المؤلفون: Tsukasa Hasegawa, MD, PhD, Kai Ryu, MD, PhD, Taiki Fukuda, MD, PhD, Yuko Mizobuchi, MD, Lynn Yoshimatsu, MD, Ryo Sato, MD, Makiko Takatsuka, MD, Kyota Shinfuku, MD, Masami Yamada, MD, PhD, Yumie Yamanaka, MD, PhD, Yusuke Hosaka, MD, PhD, Aya Seki, MD, Naoki Takasaka, MD, PhD, Takeo Ishikawa, MD, Jun Araya, MD, PhD

المصدر: Radiology Case Reports, Vol 19, Iss 6, Pp 2520-2524 (2024)

مصطلحات موضوعية: Reversed halo sign, Hypersensitivity pneumonitis, Ultrasonic humidifier lung, Ultrasonic humidifier, Organizing pneumonia, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: The reversed halo sign was initially reported as a representative computed tomography scan finding of cryptogenic organizing pneumonia. Since then, however, it has been reported in various diseases and is now considered a nonspecific finding. However, there are no cases of humidifier lung with the reversed halo sign. An 82-year-old Japanese male patient presented with moving difficulties 48 days after starting darolutamide treatment for prostate cancer. He was admitted to the hospital due to acute pneumonia, which presented as bilateral extensive nonsegmental ground-glass opacities in the peripheral regions and extensive areas of ground-glass opacity with a circumferential halo of consolidation, with the reversed halo sign on computed tomography scan. After darolutamide discontinuation with the concomitant administration of antibiotics, the patient's pneumonia improved, and he was discharged from the hospital. However, within a few days, he was again admitted to the hospital due to pneumonia. He was found to have been using an ultrasonic humidifier at home and was then diagnosed with humidifier lung based on the bronchoscopy and provocative testing findings. Hence, ultrasonic humidifier lung should be considered as a differential diagnosis in patients presenting with the reversed halo sign, and a detailed medical history must be taken.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1930043324002383Test; https://doaj.org/toc/1930-0433Test

الوصول الحر: https://doaj.org/article/734eb2f604be4946a2402efc09d76284Test

المؤلفون: Kyota Shinfuku, Naoki Takasaka, Taiki Fukuda, Kentaro Chida, Yudai Suzuki, Shun Shibata, Ayako Kojima, Tsukasa Hasegawa, Masami Yamada, Yumie Yamanaka, Yusuke Hosaka, Aya Seki, Yoshitaka Seki, Hiroshi Takeda, Takeo Ishikawa, Kazuyoshi Kuwano

المصدر: PLoS ONE, Vol 18, Iss 2 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: Background Coronavirus disease 2019 (COVID-19) pneumonia can have prolonged sequelae and lead to respiratory dysfunction, mainly because of impaired diffusion capacity for carbon monoxide (DLCO). The clinical factors associated with DLCO impairment, including blood biochemistry test parameters, remain unclear. Methods Patients with COVID-19 pneumonia who underwent inpatient treatment between April 2020 and August 2021 were included in this study. A pulmonary function test was performed 3 months after onset, and the sequelae symptoms were investigated. Clinical factors, including blood test parameters and abnormal chest shadows on computed tomography, of COVID-19 pneumonia associated with DLCO impairment were investigated. Results In total, 54 recovered patients participated in this study. Twenty-six patients (48%) and 12 patients (22%) had sequelae symptoms 2 and 3 months after, respectively. The main sequelae symptoms at 3 months were dyspnea and general malaise. Pulmonary function tests showed that 13 patients (24%) had both DLCO 686.5 ng/mL (odds ratio: 11.08, 95% confidence interval [CI]: 1.84–66.59; p = 0.009) was most strongly associated with DLCO impairment. Conclusions Decreased DLCO was the most common respiratory function impairment, and ferritin level was a significantly associated clinical factor. Serum ferritin level could be used as a predictor of DLCO impairment in cases of COVID-19 pneumonia.

وصف الملف: electronic resource

العلاقة: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934337/?tool=EBITest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/a0cc1fe79b484280ba5c135daeec80a0Test

المؤلفون: Kyota Shinfuku, Hiromichi Hara, Naoki Takasaka, Takeo Ishikawa, Jun Araya, Kazuyoshi Kuwano

