oncology, Vol , Iss 6, Pp 583-584 (2020)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2687-8941Test

الوصول الحر: https://doaj.org/article/90f06700850247afbda1edeca7fd5811Test

المؤلفون: Hania Hania, Nausheen Yaqoob, Sadia Muhammad, Kanwal Aftab, Mohammad Rafie Raza

المصدر: Journal of Ayub Medical College Abbottabad. 34:1046-1049

مصطلحات موضوعية: General Medicine

الوصف: Pilomatrix carcinoma is a rare, locally aggressive variant of pilomatrixoma with a high rate of recurrence and risk of distant metastasis. We report an unusual presentation of a pilomatrix carcinoma in a 4-year-old male child who presented with recurrent lesions on his left cheek. At the age of 1 month of life, he presented with a soft tissue swelling on his left cheek. The lesion showed a circumscribed proliferation of basaloid cells with central areas of eosinophilic ghost shadow cells and intermediate cells. Basaloid nests showed round to oval, hyperchromatic nuclei with open nuclear chromatin, prominent nucleoli and frequent mitoses but no marked nuclear pleomorphism or infiltration was identified. The lesion recurred twice at the same site. Both recurrences showed similar morphology as the primary tumor however there were extensive areas of stromal necrosis, infiltrating edges, frequent mitoses with atypical forms, and lymphovascular invasion. There was no marked nuclear pleomorphism. Morphological features favored a diagnosis of pilomatrix carcinoma. The child is still on follow-up and no recurrence has been identified to date. Pilomatric carcinoma is rarely reported in infants. Due to its rarity, aggressive histological features may be missed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::12a14043dfa9b39c37975993b1d12bafTest
https://doi.org/10.55519/jamc-04-s4-10675Test

المؤلفون: Susan M. Chang, Rohit Gupta, Soonmee Cha, Huiling Xu, Melissa Gener, Jasper Wu, Nida Zia, Damien Kee, Ajay Ravindranathan, Kathan Shah, Calixto-Hope G Lucas, Arie Perry, David A. Solomon, Kevin Ginn, Nausheen Yaqoob, Adriana Florez, Jennifer Clarke, Jairo Barreto, Mitchel S. Berger, Owen W.J. Prall, Hyun S Ko

المصدر: Acta Neuropathologica

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Oncogene Proteins, Fusion, Brain Neoplasms, Astroblastoma, Infant, Newborn, Biology, medicine.disease, Neoplasms, Neuroepithelial, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Young Adult, Correspondence, medicine, Humans, Female, Neurology (clinical), Spinal Cord Neoplasms, RNA-Binding Protein EWS, Child

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7800479816bb9094a848affc74749b24Test
http://europepmc.org/articles/PMC8732961Test