المؤلفون: Friederike Klempin, Fabricio Simão, Mauro Cunha Xavier Pinto

المصدر: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: neurorepair, angiogenesis, gliogenesis, neurogenesis, synaptic plasticity, Biology (General), QH301-705.5

العلاقة: https://www.frontiersin.org/articles/10.3389/fcell.2021.740881/fullTest; https://doaj.org/toc/2296-634XTest; https://doaj.org/article/a180bf2a607a4270951be1075699f830Test

الإتاحة: https://doi.org/10.3389/fcell.2021.740881Test
https://doaj.org/article/a180bf2a607a4270951be1075699f830Test

المؤلفون: Melanie J. Plastini, Haritha L. Desu, Roberta Brambilla

المصدر: Frontiers in Cellular Neuroscience, Vol 14 (2020)

مصطلحات موضوعية: microglia, neuroinflammation, neurorepair, multiple sclerosis, neurological disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Microglia play an essential role in maintaining central nervous system (CNS) homeostasis, as well as responding to injury and disease. Most neurological disorders feature microglial activation, a process whereby microglia undergo profound morphological and transcriptional changes aimed at containing CNS damage and promoting repair, but often resulting in overt inflammation that sustains and propagates the neurodegenerative process. This is especially evident in multiple sclerosis (MS), were microglial activation and microglia-driven neuroinflammation are considered key events in the onset, progression, and resolution of the disease. Our understanding of microglial functions in MS has widened exponentially in the last decade by way of new tools and markers to discriminate microglia from other myeloid populations. Consequently, the complex functional and phenotypical diversity of microglia can now be appreciated. This, in combination with a variety of animal models that mimic specific features and processes of MS, has contributed to filling the gap of knowledge in the cascade of events underlying MS pathophysiology. The purpose of this review is to present the most up to date knowledge of the dynamic responses of microglia in the commonly used animal models of MS, specifically the immune-mediated experimental autoimmune encephalomyelitis (EAE) model, and the chemically-induced cuprizone and lysolecithin models. Elucidating the spectrum of microglial functions in these models, from detrimental to protective, is essential to identify emerging targets for therapy and guide drug discovery efforts.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fncel.2020.00269/fullTest; https://doaj.org/toc/1662-5102Test

الوصول الحر: https://doaj.org/article/30103bbb6378495b82d02bcc6ca91709Test

المؤلفون: Plastini, Melanie J., Desu, Haritha L., Brambilla, Roberta

المصدر: Plastini , M J , Desu , H L & Brambilla , R 2020 , ' Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis ' , Frontiers in Cellular Neuroscience , vol. 14 , 269 . https://doi.org/10.3389/fncel.2020.00269Test

مصطلحات موضوعية: microglia, multiple sclerosis, neuroinflammation, neurological disease, neurorepair

الوصف: Microglia play an essential role in maintaining central nervous system (CNS) homeostasis, as well as responding to injury and disease. Most neurological disorders feature microglial activation, a process whereby microglia undergo profound morphological and transcriptional changes aimed at containing CNS damage and promoting repair, but often resulting in overt inflammation that sustains and propagates the neurodegenerative process. This is especially evident in multiple sclerosis (MS), were microglial activation and microglia-driven neuroinflammation are considered key events in the onset, progression, and resolution of the disease. Our understanding of microglial functions in MS has widened exponentially in the last decade by way of new tools and markers to discriminate microglia from other myeloid populations. Consequently, the complex functional and phenotypical diversity of microglia can now be appreciated. This, in combination with a variety of animal models that mimic specific features and processes of MS, has contributed to filling the gap of knowledge in the cascade of events underlying MS pathophysiology. The purpose of this review is to present the most up to date knowledge of the dynamic responses of microglia in the commonly used animal models of MS, specifically the immune-mediated experimental autoimmune encephalomyelitis (EAE) model, and the chemically-induced cuprizone and lysolecithin models. Elucidating the spectrum of microglial functions in these models, from detrimental to protective, is essential to identify emerging targets for therapy and guide drug discovery efforts.

وصف الملف: application/pdf

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/2980cbc9-4910-42d9-9656-50f9f0178d42Test

الإتاحة: https://doi.org/10.3389/fncel.2020.00269Test
https://portal.findresearcher.sdu.dk/da/publications/2980cbc9-4910-42d9-9656-50f9f0178d42Test
https://findresearcher.sdu.dk/ws/files/173131259/Open_Access_Version.pdfTest

المؤلفون: Fernández Agudelo, Sebastián, Zeledón Corrales, Nathalya, Rojas Jara, Andrés

المصدر: Synergy journal of medicine; Vol. 5 No. 1 (2020): January; e339 ; Revista Medica Sinergia; Vol. 5 Núm. 1 (2020): Enero; e339 ; 2215-5279 ; 2215-4523 ; 10.31434/rms.v5i1

