المؤلفون: Rosenfield D., Smits J. A. J., Hofmann S. G., Mataix-Cols D., de la Cruz L. F., Andersson E., Ruck C., Monzani B., Perez-Vigil A., Frumento P., Davis M., de Kleine R. A., Difede J., Dunlop B. W., Farrell L. J., Geller D., Gerardi M., Guastella A. J., Hendriks G. -J., Kushner M. G., Lee F. S., Lenze E. J., Levinson C. A., McConnell H., Plag J., Pollack M. H., Ressler K. J., Rodebaugh T. L., Rothbaum B. O., Storch E. A., Strohle A., Tart C. D., Tolin D. F., van Minnen A., Waters A. M., Weems C. F., Wilhelm S., Wyka K., Altemus M., Anderson P., Cukor J., Finck C., Geffken G. R., Golfels F., Goodman W. K., Gutner C. A., Heyman I., Jovanovic T., Lewin A. B., McNamara J. P., Murphy T. K., Norrholm S., Thuras P., Turner C., Otto M. W.

المساهمون: Rosenfield, D., Smits, J. A. J., Hofmann, S. G., Mataix-Cols, D., de la Cruz, L. F., Andersson, E., Ruck, C., Monzani, B., Perez-Vigil, A., Frumento, P., Davis, M., de Kleine, R. A., Difede, J., Dunlop, B. W., Farrell, L. J., Geller, D., Gerardi, M., Guastella, A. J., Hendriks, G. -J., Kushner, M. G., Lee, F. S., Lenze, E. J., Levinson, C. A., Mcconnell, H., Plag, J., Pollack, M. H., Ressler, K. J., Rodebaugh, T. L., Rothbaum, B. O., Storch, E. A., Strohle, A., Tart, C. D., Tolin, D. F., van Minnen, A., Waters, A. M., Weems, C. F., Wilhelm, S., Wyka, K., Altemus, M., Anderson, P., Cukor, J., Finck, C., Geffken, G. R., Golfels, F., Goodman, W. K., Gutner, C. A., Heyman, I., Jovanovic, T., Lewin, A. B., Mcnamara, J. P., Murphy, T. K., Norrholm, S., Thuras, P., Turner, C., Otto, M. W.

مصطلحات موضوعية: augmentation, d-cycloserine, decline effect, dosing, exposure, Adolescent, Adult, Aged, Anxiety, Anxiety Disorder, Child, Combined Modality Therapy, Cycloserine, Female, Human, Implosive Therapy, Male, Middle Aged, Treatment Outcome, Young Adult

الوصف: The apparent efficacy of d-cycloserine (DCS) for enhancing exposure treatment for anxiety disorders appears to have declined over the past 14 years. We examined whether variations in how DCS has been administered can account for this “declining effect”. We also investigated the association between DCS administration characteristics and treatment outcome to find optimal dosing parameters. We conducted a secondary analysis of individual participant data obtained from 1047 participants in 21 studies testing the efficacy of DCS-augmented exposure treatments. Different outcome measures in different studies were harmonized to a 0-100 scale. Intent-to-treat analyses showed that, in participants randomized to DCS augmentation (n = 523), fewer DCS doses, later timing of DCS dose, and lower baseline severity appear to account for this decline effect. More DCS doses were related to better outcomes, but this advantage leveled-off at nine doses. Administering DCS more than 60 minutes before exposures was also related to better outcomes. These predictors were not significant in the placebo arm (n = 521). Results suggested that optimal DCS administration could increase pre-to-follow-up DCS effect size by 50%. In conclusion, the apparent declining effectiveness of DCS over time may be accounted for by how it has been administered. Optimal DCS administration may substantially improve outcomes. Registration: The analysis plan for this manuscript was registered on Open Science Framework (https://osf.io/c39p8Test/).

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31698111; info:eu-repo/semantics/altIdentifier/wos/WOS:000502421400011; volume:68; firstpage:102149; journal:JOURNAL OF ANXIETY DISORDERS; http://hdl.handle.net/11568/1061129Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85074373774

الإتاحة: https://doi.org/10.1016/j.janxdis.2019.102149Test
http://hdl.handle.net/11568/1061129Test

المؤلفون: Storch, E. A., Lack, C. W., Simons, L. E., Goodman, W. K., Murphy, T. K., Geffken, G. R.

المصدر: Journal of Pediatric Psychology ; volume 32, issue 8, page 950-959 ; ISSN 0146-8693 1465-735X

الإتاحة: https://doi.org/10.1093/jpepsy/jsm034Test
http://academic.oup.com/jpepsy/article-pdf/32/8/950/2739231/jsm034.pdfTest

المؤلفون: Murphy, T. K.

المصدر: American Journal of Epidemiology ; volume 152, issue 9, page 847-854 ; ISSN 0002-9262

مصطلحات موضوعية: Epidemiology

الإتاحة: https://doi.org/10.1093/aje/152.9.847Test
http://academic.oup.com/aje/article-pdf/152/9/847/129524/847.pdfTest

المؤلفون: Calle, E. E., Murphy, T. K., Rodriguez, C., Thun, M. J., Heath, C. W.

المصدر: American Journal of Epidemiology ; volume 148, issue 2, page 191-197 ; ISSN 0002-9262 1476-6256

مصطلحات موضوعية: Epidemiology

الإتاحة: https://doi.org/10.1093/oxfordjournals.aje.a009623Test
http://academic.oup.com/aje/article-pdf/148/2/191/219953/148-2-191.pdfTest

المؤلفون: Gilbert, D. L., Murphy, T. K., Jankovic, J., Budman, C. L., Black, K. J., Kurlan, R. M., Coffman, K. A., McCracken, J. T., Juncos, J., Chipkin, R. E., +1 additional author