المصدر: PLoS ONE, Vol 18, Iss 2, p e0281103 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: ObjectivesSemi-quantitative CT score is generally used for evaluating the disease status of Mycobacterium abscessus (Mab) Pulmonary disease (Mab-PD). However, its accuracy and clinical usefulness are limited, since the CT score is largely affected by coexisting lung disease. Hence, we hypothesized that numerical change in CT score during the observation period may be useful for evaluating disease activity of Mab-PD.MethodsPatients diagnosed with Mab-PD based on the official ATS/ERS/ESCMID/IDSA statement at Jikei University Hospital and Jikei Daisan Hospital between 2015 January 1 and 2021 July 31 were included (n = 32). We reviewed the medical records, and bacteriological and laboratory data of the patients. Chest CT was performed at diagnosis in all 32 cases. In 18 cases, chest CT images within 4 years before diagnosis were available. The numerical change in CT score between two time points was calculated and the association of the CT scores with sputum Gaffky score and serum CRP was examined.ResultsCT score at diagnosis was not correlated with sputum Gaffky score nor serum CRP, while the difference of absolute value and change rate in CT score between at diagnosis and immediate past CT were well correlated with both sputum Gaffky score and serum CRP.ConclusionsChronological change in CT score may more precisely reflect the disease activity of airway mycobacterial burden and systemic inflammation in Mab-PD at the timing of diagnosis.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/62cf50aff43945f9845e7d4c33981205Test

المؤلفون: Ayako Kojima, Kazuyoshi Kuwano, Kyota Shinfuku, Masami Yamada, Naoki Takasaka, Shun Shibata, Takeo Ishikawa, Tsukasa Hasegawa, Yumie Yamanaka, Yusuke Hosaka, 保坂 悠介, 小島 彩子, 山中 友美絵, 山田 真紗美, 新福 響太, 柴田 駿, 桑野 和善, 石川 威夫, 長谷川 司, 高坂 直樹

المصدر: 気管支学 / The Journal of the Japan Society for Respiratory Endoscopy. 2022, 44(3):205

المؤلفون: Naoki Takasaka, Yoshitaka Seki, Ikumi Fujisaki, Shota Uchiyama, Sachi Matsubayashi, Akihito Sato, Yumie Yamanaka, Kyuto Odashima, Taisuke Kazuyori, Aya Seki, Hiroshi Takeda, Takeo Ishikawa, Kazuyoshi Kuwano

المصدر: BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-8 (2020)

مصطلحات موضوعية: Tuberculosis, Emphysema, Culture conversion, Diseases of the respiratory system, RC705-779

الوصف: Abstract Background Although cigarette smoking may have a negative impact on the clinical outcome of pulmonary tuberculosis (PTB), few studies have investigated the impact of smoking-associated lung diseases. Emphysema is a major pathological finding of smoking-related lung damage. We aimed to clarify the effect of emphysema on sputum culture conversion rate for Mycobacterium tuberculosis (MTB). Methods We retrospectively studied 79 male patients with PTB confirmed by acid-fast bacillus smear and culture at Jikei University Daisan Hospital between January 2015 and December 2018. We investigated the sputum culture conversion rates for MTB after starting standard anti-TB treatment in patients with or without emphysema. Emphysema was defined as Goddard score ≥ 1 based on low attenuation area

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12890-020-01325-1Test; https://doaj.org/toc/1471-2466Test

الوصول الحر: https://doaj.org/article/1df20cf534fc4b28bf2f95adc63ff833Test

المؤلفون: Yudai Suzuki, Naoki Takasaka, Sachi Matsubayashi, Ayako Kojima, Kyota Shinfuku, Tsukasa Hasegawa, Masami Yamada, Ikumi Fujisaki, Aya Seki, Yoshitaka Seki, Takeo Ishikawa, Kazuyoshi Kuwano

المصدر: Respirology Case Reports, Vol 9, Iss 8, Pp n/a-n/a (2021)

مصطلحات موضوعية: Adalimumab, allergic bronchopulmonary aspergillosis, ankylosing spondylitis, anti‐tumour necrosis factor‐α antibody, Diseases of the respiratory system, RC705-779

الوصف: Abstract We herein report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man treated with adalimumab for ankylosing spondylitis (AS). A 69‐year‐old man with a history of ankylosing spondylitis treated by adalimumab, an anti‐tumour necrosis factor‐α (TNF‐α) antibody, developed cough and wheezing. Chest computed tomography showed obstruction of dilated left upper lobe bronchus by high attenuation mucus as well as central bronchiectasis. Both Aspergillus‐specific immunoglobulin E (IgE) and Aspergillus precipitating antibody were positive and Aspergillus fumigatus was detected in a sputum culture. According to the new diagnostic criteria, the patient was diagnosed with ABPA. His condition rapidly improved after the withdrawal of adalimumab and initiation of prednisolone and itraconazole. Anti‐TNF‐α antibody might cause ABPA through both aggravation of the host's T‐helper 2 immunological response and anti‐fungal response.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2051-3380Test

الوصول الحر: https://doaj.org/article/a3739e1bf5434725bdc9de241fcc17e6Test

المؤلفون: Kentaro Chida, Yumie Yamanaka, Akihito Sato, Saburo Ito, Naoki Takasaka, Takeo Ishikawa, Kazuyoshi Kuwano

المصدر: Respiratory Medicine Case Reports, Vol 34, Iss , Pp 101510- (2021)

