المؤلفون: Abdelghany, Wael K., Hammed, M. S., Radwan, Ahmed Eid Ahmed, Nassar, T.

مصطلحات موضوعية: sand production, geomechanical characterization machine learning UCS, sonic log, Gulf of Suez

العلاقة: Journal of Petroleum Exploration and Production Technology, T. 13, nr 1, s. 297-312; https://ruj.uj.edu.pl/xmlui/handle/item/307740Test

الإتاحة: https://doi.org/10.1007/s13202-022-01551-9Test
https://ruj.uj.edu.pl/xmlui/handle/item/307740Test

المؤلفون: Hassan, M. Y. M., Farag, M. Y. H., Abul-Magd, A. Y., Nassar, T. E. I.

المصدر: Phys.Scr.78:045202,2008

مصطلحات موضوعية: Nuclear Theory

الوصف: Reaction cross-sections are calculated using the Coulomb modified Glauber model for deformed target nuclei. The deformed nuclear matter density of the target is expanded into multipoles of order k = 0,2,4.The reaction cross-sections between some spherical and deformed nuclei are studied at energy range (10-1000 MeV/nucleon). The most significant effects in the intermediate energy range are the Coulomb field and in-medium effect that modified the trajectory of the incident beams. Introducing the deformation effect beside the Coulomb field and in-medium effect improves the agreement with the experimental data and two empirical parameterizations in the case of not finding experimental data. Moreover it is indicated that the enhancement of the reaction cross-sections is attributed with fixed orientation in deformed nuclei.
Comment: 17 pages, 7 pages

الوصول الحر: http://arxiv.org/abs/0902.0453Test

المؤلفون: Morgan, H., Madani, A., Hussien, H., Nassar, T.

المصدر: XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

الوصف: The effects of climate change increase the demand for freshwater, particularly in arid environments, considering that groundwater is an essential water resource in these regions. The main focus of this research was to generate a groundwater potential map in the Center East Desert, Egypt, using a random forest classification machine learning model. Based on satellite data, geological maps, and field survey, fifteen effective features influencing groundwater potentiality were created. These effective features include elevation, slope angle, slope aspect, terrain ruggedness index, curvature, lithology, lineament density, distance from major fractures, topographic wetness index, stream power index, drainage density, rainfall, as well as distance from rivers and channels, soil type and land use/land cover. Collinearity analysis was used for feature selection. A 100 dependent points (57 water points and 43 non-potential mountainous areas) were labeled and classified according to hydrogeological conditions in the three main aquifers (Basement, Nubian and Quaternary Aquifers). The random forest algorithm was trained using (70%) of the dependent points. Then, it was validated using (30%) and the hyper-parameters were optimized. Groundwater potential map was predicted and classified as good (5.1%), moderate (0.1%), poor (4.2%), and non-potentiality (90.6%). Sensitivity (92%), and F1-score (94%) besides accuracy (97%) are validation methods used due to the imbalanced dataset problem. The most important effective features for groundwater potential map were determined based on the random forest and the receiver operating characteristics curve. Therefore, the random forest model is helpful for delineating groundwater potential zones and can be used in similar locations worldwide.

العلاقة: https://gfzpublic.gfz-potsdam.de/pubman/item/item_5017041Test

الإتاحة: https://doi.org/10.57757/IUGG23-0054Test
https://gfzpublic.gfz-potsdam.de/pubman/item/item_5017041Test

المؤلفون: Nassar, T., Tirkkonen, O.

المصدر: J.Phys.A31:9983-9996,1998

مصطلحات موضوعية: High Energy Physics - Theory

الوصف: We compute the finite size spectrum for the spin 1/2 XXZ chain with twisted boundary conditions, for anisotropy in the regime $0< \gamma <\pi/2$, and arbitrary twist $\theta$. The string hypothesis is employed for treating complex excitations. The Bethe Ansatz equtions are solved within a coupled non-linear integral equation approach, with one equation for each type of string. The root-of-unity quantum group invariant periodic chain reduces to the XXZ_1/2 chain with a set of twist boundary conditions ($\pi/\gamma\in Z$, $\theta$ an integer multiple of $\gamma$). For this model, the restricted Hilbert space corresponds to an unitary conformal field theory, and we recover all primary states in the Kac table in terms of states with specific twist and strings.
Comment: 16 pages, Latex; added discussion on quantum group invariance and arbitrary magnon number

الوصول الحر: http://arxiv.org/abs/hep-th/9707098Test

المؤلفون: Emad S Alhubaish, Nassar T Alibrahim, Abbas A Mansour

المصدر: Cureus.

