المؤلفون: Cihan Uysal, Tugba Yilmaz, Hafsa Kocyigit, Hulya Akgun, Murat Hayri Sipahioglu

المصدر: BMC Nephrology, Vol 24, Iss 1, Pp 1-6 (2023)

مصطلحات موضوعية: Tubulointerstitial nephritis, Microscopic polyangiitis, Acute kidney injury, Dialysis, Case report, Diseases of the genitourinary system. Urology, RC870-923

الوصف: Abstract Background Microscopic polyangiitis (MPA), a kind of antineutrophil cytoplasmic autoantibody associated vasculitis (AAV), predominantly affects small-sized vessels. MPA is a significant cause of the pulmonary-renal syndrome. Pauci-immune necrotizing and crescentic glomerulonephritis is the typical renal histological feature of AAV. Tubulointerstitial lesions may occur and mostly form with inflammatory cell infiltration in the interstitium. However, a few cases reported only tubulointerstitial involvement without glomerular lesions in patients with MPA. Case presentation We present an MPA case, a 70-year-old male patient diagnosed with acute kidney injury accompanying the dialysis requirement. Only acute tubulointerstitial nephritis was revealed in kidney biopsy without evidence of glomerular injury. Also, interstitial pulmonary fibrosis was determined on computerized tomography, and myeloperoxidase antineutrophil cytoplasmic autoantibody was positive. Consequently, we have considered the main diagnosis as MPA. We did not prefer a standard tubulointerstitial nephritis treatment regimen due to the presence of life-threatening systemic vasculitis. Treatment was established like crescentic glomerulonephritis. Induction therapy consisted of pulse steroid, cyclophosphamide, and plasmapheresis. Unfortunately, severe SARS-CoV-2 infection caused death during induction therapy in this case. Conclusions The lack of glomerular injury and solely interstitial inflammation is atypical regarding AAV involvement in the kidney. This diversity might be initially considered as only a simple histological elaboration. However, it is a significant entity for guiding the treatment of AAV.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2369Test

الوصول الحر: https://doaj.org/article/12f0478c37634093b84d1d7129e5a558Test

المؤلفون: Ismail Kocyigit, Serpil Taheri, Elif Funda Sener, Eray Eroglu, Fahir Ozturk, Aydin Unal, Kezban Korkmaz, Gokmen Zararsiz, Murat Hayri Sipahioglu, Yusuf Ozkul, Bulent Tokgoz, Oktay Oymak, Tevfik Ecder, Jonas Axelsson

المصدر: BMC Nephrology, Vol 18, Iss 1, Pp 1-10 (2017)

مصطلحات موضوعية: Diseases of the genitourinary system. Urology, RC870-923

الوصف: Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder with unclear disease mechanism. Currently, overt hypertension and increased renal volume are the best predictors of renal function. In this study, we assessed the usefulness of selected circulating microRNAs (miRs) to predict disease progress in a cohort with ADPKD. Methods Eighty ADPKD patients (44.6 ± 12.7 years, 40% female, 65% hypertensive) and 50 healthy subjects (HS; 45.4 ± 12.7, 44% female) were enrolled in the study. Serum levels of 384 miRs were determined by Biomark Real Time PCR. Groups were compared using the limma method with multiple-testing correction as proposed by Smyth (corrected p 10% loss of GFR over the following 12 months (cut-off >2.2 AU, sensitivity 83%, specificity 78%, area 0.872 [95% CI: 0.790–0.953, p

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12882-017-0600-zTest; https://doaj.org/toc/1471-2369Test

الوصول الحر: https://doaj.org/article/5d9670bcad294b82b0c04ec1bb84a0a6Test

المؤلفون: Ahmet Sen, Ali Dogan, Aydin Unal, Bulent Tokgoz, Ender Dogan, Eray Eroglu, Ismail Kocyigit, Murat Hayri Sipahioglu, Mustafa Yasan, Oktay Oymak, Ozcan Orscelik, Ozkan Gungor

المصدر: Internal Medicine. 2015, 54(1):3

المؤلفون: Ali Dogan, Aydin Unal, Bulent Tokgoz, Cigdem Karakukcu, Ender Dogan, Eray Eroglu, Ismail Kocyigit, Murat Hayri Sipahioglu, Oktay Oymak, Ozcan Orscelik, Ozkan Gungor, Serhat Karadavut

المصدر: Journal of Atherosclerosis and Thrombosis. 2015, 22(3):257

المؤلفون: Ali Dogan, Aydin Unal, Bulent Tokgoz, Eray Eroglu, Ibrahim Ozdogru, Ismail Kocyigit, Murat Hayri Sipahioglu, Mustafa Yasan, Oktay Oymak, Onur Tunca, Ozcan Orscelik, Ozkan Gungor

المصدر: Journal of Atherosclerosis and Thrombosis. 2014, 21(10):1066

المؤلفون: Eray Eroglu, Ismail Kocyigit, Sami Bahcebasi, Aydin Unal, Murat Hayri Sipahioglu, Merva Kocyigit, Bulent Tokgoz, Oktay Oymak

المصدر: Case Reports in Medicine, Vol 2013 (2013)

مصطلحات موضوعية: Medicine

الوصف: Ethylene glycol (EG) may be consumed accidentally or intentionally, usually in the form of antifreeze products or as an ethanol substitute. EG is metabolized to toxic metabolites. These metabolites cause metabolic acidosis with increased anion gap, renal failure, oxaluria, damage to the central nervous system and cranial nerves, and cardiovascular instability. Early initiation of treatment can reduce the mortality and morbidity but different clinical presentations can cause delayed diagnosis and poor prognosis. Herein, we report a case with the atypical presentation of facial paralysis, hematuria, and kidney failure due to EG poisoning which progressed to end stage renal failure and permanent right peripheral facial nerve palsy.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1687-9627Test; https://doaj.org/toc/1687-9635Test

