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61دورية أكاديمية
المؤلفون: Martinez-Donato, G, Piniella, B, Aguilar, D, Olivera, S, Perez, A, Castanedo, Y, Alvarez-Lajonchere, L, Duenas-Carrera, S, Lee, JW, Burr, N, Gonzalez-Miro, M, Rehm, BHA
مصطلحات موضوعية: Immunology, Immunology not elsewhere classified
الوصف: Hepatitis C virus (HCV) infection is a major worldwide problem. Chronic hepatitis C is recognized as one of the major causes of cirrhosis, hepatocellular carcinoma, and liver failure. Although new, directly acting antiviral therapies are suggested to overcome the low efficacy and adverse effects observed for the current standard of treatment, an effective vaccine would be the only way to certainly eradicate HCV infection. Recently, polyhydroxybutyrate beads produced by engineered Escherichia coli showed efficacy as a vaccine delivery system. Here, an endotoxin-free E. coli strain (ClearColi) was engineered to produce polyhydroxybutyrate beads displaying the core antigen on their surface (Beads-Core) and their immunogenicity was evaluated in BALB/c mice. Immunization with Beads-Core induced gamma interferon (IFN-γ) secretion and a functional T cell immune response against the HCV Core protein. With the aim to target broad T and B cell determinants described for HCV, Beads-Core mixed with HCV E1, E2, and NS3 recombinant proteins was also evaluated in BALB/c mice. Remarkably, only three immunization with Beads-Core+CoE1E2NS3/Alum (a mixture of 0.1 μg Co.120, 16.7 μg E1.340, 16.7 μg E2.680, and 10 μg NS3 adjuvanted in aluminum hydroxide [Alum]) induced a potent antibody response against E1 and E2 and a broad IFN-γ secretion and T cell response against Core and all coadministered antigens. This immunological response mediated protective immunity to viremia as assessed in a viral surrogate challenge model. Overall, it was shown that engineered biopolyester beads displaying foreign antigens are immunogenic and might present a particulate delivery system suitable for vaccination against HCV. ; Full Text
العلاقة: Clinical and Vaccine Immunology; http://hdl.handle.net/10072/342770Test
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62صورة
المؤلفون: Llàcer-Camarasa, G, Sancho-Díaz, J.A. (Julio Alberto), Movilla-Martín, J. (Juancho), Mateu-Vicens, G, Sureda, A, Pagán-Galbarro, C, Miró, M, Ferriol, P
مصطلحات موضوعية: symbionts, chemical extraction, alkaloids, Sponges
العلاقة: http://hdl.handle.net/10508/16180Test; XXI Iberian Seminar on Marine Chemistry - VIII International Symposium on Marine Sciences (ISMS 2022). (06/07/2022 - 08/07/2022. Las Palmas de Gran Canaria). 2022. . En: , . 2022: -
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63دورية أكاديمية
المؤلفون: Abdel-Rehim, M, Pedersen-Bjergaard, S, Abdel-Rehim, A, Lucena, R, Moein, MM, Cardenas, S, Miro, M
المصدر: Journal of chromatography. A. 1616:460790
مصطلحات موضوعية: Naturvetenskap, Kemi, Analytisk kemi
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64مؤتمر
المؤلفون: González-Mariño, I., Arés, L., Montes, R., Rodil, Rosario, Cela, Rafael, López-García, Ester, Postigo, Cristina, López de Alda, Miren, Pocurull, Eva, Marcé, R., Bijlsma, Lubertus, Hernández, Félix, Picó, Yolanda, Andreu Pérez, V., Rico, A., Valcárcel, Yolanda, Miró, M., Etxebarria, N., Quintana, José
الوصف: Trabajo presentado en la 1ª Jornada sobre Contaminación por Pásticos, celebrada en Barcelona (España) del 27 al 28 de octubre de 2020. ; Estimating exposure to phthalate plasticizers is crucial to perform appropriate risk assessment and develop control measures. In this study, we analyze wastewater to estimate the exposure to six phthalates within thirteen Spanish cities. Composite daily samples were collected over four consecutive days in Spring 2018 at seventeen wastewater treatment plants serving ca. 6 million people. Concentrations of phthalate metabolites were converted into population-normalized loads and used to estimate (i) metabolite levels in urine, and (ii) values of daily exposure to the parent phthalates. Population-weighted means of the estimated concentrations in urine varied between 0.7 ng/mL and 520 ng/mL. Compared to human biomonitoring data, very high levels were obtained for monomethyl phthalate, metabolite of dimethyl phthalate. This fact, together with literature data pointing to other sources of this metabolite in sewage led to its exclusion for exposure assessment. As for the remaining metabolites, results obtained on a local scale revealed the butylated phthalates as the ones posing the highest concern, particularly for toddlers. On a national scale, including all the sampled sites, di-(2-ethylhexyl) phthalate accounted for the highest percentage of total risk, followed closely by diethyl phthalate and di-iso-butyl phthalate.