مصطلحات موضوعية: General Engineering

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::082c6f6ca351afc1817a9e079ff7aa54Test
https://doi.org/10.7759/cureus.36778Test

المؤلفون: Bahaa O Sahib, Ibrahim H Hussein, Nassar T Alibrahim, Abbas A Mansour

المصدر: Cureus.

مصطلحات موضوعية: General Engineering

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6396725fef79d6949edea2f4b3447827Test
https://doi.org/10.7759/cureus.35601Test

المؤلفون: Radhi, Maher A, Alibrahim, Nassar T, Mansour, Abbas A

المصدر: Cureus ; ISSN 2168-8184

مصطلحات موضوعية: General Engineering

الإتاحة: https://doi.org/10.7759/cureus.47708Test
https://www.cureus.com/articles/197499-cut-off-value-of-thyrotropin-receptor-antibodies-in-graves-disease-in-basrahTest

المؤلفون: Alhubaish, Emad S, Alibrahim, Nassar T, Mansour, Abbas A

المصدر: Cureus ; ISSN 2168-8184

مصطلحات موضوعية: General Engineering

الإتاحة: https://doi.org/10.7759/cureus.36778Test
https://www.cureus.com/articles/138727-the-clinical-implications-of-anti-thyroid-peroxidase-antibodies-in-graves-disease-in-basrahTest

المؤلفون: Sahib, Bahaa O, Hussein, Ibrahim H, Alibrahim, Nassar T, Mansour, Abbas A

المصدر: Cureus ; ISSN 2168-8184

مصطلحات موضوعية: General Engineering

الإتاحة: https://doi.org/10.7759/cureus.35601Test
https://www.cureus.com/articles/135431-management-outcomes-in-males-with-hypogonadotropic-hypogonadism-treated-with-gonadotropinsTest

