المؤلفون: Johnson, Hannah, Narayan, Satya, Sharma, Arun K.

المصدر: Cancer Cell International ; volume 24, issue 1 ; ISSN 1475-2867

مصطلحات موضوعية: Cancer Research, Genetics, Oncology

الوصف: Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of these processes are turned toward promoting tumor progression. Considerable research has been undertaken to discover molecules capable of modulating PP2A activity in cancer. Because PP2A is capable of immense substrate specificity across many cellular processes, the therapeutic targeting of PP2A in cancer can be completed through either enzyme inhibitors or activators. PP2A modulators likewise tend to be effective in drug-resistant cancers and work synergistically with other known cancer therapeutics. In this review, we will discuss the patterns of PP2A deregulation in cancer, and its known downstream signaling pathways important for cancer regulation, along with many activators and inhibitors of PP2A known to inhibit cancer progression.

الإتاحة: https://doi.org/10.1186/s12935-023-03193-1Test

المؤلفون: Narayan, Satya, Sahoo, Soumyashree Debasis, Kar, Soumitra, Pal, Sanjit Kumar, Kangsabanik, Subhra

المساهمون: India Ministry of Science & Technology Department of Science and Technology, Ministry of Coal, ISRO Hyderabad

المصدر: Energy Geoscience ; volume 5, issue 2, page 100180 ; ISSN 2666-7592

مصطلحات موضوعية: Renewable Energy, Sustainability and the Environment, Energy (miscellaneous), Geophysics, Geology

الإتاحة: https://doi.org/10.1016/j.engeos.2023.100180Test
https://api.elsevier.com/content/article/PII:S2666759223000264?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666759223000264?httpAccept=text/plainTest

المؤلفون: Jaiswal, Aruna S, Kim, Hyun-Suk, Schärer, Orlando D, Sharma, Neelam, Williamson, Elizabeth A, Srinivasan, Gayathri, Phillips, Linda, Kong, Kimi, Arya, Shailee, Misra, Anurag, Dutta, Arijit, Gupta, Yogesh, Walter, Christi A, Burma, Sandeep, Narayan, Satya, Sung, Patrick, Nickoloff, Jac A, Hromas, Robert

المساهمون: National Institutes of Health, Cancer Prevention and Research Institute of Texas, American Lung Association, NIH, Max and Minnie Tomerlin Voelcker Foundation and NIH

المصدر: NAR Cancer ; volume 5, issue 1 ; ISSN 2632-8674

مصطلحات موضوعية: Cancer Research, Oncology

الوصف: Unrepaired oxidatively-stressed replication forks can lead to chromosomal instability and neoplastic transformation or cell death. To meet these challenges cells have evolved a robust mechanism to repair oxidative genomic DNA damage through the base excision repair (BER) pathway, but less is known about repair of oxidative damage at replication forks. We found that depletion or genetic deletion of EEPD1 decreases clonogenic cell survival after oxidative DNA damage. We demonstrate that EEPD1 is recruited to replication forks stressed by oxidative damage induced by H2O2 and that EEPD1 promotes replication fork repair and restart and decreases chromosomal abnormalities after such damage. EEPD1 binds to abasic DNA structures and promotes resolution of genomic abasic sites after oxidative stress. We further observed that restoration of expression of EEPD1 via expression vector transfection restores cell survival and suppresses chromosomal abnormalities induced by oxidative stress in EEPD1-depleted cells. Consistent with this, we found that EEPD1 preserves replication fork integrity by preventing oxidatively-stressed unrepaired fork fusion, thereby decreasing chromosome instability and mitotic abnormalities. Our results indicate a novel role for EEPD1 in replication fork preservation and maintenance of chromosomal stability during oxidative stress.

الإتاحة: https://doi.org/10.1093/narcan/zcac044Test
https://academic.oup.com/narcancer/article-pdf/5/1/zcac044/57074412/zcac044.pdfTest

المؤلفون: Narayan, Satya, Konka, Suresh, Chandra, Akash, Abdelrahman, Kamal, Andr�, Peter, Eldosouky, Ahmed M.

