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1دورية أكاديمية
المؤلفون: Gao, X.-F. (Xiao-Fei), Kan, J. (Jing), Zhang, Y. (Yaojun), Zhang, J.-J. (Jun-Jie), Tian, N.-L. (Nai-Liang), Ye, F. (Fei), Ge, Z. (Zhen), Xiao, P.-X. (Ping-Xi), Chen, F. (Feng), Mintz, G.S. (Gary), Chen, S.-L. (Shao-Liang)
المصدر: Patient Preference and Adherence vol. 8, pp. 1299-1309
مصطلحات موضوعية: Intravascular ultrasound, Major adverse cardiac events, Unprotected left main
الوصف: Background: The importance of intravascular ultrasound (IVUS)-guided stenting of the unprotected left main coronary artery (ULMCA) remains controversial and has not been fully studied in the subset of patients with ULMCA. This study evaluated the clinical outcome of IVUS-guided stenting using a drug-eluting stent for ULMCA.Methods: A total of 1,016 consecutive patients with ULMCA stenosis who underwent drug-eluting stent implantation from January 2006 to December 2011 were prospectively registered. The primary endpoint of this nonrandomized registry was the rate of one-year major adverse cardiac events (MACE, including cardiac death, myocardial infarction, and target vessel revascularization). Stent thrombosis served as the safety endpoint. Propensity score matching was used to calculate the adjusted event rate.Results: The unadjusted one-year MACE rate was 14.8% in the IVUS-guided group (n=337, 33.2%), significantly different from the 27.7% (P<0.001) in the angiography-guided group (n=679, 66.8%). After propensity score matching, 291 paired patients were matched between the two groups, and the difference in one-year MACE between IVUS-guided (16.2%) versus angiography-guided (24.4%) groups was still significant (P=0.014), mainly driven by decreased rates of cardiac death (1.7%) and target vessel revascularization (3.4%) in the IVUS-guided group when compared with 5.2% (P=0.023) and 10.0% (P=0.002) in the angiography-guided group, respectively. Although it did not reach significance (P=0.075), the adjusted one-year rate of stent thrombosis in the angiography-guided group was higher than in the IVUS-guided group.Conclusion: Compared with angiography guidance, IVUS-guided treatment of ULMCA using a drug-eluting stent was associated with a significant reduction of one-year cardiac death and target vessel revascularization, resulting in less frequent one-year MACE after propensity score matching.
وصف الملف: application/pdf
العلاقة: http://repub.eur.nl/pub/87572Test; urn:hdl:1765/87572
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2دورية أكاديمية
المؤلفون: Garcia-Garcia, H.M. (Hector), Garg, S.A. (Scot), Brugaletta, S. (Salvatore), Morocutti, G. (Giorgio), Ratner, R.E. (Robert), Kolatkar, N.S. (Nikheel), Kravitz, B.G. (Barbara), Miller, D.M. (Diane), Huang, C. (Chunmei), Nesto, R.W. (Richard), Serruys, P.W.J.C. (Patrick), Aftring, R.P. (R.), Wolstenholme, J. (Jane), Saarinen, J. (Jari), Fowler, R. (R.), Hoffman, J. (Jonathan), Steele-Norwood, D. (D.), Russell, R. (Robert), Young, S. (S.), Chou, Y.F., McMorn, S. (Steve), Kirsch, C. (Courtney), Louridas, B. (Bonnie), Olivieria, T. (Teresa), Mattioli, D. (Debra), Miller, D. (D.), Nguyen, C. (C.), Jahnke, K. (Kristoph), Mintz, G.S. (Gary), Lachin, J. (J.), Abrahamson, M. (M.), Carson, P. (P.), Jones, P. (Peter)
المصدر: International Journal of Cardiovascular Imaging vol. 28 no. 3, pp. 455-465
مصطلحات موضوعية: Atherosclerosis, IVUS, Restenosis, Type 2 diabetes
الوصف: To determine (1) the medium-term effect of rosiglitazone and glipizide on intra-stent neointima hyperplasia, (2) restenosis pattern as assessed by intravascular ultrasound (IVUS) and quantitative coronary angiography (QCA) in patients with T2DM and coronary artery disease. A total of 462 patients with T2DM were randomized to rosiglitazone or glipizide for up to 18 months in the APPROACH trial, and had evaluable baseline and follow-up IVUS examinations. There was no significant difference in the size of plaque behind stent between the rosiglitazone and glipizide groups at 18 months among those treated with a bare metal stent (-5.6 mm 3 vs. 1.9 mm 3; P = 0.61) or with a drug-eluting stent (12.1mm 3 vs. 5.5 mm 3; P = 0.09). Similarly, there was no significant difference in pe
