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1دورية أكاديمية
المصدر: Trends in Cancer ; volume 9, issue 12, page 1041-1057 ; ISSN 2405-8033
مصطلحات موضوعية: Cancer Research, Oncology
الإتاحة: https://doi.org/10.1016/j.trecan.2023.07.011Test
https://api.elsevier.com/content/article/PII:S2405803323001383?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2405803323001383?httpAccept=text/plainTest -
2دورية أكاديمية
المؤلفون: Iyer, Ravi F, Verweij, Marieke C, Nair, Sujit S, Morrow, David, Mansouri, Mandana, Chakravarty, Dimple, Beechwood, Teresa, Meyer, Christine, Uebelhoer, Luke, Lauron, Elvin J, Selseth, Andrea, John, Nessy, Thin, Tin Htwe, Dzedzik, Siarhei, Havenar-Daughton, Colin, Axthelm, Michael K, Douglas, Janet, Korman, Alan, Bhardwaj, Nina, Tewari, Ashutosh K, Hansen, Scott, Malouli, Daniel, Picker, Louis J, Früh, Klaus
المصدر: Sci Adv ; ISSN:2375-2548 ; Volume:10 ; Issue:19
الوصف: The nonpolymorphic major histocompatibility complex E (MHC-E) molecule is up-regulated on many cancer cells, thus contributing to immune evasion by engaging inhibitory NKG2A/CD94 receptors on NK cells and tumor-infiltrating T cells. To investigate whether MHC-E expression by cancer cells can be targeted for MHC-E-restricted T cell control, we immunized rhesus macaques (RM) with rhesus cytomegalovirus (RhCMV) vectors genetically programmed to elicit MHC-E-restricted CD8+ T cells and to express established tumor-associated antigens (TAAs) including prostatic acidic phosphatase (PAP), Wilms tumor-1 protein, or Mesothelin. T cell responses to all three tumor antigens were comparable to viral antigen-specific responses with respect to frequency, duration, phenotype, epitope density, and MHC restriction. Thus, CMV-vectored cancer vaccines can bypass central tolerance by eliciting T cells to noncanonical epitopes. We further demonstrate that PAP-specific, MHC-E-restricted CD8+ T cells from RhCMV/PAP-immunized RM respond to PAP-expressing HLA-E+ prostate cancer cells, suggesting that the HLA-E/NKG2A immune checkpoint can be exploited for CD8+ T cell-based immunotherapies.
العلاقة: https://doi.org/10.1126/sciadv.adm7515Test; https://pubmed.ncbi.nlm.nih.gov/38728394Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086602Test/
الإتاحة: https://doi.org/10.1126/sciadv.adm7515Test
https://pubmed.ncbi.nlm.nih.gov/38728394Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086602Test/ -
3دورية أكاديمية
المؤلفون: Chakravarty, Dimple, Muhammad, Hassan, Xie, Chensu, Jain, Parag, Brody, Rachel, Leung, Lawrence, Fatterpekar, Monali, Huang, Wei, Bhardwaj, Swati, Basu, Hirak, Wilding, George, Roy, Rajat, Nair, Sujit S., Tewari, Ashutosh K.
المصدر: Journal of Urology ; volume 211, issue 5S ; ISSN 0022-5347 1527-3792
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4رسالة جامعية
المؤلفون: Nair, Sujit S.
مرشدي الرسالة: Electrical and Computer Engineering, Bostian, Charles W., MacKenzie, Allen B., Patterson, Cameron D.
مصطلحات موضوعية: SDR, Field programmable gate arrays, DSP, GPP, Signal Classifier, Cognitive radio networks
الوصف: The Virginia Tech Universal Classifier Synchronizer (UCS) system can enable a cognitive receiver to detect, classify and extract all the parameters needed from a received signal for physical layer demodulation and configure a cognitive radio accordingly. Currently, UCS can process analog amplitude modulation (AM) and frequency modulation (FM) and digital narrow band M-PSK, M-QAM and wideband signal orthogonal frequency division multiplexing (OFDM). A fully developed prototype of UCS system was designed and implemented in our laboratory using GNU radio software platform and Universal Software Radio Peripheral (USRP) radio platform. That system introduces a lot of latency issues because of the limited USB data transfer speeds between the USRP and the host computer. Also, there are inherent latencies and timing uncertainties in the General Purpose Processor (GPP) software itself. Solving the timing and latency problems requires running key parts of the software-defined radio (SDR) code on a Field Programmable Gate Array (FPGA)/Digital Signal Processor (DSP)/GPP based hybrid platform. Our objective is to port the entire UCS system on the Lyrtech SFF SDR platform which is a hybrid DSP/FPGA/GPP platform. Since the FPGA allows parallel processing on a wideband signal, its computing speed is substantially faster than GPPs and most DSPs, which sequentially process signals. In addition, the Lyrtech Small Form Factor (SFF)-SDR development platform integrates the FPGA and the RF module on one platform; this further reduces the latency in moving signals from RF front end to the computing component. Also for UCS to be commercially viable, we need to port it to a more portable platform which can be transitioned to a handset radio in the future. This thesis is a proof of concept implementation of the coarse classifier which is the first step of classification. Both fixed point and floating point implementations are developed and no compiler specific libraries or vendor specific libraries are used. This makes transitioning the design to any other hardware like GPPs and DSPs of other vendors possible without having to change the basic framework and design.