مصطلحات موضوعية: Nontuberculous mycobacteria, Mycobacterium lentiflavum, Solitary pulmonary nodule, Diseases of the respiratory system, RC705-779

الوصف: An 82-year-old Japanese man who previously had descending colon cancer and underwent partial resection showed a growing solitary pulmonary nodule, suspected as lung cancer, on follow-up computed tomography. Thoracoscopic partial lobectomy was therefore performed. The surgical specimen showed granulomatous lesions with necrosis. Mass spectrometry was performed on the sputum specimen collected after surgery, which identified Mycobacterium lentiflavum infection. Antibiotics were not prescribed following surgery, and the patient has not experienced recurrence 2 years since the surgery. To our knowledge, this is the second case of solitary pulmonary nodule and the first case of M. lentiflavum infection treated via surgical resection.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2213007121001726Test; https://doaj.org/toc/2213-0071Test

الوصول الحر: https://doaj.org/article/54b6245228d24843b8656d9e51efbe0fTest

المؤلفون: Haruki Obara, Kazuki Iwasa, Naoki Takasaka, Tooru Sasaki, 小原 治樹, 岩佐 一記, 笹木 亮, 高坂 直樹

المصدر: Proceedings of JSPE Semestrial Meeting. 2009, :771

المؤلفون: Naoki Takasaka, Kentaro Chida, Takeo Ishikawa, Kazuyoshi Kuwano

المصدر: BMJ Case Reports; Sep2023, Vol. 16 Issue 9, p1-5, 5p

مستخلص: Allergic bronchopulmonary aspergillosis (ABPA) and Mycobacterium avium complex lung disease (MAC-LD) often coexist because bronchiectasis, caused by ABPA or MAC, might be an important predisposing factor for both conditions. Here, we describe a man with asthma symptoms who had centrilobular small nodules and mucoid impaction on chest CT. We diagnosed the patient with simultaneous ABPA and MAC-LD on the basis of bronchoscopy findings. Itraconazole monotherapy led to substantial clinical improvement, avoiding the adverse effects of systemic corticosteroids. Sputum culture conversion of MAC was achieved after switching from itraconazole monotherapy to combination therapy comprising clarithromycin, rifampicin and ethambutol. ABPA recurred but was controlled by reinitiation of itraconazole. Overall, corticosteroid management was avoided for 38 months. Itraconazole monotherapy may be selected as initial treatment for ABPA with chronic infection, including MAC. [ABSTRACT FROM AUTHOR]

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المؤلفون: Yoshitaka Seki, Ayako Kojima, Sachi Matsubayashi, Kyota Shinfuku, Yudai Suzuki, Masami Yamada, Takeo Ishikawa, Aya Seki, Kazuyoshi Kuwano, Naoki Takasaka, Ikumi Fujisaki, Tsukasa Hasegawa

المصدر: Respirology Case Reports, Vol 9, Iss 8, Pp n/a-n/a (2021)
Respirology Case Reports

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Case Report, Case Reports, Immunoglobulin E, Gastroenterology, Aspergillus fumigatus, Sputum culture, 03 medical and health sciences, Diseases of the respiratory system, 0302 clinical medicine, Internal medicine, ankylosing spondylitis, medicine, Adalimumab, allergic bronchopulmonary aspergillosis, anti‐tumour necrosis factor‐α antibody, skin and connective tissue diseases, Ankylosing spondylitis, Bronchiectasis, biology, medicine.diagnostic_test, RC705-779, business.industry, medicine.disease, biology.organism_classification, 030228 respiratory system, 030220 oncology & carcinogenesis, biology.protein, Prednisolone, Allergic bronchopulmonary aspergillosis, business, medicine.drug

الوصف: We herein report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man treated with adalimumab for ankylosing spondylitis (AS). A 69‐year‐old man with a history of ankylosing spondylitis treated by adalimumab, an anti‐tumour necrosis factor‐α (TNF‐α) antibody, developed cough and wheezing. Chest computed tomography showed obstruction of dilated left upper lobe bronchus by high attenuation mucus as well as central bronchiectasis. Both Aspergillus‐specific immunoglobulin E (IgE) and Aspergillus precipitating antibody were positive and Aspergillus fumigatus was detected in a sputum culture. According to the new diagnostic criteria, the patient was diagnosed with ABPA. His condition rapidly improved after the withdrawal of adalimumab and initiation of prednisolone and itraconazole. Anti‐TNF‐α antibody might cause ABPA through both aggravation of the host's T‐helper 2 immunological response and anti‐fungal response.
We report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man receiving adalimumab for ankylosing spondylitis. This case suggests that anti‐tumour necrosis factor‐α (TNF‐α) antibody might cause ABPA in terms of disruption of the Th2/Th1 balance and the anti‐fungal response.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11ddad6ad921fa89fd1616581539a0bTest
https://doaj.org/article/a3739e1bf5434725bdc9de241fcc17e6Test