المؤلفون: Mishra, A, Zhou, B, Rodriguez-Martinez, A, Bixby, H, Singleton, RK, Carrillo-Larco, RM, Sheffer, KE, Paciorek, CJ, Bennett, JE, Lhoste, V, Iurilli, MLC, Di Cesare, M, Bentham, J, Phelps, NH, Sophiea, MK, Stevens, GA, Danaei, G, Cowan, MJ, Savin, S, Riley, LM, Gregg, EW, Aekplakorn, W, Ahmad, NA, Baker, JL, Chirita-Emandi, A, Farzadfar, F, Fink, G, Heinen, M, Ikeda, N, Kengne, AP, Khang, YH, Laatikainen, T, Laxmaiah, A, Ma, J, Monroy-Valle, M, Mridha, MK, Padez, CP, Reynolds, A, Soric, M, Starc, G, Wirth, JP, Abarca-Gomez, L, Abdeen, ZA, Abdrakhmanova, S, Ghaffar, SA, Rahim, HFA, Abdurrahmonova, Z, Abu-Rmeileh, NM, Garba, JA, Acosta-Cazares, B, Adam, I, Adamczyk, M, Adams, RJ, Adu-Afarwuah, S, Afsana, K, Afzal, S, Agbor, VN, Agdeppa, IA, Aghazadeh-Attari, J, Aguenaou, H, Aguilar-Salinas, CA, Agyemang, C, Ahmad, MH, Ahmadi, A, Ahmadi, N, Ahmed, I, Ahmed, SH, Ahrens, W, Aitmurzaeva, G, Ajlouni, K, Al-Hazzaa, HM, Al-Lahou, B, Al-Raddadi, R, Al Hourani, HM, Al Qaoud, NM, Alarouj, M, AlBuhairan, F, AlDhukair, S, Aldwairji, MA, Alexius, S, Ali, MM, Alkandari, A, Alkerwi, A, Alkhatib, BM, Allin, K, Alvarez-Pedrerol, M, Aly, E, Amarapurkar, DN, Etxezarreta, PA, Amoah, J, Amougou, N, Amouyel, P, Andersen, LB, Anderssen, SA, Androutsos, O, Angquist, L, Anjana, RM, Ansari-Moghaddam, A, Anufrieva, E, Aounallah-Skhiri, H, Araujo, J, Ariansen, I, Aris, T, Arku, RE, Arlappa, N, Aryal, KK, Aseffa, N, Aspelund, T, Assah, FK, Assembekov, B, Assuncao, MCF, Aung, MS, Auvinen, J, Avdicova, M, Avi, S, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Azmin, M, Babu, BV, Jorgensen, MB, Baharudin, A, Bahijri, S, Bakacs, M, Balakrishna, N, Balanova, Y, Bamoshmoosh, M, Banach, M, Banegas, JR, Baran, J, Baran, R, Barbagallo, CM, Barbosa, V, Barcelo, A, Baretic, M, Barkat, A, Barnoya, J, Barrera, L, Barreto, M, Barros, AJD, Barros, MVG, Bartosiewicz, A, Basit, A, Bastos, JLD, Bata, I, Batieha, AM, Batista, AP, Batista, RL, Battakova, Z, Baur, LA, Bayauli, PM, Beaglehole, R, Bel-Serrat, S, Belavendra, A, Ben Romdhane, H, Benedics, J, Benet, M, Rolandi, GEB, Bere, E, Bergh, IH, Berhane, Y, Berkinbayev, S, Bernabe-Ortiz, A, Bernotiene, G, Carrasola, XB, Bettiol, H, Beutel, ME, Beybey, AF, Bezerra, J, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, HS, Bi, YF, Bia, D, Biasch, K, Lele, ECB, Bikbov, MM, Bista, B, Bjelica, DJ, Bjerregaard, AA, Bjerregaard, P, Bjertness, E, Bjertness, MB, Bjorkelund, C, Bloch, KV, Blokstra, A, Magnazu, MB, Bo, S, Bobak, M, Boddy, LM, Boehm, BO, Boer, JMA, Boggia, JG, Bogova, E, Boissonnet, CP, Bojesen, SE, Bonaccio, M, Bongard, V, Bonilla-Vargas, A, Bopp, M, Borghs, H, Bovet, P, Boymatova, K, Braeckevelt, L, Braeckman, L, Bragt, MCE, Brajkovich, I, Branca, F, Breckenkamp, J, Breda, J, Brenner, H, Brewster, LM, Brian, GR, Briceno, Y, Brinduse, L, Brito, M, Brophy, S, Brug, J, Bruno, G, Bugge, A, Buntinx, F, Buoncristiano, M, Burazeri, G, Burns, C, de Leon, AC, Cacciottolo, J, Cai, H, Caixeta, RB, Cama, T, Cameron, C, Camolas, J, Can, G, Candido, APC, Canete, F, Capanzana, MV, Capkova, N, Capuano, E, Capuano, R, Capuano, V, Cardol, M, Cardoso, VC, Carlsson, AC, Carmuega, E, Carvalho, J, Casajus, JA, Casanueva, FF, Casas, M, Celikcan, E, Censi, L, Cervantes-Loaiza, M, Cesar, JA, Chamukuttan, S, Chan, A, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Rahim, NCA, Chee, ML, Chen, CJ, Chen, FF, Chen, HS, Chen, SH, Chen, ZM, Cheng, CY, Cheng, YLJ, Cheraghian, B, Chetrit, A, Chikova-Iscener, E, Chinapaw, MJM, Chinnock, A, Chiolero, A, Chiou, ST, Chirlaque, MD, Cho, B, Christensen, K, Christofaro, DG, Chudek, J, Cifkova, R, Cilia, M, Cinteza, E, Cirillo, M, Claessens, F, Clarke, J, Clays, E, Cohen, E, Compan-Gabucio, LM, Concin, H, Confortin, SC, Cooper, C, Coppinger, TC, Corpeleijn, E, Cortes, LY, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crampin, AC, Cross, AJ, Crujeiras, AB, Cruz, JJ, Csanyi, T, Csilla, S, Cucu, AM, Cui, LF, Cureau, FV, Cuschieri, S, Czenczek-Lewandowska, E, D'Arrigo, G, d'Orsi, E, Dacica, L, Dallongeville, J, Damasceno, A, Damsgaard, CT, Dankner, R, Dantoft, TM, Dasgupta, P, Dastgiri, S, Dauchet, L, Davletov, K, de Assis, MAA, De Backer, G, De Bacquer, D, De Curtis, A, Hinnig, PD, de Gaetano, G, De Henauw, S, De Miguel-Etayo, P, de Oliveira, PD, De Ridder, D, De Ridder, K, de Rooij, SR, De Smedt, D, Deepa, M, Deev, AD, DeGennaro, V, Delisle, H, Delpeuch, F, Demarest, S, Dennison, E, Deren, K, Deschamps, V, Dhimal, M, Di Castelnuovo, A, Dias-da-Costa, JS, Diaz-Sanchez, ME, Diaz, A, Fernandez, PD, Ripolles, MPD, Dika, Z, Djalalinia, S, Djordjic, V, Do, HTP, Dobson, AJ, Dominguez, L, Donati, MB, Donfrancesco, C, Dong, GH, Dong, YH, Donoso, SP, Doring, A, Dorobantu, M, Dorosty, AR, Doua, K, Dragano, N, Drygas, W, Duan, JL, Duante, CA, Duboz, P, Duleva, VL, Dulskiene, V, Dumith, SC, Dushpanova, A, Dyussupova, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Echeverria, G, Eddie, R, Eftekhar, E, Egbagbe, EE, Eggertsen, R, Eghtesad, S, Eiben, G, Ekelund, U, El-Khateeb, M, El Ammari, L, El Ati, J, Eldemire-Shearer, D, Eliasen, M, Elliott, P, Endevelt, R, Engle-Stone, R, Erasmus, RT, Erbel, R, Erem, C, Ergor, G, Eriksen, L, Eriksson, JG, Escobedo-de