Master of Scienceوصف الملف: application/pdf
الإتاحة: http://hdl.handle.net/10919/76934Test
http://scholar.lib.vt.edu/theses/available/etd-12212009-235313Test/ -
5دورية أكاديمية
المؤلفون: Pandav, Krunal, Te, Austen G., Tomer, Nir, Nair, Sujit S., Tewari, Ashutosh K.
المساهمون: Intuitive Surgical, National Institutes of Health, U.S. Department of Defense
المصدر: Cancer Reports ; volume 5, issue 8 ; ISSN 2573-8348 2573-8348
الوصف: Background The field of robotic surgery has seen significant advancements in the past few years and it has been adopted in many large hospitals in the United States and worldwide as a standard for various procedures in recent years. However, the location of many hospitals in urban areas and a lack of surgical expertise in the rural areas could lead to increased travel time and treatment delays for patients in need of robotic surgical management, including cancer patients. The fifth generation (5G) networks have been deployed by various telecom companies in multiple countries worldwide. Our aim is to update the readers about the novel technology and the current scenario of surgical procedures performed using 5G technology. In this article, we also discuss how the technology could aid cancer patients requiring surgical management, the future perspectives, the potential challenges, and the limitations, which would need to overcome prior to widespread real‐life use of the technology for cancer care. Recent findings The expansion of 5G technology has enabled some countries to conduct remote surgical procedures, tele‐mentored and real‐time interactive procedures on animal models, cadavers, and humans, demonstrating that 5G networks could offer a potential solution to previously experienced latency and reliability hurdles during the remote surgeries performed in the 2000s. Conclusion New technological advancements could serve as a ground for emerging novel therapeutic applications. While limitations and challenges related to the 5G infrastructure, cost, compatibility, and security exist; researching to overcome the limitations and comprehend the potential benefits of integrating the technology into practice would be imminent before widespread clinical use. Remote and tele‐mentored 5G‐powered procedures could offer a new tool in improving the care of patients requiring robotic surgical management such as prostate cancer patients.
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6دورية أكاديمية
المؤلفون: Rayford, Walter, Beksac, Alp Tuna, Alger, Jordan, Alshalalfa, Mohammed, Ahmed, Mohsen, Khan, Irtaza, Falagario, Ugo G., Liu, Yang, Davicioni, Elai, Spratt, Daniel E., Schaeffer, Edward M., Feng, Felix Y., Mahal, Brandon, Nguyen, Paul L, Den, Robert B., Greenberger, Mark D., Bradley, Randy, Watson, Justin M., Beamer, Matthew, Stamatakis, Lambros, Carmen, Darrell J., Awasthi, Shivanshu, Hwang, Jonathan, Weil, Rachel, Merisaari, Harri, Mohamed, Nihal, Deane, Leslie A., Chakravarty, Dimple, Yadav, Kamlesh K., Yamoah, Kosj, Nair, Sujit S., Tewari, Ashutosh K.
المصدر: Department of Radiation Oncology Faculty Papers
مصطلحات موضوعية: Medicine and Health Sciences, Oncology, Radiation Medicine
الوصف: Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P < 0.001) and ETS (P = 0.02) expression, decreased SPINK1 expression (P < 0.001), and basal-like (P < 0.001) molecular subtypes. After adjusting for confounders, the AAM group was associated with higher expression of CRYBB2, GSTM3, and inflammation genes (IL33, IFNG, CCL4, CD3, ICOSLG), and lower expression of mismatch repair genes (MSH2, MSH6) (p < 0.001 for all). At the pathway level, the AAM group had higher expression of genes sets related to the immune response, apoptosis, hypoxia, and reactive oxygen species. EAM group was associated with higher levels of fatty acid metabolism, DNA repair, and WNT/beta-catenin signaling. Based on cell lines data, AAM were predicted to have higher potential response to DNA damage. In conclusion, biological characteristics of prostate tumor were substantially different in AAM when compared to EAM.