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65كتاب
المؤلفون: Miro, M., Jakschik, M., Krampe, M., Portela, M., Kuhlenkötter, B.
المصدر: Automation 2020 ; page 17-30
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66كتاب
المؤلفون: Miro, M., Kuhlenkötter, B., Schäfer, M., Wannöffel, M.
المصدر: Automation 2020 ; page 31-42
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67
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68مؤتمر
المؤلفون: Qiao, Jixin, Hou, Xiaolin, Miró, M., Cerdà, V., Roos, Per
المصدر: Qiao , J , Hou , X , Miró , M , Cerdà , V & Roos , P 2012 , High capacity lab-on-valve bead injection extraction chromatography for radip determinaiton of plutonium in human urine . in Abstracts . American Nuclear Society , 9th International Conference on methods and Application of radioanalytical Chemistry , Kailua-Kona, HI , United States , 25/03/2012 . < http://www.marcconference.orgTest/ >
وصف الملف: application/pdf
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69مؤتمر
المؤلفون: Metzger, W, Schwab, B, Schimmelpfennig, L, Aktas, C, Martinez Miro, M, Oberringer, M
المصدر: Deutscher Kongress für Orthopädie und Unfallchirurgie; 75. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 97. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 52. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20111025-20111028; Berlin; DOCPO14-639 /20111018/
مصطلحات موضوعية: ddc: 610
العلاقة: http://dx.doi.org/10.3205/11dkou613Test; http://nbn-resolving.de/urn:nbn:de:0183-11dkou6138Test; http://www.egms.de/en/meetings/dkou2011/11dkou613.shtmlTest
الإتاحة: https://doi.org/10.3205/11dkou613Test
http://nbn-resolving.de/urn:nbn:de:0183-11dkou6138Test
http://www.egms.de/en/meetings/dkou2011/11dkou613.shtmlTest -
70دورية أكاديمية
المؤلفون: Chammartin F., Lodi S., Logan R., Ryom L., Mocroft A., Kirk O., D'Arminio Monforte A., Reiss P., Phillips A., El-Sadr W., Hatleberg C. I., Pradier C., Bonnet F., Law M., De Wit S., Sabin C., Lundgren J. D., Bucher H. C., Calvo G., Dabis F., Morfeldt L., Weber R., Lind-Thomsen A., Salbol Brandt R., Hillebreght M., Zaheri S., Wit F. W. N. M., Scherrer A., Schoni-Affolter F., Rickenbach M., Tavelli A., Fanti I., Leleux O., Mourali J., Le Marec F., Boerg E., Thulin E., Sundstrom A., Bartsch G., Thompsen G., Necsoi C., Delforge M., Fontas E., Caissotti C., Dollet K., Mateu S., Torres F., Petoumenos K., Blance A., Huang R., Puhr R., Gronborg Laut K., Kristensen D., Kamara D. A., Smith C. J., Raben D., Matthews C., Bojesen A., Grevsen A. L., Powderly B., Shortman N., Moecklinghoff C., Reilly G., Smit C., Ross M., Fux C. A., Morlat P., Friis-Moller N., Kowalska J., Bohlius J., Bower M., Fatkenheuer