المؤلفون: Perkovic, Vlado, Jardine, Meg J, Neal, Bruce, Bompoint, Severine, Heerspink, Hiddo J L, Charytan, David M, Edwards, Robert, Agarwal, Rajiv, Bakris, George, Bull, Scott, Cannon, Christopher P, Capuano, George, Chu, Pei-Ling, de Zeeuw, Dick, Greene, Tom, Levin, Adeera, Pollock, Carol, Wheeler, David C, Yavin, Yshai, Zhang, Hong, Zinman, Bernard, Meininger, Gary, Brenner, Barry M, Mahaffey, Kenneth W., Perkovic V, Mahaffey KW, Agarwal R, Bakris G, Brenner BM, Cannon CP, Charytan DM, de Zeeuw D, Greene T, Jardine MJ, Heerspink HJL, Levin A, Meininger G, Neal B, Pollock C, Wheeler DC, Zhang H, Zinman B, McGuire DK, Holman R, Home P, Scharfstein D, Parfrey P, Shahinfar S, August P, Chang T, Sinha AD, Januzzi J, Kolansky D, Amerena J, Hillis G, Gorelick P, Kissela B, Kasner S, Lindley R, Fulcher G, Ounadjela S, Hufert K, von Ingersleben G, Gaglia J, Harris R, Hudson M, Turchin A, Cheifetz A, Sheth S, Feuerstein J, Cohen S, Jardine M, Li N, Kolesnyk I, Aizenberg D, Pecoits-Filho R, Cherney D 3rd, Obrador G, Chertow G, Hawley C, Ji L, Wada T, Jha V, Lim SK, Lim-Abrahan MA, Santos F, Chae DW, Hwang SJ, Vazelov E, Rychlík I, Hadjadj S, Krane V, Rosivall L, De Nicola L, Dreval A, Nowicki M, Schiller A, Distiller L, Górriz JL, Kolesnyk M, Morren F, Goykhman S, David C, Yost L, Wang H, Hettiarachchi M, Thimmaiah R, Koppolu D, George S, Schmidt M, Ignjatovic J, Chapin L, Travis K, Destree M, Sood V, Coffee L, De Brouwer K, Zaviriukha V, Starzec A, Koizumi M, Lin G, Chen E, Lin P, Leia C, Mascaro D, Amigo A, Limos A, Abrahamsen I, Jaffer S, Ahuad Guerrero RA, Albisu JP, Alvarisqueta A, Bartolacci I, Berli MA, Bordonava A, Calella P, Cantero MC, Cartasegna LR, Cercos E, Coloma GC, Colombo H, Commendatore V, Cuadrado J, Cuneo CA, Cusumano AM, Douthat WG, Dran RD, Farias E, Fernandez MF, Finkelstein H, Fragale G, Fretes JO, Garcia NH, Gastaldi A, Gelersztein E, Glenny JA, Gonzalez JP, Gonzalez Colaso PDC, Goycoa C, Greloni GC, Guinsburg A, Hermida S, Juncos LI, Klyver MI, Kraft F, Krynski F, Lanchiotti PV, Leon de la Fuente RA, Marchetta N, Mele P, Nicolai S, Novoa PA, Orio SI, Otreras F, Oviedo A, Raffaele P, Resk JH, Rista L, Rodriguez Papini N, Sala J, Santos JC, Schiavi LB, Sessa H, Smith Casabella T, Ulla MR, Valdez M, Vallejos A, Villarino A, Visco VE, Wassermann A, Zaidman CJ, Cheung NW, Droste C, Fraser I, Johnson D, Mah PM, Nicholls K, Packham D, Proietto J, Roberts A, Roger S, Tsang V, Raduan RA, Alves da Costa FA, Amodeo C, Andreotti Turatti LA, Bregman R, Camelo Sanches FC, Canani LH, Chacra AR, Cunha Borges JL, Cunha Vêncio SA, da Silva Franco RJ, d'Avila D, de Souza Portes E, de Souza P, Deboni LM, Filho FF, Geloneze Neto B, Gomes M, Kohara SK, Keitel E, Kerr Saraiva JF, Kurtz Lisboa HR, de Carvalho Contieri FL, Milagres R, Montenegro Junior R, Moreira de Brito C, Nazzer Hissa M, Nazario Sabbag ÂR, Noronha I, Panarotto D, Pecoits Filho R, Pereira MA, Saporito W, Scotton AS, Schuch T, Simões de Almeida R, Slompo Ramos C, Soares Felício J, Thomé F, Tibes Hachmann JC, Yamada S, Yoiti Hayashida C, Zanata Petry TB, Zanella MT, Andreeva V, Angelova A, Dimitrov S, Genadieva V, Genova-Hristova G, Hristozov K, Kamenov Z, Koundurdjiev A, Lozanov