المصدر: Journal Articles

مصطلحات موضوعية: Psychiatry

الوصف: © 2018 International Parkinson and Movement Disorder Society Background: Dopamine D2 receptor antagonists used to treat Tourette syndrome may have inadequate responses or intolerable side effects. We present results of a 4-week randomized, double-blind, placebo-controlled crossover study evaluating the safety, tolerability, and efficacy of the D1 receptor antagonist ecopipam in children and adolescents with Tourette syndrome. Methods: Forty youth aged 7 to 17 years with Tourette syndrome and a Yale Global Tic Severity Scale – total tic score of ≥20 were enrolled and randomized to either ecopipam (50 mg/day for weight of <34 >kg, 100 mg/day for weight of >34 kg) or placebo for 30 days, followed by a 2-week washout and then crossed to the alternative treatment for 30 days. Stimulants and tic-suppressing medications were excluded. The primary outcome measure was the total tic score. Secondary outcomes included obsessive compulsive and attention deficit/hyperactivity disorder scales. Results: Relative to changes in placebo, reduction in total tic score was greater for ecopipam at 16 days (mean difference, -3.7; 95% CI, -6.5 to -0.9; P = 0.011) and 30 days (mean difference, -3.2; 95% CI, -6.1 to -0.3; P = 0.033). There were no weight gain, drug-induced dyskinesias, or changes in laboratory tests, electrocardiograms, vital signs, or comorbid symptoms. Dropout rate was 5% (2 of 40). Adverse events reported for both treatments were rated predominantly mild to moderate, with only 5 rated severe (2 for ecopipam and 3 for placebo). Conclusions: Ecopipam reduced tics and was well tolerated. This placebo-controlled study of ecopipam supports further clinical trials in children and adolescents with Tourette syndrome. © 2018 International Parkinson and Movement Disorder Society.

العلاقة: https://academicworks.medicine.hofstra.edu/publications/4045Test

الإتاحة: https://doi.org/10.1002/mds.27457Test
https://academicworks.medicine.hofstra.edu/publications/4045Test

المؤلفون: Højgaard, D. R M A, Mortensen, E. L., Ivarsson, Tord, Hybel, Katja Anna, Skarphedinsson, Gudmundur, Nissen, Judith Becker, Valderhaug, Robert, Dahl, Kitty, Weidle, Bernhard, Torp, Nor Christian, Grados, M., Lewin, A. B., Melin, K. H., Storch, E. A., Wolters, L. H., Murphy, T. K., Sonuga-Barke, Edmund J S, Thomsen, Per Hove

المصدر: Højgaard , D R M A , Mortensen , E L , Ivarsson , T , Hybel , K A , Skarphedinsson , G , Nissen , J B , Valderhaug , R , Dahl , K , Weidle , B , Torp , N C , Grados , M , Lewin , A B , Melin , K H , Storch , E A , Wolters , L H , Murphy , T K , Sonuga-Barke , E J S & Thomsen , P H 2017 , ' Structure and clinical correlates of obsessive–compulsive symptoms in a large ....

مصطلحات موضوعية: Children and adolescents, Comorbidity, CY-BOCS, Factor analysis, Obsessive–compulsive disorder, OCD symptom patterns

الوصف: The underlying structure of obsessive–compulsive disorder (OCD) remains to be confirmed in child and adolescent populations. In this paper we report the first factor analytic study of individual OCD items from Children’s Yale-Brown Obsessive Compulsive Scale (CY-BOCS). OCD symptoms were assessed using the CY-BOCS symptom checklist in a sample of 854 patients with OCD (7–18 years of age) recruited from clinics in five countries. Pooled data were subjected to exploratory and confirmatory factor analysis (CFA) to identify the optimal factor structure. Various models were tested for age and gender subgroups. Also, the invariance of the solution across age and gender was tested and associations with demographic and clinical factors were explored. A three-factor model provided the best-fit solution. It consisted of the following factors: (1) harm/sexual, (2) symmetry/hoarding, (3) contamination/cleaning. The factor structure was invariant for age and gender across subgroups. Factor one was significantly correlated with anxiety, and factor two with depression and anxiety. Factor three was negatively correlated with tic disorder and attention-deficit/hyperactivity disorder (ADHD). Females had higher scores on factor two than males. The OCD symptom structure in children and adolescents is consistent across age and gender and similar to results from recent child and adolescents although hoarding may not be a separate factor. Our three-factor structure is almost identical to that seen in early studies on adults. Common mental disorders had specific patterns of associations with the different factors.

العلاقة: https://pure.au.dk/portal/en/publications/705ffe29-8438-4aa5-a102-6d9df8407cafTest

الإتاحة: https://doi.org/10.1007/s00787-016-0887-5Test
https://pure.au.dk/portal/en/publications/705ffe29-8438-4aa5-a102-6d9df8407cafTest
http://www.scopus.com/inward/record.url?scp=84978148924&partnerID=8YFLogxKTest

المؤلفون: Højgaard, D. R. M. A., Mortensen, E. L., Ivarsson, T., Hybel, K., Skarphedinsson, G., Nissen, J. B., Valderhaug, R., Dahl, K., Weidle, B., Torp, N. C., Grados, M., Lewin, A. B., Melin, K. H., Storch, E. A., Wolters, L. H., Murphy, T. K., Sonuga-Barke, E. J. S., Thomsen, P. H.

المساهمون: Lundbeckfonden, Central Region Denmark’s Research Fund, TrygFonden

المصدر: European Child & Adolescent Psychiatry ; volume 26, issue 3, page 281-291 ; ISSN 1018-8827 1435-165X

مصطلحات موضوعية: Psychiatry and Mental health, Developmental and Educational Psychology, General Medicine, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1007/s00787-016-0887-5Test