G., Grulich A., Sjol A., Meidahl P., Iversen J. S., Hillebregt M., Prins J. M., Kuijpers T. W., Scherpbier H. J., Van Der Meer J. T. M., Godfried M. H., Van Der Poll T., Nellen F. J. B., Geerlings S. E., Van Vugt M., Pajkrt D., Bos J. C., Wiersinga W. J., Van Der Valk M., Goorhuis A., Hovius J. W., Van Eden J., Henderiks A., Van Hes A. M. H., Mutschelknauss M., Nobel H. E., Pijnappel F. J. J., Jurriaans S., Back N. K. T., Zaaijer H. L., Berkhout B., Cornelissen M. T. E., Schinkel C. J., Thomas X. V., Van Den Berge M., Stegeman A., Baas S., Hage De Looff L., Versteeg D., Pronk M. J. H., Ammerlaan H. S. M., de Munnik E. S., Jansz A. R., Tjhie J., Wegdam M. C. A., Deiman B., Scharnhorst V., Van Der Plas A., Weijsenfeld A. M., Van Der Ende M. E., de Vries-Sluijs T. E. M. S., van Gorp E. C. M., Schurink C. A. M., Nouwen J. L., Verbon A., Rijnders B. J. A., Bax H. I., Van Der Feltz M., Bassant N., Van Beek J. E. A., Vriesde M., Van Zonneveld L. M., De Oude-Lubbers A., Van Den Berg-Cameron H. J., Bruinsma-Broekman F. B., de Groot J., De Zeeuw-De Man M., Boucher C. A. B., Koopmans M. P. G., van Kampen J. J. A., Pas S. D., Driessen G. J. A., van Rossum A. M. C., Van Der Knaap L. C., Visser E., Branger J., Rijkeboer-Mes A., Duijf-Van De Ven C. J. H. M., Schippers E. F., van Nieuwkoop C., van IJperen J. M., Geilings J., van der Hut G., Franck P. F. H., Van Eeden A., Brokking W., Groot M., Elsenburg L. J. M., Damen M., Kwa I. S., Groeneveld P. H. P., Bouwhuis J. W., Van Den Berg J. F., Van Hulzen A. G. W., Van Der Bliek G. L., Bor P. C. J., Bloembergen P., Wolfhagen M. J. H. M., Ruijs G. J. H. M., Kroon F. P., De Boer M. G. J., Bauer M. P., Jolink H., Vollaard A. M., Dorama W., Van Holten N., Claas E. C. J., Wessels E., Den Hollander J. G., Pogany K., Roukens A., Kastelijns M., Smit J. V., Smit E., Struik-Kalkman D., Tearno C., Bezemer M., van Niekerk T., Pontesilli O., Lowe S. H., Oude Lashof A. M. L., Posthouwer D., Ackens R. P., Schippers J., Vergoossen R., Weijenberg-Maes B., van Loo I. H. M., Havenith T. R. A., Leyten E. M. S., Gelinck L. B. S., van Hartingsveld A., Meerkerk C., Wildenbeest G. S., Mutsaers J. A. E. M., Jansen C. L., Mulder J. W., Vrouenraets S. M. E., Lauw F. N., van Broekhuizen M. C., Paap H., Vlasblom D. J., Smits P. H. M., Weijer S., El Moussaoui R., Bosma A. S., van Vonderen M. G. A., van Houte D. P. F., Kampschreur L. M., Dijkstra K., Faber S., Weel J., Kootstra G. J., Delsing C. E., van der Burg-Van de Plas M., Heins H., Lucas E., Kortmann W., van Twillert G., Cohen Stuart J. W. T., Diederen B. M. W., van Truijen-Oud F. A., van der Reijden W. A., Jansen R., Brinkman K., van den Berk G. E. L., Blok W. L., Frissen