L, Margaritov V, Nonchev B, Rangelov R, Shinkov A, Temelkova M, Velichkova E, Yakov A, Aggarwal N, Aronson R, Bajaj H, Chouinard G, Conway J, Cournoyer S, DaRoza G, De Serres S, Dubé F, Goldenberg R, Gupta A, Gupta M, Henein S, Khandwala H, Leiter L, Madore F, McMahon A, Muirhead N, Pichette V, Rabasa-Lhoret R, Steele A, Tangri N, Torshizi A, Woo V, Zalunardo N, Fernández Montenegro MA, Godoy Jorquera JG, Medina Fariña M, Saavedra Gajardo V, Vejar M, Chen N, Chen Q, Gan S, Kong Y, Li D, Li W, Li X, Lin H, Liu J, Lu W, Mao H, Ren Y, Song W, Sun J, Sun L, Tu P, Wang G, Yang J, Yin A, Yu X, Zhao M, Zheng H, Accini Mendoza JL, Arcos E, Avendano J, Diaz Ruiz JEA, Garcia Ortiz LH, Gonzalez A, Hernandez Triana E, Higuera JD, Malaver N, Molina de Salazar DI, Rosero R, Terront Lozano MA, Valderrama Cometa L, Valenzuela A, Vargas Alonso RD, Villegas I, Yupanqui H, Bartaskova D, Barton P, Belobradkova J, Dohnalova L, Drasnar T, Ferkl R, Halciakova K, Klokocnikova V, Kovar R, Lastuvka J, Lukac M, Pesickova S, Peterka K, Pumprla J, Rychlik I, Saudek F, Tesar V, Valis M, Weiner P, Zemek S, Alamartine E, Borot S, Cariou B, Dussol B, Fauvel JP, Gourdy P, Klein A, Le Meur Y, Penfornis A, Roussel R, Saulnier PJ, Thervet E, Zaoui P, Burst V, Faghih M, Faulmann G, Haller H, Jerwan-Keim R, Maxeiner S, Paschen B, Plassmann G, Rose L, Gonzalez Orellana RA, Haase FP, Moreira Diaz JP, Ramirez Roca LA, Sánchez Arenales JA, Sanchez Polo JV, Turcios Juarez E, Csecsei G, Csiky B, Danos P, Deak L, Dudas M, Harcsa E, Keltai K, Keresztesi S, Kiss K, Konyves L, Major L, Mileder M, Molnar M, Mucsi J, Oroszlan T, Ory I, Paragh G, Peterfai E, Petro G, Revesz K, Takacs R, Vangel S, Vasas S, Zsom M, Abraham O, Bhushan RS, Deepak D, Edwin FM, Gopalakrishnan N, Gracious N, Hansraj A, Jain D, Keshavamurthy CB, Khullar D, Manisha S, Peringat J, Prasad N, Satyanarayana RK, Sreedhar R, Sreelatha M, Sudhakar B, Vyasam RC, Bonadonna R, Castellino P, Ceriello A, Chiovato L, De Cosmo S, Derosa G, Di Carlo A, Di Cianni G, Frascà G, Fuiano G, Gambaro G, Garibotto G, Giorda C, Malberti F, Mandreoli M, Mannucci E, Orsi E, Piatti P, Santoro D, Sasso FC, Serviddio G, Stella A, Trevisan R, Veronelli AM, Zanoli L, Akiyama H, Aoki H, Asano A, Iitsuka T, Kajiyama S, Kashine S, Kawada T, Kodera T, Kono H, Koyama K, Kumeda Y, Miyauchi S, Mizuyama K, Niiya T, Oishi H, Ota S, Sakakibara T, Takai M, Tomonaga O, Tsujimoto M, Wakasugi M, Wakida Y, Watanabe T, Yamada M, Yanagida K, Yanase T, Yumita W, Gaupsiene E, Kozloviene D, Navickas A, Urbanaviciene E, Abdul Ghani R, Abdul Kadir K, Ali N, Che Yusof MD, Gan CL, Ismail M, Kong WY, Lam SW, Lee LY, Loh CL, Manocha AB, Ng KS, Nik Ahmad NNF, Ratnasingam V, Bin Shudim SS, Vengadasalam P, Abraira Munoz LD, Salazar MA, Cruz JB, Soto MB, Ramos JC, Wong AC, Correa Rotter JR, Diaz Escalante T, Enriquez Sosa FE, Flores Lozano F, Flota Cervera LF, Frenk Baron P, Garcia Ballesteros C, Gomez Rangel JD, Herrera Jimenez LE, Irizar Santana SS, Jimenez Florez F, Laviada Molina H, Luna Ceballos RI, Martin Del Camp Blanco B, Morales Franco G, Moreno Loza OT, Mustieles Rocha C, Obrador Vera G, Orozco Castellanos R, Peralta Calcaneo J, Reyes Rosano MA, Rodriguez Pattzi H, Rosas Guzman