المؤلفون: Saxena, Rahul, Chakrapani, Baskar, Sarath Krishnan, M. P., Gupta, Amit, Gupta, Sweety, Das, Jayanta, Gupta, Subash C., Mirza, Anissa A., Rao, Shalinee, Goyal, Bela

المساهمون: All India Institute of Medical Sciences, Rishikesh, India

المصدر: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has improved our understanding of molecular pathways in cancer, sparking interest in microRNA-based gene regulation. The aim of the study is to identify dysregulated miRNAs in GBC and investigate their potential as therapeutic tools for effective and targeted treatment strategies. GBC and control tissue samples were sequenced for miRNA expression using the Illumina HiSeq platform. Biological processes and related pathways were determined using the Panther and Gene Ontology databases. 439 significantly differentially expressed miRNAs were identified; 19 of them were upregulated and 29 were downregulated. Key enriched biological processes included immune cell apoptosis, endoplasmic reticulum (ER) overload response, and negative regulation of the androgen receptor (AR) signaling pathway. Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. Kirsten rat sarcoma virus (KRAS), AR, and interferon gamma (IFN-γ) pathways were identified among the key pathways potentially amenable to targeted therapy. We concluded that a combination approach involving miRNA-based interventions could enhance therapeutic outcomes. Our research emphasizes the importance of precision medicine, targeting pathways using sense and anti-sense miRNAs as potential therapies in GBC.

الإتاحة: https://doi.org/10.1038/s41598-023-44767-3Test
https://www.nature.com/articles/s41598-023-44767-3.pdfTest
https://www.nature.com/articles/s41598-023-44767-3Test

المؤلفون: SHEKHAR, SHIVAM, GOYAL, NISHANT, MIRZA, ANISSA ATIF, AGRAWAL, SANJAY

المصدر: Saudi Journal of Anaesthesia; Jul-Sep2024, Vol. 18 Issue 3, p402-409, 8p

مصطلحات موضوعية: INTRAVENOUS therapy, INTRACRANIAL tumors, CRANIOTOMY, POSTOPERATIVE pain, LIDOCAINE, DEXMEDETOMIDINE

الشركة/الكيان: INTERNATIONAL Business Machines Corp.

مستخلص: Background: Goals of anesthesia in neurosurgery include stable cerebral hemodynamics and provide relaxed brain to surgeon. Dexmedetomidine and lignocaine as an adjuvant can fulfill these criteria but literature comparing the two are sparse. We compared the effects of intravenous infusion of dexmedetomidine or lignocaine on stress response, postoperative pain, and recovery in patients undergoing craniotomy for intracranial tumors. Methods: Approval was obtained from IEC, and the study was prospectively registered (CTRI/2022/11/047434). Written and informed consent was obtained from 105 patients fulfilling inclusion criteria, and they were divided into three groups. Group D Group L received intravenous infusion of lignocaine 2 mg/kg over 15 minutes followed by infusion at rate of 1.5 mg/kg/h, received intravenous infusion of dexmedetomidine 1 mcg/kg over 15 minutes followed by infusion at rate of 0.5 mcg/kg/h, and Group N received intravenous infusion of normal saline at the rate of 4-8 ml/h till skin suturing. SPSS v23 (IBM Corp.) was used for data analysis. Results: There was a significant difference between groups in terms of intraoperative hemodynamic variations, brain relaxation score, extubation criteria, postoperative pain, stress indicator response, and quality of recovery. Conclusions: Dexmedetomidine as an adjuvant to anesthetic drugs has a better profile than lignocaine in suppressing stress response and preventing hemodynamic variations at intubation, skull pin application, and surgical incision. Dexmedetomidine increases the duration of effective analgesia more than lignocaine, in postoperative period in patients undergoing craniotomy. [ABSTRACT FROM AUTHOR]

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المؤلفون: Mirza, Anissa Atif

المصدر: Understanding Insulin and Insulin Resistance ; page xi

الإتاحة: https://doi.org/10.1016/b978-0-12-820234-0.00018-4Test
https://api.elsevier.com/content/article/PII:B9780128202340000184?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:B9780128202340000184?httpAccept=text/plainTest

المؤلفون: Singh, Ajaypal, Kant, Ravi, Raina, Rohit, Dhingra, Vandana, Nema, Rajeev, Bairwa, Mukesh Chand, Kanwar, Varsha, Mukherjee, Rifika l Sukhes, Mirza, Anissa Atif, Agarwal, Mayank

المصدر: Indian Journal of Endocrinology and Metabolism ; volume 28, issue 1, page 35-42 ; ISSN 2230-8210 2230-9500

