المؤلفون: Muhammad Al Azhar, Chainurridha ., Mururul Aisyi

المصدر: Asian Pacific Journal of Cancer Biology, Vol 6, Iss 1, Pp 37-41 (2021)

مصطلحات موضوعية: childhood acute leukemia, pd-l1, immunotherapy, immune checkpoint inhibitor, Biology (General), QH301-705.5

الوصف: Background: Programmed Death Ligand 1 (PD-L1) expression was used to determine type of patients who respond to immunotherapy using immune checkpoint inhibitor in several solid malignancies. However, the role of PD-L1 in hematological malignancies is less explored. Therefore, we aim to investigate PD-L1 mRNA expression in childhood leukemia patients. Association between PD-L1 expression and clinicopathological features was also analyzed. Method: Blood samples of 17 childhood leukemia patients and 12 healthy individuals as control were used in this study. The samples were collected in Dharmais Cancer Hospital. Real time PCR was used to analyze PD-L1 expression with GAPDH as internal control. Result: PD-L1 mRNA expression is significantly lower in childhood leukemia patients (medians: 0.0012) compared to healthy individuals (medians: 0.0041) (p=0.017). PD-L1 mRNA expressions were not correlated with age (p=1.000), sex (p=1.000), outcome (p=1.000), type of leukemia (p=1.000), hyperleukocytosis (p=1.000), and syndrome down (p=0.426). Conclusion: PD-L1 expression is lower in leukemia patients compared to healthy controls. PD-L1 expressions were not correlated with all clinicopathological features. Our result provides preliminary data of PD-L1 expression in Indonesian childhood leukemia patients.

وصف الملف: electronic resource

العلاقة: http://www.waocp.com/journal/index.php/apjcb/article/view/627Test; https://doaj.org/toc/2538-4635Test

الوصول الحر: https://doaj.org/article/fd20f18d872744e78bac9bddc15cf7c6Test

المؤلفون: Puasa, Rony, Muhammad, Al Azhar, Hasanuddin, Riskawati

المصدر: Martabe : Jurnal Pengabdian Kepada Masyarakat; Vol 7, No 3 (2024): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT; 891-903 ; 2598-1226 ; 2598-1218 ; 10.31604/jpm.v7i3

مصطلحات موضوعية: jamur, kuku, pedagang, ikan

الوصف: Onikomikosis adalah infeksi jamur yang disebabkan oleh dermatofita, Candida, dan non-dermatofita lainnya yang menyerang kuku tangan atau kaki. Infeksi onikomikosis dapat disebabkan oleh berbagai macam keadaan, antara lain faktor perilaku dan risiko yang dapat mempengaruhi pedagang ikan di Pasar Higienis Kota Ternate. Ketidakpedulian pedagang ikan terhadap dampak merendam kaki setiap hari menjadi salah satu faktor penyebab terjadinya infeksi jamur onikomikosis. Berdasarkan 39 sampel kuku kaki penjual ikan, dari penelitian Rahma Kulanca dkk terhadap penjual ikan di Pasar Higienis Kota Ternate pada tahun       2019 mengungkap terdapat 14 kasus onikomikosis. Tujuan : Membantu dan memberikan informasi kepada para pedagang ikan di pasar higienis tentang cara menghindari jamur penyebab onikomikosis pada kuku kaki. Manfaat ; antara lain meningkatkan kesadaran pedagang ikan tentang cara menghindari jamur penyebab onikomikosis pada kuku kaki. Metode: Untuk menilai pengetahuan peserta dalam menghindari onikomikosis, diberikan tes sebelum dan sesudah, serta pemberian buku saku sebagai bahan ajar. Luaran : terjadi peningkatan Pengetahuan dari penjual ikan tentang bahaya penyakit onikomikosis dan Hasil di Publis pada Jurnal Pengabdian Masyarakat.Â

وصف الملف: application/pdf

العلاقة: http://jurnal.um-tapsel.ac.id/index.php/martabe/article/view/14582/pdfTest; http://jurnal.um-tapsel.ac.id/index.php/martabe/article/view/14582Test

الإتاحة: https://doi.org/10.31604/jpm.v7i3.891-903Test
https://doi.org/10.31604/jpm.v7i3Test
http://jurnal.um-tapsel.ac.id/index.php/martabe/article/view/14582Test