P. H. J., Lettinga K. D., Schouten W. E. M., Veenstra J., Brouwer J. C., Geerders F. G., Hoeksema K., Kleene J. M., van der Meche B. I., Spelbrink M., Sulman H., Toonen A. J. M., Wijnands S., Kwa D., Witte E., Koopmans P. P., Keuter M., van der Ven A. J. A. M., ter Hofstede H. J. M., Dofferhoff A. S. M., van Crevel R., Albers M., Bosch M. E. W., Grintjes-Huisman K. J. T., Zomer J. B., Stelma F. F., Rahamat-Langendoen J., Burger D., Richter C., Gisolf H. E., Hassing J. R., ter Beest G., van Bentum P. H. M., Langebeek N., Tiemessen R., Swanink C. M. A., van Lelyveld S. F. L., Soetekouw R., Hulshoff N., van der Prijt L. M. M., van der Swaluw J., Bermon N., Herpers B. L., Veenendaal D., Verhagen W. D. M., van Wijk M., van Kasteren M. E. E., Brouwer E. A., de Kruijf-Van de Wiel B. A. F. M., Kuipers M., Santegoets R. M. W. J., van der Ven B., Marcelis H. J., Buiting A. G. M., Kabel J. P., Bierman W. F. W., Scholvinck H., Wilting R. K., Stienstra Y., de Groot-De Jonge H., van der Meulen A. P., de Weerd A. D., Ludwig-Roukema J., Niesters H. G. M., Riezebos-Brilman A., van Leer-Buter C. C., Knoester M., Hoepelman A. I. M., Mudrikova T., Ellerbroek M. P., Oosterheert J. J., Arends E. J., Barth E. R., Wassenberg M. W. M., Schadd M. E., van Elst-Laurijssen D. H. M., van Oers-Hazelzet B. E., Vervoort S., van Berkel M., Schuurman R., Verduyn-Lunel F., Wensing A. M. J., Peters E. J. G., van Agtmael A. M., Bomers M., de Vocht J., Heitmuller M., Laan M. L., Pettersson M. A., Vandenbroucke-Grauls C. M. J. E., Ang W. C., Geelen S. P. M., Wolfs T. F. W., Bont J. L., Nauta N., Bezemer O. D., van Sighem I. A., Boender S. T., de Jong A., Bergsma D., Hoekstra P., de Lang A., Grivell S., Jansen A., Rademaker J. M., Raethke M., Meijering R., Schnorr S., de Groot L., van den Akker M., Bakker Y., Claessen E., El Berkaoui A., Koops J., Kruijne E., Lodewijk C., Munjishvili L., Peeck B., Ree C., Regtop R., Ruijs Y., Rutkens T., van de Sande L., Schoorl M., Timmerman A., Tuijn E., Veenenberg L., van der Vliet S., Wisse A., Woudstra T., Tuk B., Dupon M., Gaborieau V., Lacoste D., Malvy D., Mercie P., Neau D., Pellegrin L. J., Tchamgoue S., Lazaro E., Cazanave C., Vandenhende M., Vareil O. M., Gerard Y., Blanco P., Bouchet S., Breilh D., Fleury H., Pellegrin I., Chene G., Thiebaut R., Wittkop L., Lawson-Ayayi S., Gimbert A., Desjardin S., Lacaze-Buzy L., Petrov-Sanchez V., Andre N., Bernard K., Caubet O., Caunegre L., Chossat I., Courtault C., Dauchy A. F., Dondia D., Duffau P., Dutronc H., Farbos S., Faure I., Ferrand H., Greib C., Hessamfar M., Imbert Y., Lataste P., Marie J., Mechain M., Monlun E., Ochoa A., Pistone T., Raymond I., Receveur C. M., Rispal P., Sorin