المؤلفون: Tobiume, Motoi, Yamada, Yoshiaki, Nakamura, Kogenta, Honda, Nobuaki

المصدر: International braz j urol. February 2008 34(1)

مصطلحات موضوعية: prostate neoplasms, diagnosis, prostatic specific antigen

الوصف: OBJECTIVE: We compared the safety and efficacy of the 12-core biopsy with those of the conventional systematic 6-core biopsy with PSA levels between 4.1 and 20.0 ng/mL. MATERIALS AND METHODS: This study included 428 patients who underwent a 6-core biopsy and 128 patients who underwent a 12-core biopsy. Biopsies were performed transrectally under ultrasound guidance. The 12-core biopsy scheme involved obtaining 6 far lateral cores. RESULTS: For patients with PSA level between 4.1 and 10.1 ng/mL, 47 of the 265 patients who underwent 6-core biopsy and 32 of the 91 patients who underwent a12-core biopsy were diagnosed with prostate cancer (p = 0.0006). Among the patients with a PSA level between 10.1 and 20.0 ng/mL, 48 of 163 patients who underwent the 6-core biopsy and 16 of 37 patients who underwent the 12-core biopsy were diagnosed with prostate cancer (p = 0.0606). Three of the 95 patients who were diagnosed with prostate cancer through the 6-core biopsy and 12 of the 48 patients who were diagnosed through the 12-core biopsy had cancer located in the anterior apex. The 12-core biopsy increased the diagnostic rate in the apex (p = 0.001). No statistically significant differences were found in incidence of complications. CONCLUSION: We concluded that the 12-core biopsy is a safe and more effective procedure for increasing the diagnostic rate of prostate cancer than the 6-core biopsy in patients with PSA level between 4.1 and 10.0 ng/mL, and the most useful anatomical area to be added was found to be cores from the anterior apex.

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الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382008000100003Test

المؤلفون: Nakamura, Kogenta, Kasraeian, Ali, Anai, Satoshi, Pendleton, John, Rosser, Charles J.

المصدر: International braz j urol. December 2007 33(6)

مصطلحات موضوعية: prostate cancer, prostatectomy, bladder neck, frozen sections, surgical margins

الوصف: OBJECTIVE: To determine if intraoperative frozen sections of the bladder neck during radical prostatectomy (RP) could decrease the incidence of final positive surgical margins at the bladder neck. MATERIALS AND METHODS: This prospective cohort study included 51 consecutive men who underwent anatomic RP at University of Florida & Shands Jacksonville. All patients had intraoperative frozen section of bladder neck sent for analysis. Preoperative, operative, and postoperative data were collected and analyzed. Main Outcome Measures: Outcome measures were intraoperative bladder neck margin status, final pathologic bladder neck margin status, and postoperative urinary complications. Median follow-up for the 51 patients was 22 months. RESULTS: The final positive surgical margin rate was 20% (10 patients). An additional three patients had positive surgical margins at the bladder neck intraoperatively. These patients then had a wider resection of the affected bladder neck until the frozen sections were negative for cancer or prostatic tissue. Final pathologic evaluation of bladder neck margin was negative for tumor or persistent prostatic tissue in all 51 men. CONCLUSION: With intra-operative frozen sections, we were able to obtain a negligible positive bladder neck margin rate. Surgeons who are still on the learning curve for RP should consider intra-operative frozen section of the bladder neck.

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الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382007000600002Test

المؤلفون: Nakamura, Kogenta, Kasraeian, Ali, Yacoub, Saif, Pendleton, John, Anai, Satoshi, Rosser, Charles J.

المصدر: International braz j urol. June 2007 33(3)

مصطلحات موضوعية: enoxaparin, prostatectomy, prostate cancer, venous thrombosis, pneumatic compression stockings

الوصف: OBJECTIVE: To assess the utility of enoxaparin in prevention of venous thromboembolism (VTE) in men poorly compliant with pneumatic compression stockings (PCS) in the immediate postoperative period after a radical retropubic prostatectomy (RP). MATERIALS AND METHODS: This retrospective study included 47 men who underwent RP at an inner-city tertiary care hospital. All patients were started on enoxaparin 40 mg subcutaneously 6-8 hours postoperatively and daily while hospitalized. Preoperative, operative, and postoperative data were collected and analyzed. Median follow-up was 18 months. RESULTS: Median patient age was 64 ± 7 years, median prostate-specific antigen level was 4.9 ng/mL and median prostate biopsy-determined Gleason score was 6. Forty-one men (87%) underwent a pelvic lymph node dissection. Median operative time was 181 minutes (range 164-450 minutes). Median estimated blood loss was 700 mL. Approximately 36% of the men wore PCS the recommended > 19 hours/day. On average PCS were worn 10.3 ± 7.5 hours/day. Postoperative complications were not increased in this cohort. Two patients developed pulmonary embolism requiring long-term anticoagulation. There were no mortalities. CONCLUSIONS: In men non-compliant with PCS, initiation of enoxaparin in the immediate postoperative setting was well-tolerated and maintained a low (4%) rate of VTE. Thus, enoxaparin may be useful in adjunct with PCS in these patients.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382007000300007Test

المؤلفون: Yamamura, Aya, Nayeem, Md Junayed, Muramatsu, Hiroyuki, Nakamura, Kogenta, Sato, Motohiko

