المؤلفون: Deveci, Hacı Ahmet, Nur, Gökhan, Kükürt, Abdulsamed, Kuru, Mushap, Deveci, Ayla

المساهمون: Mühendislik ve Doğa Bilimleri Fakültesi -- Biyomedikal Mühendisliği Bölümü, Nur, Gökhan

مصطلحات موضوعية: Cadmium, Caffeic acid phenethyl ester, Oxidant-antioxidant balance, Paraoxonase activity, Sialic acid, Cadmium Chlorides, Oxidative Stress, Testes, Veterinary Sciences, Aryldialkylphosphatase, High density lipoprotein, Low density lipoprotein, Animal experiment, Animal model, Animal tissue, Antioxidant activity, Apoptosis, Biochemical analysis, Cadmium poisoning, Controlled study, Degeneration, Enzymatic hydrolysis, Female, Histopathology, Liver cell, Liver protection, Liver tissue, Liver toxicity, Mouse, Nonhuman

الوصف: In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. A total of 40 female Swiss albino mice were used, with 10 mice in each group. The mice were divided into four groups (Group I - Control group, Group II - CAPE group, Group III - Cadmium group, Group IV - Cadmium + CAPE group). Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels (P<0.001, P<0.01, and P<0.01, respectively) and increased their TSA, LDL, TOC, and OSI levels (P<0.05, P<0.01, P<0.01, and P<0.01, respectively). The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage.

وصف الملف: application/pdf

العلاقة: Ankara Universitesi Veteriner Fakultesi Dergisi; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Web of Science - Scopus; Web of Science Core Collection - Science Citation Index Expanded; Deveci, H.A., Nur, G., Kükürt, A., Kuru, M., Deveci, A. (2023). The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 70(4), 367-374. https://doi.org/10.33988/auvfd.1068527Test; https://doi.org/10.33988/auvfd.1068527Test; https://hdl.handle.net/20.500.12508/2624Test; 70; 367; 374

الإتاحة: https://doi.org/20.500.12508/2624Test
https://doi.org/10.33988/auvfd.1068527Test
https://hdl.handle.net/20.500.12508/2624Test

المؤلفون: Nur, Gökhan, Çaylak, Emrah, Kılıçle, Pınar Aksu, Sandayuk, Şafak, Çelebi, Özlem Önen

المساهمون: Mühendislik ve Doğa Bilimleri Fakültesi -- Biyomedikal Mühendisliği Bölümü, Nur, Gökhan

مصطلحات موضوعية: Acetamiprid, Bcl-2, Histopathology, Immunoreactivity, Kidney, P53, Neonicotinoids, Imidacloprid, Nicotinic Receptors, General & Internal Medicine, Eosin, Formaldehyde, Hematoxylin, Protein bcl 2, Protein p53, animal cell, animal experiment, animal tissue, apoptosis, Atrophy, Bioaccumulation, Controlled study, Degeneration, Distal tubule cell, glomerulus, immunohistochemistry, kidney capsule, Kidney distal tubule, Kidney epithelium, Kidney hemorrhage

الوصف: Pesticides, which adversely affect the critical metabolic processes of organisms, disrupt the physiological balance by specifically targeting enzymes and may lead to such consequences that may lead to death. It provides benefits in agricultural activities. The p53 protein antagonizes bcl-2, an anti-apoptotic protein character, and induces apoptosis by causing mitochondrial membrane permeability. This study aims to show the effect of acetamiprid, which is an insecticide from the neonicotinoid class, on bcl-2 and p53 immunoreactivity, which has an important place in the apoptotic mechanism in kidney tissue. A total of four groups including control and three experimental groups (the acetamiprid was administered 5, 10, and 15 mg kg-1) were formed in the study. After acetamiprid was administered via gavage for 14 days, the kidney tissues taken from the mice, which were sacrificed by cervical dislocation, were fixed in 10% formaldehyde solution for histological and immunohistochemical analyses, and as a result of routine tissue follow-up, the sections were blocked in paraffin and stained with haematoxylin-eosin and immunostaining. The histopathological examinations revealed that while the kidney tissue had a normal structure in the control group, degeneration in the distal and proximal tubules, glomerular degeneration, increase in the capsular area, glomerular atrophy, and haemorrhage were determined in the acetamiprid groups at increasing severity and frequency depending on the dose of the applied substance. In the kidney tissue, Bcl-2 and p53 immunoreactivity was observed in glomerular cells, sinusoidal epithelium, and proximal and distal tubule cells. The acetamiprid caused pathological changes in the kidneys in the dose range used. This effect also affects the expression of bcl-2 and p53 genes, which are biomarkers in the apoptotic mechanism. As acetamiprid accumulates in tissues, it increases the expression of p53 from cell death receptors, while suppressing the anti-apoptotic bcl-2 expression.