المؤلفون: He, B J, Nolte, G, Nagata, K, Takano, D, Yamazaki, T, Fujimaki, Y, Maeda, T, Satoh, Y, Heckers, S, George, M S, Lopes da Silva, F, de Munck, J C, Van Houdt, P J, Verdaasdonk, R M, Ossenblok, P, Mullinger, K, Bowtell, R, Bagshaw, A P, Keeser, D, Karch, S, Segmiller, F, Hantschk, I, Berman, A, Padberg, F, Pogarell, O, Scharnowski, F, Hümmer, S, Paolini, M, Kirsch, V, Koller, G, Rauchmann, B, Kupka, M, Blautzik, J, Razavi, N, Jann, K, Koenig, T, Kottlow, M, Hauf, M, Strik, W, Dierks, T, Gotman, J, Vulliemoz, S, Lu, Y, Zhang, H, Yang, L, Worrell, G, He, B, Gruber, O, Piguet, C, Hubl, D, Homan, Ph, Kindler, J, Kim, K, Steinhoff, U, Wakai, R, Melie-García, L, Mucci, A, Volpe, U, Prinster, A, Salvatore, M, Galderisi, S, Linden, D E J, Brandeis, D, Schroeder, C E, Kayser, C, Panzeri, S, Kleinschmidt, A, Ritter, P, Walther, S, Haueisen, J, Lau, S, Flemming, L, Sonntag, H, Maess, B, Knösche, T R, Lanfer, B, Dannhauer, M, Wolters, C H, Stenroos, M, Wolters, C, Aydin, U, Lew, S, Lucka, F, Ruthotto, L, Vorwerk, J, Wagner, S, Ramon, C, Guan, C, Ang, K K, Chua, S G, Kuah, W K, Phua, K S, Chew, E, Zhou, H, Chuang, K H, Ang, B T, Wang, C, Yang, H, Chin, Z Y, Yu, H, Pan, Y, Collins, L, Mainsah, B, Colwell, K, Morton, K, Ryan, D, Sellers, E, Caves, K, Throckmorton, S, Kübler, A, Holz, E M, Zickler, C, Brown, K, Wennberg, R, Ahlfors, S P, Grova, C, Chowdhury, R, Hedrich, T, Heers, M, Zelmann, R, Hall, J A, Lina, J M, Kobayashi, E, Oostendorp, T, van Dam, P, Oosterhof, P, Linnenbank, A, Coronel, R, van Dessel, P, de Bakker, J, Rossion, B, Jacques, C, Witthoft, N, Weiner, K S, Foster, B L, Miller, K J, Hermes, D, Parvizi, J, Grill-Spector, K, Recanzone, G H, Murray, M M, Haynes, J D, Richiardi, J, Greicius, M, De Lucia, M, Müller, K-R, Formisano, E, Smieskova, R, Schmidt, A, Bendfeldt, K, Walter, A, Riecher-Rössler, A, Borgwardt, S, Fusar-Poli, P, Eliez, S, Sekihara, K, Nagarajan, S S, Schoffelen, J M, Guggisberg, A G, Balazs, S, Kermanshahi, K, Kiesenhofer, W, Binder, H, Rattay, F, Antal, A, Chaieb, L, Paulus, W, Bodis-Wollner, I, Maurer, K, Fein, G, Camchong, J, Johnstone, J, Cardenas-Nicolson, V, Fiederer, L D J, Yang, S, Dümpelmann, M, Cosandier-Rimélé, D, Schulze-Bonhage, A, Aertsen, A, Speck, O, Ball, T, Fuchs, M, Wagner, M, Kastner, J, Tech, R, Dinh, C, Baumgarten, D, Hämäläinen, M S, Vogrin, S J, D'Souza, W, Cook, M J, Custo, A, Van De Ville, D, Grouiller, F, Michel, C M, Malmivuo, J, Küpper, P, Kugel, H, Wellmer, J, Kellinghaus, C, Scherg, M, Rampp, S, Storti, S F, Boscolo Galazzo, I, Del Felice, A, Pizzini, F B, Arcaro, C, Formaggio, E, Mai, R, Manganotti, P, Koessler, L, Vignal, J, Cecchin, T, Colnat-Coulbois, S, Vespignani, H, Ramantani, G, Maillard, L, Rektor, I, Kuba, R, Brázdil, M, Chrastina, J, Rektorova, I, van Mierlo, P, Carrette, E, Strobbe, G, Montes-Restrepo, V, Vonck, K, Vandenberghe, S, Ahmed, B, Brodely, C, Carlson, C, Kuzniecky, R, Devinsky, O, French, J, Thesen, T, Bénis, D, David, O, Lachaux, J-P, Seigneuret, E, Krack, P, Fraix, V, Chabardès, S, Bastin, J, Gee, D, Kilroy, E, Cannon, T, Wang, D J, Hale, J R, Mayhew, S D, Przezdzik, I, Arvanitis, T N, Plomp, G, Quairiaux, C, Astolfi, L, Mullinger, K J, Francis, S T, Schouten, A C, Campfens, S F, van der Kooij, H, Koles, Z, Lind, J, Flor-Henry, P, Wirth, M, Haase, C M, Villeneuve, S, Vogel, J, Jagust, W J, Kambeitz-Ilankovic, L, Simon-Vermot, L, Gesierich, B, Duering, M, Ewers, M, Krajcovicova, L, Marecek, R, Mikl, M, Bracht, T, Horn, H, Federspiel, A, Schnell, S, Höfle, O, Stegmayer, K, Wiest, R, Müller, T J, Surmeli, T, Ertem, A, Eralp, E, Kos, I H, Skrandies, W, Flüggen, S, Klein, A, Britz, J, Díaz Hernàndez, L, Ro, T, Lenartowicz, A, Lau, E, Rodriguez, C, Cohen, M S, Loo, S K, Di Lorenzo, G, Pagani, M, Monaco, L, Daverio, A, Giannoudas, I, La Porta, P, Verardo, A R, Niolu, C, Fernandez, I, Siracusano, A, Bollmann, S, Ghisleni, C, O'Gorman, R, Poil, S-S, Klaver, P, Michels, L, Martin, E, Ball, J, Eich-Höchli, D, Salisbury, D F, Murphy, T K, Butera, C D, Mathalon, D H, Fryer, S L, Kiehl, K A, Calhoun, V C, Pearlson, G D, Roach, B J, Ford, J M, McGlashan, T H, Woods, S W, Merlotti, E, Vignapiano, A, Montefusco, V, Plescia, G M, Gallo, O, Romano, P, Mingoia, G, Langbein, K, Dietzek, M, Wagner, G, Smesny, null, Scherpiet, S, Maitra, R, Gaser, Ch, Sauer, H, Nenadic, I, Gonzalez Andino, S, Grave de Peralta Menendez, R, Sanchez Vives, M, Rebollo, B, Frølich, L, Andersen, T S, Mørup, M, Belfiore, P, Gargiulo, P, Vanhatalo, S, Cho, J-H, Watanabe, T, Kawabata, Y, Ukegawa, D, Kawabata, S, Adachi, Y, Herrmann, C, Burger, M, Wolters, Ch, Bauer, M, Trahms, L, Sander, T, Faber, P L, Lehmann, D, Gianotti, L R R, Pascual-Marqui, R D, Milz, P, Kochi, K, Kaneko, S, Yamashita, S, Yana, K, Kalogianni, K, Vardy, A N, van der Helm, F C T, Sorrentino, A, Luria, G, Aramini, R, Hunold, A, Funke, M, Eichardt, R, Gómez-Aguilar, F, Vázquez-Olvera, S, Cordova-Fraga, T, Castro-López, J, Hernández-Gonzalez, M A, Solorio-Meza, S, Sosa-Aquino, M, Bernal-Alvarado, J J, Vargas-Luna, M, Magyari, L, Ludewig, J, Oostenveld, R, Engwer, C, Sato, K, Nishibe, T, Furuya, M, Yamashiro, K, Ono, T, Puthanmadam