المساهمون: Japan Society for the Promotion of Science, Takeda Science Foundation

المصدر: Frontiers in Pharmacology ; volume 12 ; ISSN 1663-9812

مصطلحات موضوعية: Pharmacology (medical), Pharmacology

الوصف: Vascular endothelial growth factor (VEGF) signaling plays a critical role in the carcinogenesis and tumor development of several cancer types. However, its pathological significance in prostate cancer, one of the most frequent and lethal malignancies in men, remains unclear. In the present study, we focused on a pathological role of the VEGF receptors (VEGFRs), and examined their expression and effects of MAZ51 (an inhibitor of the tyrosine kinase of VEGFR-3) on cell proliferation, migration, and tumor growth in human prostate cancer cells. The expression level of VEGFR-3 was higher in androgen-independent and highly metastatic prostate cancer PC-3 cells than in other prostate PrEC, LNCaP, and DU145 cells. In PC-3 cells, VEGFR-3 and Akt were phosphorylated following a stimulation with 50 ng/ml VEGF-C, and these phosphorylations were blocked by 3 μM MAZ51. Interestingly, PC-3 cells themselves secreted VEGF-C, which was markedly larger amount compared with PrEC, LNCaP, and DU145 cells. MAZ51 reduced the expression of VEGFR-3 but not VEGFR-1 and VEGFR-2. The proliferation of PC-3 cells was inhibited by MAZ51 (IC 50 = 2.7 μM) and VEGFR-3 siRNA, and partly decreased by 100 nM GSK690693 (an Akt inhibitor) and 300 nM VEGFR2 Kinase Inhibitor I. MAZ51 and VEGFR-3 siRNA also attenuated the VEGF-C-induced migration of PC-3 cells. Moreover, MAZ51 blocked the tumor growth of PC-3 cells in a xenograft mouse model. These results suggest that VEGFR-3 signaling contributes to the cell proliferation, migration, and tumor growth of androgen-independent/highly metastatic prostate cancer. Therefore, the inhibition of VEGFR-3 has potential as a novel therapeutic target for the treatment for prostate cancer.

الإتاحة: https://doi.org/10.3389/fphar.2021.667474Test

المؤلفون: Goto, Yumiko, Kanao, Kent, Onishi, Masafumi, Nakamura, Kogenta

المصدر: Annals of Oncology ; volume 30, page vi123 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1093/annonc/mdz343.025Test
https://api.elsevier.com/content/article/PII:S092375341962274X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S092375341962274X?httpAccept=text/plainTest
http://academic.oup.com/annonc/article-pdf/30/Supplement_6/mdz343.025/30115816/mdz343.025.pdfTest

المؤلفون: Sugiyama, Kayo, Watanuki, Hirotaka, Okada, Masaho, Futamura, Yasuhiro, Sugimoto, Ikuo, Nakamura, Kogenta, Matsuyama, Katsuhiko

المصدر: Open Journal of Thoracic Surgery ; volume 08, issue 02, page 19-25 ; ISSN 2164-3059 2164-3067

مصطلحات موضوعية: Immunology and Allergy

الإتاحة: https://doi.org/10.4236/ojts.2018.82004Test

المؤلفون: Nishikawa, Genya, Nakamura, Kogenta, Kobayashi, Ikuo, Sugie, Miho, Muramatsu, Hiroyuki, Morinaga, Shingo, Kajikawa, Keishi, Kato, Yoshiharu, Watanabe, Masahito, Kanao, Kent, Sumitomo, Makoto

المصدر: Journal of Urology ; volume 199, issue 4S ; ISSN 0022-5347 1527-3792

الإتاحة: https://doi.org/10.1016/j.juro.2018.02.1781Test
https://api.elsevier.com/content/article/PII:S0022534718410919?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022534718410919?httpAccept=text/plainTest

المؤلفون: Kanao, Kent, Sugie, Miho, Muramatsu, Hiroyuki, Morinaga, Shingo, Kajikawa, Keishi, Kobayashi, Ikuo, NIshikawa, Genya, Kato, Yoshiharu, Watanabe, Masahito, Nakamura, Kogenta, Sumitomo, Makoto

المصدر: Journal of Urology ; volume 199, issue 4S ; ISSN 0022-5347 1527-3792

الإتاحة: https://doi.org/10.1016/j.juro.2018.02.178Test
https://api.elsevier.com/content/article/PII:S0022534718394886?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022534718394886?httpAccept=text/plainTest

المؤلفون: Kajikawa, Keishi, Kanao, Kent, Sugie, Miho, Morinaga, Shingo, Muramatsu, Hiroyuki, Kobayashi, Ikuo, Nishikawa, Genya, Kato, Yoshiharu, Watanabe, Masahito, Nakamura, Kogenta, Sumitomo, Makoto

المصدر: Journal of Urology ; volume 199, issue 4S ; ISSN 0022-5347 1527-3792

الإتاحة: https://doi.org/10.1016/j.juro.2018.02.2981Test
https://api.elsevier.com/content/article/PII:S0022534718422938?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022534718422938?httpAccept=text/plainTest

المؤلفون: Kajikawa, Keishi, Kanao, Kent, Morinaga, Shingo, Muramatsu, Hiroyuki, Saiki, Hiroshi, Kobayashi, Ikuo, Kato, Yoshiharu, Watanabe, Masahito, Nakamura, Kogenta, Sumitomo, Makoto

المصدر: Journal of Urology ; volume 197, issue 4S ; ISSN 0022-5347 1527-3792

الإتاحة: https://doi.org/10.1016/j.juro.2017.02.1216Test
https://api.elsevier.com/content/article/PII:S0022534717314404?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022534717314404?httpAccept=text/plainTest