la Pena, J, Eslami, S, Esmaeili, A, Evans, A, Faeh, D, Fakhradiyev, I, Fakhretdinova, AA, Fall, CH, Faramarzi, E, Farjam, M, Sant'Angelo, VF, Fattahi, MR, Fawwad, A, Fawzi, WW, Feigl, E, Felix-Redondo, FJ, Ferguson, TS, Fernandes, RA, Fernandez-Berges, D, Ferrante, D, Ferrao, T, Ferrari, G, Ferrari, M, Ferrario, MM, Ferreccio, C, Ferreira, HS, Ferrer, E, Ferrieres, J, Figueiro, TH, Fijalkowska, A, Fisberg, M, Fischer, K, Foo, LH, Forsner, M, Fouad, HM, Francis, DK, Franco, MD, Fras, Z, Frontera, G, Fuchs, FD, Fuchs, SC, Fujiati, II, Fujita, Y, Fumihiko, M, Furdela, V, Furusawa, T, Gaciong, Z, Gafencu, M, Cuesta, MG, Galbarczyk, A, Galenkamp, H, Galeone, D, Galfo, M, Galvano, F, Gao, JL, Gao, P, Garcia-de-la-Hera, M, Merida, MJG, Solano, MG, Gareta, D, Garnett, SP, Gaspoz, JM, Gasull, M, Gaya, ACA, Gaya, AR, Gazzinelli, A, Gehring, U, Geiger, H, Geleijnse, JM, George, R, Ghaderi, E, Ghanbari, A, Ghasemi, E, Gheorghe-Fronea, OF, Gialluisi, A, Giampaoli, S, Gianfagna, F, Gieger, C, Gill, TK, Giovannelli, J, Gironella, G, Giwercman, A, Gkiouras, K, Glushkova, N, Gluskova, N, Godara, R, Godos, J, Gogen, S, Goldberg, M, Goltzman, D, Gomez, G, Gomez, JHG, Gomez, LF, Gomez, SF, Gomula, A, da Silva, BGC, Goncalves, H, Goncalves, M, Gonzalez-Alvarez, AD, Gonzalez-Chica, DA, Gonzalez-Gil, EM, Gonzalez-Gross, M, Gonzalez-Leon, M, Gonzalez-Rivas, JP, Gonzalez-Villalpando, C, Gonzalez-Villalpando, ME, Gonzalez, AR, Gottrand, F, Graca, AP, Graff-Iversen, S, Grafnetter, D, Grajda, A, Grammatikopoulou, MG, Gregor, RD, Gregorio, MJ, Groholt, EK, Grontved, A, Grosso, G, Gruden, G, Gu, DF, Guajardo, V, Gualdi-Russo, E, Guallar-Castillon, P, Gualtieri, A, Gudmundsson, EF, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Gunter, MJ, Guo, XH, Guo, Y, Gupta, PC, Gupta, R, Gureje, O, Gonzalez, EG, Gutierrez, L, Gutzwiller, F, Gwee, X, Ha, S, Hadaegh, F, Hadjigeorgiou, CA, Haghshenas, R, Hakimi, H, Halkjaer, J, Hambleton, IR, Hamzeh, B, Hanekom, WA, Hange, D, Hanif, AAM, Hantunen, S, Hao, J, Hardman, CM, Kumar, RH, Lassen, TH, Harooni, J, Hashemi-Shahri, SM, Hassapidou, M, Hata, J, Haugsgjerd, T, Hayes, AJ, He, J, He, Y, He, YN, Heidinger-Felso, R, Heier, M, Hejgaard, T, Hendriks, ME, Henrique, RD, Henriques, A, Cadena, LH, Herrala, S, Herrera-Cuenca, M, Herrera, VM, Herter-Aeberli, I, Herzig, KH, Heshmat, R, Hill, AG, Ho, SY, Ho, SC, Hobbs, M, Hofelmann, DA, Holdsworth, M, Homayounfar, R, Homs, C, Hopman, WM, Horimoto, ARVR, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Htike, MMT, Hu, YH, Huerta, JM, Huhtaniemi, IT, Huiart, L, Petrescu, CH, Huisman, M, Husseini, A, Huu, CN, Huybrechts, I, Hwalla, N, Hyska, J, Iacoviello, L, Iakupova, EM, Ibarluzea, JM, Ibrahim, MM, Wong, NI, Ikram, MA, Iniguez, C, Iotova, V, Irazola, VE, Ishida, T, Isiguzo, GC, Islam, M, Islam, SMS, Islek, D, Ivanova-Pandourska, IY, Iwasaki, M, Jaaskelainen, T, Jackson, RT, Jacobs, JM, Jadoul, M, Jafar, T, Jallow, B, James, K, Jamil, KM, Jamrozik, K, Jansson, A, Janszky, I, Janus, E, Jarani, J, Jarvelin, MR, Jasienska, G, Jelakovic, A, Jelakovic, B, Jennings, G, Jiang, CQ, Jimenez, RO, Jockel, KH, Joffres, M, Jokelainen, JJ, Jonas, JB, Jonnagaddala, J, Jorgensen, T, Joshi, P, Josipovic, J, Joukar, F, Jozwiak, JJ, Judge, DS, Juolevi, A, Jurak, G, Simina, IJ, Juresa, V, Kaaks, R, Kaducu, FO, Kafatos, A, Kaj, M, Kajantie, EO, Kakutia, N, Kallayova, D, Kalmatayeva, Z, Kalter-Leibovici, O, Kameli, Y, Kampmann, FB, Kanala, KR, Kannan, S, Kapantais, E, Karaglani, E, Karakosta, A, Karhus, LL, Karki, KB, Katchunga, PB, Katibeh, M, Katz, J, Katzmarzyk, PT, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, GM, Kaze, FF, Ke, C, Keil, U, Boker, LK, Keinanen-Kiukaanniemi, S, Kelishadi, R, Kelleher, C, Kemper, HCG, Keramati, M, Kerimkulova, A, Kersting, M, Key, T, Khader, YS, Khaledifar, A, Khalili, D, Khaw, KT, Kheiri, B, Kheradmand, M, Khosravi, A, Khouw, IMSL, Kiechl-Kohlendorfer, U, Kiechl, SJ, Kiechl, S, Killewo, J, Kim, HC, Kim, J, Kindblom, JM, Kingston, A, Klakk, H, Klimek, M, Klimont, J, Klumbiene, J, Knoflach, M, Koirala, B, Kolle, E, Kolsteren, P, Konig, J, Korpelainen, R, Korrovits, P, Korzycka, M, Kos, J, Koskinen, S, Kouda, K, Kovacs, E, Kovacs, VA, Kovalskys, I, Kowlessur, S, Koziel, S, Kratenova, J, Kratzer, W, Kriaucioniene, V, Kriemler, S, Kristensen, PL, Krizan, H, Kroker-Lobos, MF, Krokstad, S, Kromhout, D, Kruger, HS, Kruger, R, Kryst, L, Kubinova, R, Kuciene, R, Kujala, UM, Kujundzic, E, Kulaga, Z, Kulimbet, M, Kumar, RK, Kunesova, M, Kurjata, P, Kusuma, YS, Kutsenko, V, Kuulasmaa, K, Kyobutungi, C, La, QN, Laamiri, FZ, Lachat, C, Lackner, KJ, Laid, Y, Lall, L, Lam, TH, Jimenez, ML, Landais, E, Lanska, V, Lappas, G, Larijani, B, Larissa, SP, Latt, TS, Laurenzi, M, Lauria, L, Lazo-Porras, M, Le Coroller, G, Bao, KLN, Le