المؤلفون: Henstrom, M, Diekmann, L, Bonfiglio, F, Hadizadeh, F, Kuech, EM, von Kockritz-Blickwede, M, Thingholm, LB, Zheng, TH, Assadi, G, Dierks, C, Heine, M, Philipp, U, Distl, O, Money, ME, Belheouane, M, Heinsen, FA, Rafter, J, Nardone, G, Cuomo, R, Usai-Satta, P, Galeazzi, F, Neri, M, Walter, S, Simren, M, Karling, P, Ohlsson, B, Schmidt, PT, Lindberg, G, Dlugosz, A, Agreus, L, Andreasson, A, Mayer, E, Baines, JF, Engstrand, L, Portincasa, P, Bellini, M, Stanghellini, V, Barbara, G, Chang, L, Camilleri, M, Franke, A, Naim, HY, D'Amato, M

المصدر: Gut. 67(2):263-270

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:137397791Test

المؤلفون: Francesco Plotti, Gianna Barbara Cundari, Fernando Ficarola, Corrado Terranova, Carlo De Cicco Nardone, Roberto Montera, Daniela Luvero, Federica Guzzo, Adele Silvagni, Amerigo Ferrari, Donatella Caserta, Roberto Angioli

المصدر: Healthcare, Vol 12, Iss 12, p 1190 (2024)

مصطلحات موضوعية: interstitial cystitis, bladder pain syndrome, hyaluronic acid, glycosaminoglycans, Medicine

الوصف: The efficacy of hyaluronic acid instillations as therapy for patients with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) has been demonstrated in some clinical studies, with response rates up to 70%. The aim of the study is to investigate the change in symptoms and quality of life in female patients with IC/BPS after intravesical instillations of hyaluronic acid used as first-line treatment. A retrospective single-center cohort study was conducted. Female patients, whose symptoms were compatible with the diagnosis of IC/BPS as defined by the International Continence Society, were treated with a variable number of intravesical instillations of a hyaluronic acid-based drug. Three validated questionnaires were administered by telephone to all patients, before the beginning of the treatment and 6 months after the last administration of the drug. A total of 50 patients with symptoms compatible with the diagnosis of IC/BPS were included in the study. The median number of instillations performed is 4. For all questionnaires, the median value was significantly reduced following treatment with intravesical instillations (p = 0.000). The present study has shown that intravesical hyaluronic acid treatment results in both statistically and clinically significant symptomatic improvement, thereby improving the quality of life of patients with IC/BPS.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2227-9032/12/12/1190Test; https://doaj.org/toc/2227-9032Test

الوصول الحر: https://doaj.org/article/6ce23fde98e84afa8113a0b3bb62a4e8Test

المؤلفون: Daniela Luvero, Adele Silvagni, Anna Maria Angioli, Maurizio Filippini, Francesco Plotti, Roberto Montera, Carlo De Cicco Nardone, Erika Notaro, Francesco Branda, Roberto Angioli

المصدر: Journal of Clinical Medicine, Vol 13, Iss 12, p 3550 (2024)

مصطلحات موضوعية: CO2, laser, daily pollakiuria, dysuria, urgency, interstitial cystitis, Medicine

