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1دورية أكاديمية
المؤلفون: Ward, Isobel L., Robertson, Chris, Agrawal, Utkarsh, Patterson, Lynsey, Bradley, Declan T., Shi, Ting, de Lusignan, Simon, Hobbs, F. D. Richard, Sheikh, Aziz, Nafilyan, Vahé
مصطلحات موضوعية: Public health. Hygiene. Preventive Medicine
الوصف: The emergence of the COVID-19 vaccination has been critical in changing the course of the COVID-19 pandemic. To ensure protection remains high in vulnerable groups booster vaccinations in the UK have been targeted based on age and clinical vulnerabilities. We undertook a national retrospective cohort study using data from the 2021 Census linked to electronic health records. We fitted cause-specific Cox models to examine the association between health conditions and the risk of COVID-19 death and all-other-cause death for adults aged 50-100-years in England vaccinated with a booster in autumn 2022. Here we show, having learning disabilities or Down Syndrome (hazard ratio=5.07;95% confidence interval=3.69-6.98), pulmonary hypertension or fibrosis (2.88;2.43-3.40), motor neuron disease, multiple sclerosis, myasthenia or Huntington's disease (2.94, 1.82-4.74), cancer of blood and bone marrow (3.11;2.72-3.56), Parkinson's disease (2.74;2.34-3.20), lung or oral cancer (2.57;2.04 to 3.24), dementia (2.64;2.46 to 2.83) or liver cirrhosis (2.65;1.95 to 3.59) was associated with an increased risk of COVID-19 death. Individuals with cancer of the blood or bone marrow, chronic kidney disease, cystic fibrosis, pulmonary hypotension or fibrosis, or rheumatoid arthritis or systemic lupus erythematosus had a significantly higher risk of COVID-19 death relative to other causes of death compared with individuals who did not have diagnoses. Policy makers should continue to priorities vulnerable groups for subsequent COVID-19 booster doses to minimise the risk of COVID-19 death.
وصف الملف: text
العلاقة: https://strathprints.strath.ac.uk/88856/1/Ward-etal-NC-2024-Risk-of-COVID-19-death-in-adults-who-received-booster-COVID-19-vaccinations.pdfTest; Ward, Isobel L. and Robertson, Chris and Agrawal, Utkarsh and Patterson, Lynsey and Bradley, Declan T. and Shi, Ting and de Lusignan, Simon and Hobbs, F. D. Richard and Sheikh, Aziz and Nafilyan, Vahé (2024 ) Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England. Nature Communications , 15 (1). 398. ISSN 2041-1723
الإتاحة: https://doi.org/10.1038/s41467-023-44276-xTest
https://strathprints.strath.ac.uk/88856Test/
https://strathprints.strath.ac.uk/88856/1/Ward-etal-NC-2024-Risk-of-COVID-19-death-in-adults-who-received-booster-COVID-19-vaccinations.pdfTest -
2دورية أكاديمية
المؤلفون: Thomas, Seth, Littleboy, Kathryn, Foubert, Josephine, Nafilyan, Vahe, Bannister, Neil, Routen, Ash, Morriss, Richard, Khunti, Kamlesh, Armstrong, Natalie, Gray, Laura J, Gordon, Adam L
مصطلحات موضوعية: Fractures, Bone - diagnosis - epidemiology, Pandemics, frailty, Frail Elderly, Communicable Disease Control, COVID-19, older people, Aged, Humans, Frailty - diagnosis - epidemiology, COVID-19 - epidemiology, falls, Hospitals, Cohort Studies
الوصف: Background: Older people with frailty are at risk of harm from immobility or isolation, yet data about how COVID-19 lockdowns affected them are limited. Falls and fractures are easily measurable adverse outcomes correlated with frailty. We investigated whether English hospital admission rates for falls and fractures varied from the expected trajectory during the COVID-19 pandemic, and how these varied by frailty status. Methods: NHS England Hospital Episode Statistics Admitted Patient Care data were analysed for observed versus predicted outcome rates for 24 January 2020 to 31 December 2021. An auto-regressive integrated moving average time-series model was trained using falls and fracture incidence data from 2013 to 2018 and validated using data from 2019. Models included national and age-, sex- and region-stratified forecasts. Outcome measures were hospital admissions for falls, fractures, and falls and fractures combined. Frailty was defined using the Hospital Frailty Risk Score. Results: 144,148,915 pre-pandemic hospital admissions were compared with 42,267,318 admissions after pandemic onset. For the whole population, falls and fracture rates were below predicted for the first period of national lockdown, followed by a rapid return to rates close to predicted. Thereafter, rates followed expected trends. For people living with frailty, however, falls and fractures increased above expected rates during periods of national lockdown and remained elevated throughout the study period. Effects of frailty were independent of age. Conclusions: People living with frailty experienced increased fall and fracture rates above expected during and following periods of national lockdown. These remained persistently elevated throughout the study period.