وصف الملف: application/pdf

العلاقة: Open Medicine (Poland); Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Web of Science - Scopus - PubMed; https://doi.org/10.1515/med-2022-0603Test; https://hdl.handle.net/20.500.12508/2435Test; 17; 1788; 1796

الإتاحة: https://doi.org/20.500.12508/2435Test
https://doi.org/10.1515/med-2022-0603Test
https://hdl.handle.net/20.500.12508/2435Test

المؤلفون: Deveci, Haci Ahmet, Nur, Gökhan, Deveci, Ayla, Kaya, Inan, Kaya, Müge Mavioglu, Kükürt, Abdulsamed, Gelen, Volkan, Başer, Ömer Faruk, Karapehlivan, Mahmut

المصدر: https://www.intechopen.com/books/11015Test.

مصطلحات موضوعية: Insecticides - Impact and Benefits of Its Use for Humanity

الوصف: The number of studies on insecticides, which constitute an important class of pesticides, is increasing day by day. These chemicals used in the fight against pests in the field of agriculture; It is also used to fight mosquitoes and insects in homes, gardens and rural areas. Excessive use of insecticides has adversely affected many beneficial organisms besides target organisms. As a result of the negative effects of insecticides on non-target organisms, the normal balance of nature has been disturbed and this has led to the decline of some living species in the world. In many studies from the past to the present, it has been shown that these insecticides have negative effects on the environment, human and animal health. Some of these chemicals, which have many benefits in the fight against agricultural pests, have been banned due to their harmful effects on non-target organisms as a result of excessive use. Today, however, these chemicals are still used intensively against agricultural pests, threatening non-target organisms and human health. For this reason, in this book chapter we have prepared, the negative effects of insecticides on living things are examined by reviewing biochemical and histopathological studies.

العلاقة: https://mts.intechopen.com/articles/show/title/an-overview-of-the-biochemical-and-histopathological-effects-of-insecticidesTest

الإتاحة: https://doi.org/10.5772/intechopen.100401Test
https://mts.intechopen.com/articles/show/title/an-overview-of-the-biochemical-and-histopathological-effects-of-insecticidesTest

المؤلفون: Akyuva, Yener, Nur, Gökhan, Deveci, Hacı Ahmet, Güler, Songül Kocabaş

المساهمون: Mühendislik ve Doğa Bilimleri Fakültesi -- Biyomedikal Mühendisliği Bölümü, Nur, Gökhan

مصطلحات موضوعية: Biochemical alteration, Head trauma, Multiple traumas, Total antioxidant/oxidant level, Aryldialkylphosphatase, Arylesterase, Oxidative Stress, Neurosciences & Neurology, Surgery, Brain-injury, Risk-factors, Epidemiology, Damage, Care

الوصف: AIM: To evaluate paraoxonase (PON), total antioxidant status (TAS), total oxidant status (TOS), high-density lipoproteins (HDL), CRP, AST, ALT, GGT, ALP levels in patients with head and multiple organ traumas.MATERIAL and METHODS: The study included 29 male patients undergoing treatment for head and multiple organ traumas. Blood sample analysis was performed on the first, third, and seventh days after trauma.RESULTS: The mean age, duration of hospitalization in the intensive care unit, and intubation period of the study sample was 45 years (range: 9 to 81 years), 4.29 days, and 2.94 days, respectively. One patient died, and 13 underwent surgical intervention. Comparison of PON, TAS, TOS, and CRP levels showed statistically significant differences between the first day and the third and seventh days, although no such differences were seen in HDL levels. A moderately positive correlation was observed between CRP/ AST, CRP/ALT and CRP/GGT, while a moderately negative correlation was seen between CRP/ALP.CONCLUSION: The findings of this study suggest that some oxidative parameters may play a significant role in the prognosis and follow-up of intensive care patients. Moreover, biochemical markers can provide important information about patient response to trauma.

