المؤلفون: Reni Philip, Lingam Vijaya, Shantha Balekudaru, Smita Panda, Mona Khurana, Rathini L David, Rashima Asokan, Ronnie George

المصدر: Indian Journal of Ophthalmology, Vol 72, Iss 3, Pp 432-438 (2024)

مصطلحات موضوعية: beta-blockers, glaucoma, hypertension, optical coherence tomography angiography, perfusion, Ophthalmology, RE1-994

الوصف: Purpose: The study aimed to assess the effect of hypertension, and use of systemic beta blockers (BB) and other antihypertensives on ocular perfusion by optical coherence tomography angiography (OCTA) in normal, suspect, and glaucomatous eyes. Methods: Cross-sectional study in tertiary eye care center. Prospectively recruited consenting subjects between 18 and 90 years with or without glaucoma. Measured the optic nerve peripapillary perfusion and flux and macular vessel density (MVD: 6 × 6 and 3 × 3 mm) in the superficial retinal layer using OCTA. Results: Included 200 eyes (112 patients). Compared to nonhypertensives or those on non-BB antihypertensives (NBB), hypertensives on BB had lower peripapillary perfusion (43.45,43.40, 42.05%, P = 0.003), and MVD (6 × 6 mm: 16.65, 16.70,15.75 mm/mm2, P = 0.002; 3 × 3 mm: 18.70, 18.50, 18.00 mm/mm2, P = 0.025). Those on systemic BB with vasodilatory properties had similar perfusion parameters as nonhypertensives and NBB. Those on systemic BB without vasodilating properties had significantly lower peripapillary perfusion (42.05 vs 43.30%, P = 0.011) and MVD (6 × 6 mm: 15.15 vs 16.60 mm/mm2, P < 0.001; 3 × 3 mm: 17.40 vs 18.70 mm/mm2, P = 0.005) compared to nonhypertensives. On multivariate analysis, peripapillary perfusion increased with increase in diastolic blood pressure (β:0.051, p: 0.04) and increasing age was the only factor found to be significantly associated with decreased peripapillary and macular perfusion parameters. Conclusion: Systemic BB users have worse ocular perfusion parameters compared to those on other medications or nonhypertensives on univariate analysis but similar perfusion on multivariate analysis. Those on BB with vasodilation have better ocular perfusion parameters. All BB cannot be considered equally detrimental to ocular perfusion. Further well-controlled prospective studies are needed to reassess the effects of BB with or without vasodilation on ocular perfusion.

وصف الملف: electronic resource

العلاقة: http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=3;spage=432;epage=438;aulast=PhilipTest; https://doaj.org/toc/0301-4738Test; https://doaj.org/toc/1998-3689Test

الوصول الحر: https://doaj.org/article/6c9b84497e424726b4176e14686f5b59Test

المؤلفون: Smita Panda, Mona Khurana, Lingam Vijaya, Ronnie George, Shantha Balekudaru

المصدر: Indian Journal of Ophthalmology, Vol 71, Iss 3, Pp 881-887 (2023)

مصطلحات موضوعية: ahmed glaucoma valve, conjunctival complications, conjunctival dehiscence, corneal patch graft, exposure, eye bank sclera, patch graft material, Ophthalmology, RE1-994

الوصف: Purpose: Comparison of the conjunctiva related complication rates and success rates among eyes with Ahmed glaucoma valve (AGV) implantation in which eye bank derived scleral and corneal patch grafts had been used to cover the tube. Methods: Retrospective comparative study. Patients who underwent AGV implantation between January 2000 to December 2016 were included. Demographic, clinical data, intra and post operative data was obtained from electronic medical records. Conjunctiva related complications were divided into two groups: with and without implant exposure. Conjunctiva related complication rates, success rate, risk factors among eyes with corneal and scleral patch graft were compared. Results: Three hundred and twenty three eyes of 316 patients underwent AGV implantation. Scleral patch graft was used in 214 eyes of 210 patients (65.9%) and corneal patch graft was used in 109 eyes of 107 patients (34%). Median follow up was 14 months. There was no significant difference in the conjunctiva related complication rate (7.3 % in corneal patch graft versus 7.0% in scleral patch graft;p=0.5) and conjunctival dehiscence rate (3.7% versus 4.6%, P = 0.7) among the two groups. Success rate was significantly higher in the corneal patch graft group versus the scleral patch graft group (98% versus 72%; p=0.001). Eyes with corneal patch graft had a higher survival rate (P = 0.01). Conclusion: There was no significant difference in the rate of conjunctiva related complications following corneal and scleral patch grafts used to cover the AGV tube. Eyes with corneal patch graft had a higher success rate and survival rate.