العلاقة: https://nottingham-repository.worktribe.com/output/31889608Test; Age and Ageing; Volume 53; Issue 4; https://nottingham-repository.worktribe.com/file/31889608/1/ONS%20Collaboration%20Age%20And%20Ageing%20AA-23-1653.R1Test
الإتاحة: https://doi.org/10.1093/ageing/afae071Test
https://nottingham-repository.worktribe.com/file/31889608/1/ONS%20Collaboration%20Age%20And%20Ageing%20AA-23-1653.R1Test
https://nottingham-repository.worktribe.com/output/31889608Test -
3دورية أكاديمية
المؤلفون: Ayoubkhani, Daniel, Zaccardi, Francesco, Pouwels, Koen B, Walker, A Sarah, Houston, Donald, Alwan, Nisreen A, Martin, Josh, Khunti, Kamlesh, Nafilyan, Vahé
المساهمون: Department of Health and Social Care, Welsh Government
المصدر: European Journal of Public Health ; ISSN 1101-1262 1464-360X
الوصف: Background Evidence on the long-term employment consequences of SARS-CoV-2 infection is lacking. We used data from a large, community-based sample in the UK to estimate associations between Long Covid and employment outcomes. Methods This was an observational, longitudinal study using a pre–post design. We included survey participants from 3 February 2021 to 30 September 2022 when they were aged 16–64 years and not in education. Using conditional logit modelling, we explored the time-varying relationship between Long Covid status ≥12 weeks after a first test-confirmed SARS-CoV-2 infection (reference: pre-infection) and labour market inactivity (neither working nor looking for work) or workplace absence lasting ≥4 weeks. Results Of 206 299 participants (mean age 45 years, 54% female, 92% white), 15% were ever labour market inactive and 10% were ever long-term absent during follow-up. Compared with pre-infection, inactivity was higher in participants reporting Long Covid 30 to <40 weeks [adjusted odds ratio (aOR): 1.45; 95% CI: 1.17–1.81] or 40 to <52 weeks (aOR: 1.34; 95% CI: 1.05–1.72) post-infection. Combining with official statistics on Long Covid prevalence, and assuming a correct statistical model, our estimates translate to 27 000 (95% CI: 6000–47 000) working-age adults in the UK being inactive because of Long Covid in July 2022. Conclusions Long Covid is likely to have contributed to reduced participation in the UK labour market, though it is unlikely to be the sole driver. Further research is required to quantify the contribution of other factors, such as indirect health effects of the pandemic.
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4دورية أكاديمية
المؤلفون: Hopper, Neil A, Campbell, Annie, Roberts, Cath, Ramsay, Julie, IJpelaar, Jos, Glickman, Myer, Nafilyan, Vahé, Islam, Nazrul
الوصف: We compare the impact of the first two waves of the COVID-19 pandemic on risk of age-standardized mortality by sex, UK country, and English region. Each wave is defined as lasting 26 weeks and are consecutive beginning in 2020 week 11. The expected rate is estimated from 2015 to 2019 mean and the projected mortality trend from the same period are used to estimate excess mortality. By both measures, excess mortality was highest and lowest in regions of England, London and the South-West, respectively. Excess mortality was consistently higher for males than females.
وصف الملف: text
العلاقة: https://eprints.soton.ac.uk/483703/1/Hopper_EJPH_Author_accepted_version_2023_10.1093_ckad144.pdfTest; https://eprints.soton.ac.uk/483703/2/ckad144.pdfTest; Hopper, Neil A, Campbell, Annie, Roberts, Cath, Ramsay, Julie, IJpelaar, Jos, Glickman, Myer, Nafilyan, Vahé and Islam, Nazrul (2023) A comparison of excess deaths by UK country and region during the first year of the COVID-19 pandemic. European Journal of Public Health, [ckad144]. (doi:10.1093/eurpub/ckad144 ).