المؤلفون: Muhammad, Al Azhar, Suni, Arsad, Murwidi, Imam Cahyo, Sudrajat, Ace

المصدر: Poltekita : Jurnal Ilmu Kesehatan; Vol. 17 No. 3 (2023): November; 715-721 ; 2527-7170 ; 1907-459X

مصطلحات موضوعية: Disaster Mitigation, Role of Schools, Disaster Preparedness, Capacity Building

الوصف: Earthquake disasters can occur at any time and humans are not yet able to detect when they can occur. Children are included in a group that is vulnerable to the impact of disasters because of their lack of knowledge regarding disaster mitigation. To minimize the impact of disaster events, education on disaster mitigation is needed. To determine the influence of the school's role in increasing students' disaster preparedness abilities in junior high schools in Ternate City. Quasi-experimental research type with a one-group pre-post test design. Data were analyzed using the non-parametric Wilcoxon signed-rank test. The research subjects consisted of teachers (seven respondents) and students (90 respondents). The data were processed using the non-parametric Wilcoxon signed-rank test. The analysis results showed that asymp. sign. (2-tailed) The teacher's score is 0.018 and the student's score is 0.000, where the value of 0.000 is smaller than p value = 0.05, so it can be concluded that there is an increase in disaster preparedness abilities among schoolteachers and students. The role of schools is very important in disseminating disaster mitigation education as basic knowledge that requires learning as early as possible, so that a culture of disaster mitigation grows both before, during, and after a disaster. There was an increase in the ability of teachers and students at school after a disaster preparedness simulation was carried out at a junior high school in Ternate City.

وصف الملف: application/pdf

العلاقة: http://jurnal.poltekkespalu.ac.id/index.php/JIK/article/view/3220/904Test; http://jurnal.poltekkespalu.ac.id/index.php/JIK/article/view/3220Test

الإتاحة: https://doi.org/10.33860/jik.v17i3.3220Test
http://jurnal.poltekkespalu.ac.id/index.php/JIK/article/view/3220Test

المؤلفون: Arianti, Rini, Ariani, Nia Lukita, Muhammad, Al Azhar, Sadewa, Ahmad Hamim, Farmawati, Arta, Sunarti, Hastuti, Pramudji, Kristóf, Endre

مصطلحات موضوعية: Orvostudományok, Elméleti orvostudományok

الوصف: LB

وصف الملف: application/pdf

العلاقة: Life. -11 : 6 (2021), p. 552-. -Life (Basel). - 2075-1729; http://dx.doi.org/10.3390/life11060552Test; http://webpac.lib.unideb.hu:8082/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM095790Test; http://hdl.handle.net/2437/320796Test; https://www.mdpi.com/2075-1729/11/6/552Test

الإتاحة: https://doi.org/10.3390/life11060552Test
http://hdl.handle.net/2437/320796Test
http://webpac.lib.unideb.hu:8082/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM095790Test
https://www.mdpi.com/2075-1729/11/6/552Test

المؤلفون: Muhammad, Al Azhar

المصدر: Media Publikasi Promosi Kesehatan Indonesia (MPPKI); Vol. 3 No. 1: JANUARI 2020 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI); 50-55 ; 2597-6052

مصطلحات موضوعية: Distraksi Pendengaran, Musik Instrumental, Diabetes Melitus tipe 2

الوصف: Diabetes melitus (DM) merupakan penyakit kronik pada sistem endokrin ditandai Hiperglikemia akibat kekurangan insulin, kerja insulin dan atau keduanya. Hiperglikemia mengakibatkan gangguan mikrovaskuler dan makrovaskuler. Penanganan DM dengan ketaatan diit, pengobatan, olahraga, gaya hidup dan pengobatan seumur hidup menyebabkan stres. Stres akan merangsang hormon Kortisol dan Epinefrin yang memicu hiperglikemia yang berujung pada DM. Upaya mengatasi masalah DM tidak hanya bersifat farmakologis namun memerlukan upaya non farmakologis dalam mengendalikan kadar glukosa darah diantaranya mencegah hiperglikemia akibat stres dengan terapi distraksi pendengaran. Tujuan penelitian untuk Mengkaji efek Distraksi pendengaran, frekuensi penurunan kadar glukosa darah dan mengkaji perbedaan kadar glukosa darah sebelum dan sesudah diberikan Distraksi pendengaran pada penderita DM Tipe 2 di UPTD Diabetes Center Kota Ternate. Populasi penelitian adalah seluruh pasien yang berobat di UPTD Diabetes Center Kota Ternate dan bersedia diberikan terapi distraksi pendengaran. Data dianalisis dengan uji paired sample t test untuk melihat perbedaan kadar glukosa sebelum dan sesudah terapi distraksi pendengaran. Hasil penelitian menunjukkan nilai t hitung 3,541 dengan signifikansi p=0,001. Kesimpulan terdapat pengaruh Distraksi Pendengaran terhadap penurunan kadar glukosa darah penderita DM tipe 2 di UPTD Diabetes Center Kota Ternate.