Port, A, Le, TD, Lee, J, Lee, PH, Lehmann, N, Lehtimaki, T, Lemogoum, D, Leskosek, B, Leszczak, J, Leth-Moller, KB, Leung, GM, Levitt, NS, Li, YP, Liivak, M, Lilly, CL, Lim, C, Lim, WY, Lima-Costa, MF, Lin, HH, Lin, X, Lin, YT, Lind, L, Lingam, V, Linkohr, B, Linneberg, A, Lissner, L, Litwin, M, Liu, J, Liu, LJ, Lo, WC, Loit, HM, Long, KQ, Abril, GL, Lopes, L, Lopes, MVV, Lopes, O, Lopez-Garcia, E, Lopez, T, Lotufo, PA, Lozano, JE, Lukrafka, JL, Luksiene, D, Lundqvist, A, Lunet, N, Lunogelo, C, Lustigova, M, Luszczki, E, M'Buyamba-Kabangu, JR, Ma, GS, Ma, X, Machado-Coelho, GLL, Machado-Rodrigues, AM, Macia, E, Macieira, LM, Madar, AA, Madsen, AL, Maestre, GE, Maggi, S, Magliano, DJ, Magnacca, S, Magriplis, E, Mahasampath, G, Maire, B, Majer, M, Makdisse, M, Maki, P, Malekzadeh, F, Malekzadeh, R, Malhotra, R, Rao, KM, Malyutina, SK, Maniego, LV, Manios, Y, Manix, MI, Mann, JI, Mansour-Ghanaei, F, Manyanga, T, Manzato, E, Marcil, A, Margozzini, P, Marino, J, Markaki, A, Markey, O, Ioannidou, EM, Marques-Vidal, P, Marques, LP, Marrugat, J, Martin-Prevel, Y, Martin, R, Martorell, R, Martos, E, Maruszczak, K, Marventano, S, Masala, G, Mascarenhas, LP, Masoodi, SR, Mathiesen, EB, Mathur, P, Matijasevich, A, Matlosz, P, Matsha, TE, Matsudo, V, Mavrogianni, C, Mazur, A, Mbanya, JCN, McFarlane, SR, McGarvey, ST, McKee, M, McLachlan, S, McLean, RM, McLean, SB, McNairy, ML, McNulty, BA, Benchekor, SM, Medzioniene, J, Mehdipour, P, Mehlig, K, Mehrparvar, AH, Meirhaeghe, A, Meisfjord, J, Meisinger, C, Melgarejo, JD, Melkumova, M, Mello, J, Mendez, F, Mendivil, CO, Menezes, AMB, Menon, GR, Mensink, GBM, Menzano, MT, Meshram, II, Meto, DT, Mi, J, Michaelsen, KF, Michels, N, Mikkel, K, Milkowska, K, Miller, JC, Milushkina, O, Minderico, CS, Mini, GK, Miquel, JF, Miranda, JJ, Mirjalili, MR, Mirkopoulou, D, Mirrakhimov, E, Misigoj-Durakovic, M, Mistretta, A, Mocanu, V, Modesti, PA, Moghaddam, SS, Mohajer, B, Mohamed, MK, Mohamed, SF, Mohammad, K, Mohammadi, MR, Mohammadi, Z, Mohammadifard, N, Mohammadpourhodki, R, Mohan, V, Mohanna, S, Yusoff, MFM, Mohebbi, I, Mohebi, F, Moitry, M, Mollehave, LT, Moller, NC, Molnar, D, Momenan, A, Mondo, CK, Mendoza, RAM, Monterrubio-Flores, E, Monyeki, KDK, Moon, JS, Moosazadeh, M, Mopa, HT, Moradpour, F, Moreira, LB, Morejon, A, Moreno, LA, Morey, F, Morgan, K, Morin, SN, Mortensen, EL, Moschonis, G, Moslem, A, Mossakowska, M, Mostafa, A, Mostafavi, SA, Mota-Pinto, A, Mota, J, Motlagh, ME, Motta, J, Moura-dos-Santos, MA, Movsesyan, Y, Msyamboza, KP, Mu, TT, Muc, M, Muca, F, Mugosa, B, Muiesan, ML, Muller-Nurasyid, M, Munzel, T, Mursu, J, Murtagh, EM, Musa, KI, Milanovic, SM, Musil, V, Musinguzi, G, Muyer, MTMC, Nabipour, I, Naderimagham, S, Nagel, G, Najafi, F, Nakamura, H, Nalecz, H, Namesna, J, Nang, EEK, Nangia, VB, Nankap, M, Narake, S, Nardone, P, Naseri, T, Nauck, M, Neal, WA, Nejatizadeh, A, Nekkantti, C, Nelis, K, Nenko, I, Neovius, M, Nervi, F, Ng, TP, Nguyen, CT, Nguyen, ND, Nguyen, QN, Ni, MY, Nicolescu, R, Nie, P, Nieto-Martinez, RE, Nikitin, YP, Ning, G, Ninomiya, T, Nishi, N, Nishtar, S, Noale, M, Noboa, OA, Nogueira, H, Nordendahl, M, Nordestgaard, BG, Noto, D, Nowak-Szczepanska, N, Al Nsour, M, Nuhoglu, I, Nunes, B, Nurk, E, Nuwaha, F, Nyirenda, M, O'Neill, TW, O'Reilly, D, Obreja, G, Ochimana, C, Ochoa-Aviles, AM, Oda, E, Odili, AN, Oh, K, Ohara, K, Ohlsson, C, Ohtsuka, R, Olafsson, O, Olinto, MTA, Oliveira, IO, Omar, MA, Omar, SM, Onat, A, Ong, SK, Onland-Moret, NC, Ono, LM, Ordunez, P, Ornelas, R, Ortiz, AP, Ortiz, PJ, Osler, M, Osmond, C, Ostojic, SM, Ostovar, A, Otero, JA, Overvad, K, Owusu-Dabo, E, Paccaud, FM, Pagkalos, I, Pahomova, E, de Paiva, KM, Pajak, A, Palloni, A, Palmieri, L, Pan, WH, Panda-Jonas, S, Pandey, A, Panza, F, Paoli, M, Papadopoulou, SK, Papandreou, D, Pareja, RG, Park, SW, Park, S, Parnell, WR, Parsaeian, M, Pascanu, IM, Pasquet, P, Patel, ND, Pattussi, M, Pavlyshyn, H, Pechlaner, R, Pecin, I, Pednekar, MS, Pedro, JM, Peer, N, Peixoto, SV, Peltonen, M, Pereira, AC, Peres, MA, Perez, CM, Peterkova, V, Peters, A, Petersmann, A, Petkeviciene, J, Petrauskiene, A, Kovtun, OP, Pettenuzzo, E, Peykari, N, Pfeiffer, N, Phall, MC, Pham, ST, Pichardo, RN, Pierannunzio, D, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pistelli, F, Pitakaka, F, Piwonska, A, Pizarro, AN, Plans-Rubio, P, Platonova, AG, Poh, BK, Pohlabeln, H, Polka, NS, Pop, RM, Popovic, SR, Porta, M, Posch, G, Poudyal, A, Poulimeneas, D, Pouraram, H, Pourfarzi, F, Pourshams, A, Poustchi, H, Pradeepa, R, Price, AJ, Price, JF, Prista, A, Providencia, R, Puder, JJ, Pudule, I, Puiu, M, Punab, M, Qadir, MS, Qasrawi, RF, Qorbani, M, Quintana, HK, Quiroga-Padilla, PJ, Bao, TQ, Rach, S, Radic, I, Radisauskas, R, Rahimikazerooni, S, Rahman, M, Raitakari, O, Raj, M, Rajabov, T, Rakhmatulloev, S, Rakovac, I, Rao, SR, Ramachandran, A, Ramadan, OPC, Ramires, VV, Ramke, J, Ramos, E, Ramos, R, Rampal, L, Rampal, S, Rangelova, LS, Rarra, V, Rascon-Pacheco, RA, Rech, CR, Redon, J, Reganit, PFM, Regecova, V, Renner, JDP, Repasy, JA, Reuter, CP, Revilla, L, Rezaianzadeh, A, Rho, Y, Ribas-Barba, L, Ribeiro, R, Riboli, E, Richter, A, Rigo, F, Rigotti, A, Rinaldo, N, de