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5دورية أكاديمية
المؤلفون: Bosworth, Matthew L., Shenhuy, Boran, Walker, A. Sarah, Nafilyan, Vahé, Alwan, Nisreen A., O'Hara, Margaret E., Ayoubkhani, Daniel
الوصف: Background: little is known about the risk of Long Covid following reinfection with SARS-CoV-2. We estimated the likelihood of new-onset, self-reported Long Covid after a second SARS-CoV-2 infection, and compared to a first infection. Methods: we included UK COVID-19 Infection Survey participants who tested positive for SARS-CoV-2 between 1 November 2021 and 8 October 2022. The primary outcome was self-reported Long Covid 12 to 20 weeks after each infection. Separate analyses were performed for those <16 years and ≥16 years. We estimated adjusted odds ratios (aORs) for new-onset Long Covid using logistic regression, comparing second to first infections, controlling for socio-demographic characteristics and calendar date of infection, plus vaccination status in those ≥16 years. Results: overall, Long Covid was reported by those ≥16 years after 4.0% and 2.4% of first and second infections, respectively; the corresponding estimates among those <16 years were 1.0% and 0.6%. The aOR for Long Covid after second compared to first infections was 0.72 (95% confidence interval: 0.63–0.81) for those ≥16 years and 0.93 (0.57–1.53) for those <16 years. Conclusions: the risk of new-onset Long Covid after a second SARS-CoV-2 infection is lower than that after a first infection for those ≥16 years, though there is no evidence of a difference in risk for those <16 years. However, there remains some risk of new-onset Long Covid after a second infection, with around 1 in 40 of those ≥16 years and 1 in 165 of those <16 years reporting Long Covid after a second infection.
وصف الملف: text
العلاقة: https://eprints.soton.ac.uk/482667/1/New_onset_long_COVID_after_reinfection_R1_clean_2_.docxTest; Bosworth, Matthew L., Shenhuy, Boran, Walker, A. Sarah, Nafilyan, Vahé, Alwan, Nisreen A., O'Hara, Margaret E. and Ayoubkhani, Daniel (2023) Risk of new-onset Long Covid following reinfection with SARS-CoV-2: community-based cohort study. Open Forum Infectious Diseases, 10 (11), [ofad493]. (doi:10.1093/ofid/ofad493 ).
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6دورية أكاديمية
المؤلفون: Ayoubkhani, Daniel, Zaccardi, Francesco, Pouwels, Koen B., Walker, A. Sarah, Houston, Donald, Alwan, Nisreen, Martin, Josh, Nafilyan, Vahé
الوصف: Background: evidence on the long-term employment consequences of SARS-CoV-2 infection is lacking. We used data from a large, community-based sample in the UK to estimate associations between Long Covid and subsequent employment outcomes. Methods: this was an observational, longitudinal study using a pre-post design. We included UK COVID-19 Infection Survey participants who completed questionnaires on Long Covid from 3 February 2021 to 30 September 2022 when they were aged 16 to 64 years and not in full-time education. We used conditional logit modelling to explore the time-varying relationship between Long Covid status ≥12 weeks after a first test-confirmed SARS-CoV-2 infection (reference: pre-infection) and labour market inactivity (neither working nor looking for work) or workplace absence lasting ≥4 weeks. Results: of 206,299 included participants (mean age 45 years, 54% female, 92% white), 15% were ever inactive in the labour market and 10% were ever long-term absent during follow-up. Compared with pre-infection, inactivity was higher in participants reporting Long Covid 30 to <40 weeks (adjusted odds ratio (aOR): 1.45; 95% CI: 1.17 to 1.81) or 40 to <52 weeks (1.34; 1.05 to 1.72) post-infection. Compared with pre-infection, reporting Long Covid was also associated with increased odds of long-term absence 18 to <24 weeks (1.40; 1.04 to 1.90) and 24 to <30 weeks (1.45; 1.03 to 2.04) post-infection, but not beyond 30 weeks. Combining with official statistics on Long Covid prevalence, our estimates translate to 27,000 (95% CI: 6,000 to 47,000) working-age adults in the UK being inactive because of their Long Covid symptoms in July 2022. Conclusions: Long Covid is likely to have contributed to reduced levels of participation in the UK labour market, though it is unlikely to be the sole driver. Further research is required to quantify the contribution of other factors, such as indirect health effects of the pandemic.