المصدر: Frontiers in Earth Science ; volume 11 ; ISSN 2296-6463

مصطلحات موضوعية: General Earth and Planetary Sciences

الوصف: Litho-facies classification is an essential task in characterizing the complex reservoirs in petroleum exploration and subsequent field development. The lithofacies classification at borehole locations is detailed but lacks in providing larger coverage areas. The acquired 3D seismic data provides global coverage for studying the reservoir facies heterogeneities in the study area. This study applies six supervised machine learning techniques (Random Forest, Support Vector Machine, Artificial Neural Network, Adaptive Boosting, Xtreme Gradient Boosting, and Multilayer Perceptron) to 3D post-stack seismic data to accurately estimate different litho-facies in inter-well regions and compares their performance. Initially, the efficacy of the said models was critically examined via the confusion matrix (accuracy and misclass) and evaluation matrix (precision, recall, F1-score) on the test data. It was found that all the machine learning models performed best in classifying the shale facies (87%–94%) followed by the sand (65%–79%) and carbonate facies (60%–78%) in the Penobscot field, Scotian Basin. On an overall accuracy scale, we found the multilayer perceptron method the best-performing tool, whereas the adaptive boosting method was the least-performing tool in classifying all three litho-facies in the current analysis. While other methods also performed moderately good for the classification of all three litho-facies. The predicted litho-facies using seismic attributes matched well with the log data interpreted facies on the borehole locations. It indicates that the facies estimated in inter-well regions are accurate and reliable. Furthermore, we validated the estimated results with the other seismic attributes to ascertain the accuracy and reliability of the predicted litho-facies between the borehole locations. This study recommends machine learning applications for litho-facies classification to reduce the risk associated with reservoir characterization.

الإتاحة: https://doi.org/10.3389/feart.2023.1150954Test

المؤلفون: Das, Niharika, Bhattacharya, Sumit Kumar, Narayan, Satya, Livingston, D.

المصدر: Acta Geophysica; Jun2024, Vol. 72 Issue 3, p1731-1748, 18p

مصطلحات موضوعية: GREENSTONE belts, SEDIMENTARY rocks, GRAVITY, VOLCANIC ash, tuff, etc., ROCK groups, NEOTECTONICS, OROGENIC belts

مستخلص: The late Archean Western Dharwar Craton supergroup has volcanic and sedimentary rocks deposited during 2900–2600 Ma underlain by the Sargur Group basement of 3.36–3.2 Ga granitic gneiss and older supracrustal rocks. The western part of the craton, known as the western province (Dharwar Foreland), comprises four major schist belts (Western Ghats-Bababudhan-Shimoga-Chitradurga). A regional gravity and magnetic (Total Field) survey was done in the Shimoga region. The geophysical data of the study area reveal the subsurface extension and behaviour of the exposed rocks of the area. The Euler deconvolution was used to define the depth of the anomaly sources. Euler depth solution for the spherical body (structural index 2), window size = 10, and depth tolerance = 5% depicts the depth of the various sources. The Euler depth solutions cluster over the hook-shaped schist rock of the Medur group (at the northern part of the area) reveals that the body's depth varies from 1 to 4 km in the central part, and at the northern flank, it goes up to 7 km. The solution also brought out the depth of the anomalous body near Hithala, within 4 km. The 2D forward depth modelling of the anomalous zone brings out the involvement of the tectonic forces in the generation of this anomalous body. The more precise depth from the model has been estimated between 2 and 3 km. The model clearly shows the relationship between schist rocks and the basement. However, the high-gravity anomaly has been modelled as the manganese bearing horizon, which has come to optimum depth because of folding and faulting in the region, thus providing a favourable zone for manganese deposition. [ABSTRACT FROM AUTHOR]

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المؤلفون: Krishna Rao, Vajja, Paul, Subarno, Gulkis, Mitchell, Shen, Zhihang, Nair, Haritha, Singh, Amandeep, Li, Chenglong, Sharma, Arun K., Çağlayan, Melike, Das, Chinmay, Das, Biswajit, Kundu, Chanakya N., Narayan, Satya, Guchhait, Sankar K.

المساهمون: Science and Engineering Research Board, Council of Scientific and Industrial Research, India, Cancer Center, University of Florida Health, Department of Biotechnology, Ministry of Science and Technology, India, Indian Council of Medical Research

المصدر: RSC Medicinal Chemistry ; volume 15, issue 3, page 937-962 ; ISSN 2632-8682

الوصف: In this study, a unique strategy of scaffold-hopping-based molecular editing of a bioactive agent NSC-666719 was investigated, which led to the development of new benzodithiazinedioxide-guanidine based anticancer agents with Polβ inhibition.

الإتاحة: https://doi.org/10.1039/d3md00648dTest
http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00648DTest

المؤلفون: Narayan, Satya¹ (AUTHOR), Kumar, Ujjawal² (AUTHOR), Sahoo, Soumyashree Debasis² (AUTHOR), Pal, Sanjit Kumar² (AUTHOR) sanjitismagp@iitism.ac.in

المصدر: Acta Geophysica. Feb2024, Vol. 72 Issue 1, p29-48. 20p.