الوصول الحر: https://doaj.org/article/399f0d4378474eb1be1cbc742e826c65Test

المؤلفون: Alper Yurci, Aydin Unal, Bulent Tokgoz, Cengiz Utas, Hulya Akgun, Kuddusi Erkilic, Murat Hayri Sipahioglu, Oktay Oymak

المصدر: Internal Medicine. 2008, 47(2):103

المؤلفون: Aydin Unal, Bulent Tokgoz, Cengiz Utas, Edip Torun, Mehmet Gungor Kaya, Murat Hayri Sipahioglu, Oktay Oymak

المصدر: Internal Medicine. 2008, 47(11):1017

المؤلفون: Ulaş Serkan Topaloğlu, Murat Hayri Sipahioğlu, İnayet Güntürk, Hülya Akgün, Muhammet Ensar Doğan, Gökhan Sönmez, Ferhan Elmalı, Cevat Yazıcı

المصدر: Iranian Journal of Basic Medical Sciences, Vol 22, Iss 12, Pp 1432-1439 (2019)

مصطلحات موضوعية: contrast-induced-nephropathy, inflammation, oxidative stress, nigella sativa, rat, thymoquinone, Medicine

الوصف: Objective(s): This study aimed to show the effects of thymoquinone, which is known for its antioxidant, anti-inflammatory, and renal protective effects in contrast-induced nephropathy. Materials and Methods: This is an experimental study in rats. 7 groups were included within the scope of our study: sham-vehicle (n=3), premedication-control (n=6), model (n=6), isolated thymoquinone (n=3+3), low-dose thymoquinone (n=6), and high-dose thymoquinone (n=7). In addition to 48 hr of water deprivation, we pre-medicated the rats with intra-peritoneal indomethacin and L-NAME administration. After premedication, 12.5 ml/kg dose of a high osmolar contrast agent-diatrizoat (Urografin ) was administrated. Thymoquinone was administrated in two different doses of 1 mg/kg and 1.75 mg/kg for four days intraperitoneally. Renal functions, histopathological differences, oxidative stress parameters, and inflammatory indicators of rats were evaluated at the end of the study. Results: Significant decreases were observed in levels of serum creatinine and serum BUN with low-dose thymoquinone (1 mg/kg) administration. In light microscopy, significantly less histopathological damage was observed in the low-dose thymoquinone group compared to the contrast agent group. While high-dose thymoquinone is accepted as ineffective biochemically, toxic evidence was identified histopathologically. There were no significant differences between M and TA groups for serum MDA and SOD levels, which were compared to evaluate oxidative stress (P:0.99, P:0.98; respectively). TNF-α, iNOS, and NF-кB gene expressions were not significantly different between all groups (P:0.748, P:0.531, P:0.910; respectively). Conclusion: This experimental study has demonstrated for the first time the protective effect of the TQ substance for CIN in 1 mg/kg dose, in the accompaniment of biochemical and histopathological data in rats.

العلاقة: http://ijbms.mums.ac.ir/article_13990_e398fa7bcc6e3d4e837ce7a96d9baad5.pdfTest; https://doaj.org/toc/2008-3866Test; https://doaj.org/toc/2008-3874Test; https://doaj.org/article/015d0ebddcda4927a214fb4c716029fbTest

الإتاحة: https://doi.org/10.22038/ijbms.2019.13990Test
https://doaj.org/article/015d0ebddcda4927a214fb4c716029fbTest

المؤلفون: Bulent Tokgoz, Murat Hayri Sipahioglu, Ismail Kocyigit, Cihan Uysal, Oktay Oymak, Ali Gundogdu, Sumeyra Koyuncu

المصدر: Turkish Journal of Nephrology. 30:230-234

مصطلحات موضوعية: Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, Medicine, Surgery, Hemodialysis, business, Intensive care medicine, Peritoneal dialysis

الوصف: Background: Peritoneal dialysis is a frequently used renal replacement treatment option in patients with end-stage renalfailure, and it is emphasized several times that it should be started as the first treatment in the literature. However, for manydifferent reasons, sometimes the treatment is stopped and switched to hemodialysis. In this study, we aimed to examinethe reasons and factors affecting the transition to hemodialysis in our unit.Methods: Fifty-five patients who were – transferred to hemodialysis – regularly attending the Peritoneal Dialysis Unit ofErciyes University Nephrology Department were included in our study. Biochemical analysis, peritoneal equalization test(PET), dialysis adequacy (kt/V), and creatinine clearance of these patients were recorded regularly. Regular cardiac exami-nations and ambulatory blood pressure measurements were also performed. The reasons for the transition from perito-neal dialysis to hemodialysis were also noted in detail.Results: The mean age of the patients was 54.02 ± 11.41 years, and 27 (62.8%) of the patients were male. While the shortestperiod spent on peritoneal dialysis was 13 months, the longest was 191 months. The most common type of permeabilityin PET analysis of the patients was observed as high-average. The most common reason for the transition to hemodialysiswas inadequate dialysis. Using univariate and multiple regression models, factors that predict the duration of stay in peri-toneal dialysis were examined. We found that the urine volume, total kt/V, and the number of peritonitis could be effectivein predicting this period.Conclusion: Peritoneal dialysis is a renal replacement option that has advantages such as patient comfort, preservation ofthe kidney’s remaining work, and social life. The reasons for the transition should be examined in detail, and the necessaryinterventions to prolong the time in peritoneal dialysis should be evaluated.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc595e52086542867ecb7d561ad61c3Test
https://doi.org/10.5152/turkjnephrol.2021.4654Test