المؤلفون: Hasan Cagri Yildirim, Fatih Kus, Deniz Can Guven, Ece Karaca, Yunus Kaygusuz, Omer Dizdar, Sercan Aksoy, Mustafa Erman, Suayib Yalcin, Saadettin Kilickap

المصدر: Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 4, Pp 170-176 (2023)

مصطلحات موضوعية: immunotherapy, nivolumab, biomarker, mean platelet volume to lymphocyte ratio, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Immunologic diseases. Allergy, RC581-607

الوصف: Introduction: Although immune checkpoint inhibitors (ICIs) are widely used in cancer treatment, identifying factors that predict treatment response remains a challenge in clinical practice. There is a need for biomarkers to identify patients who may not benefit from these treatments. It is crucial to identify a simple and cost-effective biomarker that can be easily incorporated into clinical practice. This study aims to investigate the mean platelet volume to lymphocyte ratio (MPVLR), as measured by a hemogram test, and median overall survival (mOS) in patients with cancer treated with nivolumab. Methods: A total of 131 adult patients with metastatic cancer, including malignant melanoma (MM), renal cell carcinoma (RCC), non–small cell lung cancer (NSCLC), and head and neck cancer (HNC), were included in this study. Baseline demographics, ECOG (Eastern Cooperative Oncology Group) performance status, tumor type, and blood count parameters were recorded. Univariate and multivariate analyses were conducted to evaluate potential risk factors. Results: The median age of the patients was 59.87 ± 11.97 years, and the median follow-up period was 20.20 months (IQR, 12.80–27.60). RCC (43.5%) and MM (25.9%) were the most common diagnoses. Patients with ECOG scores of 0–1 had a longer mOS than those with scores of 2–3 (mOS: 20.60 months [95% CI, 14.94–25.29] vs. 5.24 months [95% CI, 0–16.42], p < 0.001). Additionally, patients with lactate dehydrogenase (LDH) levels within the normal range had a longer mOS than those with high LDH levels (mOS: 24.54 months [95% CI, 14.13–34.96] vs. 13.10 months [95% CI, 4.49–21.72], p = 0.038). Patients with low MPVLR also had a longer mOS than those with high MPVLR (mOS: 33.70 months [95% CI, 25.99–41.42] vs. 11.07 months [95% CI, 6.89–15.24], p < 0.001). In the multivariate Cox regression analysis, high MPVLR, ECOG score of 2–3, and high LDH level were associated with shorter mOS (p < 0.001, p = 0.001, and p = 0.046, respectively). Conclusion: This study demonstrates that MPVLR could serve as a novel biomarker for predicting response to nivolumab treatment. Incorporating MPVLR into clinical practice may aid in identifying patients who are less likely to benefit from the treatment.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2666-2345Test; https://doaj.org/toc/2590-017XTest

الوصول الحر: https://doaj.org/article/67323cc7fe9e425d97196951b9a3b644Test

المؤلفون: Deniz Can Guven, Musa Baris Aykan, Harun Muglu, Ertugrul Bayram, Kaan Helvaci, Bengü Dursun, Melisa Celayir, Elvin Chelebiyev, Erdinc Nayir, Mustafa Erman, Ahmet Sezer, Yuksel Urun, Umut Demirci, Ozlem Er, Umut Disel, Ahmet Bilici, Cagatay Arslan, Nuri Karadurmus, Saadettin Kilickap

المصدر: Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)

مصطلحات موضوعية: immune checkpoint inhibitor, immunotherapy, rare tumor, sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Introduction The advances in immune checkpoint inhibitors (ICIs) were relatively slow in rare tumors. Therefore, we conducted a multi‐center study evaluating the efficacy of ICI monotherapy and the combination of ICIs with chemotherapy (CT) in patients with advanced rare tumors. Methods In this retrospective cohort study, we included 93 patients treated with ICIs for NCI‐defined rare tumors from the 12 cancer centers in Turkey. The primary endpoints were the overall response (ORR) and disease control rate (DCR). Results The cohort's median age was 56, and 53.8% of the patients were male. The most frequent diagnosis was sarcoma (29%), and 81.7% of the patients were previously treated with at least one line of systemic therapy in the advanced stage. The ORR and DCR were 36.8% and 63.2%, respectively. The germ cell tumors had the lowest ORR (0%), while the Merkel cell carcinoma had the highest ORR to ICIs (57.1%). Patients treated with ICI + ICI or ICI plus chemotherapy combinations had higher ORR (55.2% vs. 27.6%, p = 0.012) and DCR (82.8% vs. 53.4%, p = 0.008). The median OS was 13.47 (95% CI: 7.79–19.15) months, and the six and 12‐month survival rates were 71% and 52%. The median duration of response was 16.59 months, and the 12‐month progression‐free survival rate was 66% in responders. The median time‐to‐treatment failure was 5.06 months (95% CI: 3.42–6.71). Three patients had high‐grade irAEs with ICIs (grade 3 colitis, grade 3 gastritis, and grade 3 encephalitis in one patient each). Conclusion We observed over 30% ORR and a 13‐month median OS in patients with rare cancers treated with ICI monotherapy or ICI plus CT combinations. The response rates to ICIs or ICIs plus CT significantly varied across different tumor types. Responding patients had over 2 years of survival, highlighting a need for further trials with ICIs for patients with rare tumors.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-7634Test