مصطلحات موضوعية: *GRAVITY model (Social sciences), *GRAVITY anomalies, *DATA modeling, *MOHOROVICIC discontinuity, *SEISMIC anisotropy, *STANDARD deviations

مستخلص: This study evaluates the efficacy of GECO gravity data for geophysical studies, mapping structural and tectonic features and their impact on gravity signatures in the study area. Computed correlation coefficient (96–98%), root-mean-square error (5.1–5.3 mGal), and standard deviation (3.9–4.2 mGal) between the GECO model-derived and ship-borne free-air gravity reveal the efficacy of the GECO gravity data for the geophysical studies in the region. A total horizontal derivative approach was used in order to enhance the residual and regional responses of the Bouguer gravity anomaly. The shorter-wavelength lineaments originated from subsurface mass heterogeneities were found trending in the northwest direction, subsequently east, north–northeast and east–northeast directions. In contrast, the longer-wavelength lineaments originating from deep-seated mass heterogeneities dominated in the east-northeast direction, followed by north-northeast and northwest directions. Lineaments occurring at shallower depths are associated with sedimentary/basement columns and could be utilised in basin demarcation for hydrocarbon exploration. In contrast, deep-seated lineaments originated due to deformities at the crust-mantle boundary or in the mantle and could be used in the region's seismicity analysis. Spectral analysis and 2D forward modelling results indicate sediment thickness of ~ 2.0–6.0 km, basement thickness of ~ 6–14 km, and Moho depth of ~ 10–18 km. Delineated lineaments and computed basement and Moho depths were further validated with existing data. Anomalously high and low gravity features were interpreted based on Moho depth, basement thickness, and sediment thickness. This study concludes that anomalous gravity anomalies are mainly controlled by Moho topography despite the relatively thicker crust in the northern region. The crustal thickness mainly controls the southern latitude's gravity signatures. [ABSTRACT FROM AUTHOR]

المؤلفون: Jain, Arpit, Koyyala, Venkata Pradeep Babu, Narayan, Satya, Soni, Satyajeet, Redhu, Pallavi, Jaju, Akanksha

المصدر: Indian Journal of Medical and Paediatric Oncology ; volume 43, issue 02, page 185-188 ; ISSN 0971-5851 0975-2129

الوصف: Immune checkpoint inhibitor (ICI) restores an efficient antitumor T cell response against tumor cells fostering durable responses that can persist even after the treatment. However, these treatment effects can manifest as an unusual pattern of disease progression, pseudo-progression, or hyper-progression. Differentiating hyper progressive disease (HPD) from pseudo-progression has significant clinical implications and further decision-making for the patient on ICI. HPD is a dramatic acceleration of the rate of tumor progression with the advent of immunotherapeutic agents causing detrimental effects on the disease outcome.

الإتاحة: https://doi.org/10.1055/s-0042-1743505Test

المؤلفون: Narayan, Satya, Raza, Asif, Mahmud, Iqbal, Koo, Nayeong, Garrett, Timothy J., Law, Mary E., Law, Brian K., Sharma, Arun K.

المصدر: iScience ; volume 25, issue 7, page 104518 ; ISSN 2589-0042

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1016/j.isci.2022.104518Test
https://api.elsevier.com/content/article/PII:S2589004222007891?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2589004222007891?httpAccept=text/plainTest

المؤلفون: Narayan, Satya¹ (AUTHOR) satya.ismdhanbad@gmail.com, Sahoo, Soumyashree Debasis² (AUTHOR), Pal, S. K.² (AUTHOR), Pham, L. T.³ (AUTHOR), Kumar, Pradeep^1,4 (AUTHOR)

المصدر: Marine Geophysical Research. Dec2023, Vol. 44 Issue 4, p1-25. 25p.

مستخلص: In the recent past, an integrated analysis of predicted petrophysical properties along with acoustic impedance has emerged as an effective means of characterizing reservoirs. Model-based inversion method was applied to precisely estimate acoustic impedance (correlation: 87.9% & error: 414 m/s*g/cm3), while the multi-layer perceptron algorithm was applied to predict gamma-ray (correlation: 90.5% & error: ~ 2.5API), neutron porosity (correlation: 92.3% & error: ~ 0.01) and effective porosity (correlation: 85.8% & error: ~ 0.01) from post-stack 3D seismic data. We analyzed the entire Abenaki Formation into four parts, i.e., the Scatarie, Baccaro, Misaine shale and Artimon Members. These members have been characterized by combining the P-Imp, GR, NPHI, and PHIE responses. Well-based cross-plot study suggests that the high P-Imp, low GR and low NPHI indicate carbonate facies. In contrast, low impedance, high GR and high NPHI values indicate the shale facies from the Abenaki Formation. P-Imp, GR, and NPHI values fall in the intermediate range for the sand facies. The attribute stratal slice maps indicate the dominance of carbonate facies within the Scatarie, Baccaro, and Artimon Members, while shale facies dominate within the Misaine shale Member in the Penobscot field. The carbonate facies' hydrocarbon potentiality within different members was also accessed based on PHIE responses. The Artimon, Baccaro and Scatarie Members observed several high porosity (10–20%) zones. The current study also advocates that the integrated analysis using multi-attributes certainly minimizes the risk associated with facies discrimination in reservoir characterization for hydrocarbon exploration. Other potential prospective zones could be probed to chase the lead from well L-30 in the study area for further exploration-related works. [ABSTRACT FROM AUTHOR]