وصف الملف: application/pdf

العلاقة: Turkish Neurosurgery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Web of Science - Scopus - PubMed; Web of Science Core Collection - Science Citation Index Expanded; https://doi.org/10.5137/1019-5149.JTN.42560-22.2Test; https://hdl.handle.net/20.500.12508/3044Test; 33; 855; 861

الإتاحة: https://doi.org/20.500.12508/3044Test
https://doi.org/10.5137/1019-5149.JTN.42560-22.2Test
https://hdl.handle.net/20.500.12508/3044Test

المؤلفون: Deveci, Haci Ahmet, Akyuva, Yener, Nur, Gökhan, Nazıroğlu, Mustafa

المساهمون: BSN Health, Analysis and Innovation Ltd. Inc. Teknokent, Goller Bolgesi Teknokenti, Isparta, Turkey

المصدر: Biomedicine & Pharmacotherapy ; volume 111, page 292-304 ; ISSN 0753-3322

مصطلحات موضوعية: Pharmacology, General Medicine

الإتاحة: https://doi.org/10.1016/j.biopha.2018.12.077Test
https://api.elsevier.com/content/article/PII:S0753332218355070?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0753332218355070?httpAccept=text/plainTest

المؤلفون: Deveci, Hacı Ahmet, Kükürt, Abdulsamed, Nur, Gökhan, Alpay, Merve, Merhan, Oğuz, Bozukluhan, Kadir, Karapehlivan, Mahmut

المساهمون: DÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü

مصطلحات موضوعية: foot and mouth disease, paraoxonase activity, sialic acid, Awassi sheep

الوصف: DEVECI, HACI AHMET/0000-0002-5613-0520; ; WOS: 000427048800011 ; The aim of this study was to investigate paraoxonase (PON1) activity and total sialic acid to be measured for the first time in sheep infected naturally with foot and mouth disease, and their relationships with oxidative stress. A total of 30 Awassi sheep (aged between 2-4), which were healthy and infected with the foot and mouth disease virus (FMDV) were used in the study. Concentrations of paraoxonase activity (PON1), which is an important antioxidant against oxidative stress, high density lipoprotein (HDL) and total sialic acid (TSA), which has a critical role for immune system and is one of the significant indicators of cellular degeneration, were measured in serum samples drawn from animals. The total oxidant capacity (TOC) and total antioxidant capacity (TAC) were evaluated to determine the oxidative balance. It was observed that serum PON1 (P < 0.001) and HDL (P < 0.01) concentrations were significantly lower compared to the control group. TSA concentration was higher in the infected group (P < 0.001) compared to the healthy group. TOC was higher (P < 0.001) and TAC was lower (P < 0.01) in the infected group compared to the control group. Consequently, harmful effects of the infection of foot and mouth disease were shown as cause of oxidative cell damage and the high rate of sialic acid was produced depending on the degeneration during the infection.

العلاقة: Medycyna Weterynaryjna-Veterinary Medicine-Science And Practice; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.21521/mw.6078Test; https://hdl.handle.net/20.500.12684/4516Test; 74; 199; 202

الإتاحة: https://doi.org/20.500.12684/4516Test
https://doi.org/10.21521/mw.6078Test
https://hdl.handle.net/20.500.12684/4516Test

المؤلفون: Nur, Gökhan¹ gokhan.nur@iste.edu.tr, Barış, Büşra Nur¹, Levent, Büşra¹, Sazaklıoğlu, Buse Selin¹, Ak, Elvan²

المصدر: Natural & Engineering Sciences. Apr2023, Vol. 8 Issue 1, p18-30. 13p.

مصطلحات موضوعية: *TRANSCUTANEOUS electrical nerve stimulation, *MUSCLE cramps, *PHYSICAL therapy, *FIBROMYALGIA, *OSCILLOSCOPES

مستخلص: The Transcutaneous Electrical Nerve Stimulator (TENS) is one of the medical devices that uses electricity to stimulate the nerve and produce analgesic effects. A TENS device is a small batterypowered or city-powered device with ends attached to sticky pads called electrodes. TENS, with its main purpose of helping to reduce pain and muscle spasms, has a wide usage area, especially in arthritis, fibromyalgia, chronic pelvic pain, knee pain, menstrual pain, low back pain, sports injuries, and atrophic muscle tissue cases. In this study, a Transcutaneous electrical stimulation device, which is one of the physical therapy methods performed by applying electrical energy, was designed. Designed device; it is easy to use, low cost, and suitable for patients, and ardunio is used for integration and programming. [ABSTRACT FROM AUTHOR]

المؤلفون: MOHAMMED, Omar Mahmood, DEVECİ, Haci Ahmet, NUR, Gökhan

المصدر: Volume: 5, Issue: 2 45-49
Eurasian Journal of Biological and Chemical Sciences

مصطلحات موضوعية: Bellis, Cyprinus carpio, Total sialic acid, Total oxidant/antioxidant level, Total sialik asit, Total oksidan/antioksidan seviye, Biology, Biyoloji