الوصول الحر: https://doaj.org/article/0f697c742e7245d3a185d956a2ca5f1aTest

المؤلفون: Mustafa Erman Dorterler, Tansel Günendi, Mehmet Çakmak, Saime Shermatova

المصدر: African Journal of Paediatric Surgery, Vol 20, Iss 1, Pp 8-11 (2023)

مصطلحات موضوعية: anomaly, bezoar, child, duodenum, endoscopy, surgery, Pediatrics, RJ1-570, Surgery, RD1-811

الوصف: Background: Bezoar is formed as a result of the accumulation of undigested food or foreign substances in the gastrointestinal tract (GIS). The present study aims to investigate the bezoar types seen in children and the aetiological factors involved in bezoar formation. Methods: A total of 16 patients who underwent an endoscopy and/or surgical treatment for bezoar at Harran University, Faculty of Medicine Pediatric Surgery Clinic between 2011 and 2019 were included in the study. The demographic information, laboratory and radiological findings were obtained from the patients' file records. Results: A total of ten patients (62.5%) were female with a mean age of 7.8 ± 4.9 years. Phytobezoars were detected in ten patients, trichobezoars in two patients, lactobezoar in one patient, and other types in three patients. The aetiological factors were determined to be congenital GIS anomaly in 6 (37.5%) patients; trichotillomania in 2 (12.5%) patients; mental retardation in 2 (12.5%) patients; ingestion of a foreign body during infancy in 2 (12.5%) patients; high intake of high-fibre fruit in 3 (18.5%) patients; and postoperative dysmotility in 2 (12.5%) patients. Conclusions: Congenital GIS anomalies are mostly responsible for bezoar etiology in children and phytobezoar is the most common type of bezoar.

وصف الملف: electronic resource

العلاقة: http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2023;volume=20;issue=1;spage=8;epage=11;aulast=DorterlerTest; https://doaj.org/toc/0189-6725Test

الوصول الحر: https://doaj.org/article/96f9a050894d41f1b8662414e20c07b7Test

المؤلفون: Burak Yasin Aktaş, Beril Hüseyin, Deniz Yüce, Ömer Dizdar, Mustafa Erman, Mutlu Hayran, İsmail Çelik

المصدر: Archives of Basic and Clinical Research, Vol 5, Iss 1, Pp 178-184 (2023)

مصطلحات موضوعية: Medicine

وصف الملف: electronic resource

العلاقة: https://abcresearch.net/en/smoker-relatives-of-inpatients-a-reasonable-but-heterogeneous-target-population-for-smoking-cessation-program-13112Test; https://doaj.org/toc/2687-4482Test

الوصول الحر: https://doaj.org/article/9916d1477db24e7aafb00040c50304bcTest

المؤلفون: Rashad Ismayilov, Oktay Halit Aktepe, Konul Sardarova, Can Berk Leblebici, Mustafa Erman

المصدر: Eurasian Journal of Medicine, Vol 54, Iss 1, Pp 77-79 (2022)

مصطلحات موضوعية: Medicine (General), R5-920

وصف الملف: electronic resource

العلاقة: https://www.eajm.org/en/everolimus-and-or-nivolumab-associated-cytomegalovirus-colitis-in-a-patient-with-metastatic-renal-cell-carcinoma-133369Test; https://doaj.org/toc/1308-8742Test

الوصول الحر: https://doaj.org/article/7f1ee70ecb8d4bf5a62ed3b5bc205149Test

المؤلفون: Matthew Hellmann, Ying Cheng, Toshiaki Takahashi, Gilberto de Castro, M Catherine Pietanza, James Chih-Hsin Yang, Byoung Cho, Rosalyn Juergens, Mustafa Erman, Jessica Bauman, Paul Schwarzenberger, Pingye Zhang

المصدر: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2051-1426Test

الوصول الحر: https://doaj.org/article/2116ff1baf5349cfbe8aac848a2def32Test

المؤلفون: Omer Dizdar, Deniz Can Guven, Gurkan Guner, Mustafa Erman, Mutlu Hayran

المصدر: Journal of Oncological Sciences, Vol 5, Iss 2, Pp 45-48 (2019)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Aim: Recently, three randomized controlled trials evaluated the addition of docetaxel to ADT in advanced hormone-sensitive prostate cancer (aHSPC). Interestingly, all trials showed a trend towards improved OS in the subgroup of patients with Gleason

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2452336418300967Test; https://doaj.org/toc/2452-3364Test