Wit, TFR, Rito, AI, Ritti-Dias, RM, Rivera, JA, Roa, RG, Robinson, L, Robitaille, C, Roccaldo, R, Rodrigues, D, Rodriguez-Artalejo, F, Rodriguez-Perez, MD, Rodriguez-Villamizar, LA, Rodriguez, AY, Roggenbuck, U, Rohloff, P, Rohner, F, Rojas-Martinez, R, Rojroongwasinkul, N, Romaguera, D, Romeo, EL, Rosario, RV, Rosengren, A, Rouse, I, Rouzier, V, Roy, JGR, Ruano, MH, Rubinstein, A, Ruhli, FJ, Ruidavets, JB, Ruiz-Betancourt, BS, Ruiz-Castell, M, Moreno, ER, Rusakova, IA, Jonsson, KR, Russo, P, Rust, P, Rutkowski, M, Saamel, M, Sabanayagam, C, Sabbaghi, H, Sacchini, E, Sachdev, HS, Sadjadi, A, Safarpour, AR, Safi, S, Safiri, S, Saghi, MH, Saidi, O, Saki, N, Salaj, S, Salanave, B, Martinez, ES, Saleva, C, Salmeron, D, Salomaa, V, Salonen, JT, Salvetti, M, Samoutian, M, Sanchez-Abanto, J, Rodriguez, IS, andjaja, Sans, S, Marina, LS, Santacruz, E, Santos, DA, Santos, IS, Santos, LC, Santos, MP, Santos, O, Santos, R, Santos, TR, Saramies, JL, Sardinha, LB, Sarrafzadegan, N, Sathish, T, Saum, KU, Savva, S, Savy, M, Sawada, N, Sbaraini, M, Scazufca, M, Schaan, BD, Rosario, AS, Schargrodsky, H, Schienkiewitz, A, Schindler, K, Schipf, S, Schmidt, CO, Schmidt, IM, Schneider, A, Schnohr, P, Schottker, B, Schramm, S, Schroder, H, Schultsz, C, Schulze, MB, Schutte, AE, Sebert, S, Sedaghattalab, M, Selamat, R, Sember, V, Sen, A, Senbanjo, IO, Sepanlou, SG, Sequera, G, Serra-Majem, L, Servais, J, Sevcikova, L, Shalnova, S, Shamah-Levy, T, Shamshirgaran, SM, Shanthirani, CS, Sharafkhah, M, Sharma, SK, Shaw, JE, Shayanrad, A, Shayesteh, AA, Shengelia, L, Shi, ZM, Shibuya, K, Shimizu-Furusawa, H, Shimony, T, Shiri, R, Shrestha, N, Si-Ramlee, K, Siani, A, Siantar, R, Sibai, AM, Sidossis, LS, Silitrari, N, Silva, AM, Silva, CRD, Silva, DAS, Silva, KS, Sim, XL, Simon, M, Simons, J, Simons, LA, Sjoberg, A, Sjostrom, M, Skoblina, NA, Skodje, G, Slazhnyova, T, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, So, HK, Soares, FC, Sobek, G, Sobngwi, E, Sodemann, M, Soderberg, S, Soekatri, MYE, Soemantri, A, Sofat, R, Solfrizzi, V, Somi, MH, Sonestedt, E, Song, Y, Soofi, S, Sorensen, TIA, Sorgjerd, EP, Jerome, CS, Soto-Rojas, VE, Soumare, A, Sousa-Poza, A, Sovic, S, Sparboe-Nilsen, B, Sparrenberger, K, Spencer, PR, Spinelli, A, Spiroski, I, Staessen, JA, Stamm, H, Staub, K, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stevanovic, R, Stieber, J, Stockl, D, Stokwiszewski, J, Stoyanova, E, Stratton, G, Stronks, K, Strufaldi, MW, Sturua, L, Suarez-Medina, R, Suka, M, Sun, CA, Sun, L, Sundstrom, J, Sung, YT, Sunyer, J, Suriyawongpaisal, P, Sweis, NWG, Swinburn, BA, Sy, RG, Sylva, RC, Szklo, M, Szponar, L, Tabone, L, Tai, ESO, Tambalis, KD, Tammesoo, ML, Tamosiunas, A, Tan, EJ, Tang, X, Tanrygulyyeva, M, Tanser, F, Tao, Y, Tarawneh, MR, Tarp, J, Tarqui-Mamani, CB, Braunerova, RT, Taylor, A, Taylor, J, Tchibindat, F, Te Velde, S, Tebar, WR, Tell, GS, Tello, T, Tham, YC, Thankappan, KR, Theobald, H, Theodoridis, X, Thomas, N, Thorand, B, Thuesen, BH, Ticha, L, Timmermans, EJ, Tjandrarini, DH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topor-Madry, R, Torheim, LE, Tormo, MJ, Tornaritis, MJ, Torrent, M, Torres-Collado, L, Toselli, S, Touloumi, G, Traissac, P, Tran, TTH, Tremblay, MS, Triantafyllou, A, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tsao, YH, Tshepo, L, Tsigga, M, Tsintavis, P, Tsugane, S, Tuitele, J, Tuliakova, AM, Tulloch-Reid, MK, Tullu, F, Tuomainen, TP, Tuomilehto, J, Turley, ML, Twig, G, Tynelius, P, Tzala, E, Tzotzas, T, Tzourio, C, Ueda, P, Ugel, E, Ukoli, FAM, Ulmer, H, Unal, B, Usupova, Z, Uusitalo, HMT, Uysal, N, Vaitkeviciute, J, Valdivia, G, Vale, S, Valvi, D, van Dam, RM, van den Born, BJ, Van der Heyden, J, van der Schouw, YT, Van Herck, K, Van Lippevelde, W, Minh, HV, Van Schoor, NM, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Varbo, A, Varela-Moreiras, G, Vargas, LN, Varona-Perez, P, Vasan, SK, Vasques, DG, Vega, T, Veidebaum, T, Velasquez-Melendez, G, Velika, B, Verloigne, M, Veronesi, G, Verschuren, WMM, Victora, CG, Viegi, G, Viet, L, Vik, FN, Vilar, M, Villalpando, S, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vladulescu, M, Vlasoff, T, Vocanec, D, Vollenweider, P, Volzke, H, Voutilainen, A, Vrijheid, M, Vrijkotte, TGM, Wade, AN, Waldhor, T, Walton, J, Wambiya, EOA, Bebakar, WMW, Mohamud, WNW, Wanderley, RD Jr, Wang, MD, Wang, NL, Wang, Q, Wang, XJ, Wang, YX, Wang, YW, Wannamethee, SG, Wareham, N, Weber, A, Webster-Kerr, K, Wedderkopp, N, Weghuber, D, Wei, WB, Weres, A, Werner, B, Westbury, LD, Whincup, PH, Wickramasinghe, K, Widhalm, K, Widyahening, IS, Wiecek, A, Wild, PS, Wilks, RJ, Willeit, J, Willeit, P, Williams, J, Wilsgaard, T, Wojciech, R, Wojtyniak, B, Wolf, K, Wong-McClure, RA, Wong, A, Wong, EB, Wong, JE, Wong, TY, Woo, J, Woodward, M, Wu, FC, Wu, HY, Wu, JF, Wu, LJ, Wu, SL, Wyszynska, J, Xu, HQ, Xu, L, Yaacob, NA, Yamborisut, U, Yan, WL, Yang, L, Yang, XG, Yang, Y, Yardim, N, Yasuharu, T, Garcia, MY, Yiallouros, PK, Yngve, A, Yoosefi, M, Yoshihara, A, You, QS, You, SL, Younger-Coleman, NO, Yu, YL, Yu, YJ, Yusof, SM, Yusoff, AF, Zaccagni, L, Zafiropulos, V, Zainuddin, AA, Zakavi, SR, Zamani, F, Zambon, S, Zampelas, A, Zamrazilova, H, Zapata, ME, Zargar, AH, Zaw, KK, Zayed, AA, Zdrojewski, T, Zeglen, M, Zejglicova, K, Vrkic, TZ, Zeng, Y, Zhang, LX, Zhang, ZY, Zhao, D, Zhao, MH, Zhao, WH, Zhecheva, YV, Zhen, SQ, Zheng, W, Zheng, YF, Zholdin, B, Zhou, MG, Zhu, D, Zins, M, Zitt, E, Zocalo, Y, Zoghlami, N, Cisneros, JZ, Zuziak, M, Bhutta, ZA, Black, RE, Ezzati, M