الوصف: Background: This multicentric prospective study was carried out at Fondazione Policlinico Universitario Campus Bio Medico and Ospedale di Stato of St. Marino Republic. Between 1 January 2019, and 31 December 2022, all pre- and post-menopausal women diagnosed with recurrent, post-coital, and interstitial cystitis at both centers were included in the study. The main aim of the study was to assess the effectiveness of vaginal CO2 laser treatment, alone or combined with intravesical hyaluronic acid instillations, in managing cystitis symptoms, such as dysuria, pollakiuria, and urgency, across the entire patient cohort. The secondary objective was to investigate the reduction in number of annual cystitis episodes post-treatment. Methods: Each woman underwent three to four sessions of micro-ablative CO2 vaginal laser treatment. A follow-up examination was conducted 12 months after the final laser session (up to December 2023), during which a post-treatment VAS assessment evaluated dysuria, daily pollakiuria, and urgency. The enrolled patients recorded the number of cystitis episodes experienced during the 12-month pre- and post-treatment period. Results: Results indicated the laser’s efficacy in reducing the total number of cystitis episodes per year and an improvement in symptoms up to one year post-treatment. Greater efficacy of the CO2 laser treatment, particularly when combined with intravesical hyaluronic acid instillation, was observed in both pre- and post- menopausal women. Conclusions: Fractional CO2 laser therapy represents a safe and efficacious, non-hormonal approach for pre- and post-menopausal women diagnosed with recurrent, post-coital, and interstitial cystitis.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2077-0383/13/12/3550Test; https://doaj.org/toc/2077-0383Test

الوصول الحر: https://doaj.org/article/0982c7726027404b90928ad7707c1491Test

المؤلفون: Costantino Sgamato, Alba Rocco, Debora Compare, Kateryna Priadko, Marco Romano, Gerardo Nardone

المصدر: Antibiotics, Vol 13, Iss 6, p 484 (2024)

مصطلحات موضوعية: gastric cancer, gastric microbiota, H. pylori, Therapeutics. Pharmacology, RM1-950

الوصف: Gastric cancer (GC) still represents one of the leading causes of cancer-related mortality and is a major public health issue worldwide. Understanding the etiopathogenetic mechanisms behind GC development holds immense potential to revolutionize patients’ treatment and prognosis. Within the complex web of genetic predispositions and environmental factors, the connection between Helicobacter pylori (H. pylori) and gastric microbiota emerges as a focus of intense research investigation. According to the most recent hypotheses, H. pylori triggers inflammatory responses and molecular alterations in gastric mucosa, while non-Helicobacter microbiota modulates disease progression. In this review, we analyze the current state of the literature on the relationship between H. pylori and non-Helicobacter gastric microbiota in gastric carcinogenesis, highlighting the mechanisms by which microecological dysbiosis can contribute to the malignant transformation of the mucosa.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2079-6382/13/6/484Test; https://doaj.org/toc/2079-6382Test

الوصول الحر: https://doaj.org/article/fbfe58ddd6a24ea28a9d322f1cd9f9d3Test

المؤلفون: Isabella Nardone, Rossella Antonelli, Simona Zaccaria, Sium Wolde Sellasie, Stefania Falcone, Chiara Pecchioli, Laura Giurato, Luigi Uccioli

المصدر: Journal of Clinical Medicine, Vol 13, Iss 9, p 2670 (2024)

مصطلحات موضوعية: osteoporosis, diabetes mellitus, fragility fractures, bone mineral density (BMD), trabecular bone score (TBS), bone fragility, Medicine

الوصف: Background: Diabetes mellitus (DM) and osteoporosis are two of the most widespread metabolic diseases in the world. The aim of this study is to investigate the prevalence of DM among patients affected by osteoporosis and fragility fractures, and to search for differences in clinical characteristics. Methods: This is a single-center retrospective, case–controlled study. A total of 589 patients attending CTO Bone Unit between 2 January 2010 and 31 May 2023, due to osteoporosis and fragility fractures, were divided into two groups, according to the diagnosis of DM. The clinical and bone characteristics of patients were compared. Results: Prevalence of DM was 12.7%. Compared to patients without DM, the median age at the time of first fracture was similar: 72 years ± 13.5 interquartile range (IQR) vs. 71 years ± 12 IQR; prevalence of combination of vertebral and hip fractures was higher (p = 0.008), as well as prevalence of males (p = 0.016). Bone mineral density (BMD) at all sites was higher in DM group; trabecular bone score (TBS), instead, was significantly lower (p < 0.001). Conclusions: Patients with fragility fractures and DM more frequently show combination of major fractures with higher BMD levels. In these patients, TBS could be a better indicator of bone health than BMD and, therefore, might be used as a diagnostic tool in clinical practice.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2077-0383/13/9/2670Test; https://doaj.org/toc/2077-0383Test