J, Rucker Joerg IE, Saaveddra Sanchez SB, Sanchez Mijangos JH, Serrano Sanson P, Tamayo Y Orozco JA, Tellez Chavez E, Valdes Depeda A, Venegas Carrillo L, Villagordoa Mesa J, Zamarripa Escobedo R, Baker J, Noonan P, Scott R, Walker R, Watson E, Williams M, Young S, Abejuela Z, Agra J, Aquitania G, Caringal C, Comia RS, Delos Santos L, Gomez O, Jimeno C, Tan G, Tolentino M, Yao C, Yap YE, Ygpuara MDL, Bijata-Bronisz R, Hotlos L, Januszewicz A, Kaczmarek B, Kaminska A, Lazuka L, Madej A, Mazur S, Mlodawska-Choluj D, Orlowska-Kowalik G, Popenda G, Rewerska B, Sowinski D, Angelescu LM, Anghel V, Avram RI, Busegeanu MM, Cif A, Cosma D, Crisan C, Demian LD, Ferariu IE, Halmagyi I, Hancu N, Munteanu M, Negru D, Onaca AG, Petrica L, Popa AR, Ranetti AE, Serafinceanu C, Toarba C, Agafyina A, Barbarash O, Barysheva O, Chizhov D, Dobronravov V, Glinkina I, Grineva E, Khirmanov V, Kolmakova E, Koroleva T, Kvitkova L, Marasaev V, Mkrtumyan A, Morugova T, Nagibovich G, Nagibovich O, Nedogoda S, Osipova I, Raskina T, Samoylova Y, Sazonova O, Shamkhalova M, Shutemova E, Shwartz Y, Uriasyev O, Vorobyev S, Zateyshchikova A, Zateyshshikov D, Zykova T, Antic S, Djordjevic M, Kendereski A, Lalic K, Lalic N, Popovic-Radinovic V, Babikova J, Benusova O, Buganova I, Culak J, Dzupina A, Dzuponova J, Fulop P, Ilavska A, Martinka E, Ochodnicka Z, Pella D, Smatanova I, Ahmed F, Badat A, Breedt J, Govender V, Govender R, Joshi M, Jurgens J, Latiff G, Lombard L, Mookadam M, Ngcakani N, Nortje H, Oosthuizen H, Pillay-Ramaya L, Prozesky H, Reddy J, Rheeder P, Seeber M, Cho YM, Jeong IK, Kim SG, Kim YH, Kwon HS, Kwon MJ, Lee BW, Lee J, Lee MK, Nam MS, Oh KH, Park CY, Park SH, Yoon KH, Alvarez Garcia P, Asmarats Mercadal L, Barrios C, Cereto Castro F, Cigarran Guldris S, Dominquez Lopez M, Egido de Los Rios J, Fernandez Fresnedo G, Galan Serrano A, Garcia I, Gonzalez Martinez FJ, Jodar Gimeno JE, Muñoz Lopez Mendoza M, Malek Marin T, Morales Portillo C, Munar Vila MA, Muñoz Torres M, Nieto Iglesias J, Pantoja Perez J, Perez Vera M, Portoles Perez JM, Quesada Simón MA, Simo Canonge R, Soto Gonzalez A, Terns Riera M, Tinahones Madueno FJ, Plaza MV, Chang CT, Chuang LM, Hsia TL, Hsieh CH, Lin CC, Lu YC, Sheu WH, Barna O, Bilyk SD, Botsyurko V, Dudar I, Fushtey I, Godlevska O, Golovchenko O, Gyrina O, Kazmirchuk A, Komisarenko I, Korzh O, Kravchun N, Legun O, Mankovskyy B, Martynyuk L, Mostovoy Y, Pashkovska N, Pererva L, Pertseva T, Samoylov O, Smirnov I, Svyshchenko Y, Tomashkevych H, Topchii I, Tryshchuk N, Tseluyko V, Vizir V, Vlasenko M, Zlova T, Zub L, Abusnana S, Railey M, Abouglila K, Ainsworth P, Ali Z, Arutchelvam V, Barnard M, Bellary S, Davies E, Davies M, Davies S, Dawson A, El Kossi M, English P, Fraser D, Gnudi L, Gunstone A, Hall T, Hanif W, Jackson A, Johnson A, Joseph F, Krishnan S, Kumwenda M, MacDougall I, Nixon P, O'Hare J, Philip S, Ramtoola S, Saxena M, Sennik D, Simon G, Singh B, Stephens J, Strzelecka A, Symonds R, Turner W, Wahba M, Wakeling J, Wheeler D, Winocour P, Abdallah J, Abdullah R, Abramowitz M, Acosta I, Aiello J, Akright L, Akyea-Djamson A, Alappan R, Alicic R, Al-Karadsheh A, Allison DC, Arauz-Pacheco C, Arfeen S, Arif A, Arvind M, Atray N, Awad