وصف الملف: application/pdf
العلاقة: https://jdc.jefferson.edu/radoncfp/156Test; https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1161&context=radoncfpTest
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7دورية أكاديمية
المصدر: Cancer Reports ; volume 4, issue 5 ; ISSN 2573-8348 2573-8348
الوصف: Background African Americans (AAs) in the United States are known to have a higher incidence and mortality for Prostate Cancer (PCa). The drivers of this epidemiological disparity are multifactorial, including socioeconomic factors leading to lifestyle and dietary issues, healthcare access problems, and potentially tumor biology. Recent findings Although recent evidence suggests once access is equal, AA men have equal outcomes to Caucasian American (CA) men, differences in PCa incidence remain, and there is much to do to reverse disparities in mortality across the USA. A deeper understanding of these issues, both at the clinical and molecular level, can facilitate improved outcomes in the AA population. This review first discusses PCa oncogenesis in the context of its diverse hallmarks before benchmarking key molecular and genomic differences for PCa in AA men that have emerged in the recent literature. Studies have emphasized the importance of tumor microenvironment that contributes to both the unequal cancer burden and differences in clinical outcome between the races. Management of comorbidities like obesity, hypertension, and diabetes will provide an essential means of reducing prostate cancer incidence in AA men. Although requiring further AA specific research, several new treatment strategies such as immune checkpoint inhibitors used in combination PARP inhibitors and other emerging vaccines, including Sipuleucel‐T, have demonstrated some proven efficacy. Conclusion Genomic profiling to integrate clinical and genomic data for diagnosis, prognosis, and treatment will allow physicians to plan a “Precision Medicine” approach to AA men. There is a pressing need for further research for risk stratification, which may allow early identification of AA men with higher risk disease based on their unique clinical, genomic, and immunological profiles, which can then be mapped to appropriate clinical trials. Treatment options are outlined, with a concise description of recent work in AA specific populations, ...
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8دورية أكاديمية
المؤلفون: Nair, Sujit S., Chakravarty, Dimple, Dovey, Zachary S., Zhang, Xiangfu, Tewari, Ashutosh K.
المصدر: Current Opinion in Urology ; volume 32, issue 1, page 96-101 ; ISSN 0963-0643 1473-6586
الوصف: Purpose of review African–American men in the USA have a higher incidence of and mortality from prostate cancer (PCa), with a longstanding debate about the cause for these worse outcomes. This review examines differences in tumour biology and socioeconomics for African–American and Non-Hispanic White (NHW) men to answer the question ‘why AA men face higher risks for lethal PCa’ and draw a management consensus to redress the imbalance. Recent findings Recent evidence from over the past 2 years suggests the reasons why African–American men face a higher risk of lethal PCa are multifactorial, with contributions from differences in tumour biology as well as socioeconomic and healthcare access factors. Regarding tumour biology, genomic and transcriptome profiling suggests African–American men have upregulated expression of genes related to inflammatory pathways with downregulation of DNA repair genes. In contrast, NHW men have higher DNA repair pathways and metabolic pathways involving glycolysis and cell cycle activity. In addition, epidemiological evidence suggests equal healthcare access ensures equal PCa specific outcomes, implying African–American men's disease is not inherently more lethal. However, differences in tumour biology remain, which may explain specific differences in PCa incidence and the clinical findings of African–American men's increased response to immunotherapy and radiotherapy in recent trials. Summary Regardless of racial differences in disease outcomes and the factors causing them, African–American and NHW men seem to have diseases unique to their ancestry. This supports the exploration of personalized PCa treatment approaches, leveraging translational basic science research to uncover these differences and devise specific individualized methods therapeutic regimes to address them.
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9دورية أكاديمية
المؤلفون: Chakravarty, Dimple, Nair, Sujit S., Hammouda, Nada, Ratnani, Parita, Gharib, Yasmine, Wagaskar, Vinayak, Mohamed, Nihal, Lundon, Dara, Dovey, Zachary, Kyprianou, Natasha, Tewari, Ashutosh K.
المصدر: Communications Biology ; volume 3, issue 1 ; ISSN 2399-3642
مصطلحات موضوعية: General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, Medicine (miscellaneous)
الوصف: The recent outbreak of infections and the pandemic caused by SARS-CoV-2 represent one of the most severe threats to human health in more than a century. Emerging data from the United States and elsewhere suggest that the disease is more severe in men. Knowledge gained, and lessons learned, from studies of the biological interactions and molecular links that may explain the reasons for the greater severity of disease in men, and specifically in the age group at risk for prostate cancer, will lead to better management of COVID-19 in prostate cancer patients. Such information will be indispensable in the current and post-pandemic scenarios.
الإتاحة: https://doi.org/10.1038/s42003-020-1088-9Test
https://www.nature.com/articles/s42003-020-1088-9.pdfTest
https://www.nature.com/articles/s42003-020-1088-9Test -
10دورية أكاديمية
المؤلفون: Theise, Neil D., Arment, Anthony R., Chakravarty, Dimple, Gregg, John M. H., Jacobson, Ira M., Jung, Kie Hoon, Nair, Sujit S., Tewari, Ashutosh K., Thurston, Archie W., Van Drie, John, Westover, Jonna B.
المساهمون: NIH, NIAID, Palisades Therapeutics/Pop Test Oncology LLC
المصدر: Cell Cycle ; volume 19, issue 24, page 3632-3638 ; ISSN 1538-4101 1551-4005