وصف الملف: text
العلاقة: https://eprints.soton.ac.uk/477501/1/2023.03.21.23287524v1.full.pdfTest; [Unknown type: UNSPECIFIED]
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7دورية أكاديمية
المؤلفون: Bosworth, Matthew L, Ahmed, Tamanna, Larsen, Tim, Lorenzi, Luke, Morgan, Jasper, Ali, Raghib, Goldblatt, Peter, Islam, Nazrul, Khunti, Kamlesh, Raleigh, Veena, Ayoubkhani, Daniel, Bannister, Neil, Glickman, Myer, Nafilyan, Vahe
الوصف: Background: Ethnic minority groups in England have been disproportionately affected by the COVID-19 pandemic and have lower vaccination rates than the White British population. We examined whether ethnic differences in COVID-19 mortality in England have continued since the vaccine rollout and to what extent differences in vaccination rates contributed to excess COVID-19 mortality after accounting for other risk factors. Methods: We conducted a retrospective, population-based cohort study of 28.8 million adults aged 30–100 years in England. Self-reported ethnicity was obtained from the 2011 Census. The outcome was death involving COVID-19 during the second (8 December 2020 to 12 June 2021) and third wave (13 June 2021 to 1 December 2021). We calculated hazard ratios (HRs) for death involving COVID-19, sequentially adjusting for age, residence type, geographical factors, sociodemographic characteristics, pre-pandemic health, and vaccination status. Results: Age-adjusted HRs of death involving COVID-19 were elevated for most ethnic minority groups during both waves, particularly for groups with lowest vaccination rates (Bangladeshi, Pakistani, Black African, and Black Caribbean). HRs were attenuated after adjusting for geographical factors, sociodemographic characteristics, and pre-pandemic health. Further adjusting for vaccination status substantially reduced residual HRs for Black African, Black Caribbean, and Pakistani groups in the third wave. Fully adjusted HRs only remained elevated for the Bangladeshi group (men: 2.19 [95% CI 1.72–2.78]; women: 2.12 [1.58–2.86]) and Pakistani men (1.24 [1.06–1.46]). Conclusions: Lower COVID-19 vaccination uptake in several ethnic minority groups may drive some of the differences in COVID-19 mortality compared to White British. Public health strategies to increase vaccination uptake in ethnic minority groups would help reduce inequalities in COVID-19 mortality, which have remained substantial since the start of the vaccination campaign.
وصف الملف: text
العلاقة: https://eprints.soton.ac.uk/470499/1/2022.02.14.22270940v1.full.pdfTest; https://eprints.soton.ac.uk/470499/2/s12916_022_02704_7_1_.pdfTest; Bosworth, Matthew L, Ahmed, Tamanna, Larsen, Tim and Islam, Nazrul , et al. (2023) Ethnic differences in COVID-19 mortality in the second and third waves of the pandemic in England during the vaccine roll-out: a retrospective, population-based cohort study. BMC Medicine, 21 (1), [13]. (doi:10.1101/2022.02.14.22270940 ).
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8دورية أكاديمية
المؤلفون: Thomas, Seth, Machuel, Perrine, Foubert, Josephine, Nafilyan, Vahe, Bannister, Neil, Colvin, Helen, Routen, Ash, Morriss, Richard, Khunti, Kamlesh, Farooqi, Azhar, Armstrong, Natalie, Gray, Laura J, Gordon, Adam
الوصف: INTRODUCTION: Older people were at particular risk of morbidity and mortality during COVID-19. Consequently, they experienced formal (externally imposed) and informal (self-imposed) periods of social isolation and quarantine. This is hypothesised to have led to physical deconditioning, new-onset disability and frailty. Disability and frailty are not routinely collated at population level but are associated with increased risk of falls and fractures, which result in hospital admissions. First, we will examine incidence of falls and fractures during COVID-19 (January 2020-March 2022), focusing on differences between incidence over time against expected rates based on historical data, to determine whether there is evidence of new-onset disability and frailty. Second, we will examine whether those with reported SARS-CoV-2 were at higher risk of falls and fractures. METHODS AND ANALYSIS: This study uses the Office for National Statistics (ONS) Public Health Data Asset, a linked population-level dataset combining administrative health records with sociodemographic data of the 2011 Census and National Immunisation Management System COVID-19 vaccination data for England. Administrative hospital records will be extracted based on specific fracture-centric International Classification of Diseases-10 codes in years preceding COVID-19 (2011-2020). Historical episode frequency will be used to predict expected admissions during pandemic years using time series modelling, if COVID-19 had not occurred. Those predicted admission figures will be compared with actual admissions to assess changes in hospital admissions due to public health measures comprising the pandemic response. Hospital admissions in prepandemic years will be stratified by age and geographical characteristics and averaged, then compared with pandemic year admissions to assess more granular changes. Risk modelling will assess risk of experiencing a fall, fracture or frail fall and fracture, if they have reported a positive case of COVID-19. The combination of ...