وصف الملف: application/pdf

العلاقة: https://jurnal.unismuhpalu.ac.id/index.php/MPPKI/article/view/1027/882Test; https://jurnal.unismuhpalu.ac.id/index.php/MPPKI/article/view/1027Test

الإتاحة: https://doi.org/10.56338/mppki.v3i1.1027Test
https://jurnal.unismuhpalu.ac.id/index.php/MPPKI/article/view/1027Test

المؤلفون: Islam, Muhammad Al Azhar, Usman, Usman

المصدر: SIYASATUNA : JURNAL ILMIAH MAHASISWA SIYASAH SYAR'IYYAH; Vol. 1 No. 1 (2020); 25-33 ; Siyasatuna: Jurnal Ilmiah Mahasiswa Siyasah Syar'iyyah; Vol 1 No 1 (2020); 25-33 ; 2716-0394

الوصف: Penipuan yang banyak ditemukan di tengah masyarakat bermacam-macam yaitu salah satunya hipnotis kepada korban. Hipnotis tersebut ialah salah satu pelaku yang menghilangkan pikiran alam bawa sadar atau biasa dikatakan sugersti korban upaya bisa mengikuti apa keinginan pelaku. Permasalahan dalam penelitian tersebut yaitu peran Kepolisian dalam memberantas tindak pidana penipuan berkedok hipnotis ialah, kepolisian sudah sangat memaksimalkan upaya apa yang sudah ditugaskan dengan mengatasi tindak pidana tersebut, Pembuktian pihak kepolisian dalam menghadapi tindak pidana penipuan dengan modus hipnotis ini adalah media CCTV ini salah satu pihak kepolisian untuk mudah menangkap dan memperjelas pelaku yang melakukan tindakan kejahatan tersebut. Dan juga pembuktian yang lebih kuat yaitu saksi. Dalam pandangan hukum islam penipuan ini masuk dalam kategori takzir , yaitu hukuman yang diberikan sesuia apa yang pelaku ambil. Penerapan hukum pidana yang efisien untuk menanggulangi penipuan yang berkedok hipnotis saat ini yaitu KUHP dan dibantu oleh penegak hukum yaitu polisi untuk mengurai hipnotis di kota Makassar.Kata kunci: kepolisian, hipnotis, penipuan, penerapan hukum.AbstractFraud is found in many diverse societies, one of which is hypnosis to victims. The hypnosis is one of the actors that removes the mind's nature, bring it conscious or commonly said to suggest victims of efforts can follow what the perpetrators want. The problem in this research is the role of the Police in combating criminal acts under the guise of hypnosis is, the police have greatly maximized what efforts have been assigned by overcoming these criminal acts, Proving the police in dealing with fraud with this hypnotic mode is this CCTV media one of the parties the police to easily catch and clarify the perpetrators who committed the crime. And also stronger evidence, namely witnesses. In the view of Islamic law, this fraud falls into the category of takzir, which is a punishment given according to what the perpetrators took. The ...