الوصف: In this study, it was aimed to investigate the effect of Bellis, a fungicide widely used in agriculture, on plasma total antioxidant level (TAS), total oxidant level (TOS) and total sialic acid (TSA) levels in Cyprinus carpio. A total of 30 (250-300 g) C. carpio were used, 10 in each group. Fish were divided into 3 groups as control group, Bellis I group (0.025 mg/L Bellis) and Bellis II group (0.050 mgl/L Bellis). After 14 days of fungicide application to Belllis groups, blood samples were taken from the fish and their plasmas were obtained. TAS, TOS and TSA levels were measured in the obtained plasma samples. According to the findings obtained in the study, the TAS level in the control group was found to be statistically significantly higher (p
Bu çalışmada tarım alanında yaygın olarak kullanılan bir fungisit olan Bellis’in Cyprinus carpio’da plazma total antioksidan seviye (TAS), total oksidan seviye (TOS) ve total sialik asit (TSA) seviyelerine etkisinin araştırılması amaçlandı. Her grupta 10 adet olmak üzere toplam 30 adet (250-300g) C. carpio kullanıldı. Balıklar kontrol grubu, Bellis I grubu (0.025 mg/L Bellis) ve Bellis II grubu (0.050 mgl/L Bellis) olarak 3 gruba ayrıldı. Bellis gruplarına 14 günlük fungisit uygulamasının ardından balıklardan kan örnekleri alınarak, plazmaları elde edildi. Elde edilen plazma örneklerinde TAS, TOS ve TSA seviyeleri ölçüldü. Çalışmada elde edilen bulgulara göre kontrol grubunda TAS seviyesinin Bellis-I ve Bellis-II grubuna göre istatistiki olarak anlamlı derecede (p

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=tubitakulakb::94712a4356dbdf749e7a5372ac38f4c9Test
https://dergipark.org.tr/tr/pub/ejbcs/issue/74045/1109458Test

المؤلفون: ALJUBOURI, Akram Mudher Kareem, DEVECİ, H.ahmet, NUR, Gökhan

المصدر: Volume: 5, Issue: 1 23-29
DÜSTAD Dünya Sağlık ve Tabiat Bilimleri Dergisi

مصطلحات موضوعية: bellis,Cyprinus carpio,malondialdehyde,oxidative stress,paraoxonase activity, Engineering, Multidisciplinary, Mühendislik, Ortak Disiplinler, bellis,Cyprinus carpio,malondialdehit,oksidatif stres,paraoksonaz aktivite

الوصف: Bu çalışmada fungusit olarak kullanılmakta olan Bellis’in Cyprinus carpio’da plazma paraoksonaz aktivitesi (PON), yüksek dansiteli lipoprotein (HDL) ve malondialdehit (MDA) düzeylerine etkisinin araştırılması amaçlandı. Her grupta 8 adet olmak üzere toplam 24 adet (200-300g) C. carpio balık kullanıldı. Balıklar Grup-I (kontrol), Grup-II (0.025 mg/L Bellis) ve Grup-III 80.050 mgl/L Bellis) olmak üzere 3 gruba ayrıldı. 14 günlük uygulamanın ardından balıklardan kan örneği alındı ve plazmaları ayrıldı. Elde edilen plazma örneklerinde PON aktivitesi, HDL ve MDA düzeyleri çalışıldı. Çalışmada elde edilen bulgulara göre Grup-I’ de PON aktivitesi ve HDL düzeyleri Grup-II ve Grup-III’e göre anlamlı şekilde (p
The aim of this study is to investigate the effect of Bellis, which is used as a fungicide, on the levels of plasma paraoxonase activity (PON), high-density lipoprotein (HDL), and malondialdehyde (MDA) in Cyprinus carpio. A total of 24 (200-300g) C. carpio fish including eight (8) in each group were used. Fish were divided into three (3) groups; Group-I (control), Group-II (0.025 mg/L Bellis), and Group-III (80.050 mg/L Bellis). Blood samples were collected from the fish after 14-day application and their plasmas were separated. Plasma samples were analysed for PON activity, HDL, and MDA levels. The study findings revealed that PON activity and HDL levels were significantly higher (p

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=tubitakulakb::c493b44d89a897f35e070f38d90cdbb0Test
https://dergipark.org.tr/tr/pub/dustad/issue/70848/1079392Test

المؤلفون: DEVECİ, Haci Ahmet, NUR, Gökhan, KÜKÜRT, Abdulsamed, KURU, Mushap, DEVECİ, Ayla

المصدر: Ankara Üniversitesi Veteriner Fakültesi Dergisi

مصطلحات موضوعية: Veterinary, Antioxidant/oxidant balance, Cadmium, Caffeic acid phenethyl ester, Paraoxonase activity, Sialic acid, Veteriner Hekimlik

الوصف: In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels and increased their TSA, LDL, TOC, and OSI levels. The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=tubitakulakb::0c0569856843acfa515d7552c0342984Test
https://dergipark.org.tr/tr/pub/auvfd/issue/48904/1068527Test