وصف الملف: electronic resource

العلاقة: http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=3;spage=881;epage=887;aulast=PandaTest; https://doaj.org/toc/0301-4738Test; https://doaj.org/toc/1998-3689Test

الوصول الحر: https://doaj.org/article/6545dc19f9d143a1ac0fbb657f357c73Test

المؤلفون: R Ramakrishnan, M Jayahar Bharathi, Devendra Maheshwari, P M T Mohideen, Mona Khurana, C Shivakumar

المصدر: Indian Journal of Ophthalmology, Vol 59, Iss 6, Pp 445-453 (2011)

مصطلحات موضوعية: Myopia, prethreshold retinopathy of prematurity, retinopathy of prematurity, Retinopathy of prematurity, screening, survey, Anthrax, community-acquired methicillin-resistant Staphyloccus aureus, orbital cellulitis, preseptal cellulitis, Intrastromal corneal ring segments, keraring, post-LASIK ectasia, Blebitis, bleb leak, microbiology, ocular surface diseases, risk factors, Ophthalmology, RE1-994

الوصف: Purpose : To evaluate the microbial etiology and associated risk factors among patients with blebitis following trabeculectomy. Materials and Methods : A retrospective analysis of all culture-proven blebitis was performed in patients who underwent trabeculectomy between January 2004 and December 2008. A standardized form was filled out for each patient, documenting sociodemographic features and information pertaining to risk factors. Swabbing of the infected bleb surface was performed for all suspected cases and further subjected to microbiological analysis. Results : A total of 23 patients with culture-proven blebitis were treated during the study period, with a mean age of 59.2 years (59.2 ± SD: 12.8; range, 30-81 years). Duration of onset was early (≤36 months) in six (26%) cases and late (> 36 months) in 17 (74%) cases with a range between 15 and 144 months (mean, 82.91 months; SD: 41.89). All 23 blebs were located superiorly and of which, 21 (91%) were microcystic avascular, 1 (4%) diffuse avascular, and 1 (4%) vascular flattened. The predominant risk factor identified was bleb leak (35%; 8 of 23) followed by thin bleb (22%; 5 of 23) and blepharitis (17%; 4 of 23). Bleb leaks (100%) were recorded only in patients with late onset (≥ 9 years) of infection (P< 0.001), while the incidence of ocular surface disease (100%) occurred early (≤3 years) (P< 0.001). Use of topical steroids was associated frequently with cases of thin blebs (80%; 4 of 5) (P< 0.001), while topical antibiotics showed bleb leaks (88%; 7 of 8) (P< 0.001). Coagulase-positive staphylococci were frequently recovered from blebitis with thin blebs (71%; 5 of 7) (P = 0.001), Coagulase-negative staphylococci (CoNS) with bleb leak (100%; 8 of 8) (P< 0.001), Corynebacterium with blepharitis (100%; 3 of 3) (P = 0.001), and Streptococci with releasable sutures (75%; 3 of 4) (P = 0.001). Conclusion : Bleb leak is the principal risk factor responsible for late-onset blebitis, while early-onset blebitis could be ascribed to ocular surface diseases. Streptococci were mainly responsible for early onset of infection, while the late onset was due to CoNS.