مصطلحات موضوعية: óxido nítrico, ictus cerebral, estrés oxidativo, neurorreparación, medicina, nitric oxide, stroke, oxidative stress, neurorepair, medicine

الوصف: Multiple complex pathophysiological processes occur in cerebral stroke that determine primary and secondary brain damage. Nitric oxide plays a fundamental role in the pathophysiology of stroke, represents a primary component in its development and progression. It is closely related to the activation of the inflammatory cascade, the alteration of mitochondrial function, angiogenesis and neurogenesis. These last two processes are fundamental for post-stroke neuroreparation, which is why they have been widely studied. The three production routes of nitric oxide are involved. Nitric oxide can act as a damaging or protective agent depending on where it is produced. ; En el ictus cerebral ocurren múltiples procesos fisiopatológicos complejos que determinan el daño cerebral primario y secundario. El óxido nítrico cumple un papel fundamental en la fisiopatología del ictus, representa es un componente primario en su desarrollo y progresión. Está íntimamente relacionado con la activación de la cascada inflamatoria, la alteración de la función mitocondrial, la angiogénesis y la neurogénesis. Estos últimos dos procesos son fundamentales para la neurorreparación posterior al ictus por lo cual han sido ampliamente estudiados. Las tres vías de producción del óxido nítrico se ven involucradas. El óxido nítrico puede desempeñarse como un agente perjudicial o protector dependiendo de donde se produzca.

وصف الملف: application/pdf; text/html

العلاقة: http://revistamedicasinergia.com//article/view/339/687Test; http://revistamedicasinergia.com//article/view/339/707Test; http://revistamedicasinergia.com//article/view/339Test

الإتاحة: https://doi.org/10.31434/rms.v5i1Test
http://revistamedicasinergia.com//article/view/339Test

المؤلفون: Buket Ucar, Christian Humpel

المصدر: Neural Regeneration Research, Vol 13, Iss 4, Pp 595-598 (2018)

مصطلحات موضوعية: biomaterial, collagen scaffold, microspheres, neuroprotection, neuroregeneration, neurorepair, Alzheimer′s disease, Parkinson′s disease, Neurology. Diseases of the nervous system, RC346-429

الوصف: Biomaterials have increasingly become a focus of research on neuroprotection and neuroregeneration. Collagen, in terms of brain repair, presents many advantages such as being remarkably biocompatible, biodegradable, versatile and non-toxic. Collagen can be used to form injectable scaffolds and micro/nano spheres in order to: (i) locally release therapeutic factors with the aim of protecting degenerating neurons in neurodegenerative conditions such as Alzheimer's or Parkinson's diseases, (ii) encapsulate stem cells for safe delivery, (iii) encapsulate genetically modified cells to provide a long term source of trophic factors, (iv) fill in the voids from injury to serve as a structural support and provide a permissive microenvironment to promote axonal growth. This mini-review summarizes different applications of collagen biomaterial for central nervous system protection and repair, as well as the future perspectives. Overall, collagen is a promising natural biomaterial with various applications which has the potential to progress the development of therapeutic strategies in central nervous system injuries and degeneration.

وصف الملف: electronic resource

العلاقة: http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=4;spage=595;epage=598;aulast=UcarTest; https://doaj.org/toc/1673-5374Test

الوصول الحر: https://doaj.org/article/c3229051484b472ab4a2ebffd1ab607cTest

المؤلفون: Mushfiquddin Khan, Hamza Khan, Inderjit Singh, Avtar K Singh

المصدر: Neural Regeneration Research, Vol 12, Iss 5, Pp 696-701 (2017)

مصطلحات موضوعية: traumatic brain injury, hypoxia inducible factor-1 alpha, S-nitrosoglutathione, neurorepair, functional recovery, Neurology. Diseases of the nervous system, RC346-429

الوصف: Mild traumatic brain injury (TBI), also called concussion, initiates sequelae leading to motor deficits, cognitive impairments and subtly compromised neurobehaviors. While the acute phase of TBI is associated with neuroinflammation and nitroxidative burst, the chronic phase shows a lack of stimulation of the neurorepair process and regeneration. The deficiency of nitric oxide (NO), the consequent disturbed NO metabolome, and imbalanced mechanisms of S-nitrosylation are implicated in blocking the mechanisms of neurorepair processes and functional recovery in the both phases. Hypoxia inducible factor-1 alpha (HIF-1α), a master regulator of hypoxia/ischemia, stimulates the process of neurorepair and thus aids in functional recovery after brain trauma. The activity of HIF-1α is regulated by NO via the mechanism of S-nitrosylation of HIF-1α. S-nitrosylation is dynamically regulated by NO metabolites such as S-nitrosoglutathione (GSNO) and peroxynitrite. GSNO stabilizes, and peroxynitrite destabilizes HIF-1α. Exogenously administered GSNO was found not only to stabilize HIF-1α and to induce HIF-1α-dependent genes but also to stimulate the regeneration process and to aid in functional recovery in TBI animals.