وصف الملف: application/pdf

العلاقة: https://journal.uin-alauddin.ac.id/index.php/siyasatuna/article/view/12200/pdfTest; https://journal.uin-alauddin.ac.id/index.php/siyasatuna/article/view/12200Test

الإتاحة: https://journal.uin-alauddin.ac.id/index.php/siyasatuna/article/view/12200Test

المؤلفون: Manguntungi, Baso, Asmawati, Rian Adha Ardinata Muhammad Al Azhar, Tegar Aprilian1, Kurniawan Eka Putra

المصدر: Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati; Vol 3, No 1 (2018): February 2018; 44−52 ; 2527-323X ; 2527-3221

مصطلحات موضوعية: kelapa sawit, mikroba endofit, Endonesia, biofertilizer

الوصف: Indonesia merupakan negara produsen kelapa sawit (Elaeis guineensis) dengan jumlah produksi mencapai 48% dari total volume produksi minyak sawit di dunia. Produksi minyak kelapa sawit Indonesia menunjukkan peningkatan yang stabil selama 20 tahun terakhir yaitu sebesar 11% setiap tahunnya. Proses pembibitan kelapa sawit menjadi faktor penentu dalam keberhasilan perkebunan kelapa sawit. Penggunaan pupuk kimia pada pembibitan kelapa sawit diketahui dapat menimbulkan banyak dampak negatif terhadap lingkungan dan kesehatan manusia. Guna mengatasi permasalahan tersebut, pemanfaatan teknologi mikroba endofit indigen sebagai agen aktif dalam biofertiizer perlu dilakukan. Mikroba endofit adalah mikroba yang hidup didalam jaringan tanaman dan memiliki kemampuan untuk mendorong pertumbuhan tanaman. Penelitian ini bertujuan mendapatkan strain mikroba endofit potensial sebagai agen bioaktif dalam biofertilizer dan pengaruhnya terhadap proses pembibitan kelapa sawit. Analisis data dilakukan dengan uji ANOVA menggunakan aplikasi SPSS 20 dengan taraf kepercayaan 95%. Hasil isolasi mikroba endofit dari akar tanaman kelapa sawit diperoleh 7 isolat jamur endofit dan 9 isolat bakteri endofit. Hasil penelitian menunjukan konsorsium bakteri 20%, konsorsium bakteri 10%, dan konsorsium jamur 10% berturut-turut memiliki pengaruh terhadap peningkatan tinggi tanaman, diameter batang, dan jumlah daun kelapa sawit dibandingkan dengan perlakuan lainnya

وصف الملف: application/pdf

العلاقة: https://ojs.uajy.ac.id/index.php/biota/article/view/1892/1260Test; https://ojs.uajy.ac.id/index.php/biota/article/view/1892Test

الإتاحة: https://doi.org/10.24002/biota.v3i1.1892Test
https://ojs.uajy.ac.id/index.php/biota/article/view/1892Test

المؤلفون: Ramadhan Karsono, Muhammad Al Azhar, Siti Nadliroh, Fahreza Saputra, Teguh Aryandono, Yulia Pratiwi

المصدر: Asian Pacific Journal of Cancer Prevention : APJCP

مصطلحات موضوعية: Adult, PD-L1, Oncology, medicine.medical_specialty, PD-L2, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Breast Neoplasms, Systemic therapy, B7-H1 Antigen, systemic therapy, breast cancer, Breast cancer, Internal medicine, PD-1, medicine, Humans, RNA, Messenger, Chemotherapy, biology, business.industry, Cancer, General Medicine, Immunotherapy, Middle Aged, Prognosis, Programmed Cell Death 1 Ligand 2 Protein, medicine.disease, Primary tumor, biology.protein, Hormonal therapy, Female, immunotherapy, business, Research Article