الوصف: Introduction: Gastrointestinal neuropathies are frequently found in diabetic patients. The pathogenesis of diabetic gastroparesis (DG) is multifactorial. The usual treatment for DG includes dietary modifications, prokinetic and antiemetic agents. There is increasing demand for more effective medicines to treat DG. The current study was conducted on the Pistacia lentiscus stem extract to add to the armamentarium of DG treatment and to find the efficacy of P. lentiscus plant extract (mastic gum) in comparison to levosulpiride in DG for improvement in gastroparesis symptoms and gastric emptying scintigraphy (GES) in a single centric double-blind non-inferiority randomised control trial. Methods: Thirty-eight individuals were recruited and equally randomised into two study groups based on Gastroparesis Cardinal Symptom Index (GCSI) score and TC 99 Radionuclide GES, mastic gum group and levosulpiride group. Both pre and post-intervention (8 weeks) GCSI scores were calculated, GES was performed to quantify the improvement in gastric emptying. Power analysis was performed using G*POWER software version 3.1.9.7 and data analysis using SPSS 23.0, variables measured in mean ± standard deviation (SD). Various statistical tests were used such as independent t-test, Chi-square test or Fisher’s exact test, Wilcox Mann–Whitney test, analysis of variance (ANOVA) test, and posthoc pairwise tests. Results: The mastic gum is found effective in the improvement of 4 h gastric emptying percentage from the mean (SD) 76.60 (± 9.96) to mean (SD) 97.20 (2.17)% ( P < 0.001). Mastic gum has the property of HbA1c reduction, which is more significant than that of levosulpiride ( P = 0.044). Mastic gum also had significant Low density lipoprotein (LDL) (mg/dL) levels reduction, ( P < 0.001), compared to levosupiride. An absolute increase was observed in haemoglobin (HB) level in mastic gum at a 2-month mean (SD) of 1.03 (0.77) (g/dL) ( P -value <0.001). Conclusions: To our knowledge, this is the first study to compare the ...

الإتاحة: https://doi.org/10.4103/ijem.ijem_84_23Test

المؤلفون: Usmani, Hina, Malik, Saloni, Arya, Anshu, Mahto, Pintu Kumar, Kant, Ravi, Dua, Ruchi, Sindhwani, Girish, Mirza, Anissa Atif, Panda, Prasanna Kumar

المصدر: Recent Advances in Anti-Infective Drug Discovery ; volume 19, issue 1, page 3-11 ; ISSN 2772-4344

مصطلحات موضوعية: Pharmacology (medical), Infectious Diseases, Drug Discovery

الوصف: Background: SARS-CoV-2 infection that led to the COVID-19 pandemic has changed human health and the economy globally. SARS-CoV-2 is a type of Coronaviruses that has caused pneumonia and its complications with many deaths over the past two years. The use of hydroxychloroquine and chloroquine, accepted as generally safe for patients with autoimmune diseases or malaria, was attempted in many trials for COVID-19 treatment. Nigella sativa (NS) (black caraway, also known as black cumin, Nigella or Kalonji) is an annual flowering plant of the Ranunculaceae family, chemically composed of the main constituent natural Thymoquinone (TQ) (30%-48%) in forms of thymohydroquinone, dithymoquinone (Nigellone) is a native to wider regions, including parts of eastern Europe, west Asia, North of Africa and east of Myanmar. In this review, we explored the Randomized Controlled Trial, Controlled Trial, and Systematic review studies that support Nigella sativa Thymoquinone-targeted SARS-CoV-2 targeting. Therefore, A literature search was performed for publications published on the electronic databases (PubMed, Embase, Scopus, CNKI, and Google Scholar) for Nigella sativa, black seeds, Kalonji, coronavirus, SARS-CoV-2 and COVID-19. This review aimed to find relevant evidence of Nigella sativa preferences as a natural feasible remedy with no side effects in COVID-19. Studies reported the benefits of NS as beneficial, another appropriate remedy for patients with COVID-19. However, all studies have shown limitations, such as limiting clinical symptom outcomes due to regulations imposed by isolation policies and lack of adequate funding. Therefore, the evidence suggests that the chemical contents of NS are a safe and possible treatment for COVID-19 patients that helps to improve COVID-19 infection in patients with no side effects. Conclusion: Nigella sativa seeds were one of the well-documented herbal products. Three reviewed randomized controlled trials reported that NS reduced COVID-19 risk and could improve immune function. It was also ...