Subramaniyam, N, Hyttinen, J, Güllmar, D, Grasedyck, L, Maeß, B, Freitag, S, Graichen, U, Fiedler, P, Strohmeier, D, Hauk, O, Grigutsch, M, Felber, M, Herrmann, B, Cárdenas-Peña, D, Castellanos-Dominguez, G, Paul-Jordanov, I, Ito, Y, Sato, D, Kamada, K, Kobayashi, T, Dalal, S S, Willomitzer, F, Arold, O, Fouladi-Movahed, S, Häusler, G, Stefan, H, Ettl, S, Zhang, S, Zhang, Y, Li, H, Kong, X, Wong, D D E, Bidet-Caulet, A, Knight, R T, Crone, N E, Birot, G, Spinelli, L, Vulliémoz, S, Seeck, M, Emory, H, Wells, C, Mizrahi, N, Karahanoglu, F I, Caballero-Gaudes, C, Megevand, P, Genetti, M, Schaller, K, Michel, C, Tyrand, R, Heinzer, S, Delattre, B, Lazeyras, F, Pittau, F, Ratib, O, Vargas, M, Garibotto, V, Bailey, C A, Kean, M, Warren, A E, Davidson, A, Seal, M, Harvey, A S, Archer, J S, Papadopoulou, M, Leite, M, Boon, P, Friston, K, Marinazzo, D, Holmes, M, Rikir, E, Gavaret, M, Bartolomei, F, Vignal, J P, Centeno, M, Perani, S, Pier, K, Lemieux, L, Clayden, J, Clark, C, Pressler, R, Cross, H, Carmichael, D W, Spring, A, Bessemer, R, Pittman, D, Aghakhani, Y, Federico, P, Badier, J M, Bénar, C-G, Cruto, C, Chauvel, P, Brodbeck, V, van Leeuwen, T, Tagliazzuchi, E, Melloni, L, Laufs, H, Griskova-Bulanova, I, Dapsys, K, Klein, C, Hänggi, J, Jäncke, L, Ehinger, B V, Fischer, P, Gert, A L, Kaufhold, L, Weber, F, Marchante Fernandez, M, Pipa, G, König, P, Hiyama, E, Koga, R, Iannilli, E, Bartmuss, A-L, Gupta, N, Hummel, T, Boecker, R, Holz, N, Buchmann, A F, Blomeyer, D, Plichta, M M, Wolf, I, Baumeister, S, Meyer-Lindenberg, A, Banaschewski, T, Laucht, M, Natahara, S, Ueno, M, Bänninger, A, Schwab, S, Natsukawa, H, Tüshaus, L, Achermann, P, Wilson, R S, Assecondi, S, Darque, A, Rihs, T A, Ha-Vinh Leuchter, R, Caballero, C, Hüppi, P S, Hauser, T U, Hunt, L T, Iannaccone, R, Stämpfli, P, Dolan, R J, Walitza, S, Brem, S, Zanow, F, Lordier, L, Van de Ville, D, Sancho Rossignol, A, Cordero, I, Ansermet, F, Hüppi, P, Schläpfer, A, Rubia, K, Tamura, K, Karube, C, Mizuba, T, Matsufuji, M, Takashima, S, Iramina, K, Ostwald, D, Brazdil, M, Lamos, M, Slavícek, T, Jan, J, Meier, N M, Perrig, W, Minami, T, Noritake, Y, Nakauchi, S, Azuma, K, Kinoshita, H, Kaneko, M, Ide, J, Noguchi, Y, Douglas, P K, Rodriguez, C M, Xia, H J, Zimmerman, E M, Konopka, C J, Epstein, P S, Konopka, L M, Giezendanner, S, Fisler, M, Soravia, L, Andreotti, J, Okano, K, Mizutani, N, Thelen, A, Murray, M, Pastena, L, Faralli, F, Melucci, M, Gagliardi, R, Ricciardi, L, Ruffino, G, Coito, A, Macku, P, Fischmeister, F Ph S, Glaser, J, Schöpf, V, Bauer, H, Beisteiner, R, Deligianni, F, Smesny, St, Dürschmid, S, Zaehle, T, Pannek, H, Chang, H F, Voges, J, Rieger, J, Heinze, H-J, Hinrichs, H, Tsatsishvili, V, Cong, F, Puoliväli, T, Alluri, V, Toiviainen, P, Nandi, A K, Brattico, E, Ristaniemi, T, Grieder, M, Crinelli, R M, Stein, M, Wahlund, L-O, Atsumori, H, Yamaguchi, R, Okano, Y, Sato, H, Funane, T, Sakamoto, K, Kiguchi, M, Tränkner, A, Schindler, S, Schmidt, F, Strauß, M, Trampel, R, Hegerl, U, Turner, R, Geyer, S, Schönknecht, P, Kebets, V, van Assche, M, Goldstein, R, van der Meulen, M, Vuilleumier, P, Assal, F, Wozniak-Kwasniewska, A, Szekely, D, Harquel, S, Bougerol, T, Jones, D K, Sos, P, Klirova, M, Novak, T, Brunovsky, M, Horacek, J, Bares, M, Hoschl C, C, Fellhauer, I, Zöllner, F G, Schröder, J, Kong, L, Essig, M, Schad, L R, Arrubla, J, Neuner, I, Hahn, D, Boers, F, Shah, N Jon, Jon Shah, N, Suriya Prakash, M, Sharma, R, Kawaguchi, H, Griebel, S, Biller, S, Fonseca, C, Vaz, F, Zentner, L, Rochas, V, Rihs, T, Thut, G, Rosenberg, N, Landis, Th, Michel, Ch, Moliadze, V, Schmanke, T, Lyzhko, E, Bassüner, S, Freitag, Ch, Siniatchkin, M, Thézé, R, Nahum, L, Schnider, A, Meier, L, Friedrich, H, Landis, B, Witte, M, Kober, S E, Neuper, C, Wood, G, König, R, Matysiak, A, Kordecki, W, Sieluzycki, C, Zacharias, N, Heil, P, Wyss, C, Dammers, J, Kawohl, W, Shah, N J, Braboszcz, C, Cahn, R B, Levy, J, Fernandez, M, Delorme, A, Rosas-Martinez, L, Milne, E, Zheng, Y, Urakami, Y, Kawamura, K, Washizawa, Y, Hiyoshi, K, Cichocki, A, Giroud, N, Dellwo, V, Meyer, M, Rufener, K S, Liem, F, Jones-Rounds, J D, Raizada, R, Staljanssens, W, Van Holen, R, Pefkou, M, Becker, R, Hervais-Adelman, A, He, W, Brock, J, Johnson, B, Ohla, K, Hitz, K, Heekeren, K, Obermann, C, Huber, T, Juckel, G, Gabriel, D, Comte, A, Henriques, J, Magnin, E, Grigoryeva, L, Ortega, J-P, Haffen, E, Moulin, T, Pazart, L, Aubry, R, Kukleta, M, Baris Turak, B, Louvel, J, Crespo-Garcia, M, Cantero, J L, Atienza, M, Connell, S, Kilborn, K, Damborská, A, Koberda, J L, Bienkiewicz, A, Koberda, I, Koberda, P, Moses, A, Tomescu, M, Schneider, M, Debbané, M, Wang, G Y, Kydd, R, Wouldes, T A, Jensen, M, Russell, B R, Dissanayaka, N, Au, T, Angwin, A, O'Sullivan, J, Byrne, G, Silburn, P, Marsh, R, Mellic, G, Copland, D, Mathys, C, Drechsler, R, Boeijinga, P H, Pang, E W, Valica, T, Macdonald, M J, Oh, A, Lerch, J P, Anagnostou, E, Shimada, T, Matsuda, Y, Monkawa, A, Monkawa, T, Hashimoto, R, Watanabe, K, Kawasaki, Y, Laimböck, K, Koorenhof, L J, Swithenby, S J, Martins-Mourao, A, Song, K W, Knebel, J F, Laimboeck, K, Fusar-Poli P