الوصف: Objective The association between PD-1, PD-L1, and PD-L2 expression and prognosis has been extensively studied in various cancers but remained controversial in breast cancer. Besides, little is known about the prognostic value of PD-1, PD-L1, and PD-L2 upregulation or downregulation following systemic therapy (chemotherapy and hormonal therapy) in breast cancer. Therefore, we aim to investigate the change of PD-1, PD-L1, and PD-L2 expression in mRNA level after primary systemic therapy in breast cancer patients and its clinical implications. Methods Expression of PD-1, PD-L1, and PD-L2 mRNA were measured before-after chemotherapy and hormonal therapy with real-time PCR in 80 advanced breast cancer patients. The correlation between alteration of PD-1, PD-L1, and PD-L2 expression and clinicopathological characteristics as well as overall survival was also statistically analyzed. Results Chemotherapy and hormonal therapy altered PD-1, PD-L1, and PD-L2 expression in breast cancer with most patients have an increase expression. As much as 57.1%, 62.9% and 60% patients have an increase PD-1, PD-L1, and PD-L2 expression after chemotherapy, while 60%, 60%, and 64% patients have an increase PD-1, PD-L1, and PD-L2 expression after hormonal therapy. Alteration of PD-1, PD-L1, and PD-L2 expression was not correlated with all clinicopathological characteristics. Increase in PD-1, PD-L1, and PD-L2 expression was significantly associated with better OS (p=0.031, p=0.019, and p=0.019 for PD-1, PD-L1, and PD-L2, respectively), which remained significant in multivariate analysis including age, stage, primary systemic therapy, histology grade, subtype and primary tumor histology (HR PD-1 0.5 (95% CI 0.28-0.88) p=0.031; HR PD-L1 0.43 (95% CI 0.24-0.8) p=0.019; HR PD-L2 (95% CI 0.24-0.87) p=0.019). Conclusion: Expression of PD-1, PD-L1, and PD-L2 in breast cancer patients is mostly enhanced after chemotherapy and hormonal therapy, and the enhancement is associated with good OS. This result revealed the potential of measuring PD-1, PD-L1, and PD-L2 mRNA expression in predicting clinical outcome.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9119c1ae7b363c5f6b60c1cd4dc6aedTest
https://doi.org/10.31557/apjcp.2021.22.7.2069Test

المؤلفون: Handoko Handoko, Cita Herawati, Demak Lumban Tobing, Siti Nadliroh, Karisma Prameswari, Muhammad Al Azhar

المصدر: MCBS (Molecular and Cellular Biomedical Sciences), Vol 4, Iss 3, Pp 121-7 (2020)

مصطلحات موضوعية: Oncology, medicine.medical_specialty, biology, business.industry, medicine.medical_treatment, General Engineering, Immunotherapy, medicine.disease, Peripheral blood, law.invention, Metastasis, lcsh:Biochemistry, Nasopharyngeal carcinoma, law, Internal medicine, PD-L1, biology.protein, lcsh:Pathology, Medicine, lcsh:QD415-436, Stage (cooking), business, Body mass index, Polymerase chain reaction, lcsh:RB1-214

الوصف: Background: Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) expression is associated with prognostic and respond to immunotherapy with immune checkpoint inhibitor in several solid malignancies. However, the prognostic roles of PD-1 and PD-L1 expression in nasopharyngeal carcinoma (NPC) are less clear. This study aims to investigate PD-1 and PD-L1 mRNA expression levels in peripheral blood of Indonesian NPC patients and its association with clinicopathological features. Materials and Methods: This study used blood samples of 21 NPC patients and 10 healthy volunteers as controls. Real-time polymerase chain reaction (PCR) was used to measure mRNA expression of PD-1 and PD-L1. Results: PD-1 mRNA expression levels were significantly lower in NPC patients (∆CT mean: 9.65±2.04) compared to healthy individuals (∆CT mean: 8.04±1.51) ( p =0.031). In contrast, PD-L1 mRNA expression levels were higher in NPC patients (∆CT mean: 6.96±1.32) compared to healthy individuals (∆CT mean: 7.11±0.55), but the difference was not statistically significant ( p =0.554). The expression of PD-1 was associated with tumour-node-metastasis (TNM) stage ( p =0.030) but not associated with age ( p =1.000), sex ( p =1.000), body mass index ( p =0.350), tumor stage ( p =0.338), nodal stage ( p =0.579), metastasis stage ( p =0.371), and Eastern Cooperative Oncology Group (ECOG) status ( p =0.228). Meanwhile PD-L1 expression was not associated with all clinicophatological features. Conclusion: The PD-1 mRNA expression levels were significantly lower, while PD-L1 expression levels were higher in NPC patients compared to healthy controls. PD-1 expression was correlated with TNM stage. Keywords: nasopharyngeal carcinoma, immune checkpoint inhibitors, PD-1, PD-L1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed31637e110800b868042b9376a9d389Test
https://cellbiopharm.com/ojs/index.php/MCBS/article/view/143Test

المؤلفون: Rini Andriani, Siti Nadliroh, Muhammad Al Azhar, Siswanto Agus Wilopo

المصدر: WFNOS 2022 Abstract Book.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f65e9e70f0cb8c0935fea953fe10843cTest
https://doi.org/10.14791/btrt.2022.10.f-2662Test