العلاقة: https://nottingham-repository.worktribe.com/output/19001681Test; BMJ Open; Volume 13; Issue 5; https://nottingham-repository.worktribe.com/file/19001681/1/Study%20protocol%20for%20the%20use%20of%20time%20series%20forecasting%20and%20risk%20analyses%20to%20investigate%20the%20effect%20of%20the%20COVID-19%20pandemic%20on%20hospital%20admissions%20associated%20with%20new-onset%20disability%20and%20frailty%20in%20a%20national,%20linked%20electronic%20health%20data%20settingTest
الإتاحة: https://doi.org/10.1136/bmjopen-2022-067786Test
https://nottingham-repository.worktribe.com/file/19001681/1/Study%20protocol%20for%20the%20use%20of%20time%20series%20forecasting%20and%20risk%20analyses%20to%20investigate%20the%20effect%20of%20the%20COVID-19%20pandemic%20on%20hospital%20admissions%20associated%20with%20new-onset%20disability%20and%20frailty%20in%20a%20national,%20linked%20electronic%20health%20data%20settingTest
https://nottingham-repository.worktribe.com/output/19001681Test -
9دورية أكاديمية
المؤلفون: Matz, M, Rhodes, S, Van Tongeren, M, Coleman, MP, Allemani, C, Nafilyan, Vahé, Pearce, Neil
المصدر: Matz , M , Rhodes , S , Van Tongeren , M , Coleman , MP , Allemani , C , Nafilyan , V & Pearce , N 2023 , ' Excess mortality among essential workers in England and Wales during the COVID-19 pandemic : an updated analysis ' , Journal of Epidemiology and Community Health , vol. 77 , no. 8 , pp. 481-484 . https://doi.org/10.1136/jech-2023-220391Test
مصطلحات موضوعية: COVID-19, EPIDEMIOLOGY, MORTALITY
الوصف: Background Excess mortality from all causes combined during the COVID-19 pandemic in England and Wales in 2020 was predominantly higher for essential workers. In 2021, the vaccination programme had begun, new SARS-CoV-2 variants were identified and different policy approaches were used. We have updated our previous analyses of excess mortality in England and Wales to include trends in excess mortality by occupation for 2021. Methods We estimated excess mortality for working age adults living in England and Wales by occupational group for each month in 2021 and for the year as a whole. Results During 2021, excess mortality remained higher for most groups of essential workers than for non-essential workers. It peaked in January 2021 when all-cause mortality was 44.6% higher than expected for all occupational groups combined. Excess mortality was highest for adults working in social care (86.9% higher than expected). Conclusion Previously, we reported excess mortality in 2020, with this paper providing an update to include 2021 data. Excess mortality was predominantly higher for essential workers during 2021. However, unlike the first year of the pandemic, when healthcare workers experienced the highest mortality, the highest excess mortality during 2021 was experienced by social care workers.
الإتاحة: https://doi.org/10.1136/jech-2023-220391Test
https://research.manchester.ac.uk/en/publications/1b14b5a7-e4fa-44a9-8ff7-50a424c2b28aTest
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_starter&SrcAuth=WosAPI&KeyUT=WOS:000999674100001&DestLinkType=FullRecord&DestApp=WOSTest -
10دورية أكاديمية
المؤلفون: Carrino, Ludovico, Nafilyan, Vahé, Avendano, Mauricio
المصدر: Journal of Policy Analysis and Management, vol. 42, no. 2, pp. 424-455
مصطلحات موضوعية: Public Administration, Sociology and Political Science, General Business, Management and Accounting
وصف الملف: application/pdf
العلاقة: info:eu-repo/semantics/altIdentifier/pissn/0276-8739; info:eu-repo/semantics/altIdentifier/pissn/1520-6688; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_655FCE5A280F3; https://serval.unil.ch/notice/serval:BIB_655FCE5A280FTest; https://serval.unil.ch/resource/serval:BIB_655FCE5A280F.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_655FCE5A280F3Test
الإتاحة: https://doi.org/10.1002/pam.22457Test
https://serval.unil.ch/notice/serval:BIB_655FCE5A280FTest
https://serval.unil.ch/resource/serval:BIB_655FCE5A280F.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_655FCE5A280F3Test