المساهمون: B J, He, Nolte, G, Nagata, K, Takano, D, Yamazaki, T, Fujimaki, Y, Maeda, T, Satoh, Y, Heckers, S, George, M S, Lopes da Silva, F, de Munck, J C, Van Houdt, P J, Verdaasdonk, R M, Ossenblok, P, Mullinger, K, Bowtell, R, Bagshaw, A P, Keeser, D, Karch, S, Segmiller, F, Hantschk, I, Berman, A, Padberg, F, Pogarell, O, Scharnowski, F, Hümmer, S, Paolini, M, Kirsch, V, Koller, G, Rauchmann, B, Kupka, M, Blautzik, J, Razavi, N, Jann, K, Koenig, T, Kottlow, M, Hauf, M, Strik, W, Dierks, T, Gotman, J, Vulliemoz, S, Lu, Y, Zhang, H, Yang, L, Worrell, G, He, B, Gruber, O, Piguet, C, Hubl, D, Homan, Ph, Kindler, J, Kim, K, Steinhoff, U, Wakai, R, Melie-García, L, Mucci, A, Volpe, U, Prinster, A, Salvatore, M, Galderisi, S, Linden, D E J, Brandeis, D, Schroeder, C E, Kayser, C, Panzeri, S, Kleinschmidt, A, Ritter, P, Walther, S, Haueisen, J, Lau, S, Flemming, L, Sonntag, H, Maess, B, Knösche, T R, Lanfer, B, Dannhauer, M, Wolters, C H, Stenroos, M, Wolters, C, Aydin, U, Lew, S, Lucka, F, Ruthotto, L, Vorwerk, J, Wagner, S, Ramon, C, Guan, C, Ang, K K, Chua, S G, Kuah, W K, Phua, K S