الوصول الحر: https://doaj.org/article/38b91bdbfa5842a3918ad42b195e3c97Test

المؤلفون: Hasan Cagri Yildirim, Deniz Can Guven, Oktay Halit Aktepe, Hakan Taban, Feride Yilmaz, Serkan Yasar, Sercan Aksoy, Mustafa Erman, Saadettin Kilickap, Suayib Yalcin

المصدر: Journal of Clinical Medicine, Vol 11, Iss 17, p 5171 (2022)

مصطلحات موضوعية: immunotherapy, hyperprogression, HPD, NLR, hypoalbuminemia, Medicine

الوصف: Purpose: With the widespread use of immunotherapy agents, we encounter treatment responses such as hyperprogression disease (HPD) that we have not seen with previous standard chemotherapy and targeted therapies. It is known that survival in patients with HPD is shorter than in patients without HPD. Therefore, it is important to know the factors that will predict HPD. We aimed to identify HPD-related factors in patients treated with immunotherapy. Methods: A total of 121 adult metastatic cancer patients treated with immunotherapy for any cancer were included. Baseline demographics, the ECOG performance status, type of tumors and baseline blood count parameters were recorded. Possible predisposing factors were evaluated with univariate and multivariate analyses. Results: The median age was 62.28 (interquartile range (IQR) 54.02–67.63) years, and the median follow-up was 12.26 (IQR 5.6–24.36) months. Renal cell carcinoma (33%) and melanoma (33.8%) were the most common diagnoses. Twenty patients (16.5%) had HPD. A high LDH level (p: 0.001), hypoalbuminemia (p: 0.016) and an NLR > 5 (p: 0.007) were found to be associated with hyperprogression. Sex (female vs. male, p: 0.114), age (>65 vs. p: 0.772), ECOG (0 vs. 1–4, p: 0.480) and the line of treatment (1–5, p: 0.112) were not found to be associated with hyperprogression. Conclusions: In this study, we observed HPD in 16.5% of immunotherapy-treated patients and increased HPD risk in patients with a high LDH level (p: 0.001), hypoalbuminemia (p: 0.016) and an NLR > 5 (p: 0.007).

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2077-0383/11/17/5171Test; https://doaj.org/toc/2077-0383Test

الوصول الحر: https://doaj.org/article/f4df09dd939543adb226a19eb76fc562Test

المؤلفون: Deniz Can Guven, Taha Koray Sahin, Enes Erul, Ibrahim Yahya Cakir, Enes Ucgul, Hasan Cagri Yildirim, Oktay Halit Aktepe, Mustafa Erman, Saadettin Kilickap, Sercan Aksoy, Suayib Yalcin

المصدر: Journal of Clinical Medicine, Vol 11, Iss 15, p 4523 (2022)

مصطلحات موضوعية: biomarker, cancer, Charlson Comorbidity Index, immunotherapy, neutrophil–lymphocyte ratio, NLR2-CEL, Medicine

الوصف: Dynamic changes in the blood-based biomarkers could be used as a prognostic biomarker in patients treated with immune checkpoint inhibitors (ICIs), although the data are limited. We evaluated the association between the neutrophil–lymphocyte ratio (NLR) and early NLR changes with survival in ICI-treated patients. We retrospectively evaluated the data of 231 patients with advanced-stage cancer. We recorded baseline clinical characteristics, baseline NLR and fourth-week NLR changes, and survival data. A compound prognostic score, the NLR2-CEL score, was developed with the following parameters: baseline NLR (p = 0.002), 10% or over NLR increase in the fourth week of treatment (HR: 1.807, p = 0.001), higher ECOG performance score (HR: 1.552, p = 0.006), higher LDH levels (HR: 1.454, p = 0.017), and higher CCI (HR: 1.400, p = 0.041) were associated with decreased OS. Compared to patients with the lowest scores, patients in the highest score group had significantly lower OS (HR: 7.967, 95% CI: 3.531–17.979, p < 0.001) and PFS. The composite score had moderate success for survival prediction, with an AUC of 0.702 (95% CI: 0.626–0.779, p < 0.001). We observed significantly lower survival in patients with higher baseline NLR values and increased NLR values under treatment.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2077-0383/11/15/4523Test; https://doaj.org/toc/2077-0383Test

الوصول الحر: https://doaj.org/article/24e99e8abf0a47299126c368135c8af9Test

المؤلفون: Mustafa Erman, Bivas Biswas, Pongwut Danchaivijitr, Lingwu Chen, Yoke Fui Wong, Tarek Hashem, Chun Sen Lim, Bulent Karabulut, Hsiao-Jen Chung, Chandrasekhar Chikatapu, Sara Ingles, Khemaies Slimane, Ravindran Kanesvaran

المصدر: BMC Cancer, Vol 21, Iss 1, Pp 1-2 (2021)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2407Test

الوصول الحر: https://doaj.org/article/c4088abcfc2b4a2295bba6b69afcf827Test