الإتاحة: https://doi.org/10.2174/2772434418666230222140805Test
https://www.eurekaselect.com/213919/articleTest

المؤلفون: Ranjan, Satish Kumar, Mittal, Ankur, Mirza, Anissa Atif, Kumar, Sunil, Panwar, Vikas Kumar, Navriya, Shivcharan, Mandal, Arup Kumar, Mammen, Kim Jacob

المصدر: Current Urology ; volume 17, issue 1, page 36-40 ; ISSN 1661-7649

الوصف: Background Nephrolithiasis is a global health problem. The recurrence rate after the first stone clearance is approximately 50% at 5 years. Metabolic abnormalities are an important factor responsible for stone recurrence. Our prevalidated study aimed to evaluate metabolic abnormalities associated with first-time uncomplicated renal stone formers (FTURSF). Materials and methods In this prospective, exploratory, time-bound, descriptive study, 30 first-time renal stone formers were evaluated for metabolic abnormalities. High-risk stone formers were excluded from the study. Data were collected in a predefined proforma, transferred to an Excel sheet, and analyzed using the Statistical Package for Social Sciences 20 and Epi Info 7. Fisher exact test, Mann-Whitney U test, paired t test, and Pearson correlation coefficient were used for statistical analyses. Results The mean age of the participants was 35.57 ± 11.07 years, with a male-to-female ratio of 1.72. The most common abnormality was a 24-hour urine volume of <2.5 L in 73.33% of the participants. One or more metabolic abnormalities were detected in 76.67% of the participants. Other common metabolic abnormalities detected were hypocitraturia (60%), hypercalciuria (16.67%), hyperoxaluria (13.33%), and hyperuricosuria (3.33%). Parathyroid adenoma was detected in one participant (3.33%). Conclusions Our study documented significant metabolic abnormalities in FTURSF. Therefore, a simplified metabolic evaluation protocol should be adopted while evaluating FTURSF. Detection of an underlying metabolic abnormality would enable the early institution of preventive measures to reduce stone recurrence and related complications.

الإتاحة: https://doi.org/10.1097/cu9.0000000000000169Test

المؤلفون: Kaushal, Karanvir, Kaur, Hardeep, Sarma, Phulen, Bhattacharyya, Anusuya, Sharma, Dibya Jyoti, Prajapat, Manisha, Pathak, Mona, Kothari, Ashish, Kumar, Subodh, Rana, Satyavati, Kaur, Manpreet, Prakash, Ajay, Mirza, Anissa Atif, Panda, Prasan Kumar, Vivekanandan, S., Omar, Balram Ji, Medhi, Bikash, Naithani, Manisha

المساهمون: PGIMER

المصدر: Journal of Critical Care ; volume 67, page 172-181 ; ISSN 0883-9441

الإتاحة: https://doi.org/10.1016/j.jcrc.2021.09.023Test
https://api.elsevier.com/content/article/PII:S0883944121002185?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0883944121002185?httpAccept=text/plainTest

المؤلفون: Rathi, Himani, Burman, Vishakha, Datta, Sudip Kumar, Rana, Satya Vati, Mirza, Anissa Atif, Saha, Sarama, Kumar, Raman, Naithani, Manisha

المصدر: Indian Journal of Clinical Biochemistry ; volume 36, issue 1, page 3-22 ; ISSN 0970-1915 0974-0422

مصطلحات موضوعية: Clinical Biochemistry

الإتاحة: https://doi.org/10.1007/s12291-020-00953-yTest

المؤلفون: Malik, Saloni, Naithani, Manisha, Mirza, Anissa Atif, Darbari, Anshuman, Saxena, Rahul

المصدر: Heart and Mind ; volume 5, issue 3, page 65-72 ; ISSN 2468-6476

الوصف: More than 20 million human beings got infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suffered from coronavirus disease 2019 (COVID-19) disease in the current global pandemic. This disease flow showed a heterogeneous spectrum due to various personalized underlying causes and immunogenetics makeup of an individual. Substantial evidence suggests that the severity of pneumonia, acute respiratory distress syndrome, multi-organ failures, and deaths in COVID-19 is attributable to cytokine storm. Thus, in a cytokine storm, the dysregulated immune system is triggered by superantigen of SARS-CoV-2 to release various cytokines with high speed and increased blood circulation concentrations, leading to diverse clinical manifestations of massive multi-organ destruction and death due to exuberant hyperinflammation at a local and systemic level. SARS-CoV-2 can also significantly affect the cardiovascular system of the infected persons through a systemic outburst of the cytokine storm. SARS-CoV-2 infection accompanies many cardiovascular complications that include myocardial infarction, myocarditis, microangiopathy, venous thromboembolism, and a cytokine storm burden resulting in heart failure. This narrative review attempts to gather all recent evidence by Internet-based literature search with relevant keywords related to coronavirus disease with main objective and focus on possible mechanisms of pathophysiology of troponin elevation and cardiovascular complications, with its diagnosis and recent guidelines for its management.

الإتاحة: https://doi.org/10.4103/hm.hm_16_21Test

المؤلفون: Kapoor, Mayank, Dhar, Minakshi, Mirza, Anissa, Saxena, Vartika, Pathania, Monika

المصدر: Indian Heart Journal ; volume 73, issue 5, page 644-646 ; ISSN 0019-4832

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.ihj.2021.07.003Test
https://api.elsevier.com/content/article/PII:S0019483221001474?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0019483221001474?httpAccept=text/plainTest