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/24368763; volume:44; issue:4; firstpage:E1; lastpage:E121; journal:CLINICAL EEG AND NEUROSCIENCE; http://hdl.handle.net/11571/1313632Test

الإتاحة: https://doi.org/10.1177/1550059413507209Test
http://hdl.handle.net/11571/1313632Test

المؤلفون: He, B. J., Nolte, G., Nagata, K., Takano, D., Yamazaki, T., Fujimaki, Y., Maeda, T., Satoh, Y., Heckers, S., George, M. S., Phua, K. S., He, W., Brock, J., Johnson, B., Ohla, K., Hitz, K., Heekeren, K., Obermann, C., Huber, T., Juckel, G., Kawohl, W., Chew, E., Gabriel, D., Comte, A., Henriques, J., Magnin, E., Grigoryeva, L., Ortega, J.-P., Haffen, E., Moulin, T., Pazart, L., Aubry, R., Zhou, H., Kukleta, M., Baris Turak, B., Louvel, J., Crespo-Garcia, M., Cantero, J. L., Atienza, M., Connell, S., Kilborn, K., Damborska, A., Brazdil, M., Chuang, K. H., Rektor, I., Koberda, J. L., Bienkiewicz, A., Koberda, I., Koberda, P., Moses, A., Tomescu, M., Rihs, T., Britz, J., Ang, B. T., Custo, A., Grouiller, F., Schneider, Maggy, Debbané, Martin, Eliez, S., Michel, C, Wang, G. Y., Kydd, R., Wouldes, T. A., Jensen, M., Wang, C., Russell, B. R., Dissanayaka, N., Au, T., Angwin, A., O'Sullivan, J., Byrne, G., Silburn, P., Marsh, R., Mellic, G., Copland, D., Zhang, H, Banninger, A., Kottlow, M., Diaz Hernandez, L., Koenig, T., Hauser, T. U., Iannaccone, R., Mathys, C, Yang, H., Ball, J., Drechsler, R., Brandeis, D., Walitza, S., Brem, S., Boeijinga, P. H., Pang, E. W., Valica, T., Macdonald, M. J., Oh, A., Chin, Z. Y., Lerch, J. P., Anagnostou, E., Vorwerk, J., Wolters, C. H., Grasedyck, L., Haueisen, J., Maess, B., Freitag, S., Graichen, U., Worrell, G., Fiedler, P., Strohmeier, D., Carmichael, D. W., Stenroos, M., Hauk, O., Grigutsch, M., Felber, M., Herrmann, B., Strobbe, G., He, B., van Mierlo, P., Spring, A., Vandenberghe, S., Cardenas-Pena, D., Montes-Restrepo, V., Castellanos-Dominguez, G., Lanfer, B., Paul-Jordanov, I., Gruber, O., Bessemer, R., Scherg, M., Ito, Y., Sato, D., Kamada, K., Kobayashi, T., Dalal, S. S., Rampp, S., Willomitzer, F., Arold, O., Pittman, D., Piguet, C., Fouladi-Movahed, S., Hausler, G., Stefan, H., Ettl, S., Zhang, S., Zhang, Y., Li, H., Kong, X., Aghakhani, Y., Hubl, D., Wong, D. D. E., Bidet-Caulet, A., Knight, R. T., Crone, N. E., Birot, G., Federico, P., Spinelli, L., Vulliemoz, S., Homan, Ph, Seeck, M., Emory, H., Wells, C., Mizrahi, N., Vogrin, S. J., Lau, S., Pittau, F., Cook, M. J., Karahanoglu, F. I., Kindler, J., Caballero-Gaudes, C., Van De Ville, D., Megevand, P., Genetti, M., Schaller, K., Dierks, T., Tyrand, R., Melie-Garcia, L., Kim, K., Heinzer, S., Delattre, B., Lazeyras, F., Ratib, O., Vargas, M., Garibotto, V., Steinhoff, U., Bailey, C. A., Kean, M., Warren, A. E., Davidson, A., Seal, M., Harvey, A. S., Archer, J. S., Papadopoulou, M., Leite, M., Wakai, R., Vonck, K., Gotman, J., Boon, P., Friston, K., Marinazzo, D., Ramon, C., Holmes, M., Koessler, L., Rikir, E., Gavaret, M., Bartolomei, F., Badier, J. M., Vignal, J. P., Vespignani, H., Maillard, L., Centeno, M., Perani, S., Pier, K., Lemieux, L., Clayden, J., Clark, C., Benar, C.-G., Pressler, R., Cross, H., Cruto, C., Chauvel, P., Brodbeck, V., van Leeuwen, T., Mucci, A., Lamos, M., Tagliazzuchi, E., Melloni, L., Laufs, H., Griskova-Bulanova, I., Dapsys, K., Klein, C., Hanggi, J., Jancke, L., Ehinger, B. V., Fischer, P., Slavicek, T., Volpe, U., Gert, A. L., Kaufhold, L., Weber, F., Marchante Fernandez, M., Pipa, G., Konig, P., Sekihara, K., Hiyama, E., Koga, R., Marecek, R., Iannilli, E., Prinster, A., Bartmuss, A.-L., Gupta, N., Hummel, T., Boecker, R., Holz, N., Buchmann, A. F., Blomeyer, D., Jan, J., Plichta, M. M., Wolf, I., Salvatore, M., Baumeister, S., Meyer-Lindenberg, A., Banaschewski, T., Laucht, M., Natahara, S., Ueno, M., Meier, N. M., Galderisi, S., Schwab, S., Federspiel, A., Jann, K., Perrig, W., Natsukawa, H., Tushaus, L., Linden, D. E. J., Achermann, P., Wilson, R. S., Mayhew, S. D., Assecondi, S., Arvanitis, T. N., Bagshaw, A. P., Darque, A., Rihs, T. A., Ha-Vinh Leuchter, R., Caballero, C., Minami, T., Huppi, P. S., Hunt, L. T., Stampfli, P., Schroeder, C. E., Dolan, R. J., Walther, S., Eichardt, R., Zanow, F., Kayser, C., Lordier, L., Trampel, R., Van de Ville, D., Sancho Rossignol, A., Cordero, I., Ansermet, F., Huppi, P., Schlapfer, A., Rubia, K., Panzeri, S., Noritake, Y., Di Lorenzo, G., Pagani, M., Monaco, L., Daverio, A., Giannoudas, I., Verardo, A. R., La Porta, P., Niolu, C., Fernandez, I., Kleinschmidt, A., Nakauchi, S., Siracusano, A., Tamura, K., Karube, C., Mizuba, T., Matsufuji, M., Takashima, S., Iramina, K., Ostwald, D., Azuma, K., Ritter, P., Rodriguez, C., Lenartowicz, A., Cohen, M, Hegerl, U., Kinoshita, H., Kaneko, M., Ide, J., Noguchi, Y., Turner, R., Douglas, P. K., Rodriguez, C. M., Xia, H. J., Zimmerman, E. M., Konopka, C. J., Epstein, P. S., Konopka, L. M., Giezendanner, S., Fisler, M., Geyer, S., Soravia, L., Andreotti, J., Flemming, L., Wiest, R., Razavi, N., Hauf, M., Schonknecht, P., Sonntag, H., Okano, K., Mizutani, N., Thelen, A., Murray, M., Kebets, V., Pastena, L., Formaggio, E., Storti, S. F., Faralli, F., Melucci, M., Gagliardi, R., Ricciardi, L., Ruffino, G., Coito, A., van Assche, M., Macku, P., Astolfi, L., Knosche, T. R., Plomp, G., Goldstein, R., Fischmeister, F. Ph S., Glaser, J., Schopf, V., Bauer, H., Beisteiner, R., Deligianni, F., van der Meulen, M., Mingoia, G., Langbein, K., Dietzek, M., Wagner, G., Smesny, St, Scherpiet, S., Maitra, R., Dannhauer, M., Gaser, Ch, Sauer, H., Vuilleumier, P., Nenadic, I., Durschmid, S., Zaehle, T., Pannek, H., Chang, H. F., Voges, J., Rieger, J., Heinze, H.