وصف الملف: application/pdf
العلاقة: http://repub.eur.nl/pub/62843Test; urn:hdl:1765/62843
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3دورية أكاديمية
المؤلفون: Tearney, G.J. (Guillermo), Regar, E.S. (Eveline), Akasaka, T. (Takashi), Adriaenssens, S. (Stef), Barlis, P. (Peter), Bezerra, H.G. (Hiram), Bouma, B.E. (Brett), Bruining, N. (Nico), Cho, J.-M. (Jin-Man), Chowdhary, S. (Saqib), Costa, M.A. (Marco), Silva, R. (Ranil) de, Dijkstra, J. (Jouke), Mario, C. (Carlo) di, Dudeck, D. (Darius), Falk, E. (Erling), Feldman, M.D. (Marc), Fitzgerald, P.J. (Peter), Garcia-Garcia, H.M. (Hector), Gonzalo, N. (Nieves), Granada, J.F. (Juan), Guagliumi, G. (Giulio), Holm, N.R. (Niels), Honda, Y. (Yasuhiro), Ikeno, F. (Fumiaki), Kawasaki, Y., Kochman, W. (Waclav), Koltowski, L. (Lukasz), Kubo, T. (Takashi), Kume, T. (Teruyoshi), Kyono, H. (Hiroyuki), Lam, C.C.S. (Cheung Chi Simon), Lamouche, G. (Guy), Lee, D.P. (David), Leon, M.B. (Martin), Maehara, A. (Akiko), Manfrini, O. (Olivia), Mintz, G.S. (Gary), Mizuno, K. (Kyiouchi), Morel, M-A.M. (Marie-Angèle), Nadkarni, S. (Seemantini), Okura, H. (Hiroyuki), Otake, H. (Hiromasa), Pietrasik, A. (Arkadiusz), Prati, F. (Francesco), Rber, L. (Lorenz), Radu, M. (Maria), Rieber, N. (Nikolaus), Riga, M. (Maria), Rollins, S.M., Rosenberg, M. (Mireille), Sirbu, V. (Vasile), Serruys, P.W.J.C. (Patrick), Shimada, K., Shinke, T. (Toshiro), Shite, J. (Junya), Siegel, E. (Eliot), Sonada, S. (Shinjo), Suter, U. (Ueli), Takarada, S. (Shigeho), Tanaka, A. (Atsushi), Terashima, M. (Mitsuyasu), Troels, T. (Thim), Uemura, M. (Mayu), Ughi, G.J. (Giovanni), Beusekom, H.M.M. (Heleen) van, Steen, A.F.W. (Ton) van der, Es, G.A. (Gerrit Anne) van, Soest, G. (Gijs) van, Virmani, R. (Renu), Waxman, S. (Sergio), Weissman, N.J. (Neil), Weisz, G. (Giora)
المصدر: Journal of the American College of Cardiology vol. 59 no. 12, pp. 1058-1072
مصطلحات موضوعية: atherosclerosis, consensus document, coronary artery, intravascular ultrasound, optical coherence tomography
الوصف: Objectives: The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease. Background: Intravascular optical coherence tomography (IVOCT) is a catheter-based modality that acquires images at a resolution of ∼10 μm, enabling visualization of blood vessel wall microstructure in vivo at an unprecedented level of detail. IVOCT devices are now commercially available worldwide, there is an active user base, and the interest in using this technology is growing. Incorporation of IVOCT in research and daily clinical practice can be facilitated by the development of uniform terminology and consensus-based standards on use of the technology, interpretation of the images, and reporting of IVOCT results. Methods: The IWG-IVOCT, comprising more than 260 academic and industry members from Asia, Europe, and the United States, formed in 2008 and convened on the topic of IVOCT standardization through a series of 9 national and international meetings. Results: Knowledge and recommendations from this group on key areas within the IVOCT field were assembled to generate this consensus document, authored by the Writing Committee, composed of academicians who have participated in meetings and/or writing of the text. Conclusions: This document may be broadly used as a standard reference regarding the current state of the IVOCT imaging modality, intended for researchers and clinicians who use IVOCT and analyze IVOCT data.