L., Valette C., Viallard J. F., Wille H., Wirth G., Lafon M., Trimoulet P., Bellecave P., Tumiotto C., Haramburu F., Miremeont-Salame G., Blaizeau J. M., Decoin M., Hannapier C., Lenaud E., Pougetoux A., Delveaux S., D'Ivernois C., Diarra F., Uwamaliya-Nziyumvira B., Palmer G., Conte V., Sapparrart V., Moore R., Edwards S., Hoy J., Watson K., Roth N., Lau H., Bloch M., Baker D., Carr A., Cooper D., O'Sullivan M., Nolan D., Guelfi G., Domingo P., Sambeat A. M., Gatell J., Del Cacho E., Cadafalch J., Fuster M., Codina C., Sirera G., Vaque A., Clumeck N., Gennotte F. A., Gerard M., Kabeya K., Konopnicki D., Libois A., Martin C., Payen C. M., Semaille P., Van Laethem Y., Neaton J., El-Sadr M. W., Krum E., Thompson G., Wentworth D., Luskin-Hawk R., Telzak E., Abrams I. D., Cohn D., Markowitz N., Arduino R., Mushatt D., Friedland G., Perez G., Tedaldi E., Fisher E., Gordin F., Crane R. L., Sampson J., Baxter J., Gazzard B., Horban A., Karpov I., Pedersen C., Ristola M., Rockstroh J., Peters L., Fischer H. A., Larsen F. J., Podlekareva D., Cozzi-Lepri A., Shepherd L., Schultze A., Amele S., Losso M., Kundro M., Schmied B., Zangerle R., Vassilenko A., Mitsura M. V., Paduto D., Florence E., Vandekerckhove L., Hadziosmanovic V., Begovac J., Machala L., Jilich D., Sedlacek D., Kronborg G., Benfield T., Gerstoft J., Katzenstein T., Moller F. N., Ostergaard L., Wiese L., Nielsen N. L., Zilmer K., Smidt J., Aho I., Viard J. P., Girard P. M., Duvivier C., Schmidt R., Degen O., Stellbrink J. H., Stefan C., Bogner J., Chkhartishvili N., Gargalianos P., Xylomenos G., Armenis K., Sambatakou H., Szlavik J., Gottfredsson M., Mulcahy F., Yust I., Turner D., Burke M., Shahar E., Hassoun G., Elinav H., Haouzi M., Elbirt D., Sthoeger M. Z., Esposito R., Mazeu I., Mussini C., Mazzotta F., Gabbuti A., Vullo V., Lichtner M., Zaccarelli M., Antinori A., Acinapura R., Plazzi M., Lazzarin A., Castagna A., Gianotti N., Galli M., Ridolfo A., Rozentale B., Uzdaviniene V., Matulionyte R., Staub T., Hemmer R., Ormaasen V., Maeland A., Bruun J., Knysz B., Gasiorowski J., Inglot M., Bakowska E., Flisiak R., Grzeszczuk A., Parczewski M., Maciejewska K., Aksak-Was B., Beniowski M., Mularska E., Smiatacz T., Gensing M., Jablonowska E., Malolepsza E., Wojcik K., Mozer-Lisewska I., Caldeira L., Mansinho K., Maltez F., Radoi R., Oprea C., Panteleev A., Panteleev O., Yakovlev A., Trofimora T., Khromova I., Kuzovatova E., Borodulina E., Vdoushkina E., Jevtovic D., Tomazic J., Miro M. J., Moreno S., Rodriguez J. M., Clotet B., Jou A., Paredes R., Tural C., Puig J., Bravo I., Gutierrez M., Mateo G., Laporte M. J., Falconer K., Thalme A., Sonnerborg A., Blaxhult A., Flamholc