-J., Hinrichs, H., Tsatsishvili, V., Cong, F., Puolivali, T., Alluri, V., Toiviainen, P., Nandi, A. K., Brattico, E., Ristaniemi, T., Aydin, U., Grieder, M., Crinelli, R. M., Wirth, M., Stein, M., Wahlund, L.-O., Atsumori, H., Richiardi, J., Yamaguchi, R., Okano, Y., Sato, H., Funane, T., Sakamoto, K., Kiguchi, M., Trankner, A., Schindler, S., Schmidt, F., Strauss, M., Wolters, C., Assal, F., Wozniak-Kwasniewska, A., Szekely, D., Harquel, S., Bougerol, T., David, O., Bracht, T., Jones, D. K., Horn, H., Muller, T. J., Sos, P., Klirova, M., Novak, T., Brunovsky, M., Horacek, J., Bares, M., Hoschl C, C., Lew, S., Fellhauer, I., Zollner, F. G., Schroder, J., Kong, L., Essig, M., Schad, L. R., Arrubla Martinez, Jorge Andres, Neuner, I., Hahn, D., Boers, F., Lucka, F., Shah, N. Jon, Arrubla, J., Jon Shah, N., Suriya Prakash, M., Sharma, R., Kawaguchi, H., Ruthotto, L., Griebel, S., Biller, S., Fonseca, C., Vaz, F., Zentner, L., Rochas, V., Thut, G., Rosenberg, N., Landis, Th, Moliadze, V., Schmanke, T., Lyzhko, E., Bassuner, S., Freitag, Ch, Siniatchkin, M., Wagner, S., Theze, R., Guggisberg, A. G., Nahum, L., Schnider, Armin, Meier, L., Friedrich, H., Landis, B., Strik, W., Yu, H., Witte, M., Kober, S. E., Neuper, C., Wood, G., Konig, R., Matysiak, A., Kordecki, W., Sieluzycki, C., Guan, C., Zacharias, N., Heil, P., Wyss, C., Dammers, J., Shah, N. J., Braboszcz, C., Ang, K. K., Cahn, R. B., Levy, J., Fernandez, M., Delorme, A., Rosas-Martinez, L., Milne, E., Zheng, Y., Urakami, Y., Kawamura, K., Washizawa, Y., Shimada, T., Chua, S. G., Hiyoshi, K., Cichocki, A., Giroud, N., Dellwo, V., Meyer, M., Rufener, K. S., Liem, F., Matsuda, Y., Jones-Rounds, J. D., Kuah, W. K., Raizada, R., Staljanssens, W., Van Holen, R., Pefkou, M., Becker, R., Monkawa, A., Hervais-Adelman, A., Monkawa, T., Hashimoto, R., Watanabe, K., Kawasaki, Y., Matsuda, K, Lopes da Silva, F., Pan, Y., Stegmayer, K., Collins, L., Laimbock, K., Koorenhof, L. J., Swithenby, S. J., Martins-Mourao, A., Mainsah, B., Song, K. W., Knebel, J. F., Michel, C., Merlotti, E., Vignapiano, A., Colwell, K., Montefusco, V., Plescia, G. M., Gallo, O., Romano, P., Laimboeck, K., Morton, K., Ryan, D., Sellers, E., Caves, K., Throckmorton, S., Kubler, A., de Munck, J. C., Holz, E. M., Zickler, C., Brown, K., Van Houdt, P. J., Wennberg, R., Ahlfors, S. P., Grova, C., Chowdhury, R., Hedrich, T., Heers, M., Zelmann, R., Hall, J. A., Lina, J. M., Kobayashi, E., Verdaasdonk, R. M., Oostendorp, T., van Dam, P., Oosterhof, P., Linnenbank, A., Coronel, R., van Dessel, P., de Bakker, J., Rossion, B., Jacques, C, Witthoft, N., Ossenblok, P., Weiner, K. S., Foster, B. L., Miller, K. J., Hermes, D., Parvizi, J., Grill-Spector, K., Recanzone, G. H., Murray, M. M., Haynes, J. D., Mullinger, K., Greicius, M., De Lucia, M., Muller, K.-R., Formisano, E., Smieskova, R., Schmidt, A., Bendfeldt, K., Walter, A., Riecher-Rossler, A., Borgwardt, S., Bowtell, R., Fusar-Poli, P., Nagarajan, S. S., Schoffelen, J. M., Balazs, S., Kermanshahi, K., Kiesenhofer, W., Binder, H., Rattay, F., Antal, A., Chaieb, L., Paulus, W., Bodis-Wollner, I., Maurer, K., Fein, G., Camchong, J., Keeser, D., Johnstone, J., Cardenas-Nicolson, V., Fiederer, L. D. J., Yang, S., Dumpelmann, M., Cosandier-Rimele, D., Schulze-Bonhage, A., Aertsen, A., Karch, S., Speck, O., Ball, T., Fuchs, M., Wagner, M., Kastner, J., Tech, R., Dinh, C., Baumgarten, D., Segmiller, F., Hamalainen, M. S., D'Souza, W., Hantschk, I., Malmivuo, J., Kupper, P., Kugel, H., Wellmer, J., Kellinghaus, C., Berman, A., Boscolo Galazzo, I., Del Felice, A., Pizzini, F. B., Arcaro, C., Mai, R., Manganotti, P., Padberg, F., Vignal, J., Cecchin, T., Colnat-Coulbois, S., Ramantani, G., Kuba, R., Pogarell, O., Chrastina, J., Rektorova, I., Carrette, E., Ahmed, B., Brodely, C., Scharnowski, F., Carlson, C., Kuzniecky, R., Devinsky, O., French, J., Thesen, T., Benis, D., Lachaux, J.-P., Seigneuret, E., Krack, P., Fraix, V., Chabardes, S., Bastin, J., Gee, D., Kilroy, E., Cannon, T., Wang, D. J., Hale, J. R., Hummer, S., Przezdzik, I., Quairiaux, C., Mullinger, K. J., Francis, S. T., Schouten, A. C., Campfens, S. F., van der Kooij, H., Koles, Z., Lind, J., Flor-Henry, P., Haase, C. M., Paolini, M., Villeneuve, S., Vogel, J., Jagust, W. J., Kambeitz-Ilankovic, L., Simon-Vermot, L., Gesierich, B., Duering, M., Ewers, M., Krajcovicova, L., Kirsch, V., Mikl, M., Schnell, S., Hofle, O., Koller, G., Surmeli, T., Ertem, A., Eralp, E., Kos, I. H., Skrandies, W., Fluggen, S., Klein, A., Rauchmann, B., Ro, T., Lau, E., Loo, S. K., Kupka, M., Blautzik, J., Bollmann, S., Ghisleni, C., O'Gorman, R., Poil, S.-S., Klaver, P., Michels, L., Martin, E., Eich-Hochli, D., Salisbury, D. F., Murphy, T. K., Butera, C. D., Mathalon, D. H., Fryer, S. L., Kiehl, K. A., Calhoun, V. C., Pearlson, G. D., Roach, B. J., Ford, J. M., McGlashan, T. H., Woods, S. W., Smesny, Gonzalez Andino, S., Grave de Peralta Menendez, R., Sanchez Vives, M., Rebollo, B., Frolich, L., Andersen, T. S., Morup, M., Belfiore, P., Gargiulo, P., Vanhatalo, S., Cho, J.-H., Watanabe, T., Kawabata, Y., Ukegawa, D., Kawabata, S., Adachi, Y., Herrmann, C., Burger, M., Wolters, Ch, Bauer, M., Trahms, L., Sander, T., Faber, P. L., Lehmann, D., Gianotti, L, Pascual-Marqui, R. D., Milz, P., Kochi, K., Kaneko, S., Yamashita, S., Yana, K., Kalogianni, K., Vardy, A. N., van der Helm, F. C. T., Sorrentino, A., Luria, G., Aramini, R., Hunold, A., Funke, M., Gomez-Aguilar, F., Vazquez-Olvera, S., Cordova-Fraga, T., Castro-Lopez, J., Hernandez-Gonzalez, M. A., Solorio-Meza, S., Sosa-Aquino, M., Bernal-Alvarado, J. J., Lu, Y., Vargas-Luna, M., Magyari, L., Ludewig, J., Oostenveld, R., Engwer, C., Sato, K., Nishibe, T., Furuya, M., Yamashiro, K., Ono, T., Puthanmadam Subramaniyam, N., Hyttinen, J., Gullmar, D., Yang, L.