وصف الملف: electronic resource

العلاقة: http://www.ijo.in/article.asp?issn=0301-4738;year=2011;volume=59;issue=6;spage=445;epage=453;aulast=RamakrishnanTest; https://doaj.org/toc/0301-4738Test; https://doaj.org/toc/1998-3689Test

الوصول الحر: https://doaj.org/article/b0904c6a54d645d4b6ee75cc7eb5089eTest

المؤلفون: Neha Shrirao, Mona Khurana, Bipasha Mukherjee

المصدر: Indian Journal of Ophthalmology, Vol 64, Iss 6, Pp 459-459 (2016)

مصطلحات موضوعية: Antiglaucoma medication, fat atrophy, periorbitopathy, prostaglandin analogs, ptosis, Ophthalmology, RE1-994

وصف الملف: electronic resource

العلاقة: http://www.ijo.in/article.asp?issn=0301-4738;year=2016;volume=64;issue=6;spage=459;epage=459;aulast=ShriraoTest; https://doaj.org/toc/0301-4738Test; https://doaj.org/toc/1998-3689Test

الوصول الحر: https://doaj.org/article/135ed8a89b1c4dfb8ab6232daa7e5ea0Test

المؤلفون: Michael Zeisberg, Mona Khurana, Velidi H Rao, Dominic Cosgrove, Jean-Philippe Rougier, Michelle C Werner, Charles F Shield, Zena Werb, Raghu Kalluri

المصدر: PLoS Medicine, Vol 3, Iss 4, p e100 (2006)

مصطلحات موضوعية: Medicine

الوصف: Glomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans. Mutations or deletions involving alpha3(IV), alpha4(IV), or alpha5(IV) chains of type IV collagen in the GBM have been identified as the cause for Alport syndrome in humans, a progressive hereditary kidney disease associated with deafness. The pathological mechanisms by which such mutations lead to eventual kidney failure are not completely understood.We showed that increased susceptibility of defective human Alport GBM to proteolytic degradation is mediated by three different matrix metalloproteinases (MMPs)--MMP-2, MMP-3, and MMP-9--which influence the progression of renal dysfunction in alpha3(IV)-/- mice, a model for human Alport syndrome. Genetic ablation of either MMP-2 or MMP-9, or both MMP-2 and MMP-9, led to compensatory up-regulation of other MMPs in the kidney glomerulus. Pharmacological ablation of enzymatic activity associated with multiple GBM-degrading MMPs, before the onset of proteinuria or GBM structural defects in the alpha3(IV)-/- mice, led to significant attenuation in disease progression associated with delayed proteinuria and marked extension in survival. In contrast, inhibition of MMPs after induction of proteinuria led to acceleration of disease associated with extensive interstitial fibrosis and early death of alpha3(IV)-/- mice.These results suggest that preserving GBM/extracellular matrix integrity before the onset of proteinuria leads to significant disease protection, but if this window of opportunity is lost, MMP-inhibition at the later stages of Alport disease leads to accelerated glomerular and interstitial fibrosis. Our findings identify a crucial dual role for MMPs in the progression of Alport disease in alpha3(IV)-/- mice, with an early pathogenic function and a later protective action. Hence, we propose possible use of MMP-inhibitors as disease-preventive drugs for patients with Alport syndrome with identified genetic defects, before the onset of proteinuria.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC1391977?pdf=renderTest; https://doaj.org/toc/1549-1277Test; https://doaj.org/toc/1549-1676Test

الوصول الحر: https://doaj.org/article/e5e417156fb0458fab0fa3c51dd4f542Test

المؤلفون: Mona Khurana, Gunter F. Egger, Lynne Yao, Aliza Thompson, Chrissi Pallidis, Stuart L. Goldstein, Benjamin L. Laskin, Shamir Tuchman, Meaghan A. Malley, Katrin Uhlig

المصدر: Clinical Journal of the American Society of Nephrology.