وصف الملف: application/pdf
العلاقة: http://repub.eur.nl/pub/64850Test; urn:hdl:1765/64850
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4دورية أكاديمية
المؤلفون: Ruiz-García, J. (Juan), Lerman, A. (Amir), Weisz, G. (Giora), Maehara, A. (Akiko), Mintz, G.S. (Gary), Fahy, M. (Martin), Xu, K. (Kai), Lansky, A.J. (Alexandra), Cristea, E. (Ecaterina), Farah, T.G. (Tony), Teles, R.C. (Rui), Bøtker, H.E. (Hans), Templin, B. (Barry), Zhang, Z. (Zhen), Bruyne, B. (Bernard) de, Serruys, P.W.J.C. (Patrick), Stone, G.W. (Gregg)
المصدر: EuroIntervention vol. 8 no. 8, pp. 929-938
مصطلحات موضوعية: Acute coronary syndrome, Elderly, Fibroatheroma, Necrotic core, Plaque burden, Women
الوصف: Aims: Atherosclerosis accelerates with increasing age; however, young women presenting with acute coronary syndromes (ACS) have adverse outcomes compared to men despite less obstructive coronary artery disease. We sought to evaluate the in vivo plaque characteristics and composition of untreated non-culprit lesions (NCL) at two ages (<65 years old and ≥65 years old) in patients with ACS and examine the effect of sex in both groups. Methods and results: Untreated NCLs from 697 patients with ACS were imaged with greyscale and radiofrequency intravascular ultrasound. NCL plaque morphology, burden, composition, and major adverse cardiac events (MACE) were analysed in both age groups, and a posterior sex-based sub-analysis was performed. Plaques from patients ≥65 (n=974) vs. <65 (n=2,275) years old were longer (median 12.62 mm vs. 10.75 mm, p=0.008) and had greater plaque burden (48.2% vs. 47.5%, p=0.001), necrotic core (12.5% vs. 11.0%, p=0.001) and dense calcium (5.7% vs. 4.0%, p<0.0001). Men <65 years old also had a greater number of fibroatheromas (3.0 vs. 2.0, p=0.007) and NCLs per patient (5.0 vs. 4.0, p=0.004) with larger plaque volumes (47.7% vs. 46.8%, p=0.04), and fewer fibrotic plaques (2.2% vs. 4.4%, p=0.03) than women in the same age group. These sex differences were not observed in patients ≥65 years old. The incidence of MACE during median 3.4 year follow-up did not significantly differ according to age in this study. Conclusions: The current study confirms in vivo that, with aging, plaque burden, necrotic core and calcium content increase significantly. Moreover, gender-specific differences in the extent and composition of coronary plaque are present in patients <65 years (but not ≥65 years) of age, which suggest differential sex-related effects on atherosclerosis development and progression.
العلاقة: http://repub.eur.nl/pub/74817Test; urn:hdl:1765/74817
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5دورية أكاديمية
المؤلفون: Maehara, A. (Akiko), Cristea, E. (Ecaterina), Mintz, G.S. (Gary), Lansky, A.J. (Alexandra), Dressler, O. (Ovidiu), Biro, S. (Sinan), Templin, B. (Barry), Virmani, R. (Renu), Bruyne, B. (Bernard) de, Serruys, P.W.J.C. (Patrick), Stone, G.W. (Gregg)
المصدر: JACC: Cardiovascular Imaging vol. 5 no. 3 SUPPL.
مصطلحات موضوعية: acute coronary syndromes, coronary angiography, intravascular ultrasound
الوصف: Objectives: In a prospective study of the natural history of coronary atherosclerosis using angiography and grayscale and radiof
وصف الملف: application/pdf
العلاقة: http://repub.eur.nl/pub/73101Test; urn:hdl:1765/73101
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6دورية أكاديمية
المؤلفون: Mintz, G.S. (Gary), Garcia-Garcia, H.M. (Hector), Nicholls, S.J. (Stephen), Weissman, N.J. (Neil), Bruining, N. (Nico), Crowe, S. (Suzanne), Tardif, J.-C. (Jean-Claude), Serruys, P.W.J.C. (Patrick)
المصدر: EuroIntervention vol. 6 no. 9, pp. 1123-1130
الوصف: Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality despite the widespread use of established medical therapies. This has prompted the search to identify new therapeutic approaches to achieve more effective prevention of cardiovascular events. Considerable interest has focused on the role of surrogate markers of therapeutic efficacy in the early evaluation of novel anti-atherosclerotic therapies. Monitoring changes in the extent of coronary atherosclerosis with intravascular ultrasound (IVUS) has been increasingly employed in clinical trials to assess progression and regression of atherosclerosis. This is based on the pivotal role that atherosclerotic plaque plays in the natural history of cardiovascular disease and the acceptance of validated arterial imaging approaches including coronary angiography and carotid intimal-medial thickness by regulatory authorities. The ability to generate high-resolution imaging of the entire thickness of the cor
العلاقة: http://repub.eur.nl/pub/61674Test; urn:hdl:1765/61674
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7دورية أكاديمية