المصدر: Nature. 615(7954):874-883

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:153300414Test

المؤلفون: Mastropaolo, Antonio, Nardone, Vittoria, Bavota, Gabriele, Di Penta, Massimiliano

مصطلحات موضوعية: Computer Science - Software Engineering

الوصف: Generative deep learning (DL) models have been successfully adopted for vulnerability patching. However, such models require the availability of a large dataset of patches to learn from. To overcome this issue, researchers have proposed to start from models pre-trained with general knowledge, either on the programming language or on similar tasks such as bug fixing. Despite the efforts in the area of automated vulnerability patching, there is a lack of systematic studies on how these different training procedures impact the performance of DL models for such a task. This paper provides a manyfold contribution to bridge this gap, by (i) comparing existing solutions of self-supervised and supervised pre-training for vulnerability patching; and (ii) for the first time, experimenting with different kinds of prompt-tuning for this task. The study required to train/test 23 DL models. We found that a supervised pre-training focused on bug-fixing, while expensive in terms of data collection, substantially improves DL-based vulnerability patching. When applying prompt-tuning on top of this supervised pre-trained model, there is no significant gain in performance. Instead, prompt-tuning is an effective and cheap solution to substantially boost the performance of self-supervised pre-trained models, i.e., those not relying on the bug-fixing pre-training.

الوصول الحر: http://arxiv.org/abs/2404.17896Test

المؤلفون: Iglesias, Jose Manuel, Nardone, Alejandra, Rengel, Raul, Kalna, Karol, Martin, Maria J., Pascual, Elena

المصدر: 2D Materials, 14, 025011 (2023)

مصطلحات موضوعية: Physics - Applied Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science

الوصف: The effect of degeneracy and the impact of free-carrier screening on a low-field mobility and a high-field drift velocity in MoS2 and WS2 are explored using an in-house ensemble Monte Carlo simulator. Electron low field mobility increases to 8400 cm2/Vs for MoS2 and to 12040 cm2/Vs for WS2 when temperature decreases to 77 K and carrier concentration is around 5e12 cm-2. In the case of holes, best mobility values were 9320 cm2/Vs and 13290 cm2 per Vs, reached at 77 K, while at room temperature these fall to 80 cm2/Vs and 150 cm2/Vs for MoS2 and WS2, respectively. The carrier screening effect plays a major role at low fields, and low and intermediate temperatures, where a combination of large occupancy of primary valleys and carrier-phonon interactions dominated by relatively low energy exchange processes results in an enhanced screening of intrinsic scattering. For electrons, degeneracy yields to transport in secondary valleys, which plays an important role in the decrease of the low field mobility at high concentrations and/or at room temperature. The high-field drift velocity is not much affected by carrier screening because of an increased carrier scattering with surface optical polar phonons, favouring larger phonon wavevector interactions with small dielectric function values.
Comment: 10 pages, 5 figures. Published in 2D Materials, 14, 025011 (2023)