مصطلحات موضوعية: Transplantation, Nephrology, Epidemiology, Critical Care and Intensive Care Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f7be821694b2d7b5c126ed84e14bcea4Test
https://doi.org/10.2215/cjn.0000000000000167Test

المؤلفون: Daniel Schaufelberger, Asha Rajapakshe, Stephen W. Hoag, Matthew Santangelo, Jing Liu, Ramesh Sood, Trupti Dixit, Steven Mount, Erica Radden, Karen C. Thompson, Mona Khurana, Shailly Mehrotra, Jian Wang, Biplob Mitra, Jamzad Shahla, Sandra Klein, John J. Alexander, Maren Kuhli, Robert Louis Ternik, Jennifer Walsh, Arzu Selen, Yuet Mei Khong, Elizabeth Galella, Stuart Charlton, David Cheng Thiam Tan, Elimika Pfuma Fletcher

المصدر: European Journal of Pharmaceutics and Biopharmaceutics. 164:54-65

مصطلحات موضوعية: Chemistry, Pharmaceutical, Center of excellence, education, Pharmaceutical Science, 02 engineering and technology, Pediatrics, 030226 pharmacology & pharmacy, Session (web analytics), Excipients, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Humans, Regulatory science, Child, Panel discussion, Medical education, General Medicine, 021001 nanoscience & nanotechnology, Pediatric drug, Framing (social sciences), Pharmaceutical Preparations, Drug product, 0210 nano-technology, Psychology, Regional differences, Tablets, Biotechnology

الوصف: A workshop on "Pediatric Formulation Development: Challenges of Today and Strategies for Tomorrow" was organized jointly by the University of Maryland's Center of Excellence in Regulatory Science and Innovation (M-CERSI), the U.S. Food and Drug Administration (FDA) and the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Drug Product Pediatric Working Group (PWG). This multi-disciplinary, pediatric focused workshop was held over a two-day period (18-19 Jun 2019) and consisted of participants from industry, regulatory agencies, academia and other organizations from both US and Europe. The workshop consisted of sequential sessions on formulation, analytical, clinical, and regulatory and industry lessons learned and future landscape. Each session began with a series of short framing presentations, followed by facilitated breakout sessions and panel discussion. The formulation session was dedicated to three main topics pertaining to drug product acceptability, excipients in pediatrics and oral administration device considerations. The analytical session discussed key considerations for dosing vehicle selection and analytical strategies for testing of different dosage forms, specifically mini-tablets (multiparticulates). The clinical session highlighted the influence of pediatric pharmacokinetics prediction on formulation design, pediatric drug development strategies and clinical considerations to support pediatric formulation design. The regulatory and industry lessons learned and future landscape session explored the regional differences that exist in regulatory expectations, requirements for pediatric formulation development, and key patient-centric factors to consider when developing novel pediatric formulations. This session also discussed potential collaboration opportunities and tools for pediatric formulation development. This manuscript summarizes the key discussions and outcomes of all the sessions in the workshop with a broadened review and discussion of the topics that were covered.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723020a59663ca6762cbc652a51b84e3Test
https://doi.org/10.1016/j.ejpb.2021.04.011Test

المؤلفون: Ashutosh Ganeshpuri Jaiswal, Nagalekshmi Ganesh, Lingam Vijaya, Ronnie George, Mona Khurana, Shantha Balekudaru

المصدر: Journal of Glaucoma. 31:41-47

مصطلحات موضوعية: Anterior lens, medicine.medical_specialty, Biometry, Anterior Chamber, Glaucoma, Eye care, Lens thickness, Ophthalmology, Lens, Crystalline, medicine, Humans, Intraocular Pressure, Shallow AC, Aged, Retrospective Studies, business.industry, Middle Aged, medicine.disease, eye diseases, Peripheral zone, Cross-Sectional Studies, medicine.anatomical_structure, Increased risk, Lens (anatomy), Female, sense organs, Glaucoma, Angle-Closure, business