المصدر: Clinical EEG and Neuroscience (2013)

مصطلحات موضوعية: Human health sciences, Radiology, nuclear medicine & imaging, Sciences de la santé humaine, Radiologie, médecine & imagerie nucléaire

الوصف: peer reviewed

العلاقة: urn:issn:1550-0594; urn:issn:2169-5202; https://orbi.uliege.be/handle/2268/207114Test; info:hdl:2268/207114; scopus-id:2-s2.0-84897868137; info:pmid:24368761

الإتاحة: https://doi.org/10.1093/fampra/cmt081Test
https://orbi.uliege.be/handle/2268/207114Test

المؤلفون: Van Seventer, R., Bach, F. W., Toth, C. C., Serpell, M., Temple, J., Murphy, T. K., Nimour, M.

الوصف: Background: Pregabalin is effective in the treatment of peripheral and central neuropathic pain. This study evaluated pregabalin in the treatment of post-traumatic peripheral neuropathic pain (including post-surgical). Methods: Patients with a pain score >= 4 (0-10 scale) were randomized and treated with either flexible-dose pregabalin 150-600 mg/day (n = 127) or placebo (n = 127) in an 8-week double-blind treatment period preceded by a 2-week placebo run-in. Results: Pregabalin was associated with a significantly greater improvement in the mean end-point pain score vs. placebo; mean treatment difference was -0.62 (95% CI -1.09 to -0.15) (P = 0.01). The average pregabalin dose at end-point was similar to 326 mg/day. Pregabalin was also associated with significant improvements from baseline in pain-related sleep interference, and the Medical Outcomes Study sleep scale sleep problems index and sleep disturbance subscale (all P < 0.001). In the all-patient group (ITT), pregabalin was associated with a statistically significant improvement in the Hospital Anxiety and Depression Scale anxiety subscale (P < 0.05). In total, 29% of patients had moderate/severe baseline anxiety; treatment with pregabalin in this subset did not significantly improve anxiety. More patients reported global improvement at end-point with pregabalin than with placebo (68% vs. 43%; overall P < 0.01). Adverse events led to discontinuation of 20% of patients from pregabalin and 7% from placebo. Mild or moderate dizziness and somnolence were the most common adverse events in the pregabalin group. Conclusion: Flexible-dose pregabalin 150-600 mg/day was effective in relieving neuropathic pain, improving disturbed sleep, improving overall patient status, and was generally well tolerated in patients with post-traumatic peripheral neuropathic pain.

العلاقة: Van Seventer, R., Bach, F. W., Toth, C. C., Serpell, M. , Temple, J., Murphy, T. K. and Nimour, M. (2010) Pregabalin in the treatment of post-traumatic peripheral neuropathic pain: a randomized double-blind trial. European Journal of Neurology , 17(8), pp. 1082-1089. (doi:10.1111/j.1468-1331.2010.02979.x )

الإتاحة: https://doi.org/10.1111/j.1468-1331.2010.02979.xTest
http://eprints.gla.ac.uk/39635Test/