الوصول الحر: http://arxiv.org/abs/2402.07835Test

المؤلفون: Trpchevska, N, Freidin, MB, Broer, L, Oosterloo, BC, Yao, SY, Zhou, YT, Vona, B, Bishop, C, Bizaki-Vallaskangas, A, Canlon, B, Castellana, F, Chasman, DI, Cherny, S, Christensen, K, Concas, MP, Correa, A, Elkon, R, Mengel-From, J, Gao, Y, Giersch, ABS, Girotto, G, Gudjonsson, A, Gudnason, V, Heard-Costa, NL, Hertzano, R, Hjelmborg, JVB, Hjerling-Leffler, J, Hoffman, HJ, Kaprio, J, Kettunen, J, Krebs, K, Kahler, AK, Lallemend, F, Launer, LJ, Lee, IM, Leonard, H, Li, CM, Lowenheim, H, Magnusson, PKE, van Meurs, J, Milani, L, Morton, CC, Makitie, A, Nalls, MA, Nardone, GG, Nygaard, M, Palviainen, T, Pratt, S, Quaranta, N, Ramo, J, Saarentaus, E, Sardone, R, Satizabal, CL, Schweinfurth, JM, Seshadri, S, Shiroma, E, Shulman, E, Simonsick, E, Spankovich, C, Tropitzsch, A, Lauschke, VM, Sullivan, PF, Goedegebure, A, Cederroth, CR, Williams, FM, Nagtegaal, AP

المصدر: American journal of human genetics. 109(6):1077-1091

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:150182567Test

المؤلفون: Riddell, A, Cook, A, Khavessian, N, Ellis, S, Bilardi, D, Correia, E, Kostyanev, T, Nardone, A, Russell, N, Vilken, T, Stohr, W, Adhisivam, B, de Moraes, IRA, Ahmed, NU, Bekker, A, Berezin, EN, Boonkasidecha, S, Carvalheiro, CG, Chauhan, P, Chiurchiu, S, Chorafa, E, Dramowski, A, Madhusudhan, DS, Feng, JX, Jia, SN, Kong, Y, Kyohere, M, Kontou, A, Lochindarat, S, De Luca, M, Mphaphuli, A, Mussi-Pinhata, MM, Murunga, S, Nakwa, FL, Nangia, S, Nassolo, E, Hoang, NTB, Obiero, CW, Olson, L, Ping, W, Plakkal, N, Prasad, P, Preedisripipat, K, Rahman, SW, Seef, T, Sukrakanchana, PO, Thomas, R, Yu, Z, Zhang, QR, Walker, AS, Bielicki, J, Heath, PT, Sharland, M, Munera-Huertas, T

المصدر: Antibiotics (Basel, Switzerland). 12(5)

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:153132342Test

المؤلفون: Albert Grinshpun, Douglas Russo, Wen Ma, Ana Verma, Francisco Hermida-Prado, Shira Sherman, Giorgio Gaglia, Sheheryar Kabraji, Gregory Kirkner, Melissa E. Hughes, Nancy U. Lin, Zachary Sandusky, Agostina Nardone, Cristina Guarducci, Quang-De Nguyen, Sandro Santagata, Zsuzsanna Nagy, Rinath Jeselsohn

المصدر: npj Breast Cancer, Vol 10, Iss 1, Pp 1-12 (2024)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract The ESR1 ligand binding domain activating mutations are the most prevalent genetic mechanism of acquired endocrine resistance in metastatic hormone receptor-positive breast cancer. These mutations confer endocrine resistance that remains estrogen receptor (ER) dependent. We hypothesized that in the presence of the ER mutations, continued ER blockade with endocrine therapies that target mutant ER is essential for tumor suppression even with chemotherapy treatment. Here, we conducted comprehensive pre-clinical in vitro and in vivo experiments testing the efficacy of adding fulvestrant to fluorouracil (5FU) and the 5FU pro-drug, capecitabine, in models of wild-type (WT) and mutant ER. Our findings revealed that while this combination had an additive effect in the presence of WT-ER, in the presence of the Y537S ER mutation there was synergy. Notably, these effects were not seen with the combination of 5FU and selective estrogen receptor modulators, such as tamoxifen, or in the absence of intact P53. Likewise, in a patient-derived xenograft (PDX) harboring a Y537S ER mutation the addition of fulvestrant to capecitabine potentiated tumor suppression. Moreover, multiplex immunofluorescence revealed that this effect was due to decreased cell proliferation in all cells expressing ER and was not dependent on the degree of ER expression. Taken together, these results support the clinical investigation of the combination of ER antagonists with capecitabine in patients with metastatic hormone receptor-positive breast cancer who have experienced progression on endocrine therapy and targeted therapies, particularly in the presence of an ESR1 activating mutation.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2374-4677Test