الوصف: PRECIS Angle closure disease was present in 59.3% of eyes with long anterior zonules. The cause is multifactorial including a thick anteriorly positioned crystalline lens, shorter axial length and increased lens thickness to axial length factor. PURPOSE To study the profile of eyes with long anterior zonules (LAZ) presenting in a glaucoma clinic in a tertiary eye care centre and understand the pathogenesis of angle closure disease in these eyes. METHODS Retrospective cross sectional study.All patients with LAZ seen from January 2014-December 2018 were included. Demographic and clinical characteristics were noted. LAZ eyes (177 eyes of 177 patients) were compared with an equal number of age and gender matched controls. LAZ was defined as radially oriented zonular fibres (both pigmented and non pigmented), extending central to the normal zonular termination zone on the anterior lens surface more than 1▒mm beyond their usual insertion of 1.42±0.24▒mm from the lens equator onto the mid peripheral zone or central to it, as seen on slit lamp examination, following pupillary dilation by a single examiner. Glaucoma was defined according to the International Society for Geographical and Epidemiological Ophthalmology classification. The following biometric parameters were compared: anterior chamber depth (ACD), axial length (AXL), lens thickness (LT), lens position (LP=ACD+0.5*LT), relative lens position (RLP=LP/AXL); lens thickness to axial length factor (LAF=(LT/AXL)×10). LAZ eyes without angle closure disease were also compared with controls. RESULTS Mean age of patients with LAZ was 64.8±8.1 years. Of these, 63.3% were females. Angle closure disease was present in 59.3% (105 of 177) patients. Majority of these eyes were primary angle closure suspects (53.3%, n=56). Significant differences were found between LAZ eyes and controls for LT (4.8±0.38▒mm vs. 4.49±0.40▒mm P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13674772c39a34dac8fada8119782638Test
https://doi.org/10.1097/ijg.0000000000001898Test

المؤلفون: Mona Khurana, Smita Panda, Lingam Vijaya, Ronnie George, Shantha Balekudaru

المصدر: Indian Journal of Ophthalmology. 71:881

مصطلحات موضوعية: Ophthalmology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7f06f32c1f31ea14e45dcac6fe80586cTest
https://doi.org/10.4103/ijo.ijo_1846_22Test

المؤلفون: Mona Khurana, Pukhraj Rishi, Ekta Rishi, Gitanjli Sood

المصدر: Nepalese Journal of Ophthalmology. 12:323-327

مصطلحات موضوعية: medicine.medical_specialty, genetic structures, business.industry, Decompression, medicine.medical_treatment, General Medicine, medicine.disease, eye diseases, Vein occlusion, Topical medication, Edema, Ophthalmology, Vitreous hemorrhage, Medicine, Trabeculectomy, sense organs, medicine.symptom, business, Macular edema, Retinopathy

الوصف: Introduction: Decompression retinopathy (DR) can have varied manifestations as retinal and vitreous hemorrhage, disc edema, and macular edema. Vein occlusion associated with choroidal detachment (CD) has not been reported so far as a feature of DR. Case: We report a case of a 78 year old male with bilateral primary open angle glaucoma (POAG) on maximal topical medication with progressive field loss. Trabeculectomy with mitomycin C was done in the left eye, and the patient developed hypotony in the immediate postoperative period which was managed conservatively. After six weeks he developed CD, vein occlusion and macular edema. Thus, Anti VEGF was given and in other eye filtration surgery was done with all measures to avoid sudden hypotony. Patient still developed CD in the right eye. For which, he was given oral and topical steroids in tapering dose. After one month there was resolution of macular edema in the left eye and choroidal detachment resolved in both eyes and IOP was in lower teens in both eyes. Conclusion: Venous stasis retinopathy and choroidal detachment can be the manifestations of decompression retinopathy following glaucoma filtering surgery. The advancement in imaging modalities now can help us find the pathogenesis of the condition and validation of previous hypothesis proposed. Early identification and management of retinopathy helps in resolution with good visual recovery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d4e8a67fbf260b01f31bf535e3055a06Test
https://doi.org/10.3126/nepjoph.v12i2.29247Test