الوصول الحر: https://doaj.org/article/0a4ba54c6dd749d9b925e9e686ee38a8Test

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Aounallah-Skhiri, H, Araujo, J, Ariansen, I, Aris, T, Arku, RE, Arlappa, N, Aryal, KK, Aspelund, T, Assah, FK, Assuncao, MCF, Aung, MS, Auvinen, J, Avdicova, M, Avi, S, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Azmin, M, Babu, B, Jorgensen, MB, Baharudin, A, Bahijri, S, Baker, JL, Balakrishna, N, Bamoshmoosh, M, Banach, M, Bandosz, P, Banegas, JR, Baran, J, Barbagallo, CM, Barcelo, A, Barkat, A, Barros, AJ, Barros, MVG, Basit, A, Bastos, JLD, Bata, I, Batieha, AM, Batista, RL, Battakova, Z, Batyrbek, A, Baur, LA, Beaglehole, R, Bel-Serrat, S, Belavendra, A, Ben Romdhane, H, Benedics, J, Benet, M, Bergh, IH, Berkinbayev, S, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bezerra, J, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bhutta, ZA, Bi, HS, Bi, YF, Bia, D, Lele, ECB, Bikbov, MM, Bista, B, Bjelica, DJ, Bjerregaard, P, Bjertness, E, Bjertness, MB, Bjorkelund, C, Bloch, K, Blokstra, A, Bo, S, Bobak, M, Boddy, LM, Boehm, BO, Boeing, H, Boggia, JG, Bogova, E, Boissonnet, CP, Bojesen, SE, 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المصدر: eLife. 10

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:146154487Test

المؤلفون: Patrizia Ciammella, Salvatore Cozzi, Paolo Borghetti, Marco Galaverni, Valerio Nardone, Maria Paola Ruggieri, Matteo Sepulcri, Vieri Scotti, Alessio Bruni, Francesca Zanelli, Roberto Piro, Elena Tagliavini, Andrea Botti, Federico Iori, Emanuele Alì, Chiara Bennati, Marcello Tiseo

المصدر: Frontiers in Oncology, Vol 14 (2024)

مصطلحات موضوعية: locally advanced non-small cell lung cancer, chemo-radiation, PD-L1 expression, PD-L1 negative patients, re-biopsy, durvalumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: BackgroundChemoradiation therapy (CRT) is the treatment of choice for locally advanced non-small cell lung cancer (LA-NSCLC). Several clinical trials that combine programmed cell death 1 (PD1) axis inhibitors with radiotherapy are in development for patients with LA-NSCLC. However, the effect of CRT on tumor cells programmed cell death ligand-1 (PD-L1) expression is unknown.MethodsIn this multicentric retrospective study, we analyzed paired NSCLC specimens that had been obtained pre- and post-CRT. PD-L1 expression on tumor cells was studied by immunohistochemistry. The purpose of this study was to evaluate the feasibility, risk of complications, and clinical relevance of performing re-biopsy after CRT in patients with PD-L1 negative LA-NSCLC.ResultsOverall, 31 patients from 6 centers with PD-L1 negative LA-NSCLC were analyzed. The percentage of tumor cells with PD-L1 expression significantly increased between pre- and post-CRT specimens in 14 patients (45%). Nine patients had unchanged PD-L1 expression after CRT, in five patients the rebiopsy material was insufficient for PD-L1 analysis and in two patients no tumor cells at rebiopsy were found. The post-rebiopsy complication rate was very low (6%). All patients with positive PD-L1 re-biopsy received Durvalumab maintenance after CRT, except one patient who had a long hospitalization for tuberculosis reactivation. Median PFS of patients with unchanged or increased PD-L1 expression was 10 and 16.9 months, respectively.ConclusionCRT administration can induce PD-L1 expression in a considerable fraction of PD-L1 negative patients at baseline, allowing them receiving the maintenance Durvalumab in Europe. Hence, after a definitive CRT, PD-L1 redetermination should be considered in patients with LA-NSCLC PD-L1 negative, to have a better selection of maintenance Durvalumab candidates.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2024.1325249/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/5295884ae5854ba4ba4dd0e47e0a1c72Test

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مصطلحات موضوعية: ddc:330

الوصف: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.