الوصول الحر: https://doaj.org/article/7c7a103652a4404eac1f649798184d56Test

المؤلفون: Chappell, E, Turkova, A, Goetghebuer, T, Jackson, C, Chiappini, E, Galli, L, Gingaras, C, Judd, A, Spoulou, V, Lisi, C, Ansone, S, Wolfs, T, Marczynska, M, Ene, L, Plotnikova, Y, Voronin, E, Samarina, A, Jourdain, G, Ngo-Giang-Huong, N, Fortuny, C, Navarro, ML, Ramos, JT, Naver, L, Crisinel, PA, Bailey, H, Malyuta, R, Volokha, A, Bamford, A, Crichton, S, Foster, C, Thorne, C, Collins, IJ, Giaquinto, C, Gibb, DM, Critchton, S, Duff, C, Goodall, R, Gomezpena, D, Lundin, R, Mangiarini, L, Milanzi, E, Nardone, A, Hainaut, M, Van der Kelen, E, Delforge, M, de Martino, M, Tovo, PA, Gabiano, C, Carloni, I, Larovere, D, Baldi, F, Miniaci, A, Pession, A, Badolato, R, Panto, G, Anastasio, E, Montagnani, C, Venturini, E, Bianchi, L, Allodi, A, Di Biagio, A, Grignolo, S, Giacomet, V, Marchisio, P, Banderali, G, Tagliabue, C, Cellini, M, Bruzzese, E, Di Costanzo, P, Lo Vecchio, A, Dona, D, Rampon, O, Romano, A, Dodi, I, Esposito, S, Zuccaro, V, Zanaboni, D, Consolini, R, Bernardi, S, Genovese, O, Cristiano, L, Mazza, A, Garazzino, S, Mignone, F, Silvestro, E, Portelli, V, Pajkrt, D, Scherpbier, HJ, Weijsenfeld, AM, de Boer, CG, Jurriaans, S, Back, NKT, Zaaijer, HL, Berkhout, B, Cornelissen, MTE, Schinkel, CJ, Wolthers, KC, Fraaij, PLA, van Rossum, AMC, Vermont, CL, van der Knaap, LC, Visser, EG, Boucher, CAB, Koopmans, MPG, van Kampen, JJA, Pas, SD, Henriet, SSV, van de Flier, M, van Aerde, K, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, FF, Scholvinck, EH, de Groot-de Jonge, H, Niesters, HGM, van Leer-Buter, CC, Knoester, M, Bont, LJ, Geelen, SPM, Wolfs, TFW, Nauta, N, Schuurman, R, Verduyn-Lunel, F, Wensing, AMJ, Reiss, P, Zaheri, S, Bezemer, DO, van Sighem, AI, Smit, C, Wit, FWMN, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Grivell, S, Meijering, R, Raethke, M, Rutkens, T, de Groot, L, van den Akker, M, Bakker, Y, Bezemer, M, El Berkaoui, A, Geerlinks, J, Koops, J, Kruijne, E, Lodewijk, C, Lucas, E, van der Meer, R, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, van de Sande, L, Schoorl, M, Schnorr, P, Tuijn, E, Veenenberg, L, van der Vliet, S, Wisse, A, Witte, EC, Tuk, B, Popielska, J, Pokorska-Spiewak, M, Oldakowska, A, Zawadka, K, Coupland, U, Doroba, M, Okhonskaia, L, Miloenko, M, Labutina, S, Soler-Palacin, P, Frick, MA, Perez-Hoyos, S, Mur, A, Lopez, N, Mendez, M, Mayol, L, Vallmanya, T, Calavia, O, Garcia, L, Coll, M, Pineda, V, Rius, N, Rovira, N, Duenas, J, Noguera-Julian, A, Mellado, MJ, Escosa, L, Hortelano, MG, Sainz, T, Gonzalez-Tome, MI, Rojo, P, Blazquez, D, Prieto, L, Guillen, S, Saavedra, J, Santos, M, Munoz, MA, Ruiz, B, Mc Phee, CF, de Ory, SJ, Alvarez, S, Roa, MA, Beceiro, J, Martinez, J, Badillo, K, Apilanez, M, Pocheville, I, Garrote, E, Colino, E, Sirvent, JG, Garzon, M, Roman, V, Montesdeoca, A, Mateo, M, Munoz, MJ, Angulo, R, Neth, O, Falcon, L, Terol, P, Santos, JL, Moreno, D, Lendinez, F, Grande, A, Romero, FJ, Perez, C, Lillo, M, Losada, B, Herranz, M, Bustillo, M, Guerrero, C, Collado, P, Couceiro, JA, Perez, A, Piqueras, AI, Breton, R, Segarra, I, Gavilan, C, Jareno, E, Montesinos, E, Dapena, M, Alvarez, C, Andres, AG, Marugan, V, Ochoa, C, Alfayate, S, Menasalvas, AI, de Miguel, E, Soeria-Atmadja, S, Belfrage, E, Hagas, V, Aebi-Popp, K, Anagnostopoulos, A, Asner, S, Battegay, M, Baumann, M, Bernasconi, E, Boni, J, Braun, DL, Bucher, HC, Calmy, A, Cavassini, M, Ciuffi, A, Duppenthaler, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Francini, K, Furrer, H, Fux, CA, Grawe, C, Gunthard, HF, Haerry, D, Hasse, B, Hirsch, HH, Hoffmann, M, Hosli, I, Huber, M, Kahlert, CR, Kaiser, L, Keiser, O, Klimkait, T, Kottanattu, L, Kouyos, RD, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, BM, Marzolini, C, Metzner, KJ, Muller, N, Nicca, D, Paioni, P, Pantaleo, G, Perreau, M, Ch, P, Rauch, A, Rudin, C, Scherrer, AU, Schmid, P, Speck, R, Stockle, M, Tarr, P, Lecompte, MT, Trkola, A, Vernazza, P, Wagner, N, Wandeler, G, Weber, R, Wyler, CA, Yerly, S, Wannarit, P, Techakunakorn, P, Hansudewechakul, R, Kham, C, Wanchaitanawong, V, Theansavettrakul, S, Sai, M, Nanta, S, Ngampiyaskul, C, Phanomcheong, S, Hongsiriwon, S, Karnchanamayul, W, Chacheongsao, B, Kwanchaipanich, R, Kanjanavanit, S, Prapinklao, S, Kamonpakorn, N, Nantarukchaikul, M, Adulyadej, B, Layangool, P, Mekmullica, J, Lucksanapisitkul, P, Watanayothin, S, Lertpienthum, N, Yai, H, Warachit, B, Kaen, K, Hanpinitsak, S, Khai, N, Potchalongsin, S, Thanasiri, P, Krikajornkitti, S, Attavinijtrakarn, P, Srirojana, S, Bunjongpak, S, Puangsombat, A, Na-Rajsima, S, Ananpatharachai, P, Akarathum, N, Phuket, V, Lawtongkum, W, Kheunjan, P, Suriyaboon, T, Saipanya, A, Than-In-At, K, Jaisieng, N, Suaysod, R, Chailoet, S, Naratee, N, Kawilapat, S, Kaleeva, T, Baryshnikova, Y, Soloha, S, Bashkatova, N, Raus, I, Glutshenko, O, Ruban, Z, Prymak, N, Kiseleva, G, Lyall, H, Butler, K, Doerholt, K, Doherty, C, Harrison, I, Kenny, J, Klein, N, Letting, G, McMaster, P, Murau, F, Nsangi, E, Prime, K, Riordan, A, Shackley, F, Shingadia, D, Storey, S, Tudor-Williams, G, Welch, S, Cook, C, Dobson, D, Fairbrother, K, Le Prevost, M, Van Looy, N, Peters, H, Francis, K, Thrasyvoulou, L, Fidler, K, Bernatoniene, J, Manyika, F, Sharpe, G, Subramaniam, B, Hague, R, Price, V, Flynn, J, Cardoso, A, Abou-Rayyah, M, Yeadon, S, Segal, S, Hawkins, S, Dowie, M, Bandi, S, Percival, E, Eisenhut, M, Duncan, K, Anguvaa, L, Wren, L, Flood, T, Pickering, A, Murphy, C, Daniels, J, Lees, Y, Thompson, F, Williams, A, Williams, B, Pope, S, Libeschutz, S, Cliffe, L, Southall, S, Freeman, A, Freeman, H, Christie, S, Gordon, A, Hague, DR, Clarke, L, Jones, L, Brown, L, Greenberg, M, Benson, C, Ibberson, L, Patel, S, Hancock, J, Sharland, M, Lyall, EGH, Seery, P, Kirkhope, N, Raghunanan, S, Callaghan, A, Bridgwood, A, Evans, J, Blake, E, Yannoulias, A

المصدر: AIDS (London, England). 35(12):1973-1985

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Infektionsmedicin, Pediatrik, Hälsovetenskap, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:147953831Test

المؤلفون: Giberson, Jeremy, Nardone, Natalie, Addo, Newton, Khan, Sameera, Jacob, Peyton, Benowitz, Neal, St.Helen, Gideon

المصدر: Nicotine & Tobacco Research. 25(8)

مصطلحات موضوعية: Epidemiology, Public Health, Health Sciences, Tobacco Smoke and Health, Substance Misuse, Clinical Research, Brain Disorders, Prevention, Tobacco, Drug Abuse (NIDA only), Good Health and Well Being, Adult, Humans, Male, Female, Nicotine, Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking, Surveys and Questionnaires, Vaping, Clinical Sciences, Public Health and Health Services, Marketing, Public health