L., Cavassini M., Calmy A., Furrer H., Battegay M., Schmid P., Kuznetsova A., Kyselyova G., Sluzhynska M., Johnson A. M., Simons E., Orkin C., Weber J., Scullard G., Clarke A., Leen C., Thulin G., Akerlund B., Koppel K., Karlsson A., Hakangard C., Castelli F., Cauda R., Di Perri G., Iardino R., Ippolito G., Marchetti C. G., Perno F. C., von Schloesser F., Viale P., Ceccherini-Silberstein F., Girardi E., Lo Caputo S., Puoti M., Andreoni M., Ammassari A., Balotta C., Bandera A., Bonfanti P., Bonora S., Borderi M., Calcagno A., Calza L., Capobianchi R. M., Cingolani A., Cinque P., De Luca A., Di Biagio A., Gori A., Guaraldi G., Lapadula G., Madeddu G., Maggiolo F., Marcotullio S., Monno L., Nozza S., Quiros Roldan E., Rossotti R., Rusconi S., Santoro M. M., Saracino A., Galli L., Lorenzini P., Rodano A., Shanyinde M., Carletti F., Carrara S., Di Caro A., Graziano S., Petrone F., Prota G., Quartu S., Truffa S., Giacometti A., Costantini A., Barocci V., Angarano G., Santoro C., Suardi C., Donati V., Verucchi G., Minardi C., Quirino T., Abeli C., Manconi E. P., Piano P., Cacopardo B., Celesia B., Vecchiet J., Falasca K., Pan A., Lorenzotti S., Sighinolfi L., Segala D., Vichi F., Cassola G., Viscoli C., Alessandrini A., Bobbio N., Mazzarello G., Mastroianni C., Belvisi V., Caramma I., Chiodera A., Milini P., Rizzardini G., Moioli C. M., Piolini R., Ridolfo L. A., Salpietro S., Tincati C., Puzzolante C., Abrescia N., Chirianni A., Borgia G., Orlando R., Bonadies G., Di Martino F., Gentile I., Maddaloni L., Cattelan M. A., Marinello S., Cascio A., Colomba C., Baldelli F., Schiaroli E., Parruti G., Sozio F., Magnani G., Ursitti A. M., Cristaudo A., Baldin G., Capozzi M., Cicalini S., Fontanelli Sulekova L., Iaiani G., Latini A., Mastrorosa I., Savinelli S., Vergori A., Cecchetto M., Viviani F., Bagella P., Rossetti B., Franco A., Fontana Del Vecchio R., Francisci D., Di Giuli C., Caramello P., Orofino C. G., Sciandra M., Bassetti M., Londero A., Pellizzer G., Manfrin V., Starnini G., Ialungo A., Dellamonica P., Bernard E., Courjon J., Cua E., De Salvador-Guillouet F., Durant J., Etienne C., Ferrando S., Mondain-Miton V., Naqvi A., Perbost I., Pillet S., Prouvost-Keller B., Pugliese P., Rio V., Risso K., Roger M. P., Aubert V., Bernasconi E., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Gunthard F. H., Haerry D., Hasse B., Hirsch H. H., Hoffmann M., Hosli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos D. R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Marzolini C., Metzner J. K., Muller N., Nicca D., Pantaleo G., Paioni P., Rauch A., Rudin C., Speck R., Stockle M., Tarr P., Trkola A., Vernazza P., Wandeler G., Yerly S.