وصف الملف: electronic resource

العلاقة: http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=5;spage=696;epage=701;aulast=KhanTest; https://doaj.org/toc/1673-5374Test

الوصول الحر: https://doaj.org/article/1b28811cad344995a895faa88778cfe7Test

المؤلفون: Juan Pías-Peleteiro, Francisco Campos, José Castillo, Tomás Sobrino

المصدر: Neural Regeneration Research, Vol 12, Iss 4, Pp 558-561 (2017)

مصطلحات موضوعية: cellular therapy, endothelial progenitor cells, growth factors, intracerebral hemorrhage, neurorepair, outcome, Neurology. Diseases of the nervous system, RC346-429

الوصف: Intracerebral hemorrhage (ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells (EPCs) have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice.

وصف الملف: electronic resource

العلاقة: http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=558;epage=561;aulast=PTestías-Peleteiro; https://doaj.org/toc/1673-5374Test

الوصول الحر: https://doaj.org/article/a22632561e7b4bb9978255db24b38e41Test

المؤلفون: Tottenham, Isabelle Elaine Louise

مصطلحات موضوعية: multiple sclerosis, remyelination, remote ischemic conditioning, remote ischemic postconditioning, hypoxia, oligodendrocyte, oligodendrocyte precursor cell, neuroprotection, neurorepair, Neuroscience

الوصف: Multiple sclerosis (MS) is a chronic, autoimmune neurodegenerative disease that is characterized by nervous system demyelination and heterogenous disability. Current disease modifying treatments accessible to Canadians are limited because they are primarily targeting the neuroinflammatory component of the disease, not the neurodegenerative component. There is a need for focus on development of therapies that target the demyelinating insults that people with MS experience. In this study, we evaluate the use of repeated remote ischemic postconditioning (RIC) as a therapeutic target for promoting white matter repair and protection. Due to the novelty of the intervention in the MS field, we first wanted to identify transcriptomic and proteomic changes to the spinal cord with repeated RIC. We found that targets involved in antioxidant, protein synthesis, angiogenesis, axonogenesis, and remyelination pathways (among others) were upregulated with 14 days of consecutive RIC. Using a focal demyelinating mouse model, ...

الإتاحة: https://doi.org/10.11575/prism/42017Test
https://prism.ucalgary.ca/handle/1880/117175Test

المؤلفون: Shenandoah Robinson, Fatu S. Conteh, Akosua Y. Oppong, Tracylyn R. Yellowhair, Jessie C. Newville, Nagat El Demerdash, Christine L. Shrock, Jessie R. Maxwell, Stephen Jett, Frances J. Northington, Lauren L. Jantzie

المصدر: Frontiers in Cellular Neuroscience, Vol 12 (2018)

مصطلحات موضوعية: intraventricular hemorrhage (IVH), chorioamnionitis, neurorepair, ventriculomegaly, diffusion tensor imaging (DTI), preterm, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Posthemorrhagic hydrocephalus of prematurity (PHHP) remains a global challenge. Early preterm infants (

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fncel.2018.00322/fullTest; https://doaj.org/toc/1662-5102Test

الوصول الحر: https://doaj.org/article/e2ec6ea55e394a0a92555124ef60fa41Test

المؤلفون: Feifei Ma, Pablo Martínez-San Segundo, Verónica Barceló, Anna Morancho, Marina Gabriel-Salazar, Dolors Giralt, Joan Montaner, Anna Rosell

المصدر: Neurobiology of Disease, Vol 91, Iss , Pp 236-246 (2016)

مصطلحات موضوعية: Cerebral ischemia, MMP-13, Angiogenesis, Neurorepair, Neurogenesis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: New neuroreparative and neuroprotective therapies are being sought to treat stroke patients. One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular repair when matrix metalloproteinases (MMPs) are thought to be key players. Our aim was to investigate the role of MMP-13 (collagenase-3) in the acute (24 h and 3 days) and delayed (2 weeks) phases of stroke. Permanent and transient cerebral ischemia models involving the cortex were induced in MMP-13 knock-out (KO) and wild-type (WT) mice. In the transient model, MMP-13 deficiency reduced the amount of TTC-stained infarct tissue, reduced hemorrhagic events and improved functional outcomes (p

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0969996116300626Test; https://doaj.org/toc/1095-953XTest

الوصول الحر: https://doaj.org/article/d70cd8c857ca45da8cd1ae336c393803Test