A, Barnhill P, Barranco E, Barrera C, Beacom M, Behara V, Belo D, Bentley-Lewis R, Berenguer R, Bermudez L, Bernardo M, Biscoveanu M, Bowman-Stroud C, Brandon D, Brusco O, Busch R, Canaan Y, Chilito A, Christensen T, Christiano C, Christofides E, Chuateco C, Cohen K, Cohen R, Cohen-Stein D, Cook C, Coyne D, Daboul N, Darwish R, Daswani A, Deck K, Desouza C, Dev D, Dhillon M, Dua S, Eder F, Elosegui AM, El-Shahawy M, Ervin J, Esquenazi A, Evans J, Fishbane S, Frias J, Galindo-Ramos E, Galphin C, Ghazi A, Gonzalez E, Gorson D, Gowda A, Greco B, Grubb S, Gulati R, Hammoud J, Handelsman S, Hartman I, Hershon K, Hiser D, Hon G, Jacob R, Jaime M, Jamal A, Kaupke C, Keightley G, Kern E, Khanna R, Khitan Z, Kim S, Kopyt N, Kovesdy C, Krishna G, Kropp J, Kumar A, Kumar J, Kumar N, Kusnir J, Lane W, Lawrence M, Lehrner L, Lentz J, Levinson D, Lewis D, Liss K, Maddux A, Maheshwari H, Mandayam S, Marar I, Mehta B, Middleton J, Mordujovich J, Moreda R, Moustafa M, Mujica Trenche S, Narayanan M, Narvarte J, Nassar T, Newman G, Nichol B, Nicol P, Nisnisan J, Nossuli AK, Obialo C, Olelewe S, Oliver M, O'Shaughnessy A, Padron J, Pankhaniya R, Parker R, Patel D, Patel G, Patel N, Pavon H, Perez A, Perez C, Perlman A, Pettis K, Pharr W, Phillips A, Purighalla R, Quesada-Suarez L, Ranjan R, Rastogi S, Rendell M, Rich L, Robinson M, Rodriguez H, Rosas S, Saba F, 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المساهمون: Perkovic, Vlado, Jardine, Meg J, Neal, Bruce, Bompoint, Severine, Heerspink, Hiddo J L, Charytan, David M, Edwards, Robert, Agarwal, Rajiv, Bakris, George, Bull, Scott, Cannon, Christopher P, Capuano, George, Chu, Pei-Ling, de Zeeuw, Dick, Greene, Tom, Levin, Adeera, Pollock, Carol, Wheeler, David C, Yavin, Yshai, Zhang, Hong, Zinman, Bernard, Meininger, Gary, Brenner, Barry M, Mahaffey, Kenneth W., Perkovic, V, Mahaffey, Kw, Agarwal, R, Bakris, G, Brenner, Bm, Cannon, Cp, Charytan, Dm, de Zeeuw, D, Greene, T, Jardine, Mj, Heerspink, Hjl, Levin, A, Meininger, G, Neal, B, Pollock, C, Wheeler, Dc, Zhang, H, Zinman, B, Mcguire, Dk, Holman, R, Home, P, Scharfstein, D, Parfrey, P, Shahinfar, S, August, P, Chang, T, Sinha, Ad, Januzzi, J, Kolansky, D, Amerena, J, Hillis, G, Gorelick, P, Kissela, B, Kasner, S, Lindley, R, Fulcher, G, Ounadjela, S, Hufert, K, von Ingersleben, G, Gaglia, J, Harris, R, Hudson, M, Turchin, A, Cheifetz, A, Sheth, S, Feuerstein, J, Cohen, S, Jardine, M, Li, N, Kolesnyk, I, Aizenberg, D, Pecoits-Filho, R, Cherney, D 3rd, Obrador, G, Chertow, G, Hawley, C, Ji, L, Wada, T, Jha, V, Lim, Sk, Lim-Abrahan, Ma, Santos, F, Chae, Dw, Hwang, Sj, Vazelov, E, Rychlík, I, Hadjadj, S, Krane, V, Rosivall, L, De Nicola, L, Dreval, A, Nowicki, M, Schiller, A, Distiller, L, Górriz, Jl, Kolesnyk, M

مصطلحات موضوعية: diabetic nephropathy

الوصف: BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30990260; info:eu-repo/semantics/altIdentifier/wos/WOS:000471299100008; volume:380 (24); firstpage:2295; lastpage:2306; numberofpages:12; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11567/947620Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85066483412

الإتاحة: https://doi.org/10.1056/NEJMoa1811744Test
http://hdl.handle.net/11567/947620Test