المساهمون: Chammartin, F., Lodi, S., Logan, R., Ryom, L., Mocroft, A., Kirk, O., D'Arminio Monforte, A., Reiss, P., Phillips, A., El-Sadr, W., Hatleberg, C. I., Pradier, C., Bonnet, F., Law, M., De Wit, S., Sabin, C., Lundgren, J. D., Bucher, H. C., Calvo, G., Dabis, F., Morfeldt, L., Weber, R., Lind-Thomsen, A., Salbol Brandt, R., Hillebreght, M., Zaheri, S., Wit, F. W. N. M., Scherrer, A., Schoni-Affolter, F., Rickenbach, M., Tavelli, A., Fanti, I., Leleux, O., Mourali, J., Le Marec, F., Boerg, E., Thulin, E., Sundstrom, A., Bartsch, G., Thompsen, G., Necsoi, C., Delforge, M., Fontas, E., Caissotti, C., Dollet, K., Mateu, S., Torres, F., Petoumenos, K., Blance, A., Huang, R., Puhr, R., Gronborg Laut, K., Kristensen, D., Kamara, D. A., Smith, C. J., Raben, D., Matthews, C., Bojesen, A., Grevsen, A. L., Powderly, B., Shortman, N., Moecklinghoff, C., Reilly, G., Smit, C., Ross, M., Fux, C. A., Morlat, P., Friis-Moller, N., Kowalska, J., Bohlius, J., Bower, M., Fatkenheuer, G., Grulich, A., Sjol, A., Meidahl, P., Iversen, J. S., Hillebregt, M., Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., Van Der Meer, J. T. M., Godfried, M. H., Van Der Poll, T., Nellen, F. J. B., Geerlings, S. E., Van Vugt, M., Pajkrt, D., Bos, J. C., Wiersinga, W. J., Van Der Valk, M., Goorhuis, A., Hovius, J. W., Van Eden, J., Henderiks, A., Van Hes, A. M. H., Mutschelknauss, M., Nobel, H. E., Pijnappel, F. J. J., Jurriaans, S., Back, N. K. T.
مصطلحات موضوعية: Adult, Anti-HIV Agents, CD4 Lymphocyte Count, Female, HIV Infections, Humans, Incidence, Male, Middle Aged, Neoplasms, Prospective Studies, Risk Factors, Viral Load, Time-to-Treatment
الوصف: Background: Immediate initiation of antiretroviral therapy (ART) regardless of CD4 cell count reduces risk for AIDS and non-AIDS-related events in asymptomatic, HIV-positive persons and is the standard of care. However, most HIV-positive persons initiate ART when their CD4 count decreases below 500 × 109 cells/L. Consequences of delayed ART on risk for non-AIDS-defining and AIDS-defining cancer, one of the most common reasons for death in HIV, are unclear. Objective: To estimate the long-term risk difference for cancer with the immediate ART strategy. Design: Multinational prospective cohort study. Setting: The D:A:D (Data collection on Adverse events of anti-HIV Drugs) study, which included HIV-positive persons from Europe, Australia, and the United States. Participants: 8318 HIV-positive persons with at least 1 measurement each of CD4 cell count and viral load while ART-naive (study period, 2006 to 2016). Measurements: The parametric g-formula was used, with adjustment for baseline and time-dependent confounders (CD4 cell count and viral load), to assess the 10-year risk for non-AIDS-defining and AIDS-defining cancer of immediate versus deferred (at CD4 counts < 350 and < 500 × 109 cells/L) ART initiation strategies. Results: During 64 021 person-years of follow-up, 231 cases of non-AIDS-defining cancer and 272 of AIDS-defining cancer occurred among HIV-positive persons with a median age of 36 years (interquartile range, 29 to 43 years). With immediate ART, the 10-year risk for non-AIDS-defining cancer was 2.97% (95% CI, 2.37% to 3.50%) and that for AIDS-defining cancer was 2.50% (CI, 2.37% to 3.38%). Compared with immediate ART initiation, the 10-year absolute risk differences when deferring ART to CD4 counts less than 500 × 109 cells/L and less than 350 × 109 cells/L were 0.12 percentage point (CI, -0.01 to 0.26 percentage point) and 0.29 percentage point (CI, -0.03 to 0.73 percentage point), respectively, for non-AIDS-defining cancer and 0.32 percentage point (CI, 0.21 to 0.44 percentage point) and ...
وصف الملف: STAMPA
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33721519; info:eu-repo/semantics/altIdentifier/wos/WOS:000661788700016; volume:174; issue:6; firstpage:768; lastpage:776; numberofpages:9; journal:ANNALS OF INTERNAL MEDICINE; http://hdl.handle.net/11391/1523306Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85108303283
النص الكامل