الوصف: IntroductionThis study examined user behavior, e-cigarette dependence, and device characteristics on nicotine intake among users of pod-mod e-cigarettes.Aims and methodsIn 2019-2020, people who use pod-mods in the San Francisco Bay Area completed questionnaires and provided a urine sample for analysis of total nicotine equivalents (TNE). The relationship between TNE and e-cigarette use, e-cigarette brands, e-liquid nicotine strength, e-cigarette dependence, and urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), as a measure of combustible cigarette exposure, were examined.ResultsOf 100 participants (64% male, 71% in the 18-34 age group, 45% white), 53 used JUUL primarily, 12 used Puff Bar primarily, and 35 used other brands, including Suorin; 48 participants reported current cigarette smoking. Participants most often reported use of e-liquid with 4.5%-6.0% nicotine (68%), fruit (35%), tobacco (28%), and menthol or mint flavors (26%), used e-cigarettes on 25.5 (SD = 6.3) days a month, 10.2 (SD = 14.2) times a day, and 40% used 1-2 pods/cartridges per week. In bivariate analysis, urinary TNE was higher with greater frequency (days used) and intensity (number of pods used) of e-cigarette use, e-cigarette dependence, and combustible cigarette use. In multivariable analysis, days of e-cigarette use in the last 30 days, number of pods used per week, and NNAL levels were significantly associated with TNE. There was no significant impact of e-liquid nicotine strength on TNE.ConclusionsNicotine intake among people who used pod-mod e-cigarettes increased with e-cigarette consumption and e-cigarette dependence, but not with e-liquid nicotine strength. Our findings may inform whether FDA adopts a nicotine standard for e-cigarettes.ImplicationsThe study examined how device and user characteristics influence nicotine intake among pod-mod e-cigarette users. Nicotine intake increased with frequency (days of e-cigarette use in past 30 days) intensity of use (number of pods used per day) and e-cigarette dependence but not with the flavor or nicotine concentration of the e-liquids. Regulation of nicotine concentration of e-liquids is unlikely to influence nicotine exposure among adult experienced pod-mod users.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7gm5809bTest

المؤلفون: Sara Del Tufo, Umberto Atripaldi, Antonella Nicastro, Iacopo Panarese, Davide Ciardiello, Valerio Nardone, Francesco Selvaggi, Roberto Grassi, Salvatore Cappabianca, Erika Martinelli, Alfonso Reginelli

المصدر: Radiology Case Reports, Vol 19, Iss 9, Pp 3626-3630 (2024)

مصطلحات موضوعية: Rectal cancer, Biomarkers, Perineural invasion, MRI, Staging, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Treatment of rectal cancer has improved over the years thanks to a multidisciplinary approach. A correct staging has a fundamental role for risk stratification and to define the best treatment for each patient. Unfortunately, approximately 30% of patients with locally advanced rectal cancers will experience tumor recurrence. Thus, the identification of novel clinical-pathological and radiological prognostic factors represents an urgent unmet clinical need. Here we report the case of a patient with radically resected localized rectal cancer who developed an impressive early pelvic recurrence. To better understand the clinical scenario, we have studied the possible factors related to the aggressiveness of the disease. The only poor prognosticfactor that was evidenced at histological report was perineural invasion. Therefore, we questioned whether we could evaluate perineural invasion with imaging, similar to head and neck tumors. Learning from this clinical case, we believe that improving the risk stratification and radiology reporting is necessary to provide the best care for the patient and allow for a better prognosis prediction. Of course, our data should be considered as hypothesis generating and should be further investigated and validated in larger and prospective studies.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S193004332400428XTest; https://doaj.org/toc/1930-0433Test

الوصول الحر: https://doaj.org/article/eec5cbb29fdd4342a5a6cb660c4ec7b4Test

المؤلفون: Longo V., Della Corte C. M., Russo A., Spinnato F., Ambrosio F., Ronga R., Marchese A., Del Giudice T., Sergi C., Casaluce F., Gilli M., Montrone M., Gristina V., Sforza V., Reale M. L., Di Liello R., Servetto A., Lipari H., Longhitano C., Vizzini L., Manzo A., Cristofano A., Paolelli L., Nardone A., De Summa S., Perrone A., Bisceglia C., Derosa C., Nardone V., Viscardi G., Galetta D., Vitiello F.

المساهمون: Longo V., Della Corte C.M., Russo A., Spinnato F., Ambrosio F., Ronga R., Marchese A., Del Giudice T., Sergi C., Casaluce F., Gilli M., Montrone M., Gristina V., Sforza V., Reale M.L., Di Liello R., Servetto A., Lipari H., Longhitano C., Vizzini L., Manzo A., Cristofano A., Paolelli L., Nardone A., De Summa S., Perrone A., Bisceglia C., Derosa C., Nardone V., Viscardi G., Galetta D., Vitiello F.

مصطلحات موضوعية: chemoimmunotherapy, consolidative radiotherapy, innate immunity, safety, SCLC - small cell lung cancer

الوصف: Background: Consolidative thoracic radiotherapy (TRT) has been commonly used in the management of extensive-stage small cell lung cancer (ES-SCLC). Nevertheless, phase III trials exploring first-line chemoimmunotherapy have excluded this treatment approach. However, there is a strong biological rationale to support the use of radiotherapy (RT) as a boost to sustain anti-tumor immune responses. Currently, the benefit of TRT after chemoimmunotherapy remains unclear. The present report describes the real-world experiences of 120 patients with ES-SCLC treated with different chemoimmunotherapy combinations. Preclinical data supporting the hypothesis of anti-tumor immune responses induced by RT are also presented. Methods: A total of 120 ES-SCLC patients treated with chemoimmunotherapy since 2019 in the South of Italy were retrospectively analyzed. None of the patients included in the analysis experienced disease progression after undergoing first-line chemoimmunotherapy. Of these, 59 patients underwent TRT after a multidisciplinary decision by the treatment team. Patient characteristics, chemoimmunotherapy schedule, and timing of TRT onset were assessed. Safety served as the primary endpoint, while efficacy measured in terms of overall survival (OS) and progression-free survival (PFS) was used as the secondary endpoint. Immune pathway activation induced by RT in SCLC cells was explored to investigate the biological rationale for combining RT and immunotherapy. Results: Preclinical data supported the activation of innate immune pathways, including the STimulator of INterferon pathway (STING), gamma-interferon-inducible protein (IFI-16), and mitochondrial antiviral-signaling protein (MAVS) related to DNA and RNA release. Clinical data showed that TRT was associated with a good safety profile. Of the 59 patients treated with TRT, only 10% experienced radiation toxicity, while no ≥ G3 radiation-induced adverse events occurred. The median time for TRT onset after cycles of chemoimmunotherapy was 62 days. Total radiation ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38304255; info:eu-repo/semantics/altIdentifier/wos/WOS:001154316800001; volume:14; firstpage:1; lastpage:9; numberofpages:9; journal:FRONTIERS IN IMMUNOLOGY; https://hdl.handle.net/10447/623973Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85183811990

الإتاحة: https://doi.org/10.3389/fimmu.2023.1289434Test
https://hdl.handle.net/10447/623973Test