العلاقة: Journal: The Lancet; Volume: 403; Year: 2024; Issue: 10431; Pages: 1027-1050; Amsterdam: Elsevier BV; https://hdl.handle.net/10419/295105Test; RePEc:zbw:ifwkie:295105

الإتاحة: https://doi.org/10.1016/S0140-6736Test(23)02750-2
https://hdl.handle.net/10419/295105Test

المؤلفون: Richard, S., Tasso, D., Rajana, M., Saker, A., Ramirez Santos, A., Makhloufi, C., Meynet, N., Hary, B., Nardone, S., Marino, G., Thomas, M., Italiano, C., Vita, A., Gallucci, F.

المصدر: Richard , S , Tasso , D , Rajana , M , Saker , A , Ramirez Santos , A , Makhloufi , C , Meynet , N , Hary , B , Nardone , S , Marino , G , Thomas , M , Italiano , C , Vita , A & Gallucci , F 2024 , ' Comparison of thermo-hydraulic performance among different 3D printed periodic open cellular structures ' , Chemical Engineering Journal , vol. 492 , 152005 . https://doi.org/10.1016/j.cej.2024.152005Test

مصطلحات موضوعية: Additive manufacturing, CFD, Heat transfer, LPBF, POCS, Pressure drop, Process intensification, Thermo-hydraulic

الوصف: As additive manufacturing of periodic open cellular structures (POCS) is gaining interest in structured catalytic reactor research, this work seeks to thermohydraulically compare the well-known Kelvin lattice structure with the lesser-researched BCC and gyroid lattice structures. Using a combined CFD (Computational Fluid Dynamic) and experimental approach, the selected POCS are fabricated through Laser Powder Bed Fusion (LPBF), characterized, and subsequently subjected to numerical analysis. From the manufacturability point of view, the 3D printed samples closely matched their CAD designs, showing a maximum porosity deviation of 15% below design values. A CFD model, validated through pressure drop experiment, was employed to compare the POCS designs on shared geometric attributes such as specific surface area and porosity. While all structures exhibited comparable performance in term of heat and momentum transfer, our findings suggest that the Gyroid lattice may provide the optimal balance between momentum and heat transfer rates in low-velocity region. Conversely, the BCC configuration may be more favourable at higher velocity. An Ergun-like correlation was also developed and validated for each lattice type, with a Mean Absolute Percentage Error (MAPE) below 10%. Our pressure drop results align quite well with existing literature correlations, showing a MAPE under 20%. Concerning heat transfer, the values forecasted in this research show a reasonable alignment with literature's results, though they tend to be on the lower spectrum.

وصف الملف: application/pdf

العلاقة: https://research.tue.nl/en/publications/ac9a15a8-7d20-4124-bae1-20e10bbcdc82Test

الإتاحة: https://doi.org/10.1016/j.cej.2024.152005Test
https://research.tue.nl/en/publications/ac9a15a8-7d20-4124-bae1-20e10bbcdc82Test
https://pure.tue.nl/ws/files/331613306/1-s2.0-S1385894724034922-main.pdfTest
http://www.scopus.com/inward/record.url?scp=85193903751&partnerID=8YFLogxKTest

المؤلفون: NARDONE, STEFANO

العلاقة: https://dx.doi.org/10.5281/zenodo.11117040Test

الإتاحة: https://doi.org/10.5281/zenodo.1111703910.5281/zenodo.11117040Test