المؤلفون: Waksman, R. (Ron), White, L.R. (Larry), Chan, R.C., Bass, B.G. (Bill), Leon, M.B. (Martin), Geirlach, L., Mintz, G.S. (Gary), Satler, L.F., Pichard, A.D., Mehran, R. (Roxana), Kent, K.M. (Kenneth), Lansky, A.J. (Alexandra), Bhargava, B., Serruys, P.W.J.C. (Patrick), Fitzgerald, P.J. (Peter)
المصدر: Circulation (Baltimore) vol. 101 no. 18, pp. 2165-2171
مصطلحات موضوعية: Stents, Aged, Angioplasty, Balloon, Coronary Disease/physiopathology/*radiotherapy/surgery, Double-Blind Method, Female, Gamma Rays/*therapeutic use, Humans, Male, Middle aged, Recurrence, Research Support, Non-U.S. Gov't, Treatment Outcome
الوصف: BACKGROUND: Treatment of in-stent restenosis presents a critical limitation of intracoronary stent implantation. Ionizing radiation has been shown to decrease neointimal formation within stents in animal models and in initial clinical trials. We studied the effects of intracoronary gamma-radiation therapy versus placebo on the clinical and angiographic outcomes of patients with in-stent restenosis. METHODS AND RESULTS: One hundred thirty patients with in-stent restenosis underwent successful coronary intervention and were then blindly randomized to receive either intracoronary gamma-radiation with (192)Ir (15 Gy) or placebo. Four independent core laboratories blinded to the treatment protocol analyzed the angiographic and intravascular ultrasound end points of restenosis. Procedural success and in-hospital and 30-day complications were similar among the groups. At 6 months, patients assigned to radiation therapy required less target lesion revascularization and target vessel revascularization (9 [13.8%] and 17 [26.2%], respectively) compared with patients assigned to placebo (41 [63.1%, P=0.0001] and 44 [67.7%, P=0.0001], respectively). Binary angiographic restenosis was lower in the irradiated group (19% versus 58% for placebo, P=0.001). Freedom from major cardiac events was lower in the radiation group (29.2% versus 67.7% for placebo, P<0.001). CONCLUSIONS: Intracoronary gamma-radiation used as adjunct therapy for patients with in-stent restenosis significantly reduces both angiographic and clinical restenosis.
وصف الملف: application/pdf
العلاقة: http://repub.eur.nl/pub/9362Test; urn:hdl:1765/9362
الإتاحة: http://repub.eur.nl/pub/9362Test
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8دورية أكاديمية
المؤلفون: Birgelen, C. (Clemens) von, Mintz, G.S. (Gary), Vrey, E.A. (Evelyn) de, Kimura, T. (Takeshi), Nobuyoshi, M. (Masakiyo), Serruys, P.W.J.C. (Patrick)
المصدر: Heart
مصطلحات موضوعية: Ultrasonography, Interventional, Adult, Aged, Angioplast Transluminal, Percutaneous Coronary/methods, Arteriosclerosis/pathology/therapy/*ultrasonography, Atherectomy, Coronary/methods, Female, Humans, Male, Middle Aged, Research Support, Non-U.S. Gov't
الوصف: AIMS: To classify atherosclerotic coronary lesions on the basis of adequate or inadequate compensatory vascular enlargement, and to examine changes in lumen, plaque, and vessel volumes during balloon optimised directional coronary atherectomy procedures in relation to the state of adaptive remodelling before the intervention. DESIGN: 29 lesion segments in 29 patients were examined with intravascular ultrasound before and after successful balloon optimised directional coronary atherectomy procedures, and a validated volumetric intravascular ultrasound analysis was performed off-line to assess the atherosclerotic lesion remodelling and changes in plaque and vessel volumes that occurred during the intervention. Based on the intravascular ultrasound data, lesions were classified according to whether there was inadequate (group I) or adequate (group II) compensatory enlargement. RESULTS: There was no significant difference in patient and lesion characteristics between groups I and II (n = 10 and 19), including lesion length and details of the intervention. Quantitative coronary angiographic data were similar for both groups. However, plaque and vessel volumes were significantly smaller in group I than in II. In group I, 9 (4)% (mean (SD)) of the plaque volume was ablated, while in group II 16 (11)% was ablated (p = 0.01). This difference was reflected in a lower lumen volume gain in group I than in group II (46 (18) mm(3) v 80 (49) mm(3) (p < 0.02)). CONCLUSIONS: Preintervention lesion remodelling has an impact on the operative mechanisms of balloon optimised directional coronary atherectomy procedures. Plaque ablation was found to be particularly low in lesions with inadequate compensatory vascular enlargement.
وصف الملف: application/pdf
العلاقة: http://repub.eur.nl/pub/8320Test; urn:hdl:1765/8320
الإتاحة: http://repub.eur.nl/pub/8320Test
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9دورية أكاديمية
المؤلفون: Birgelen, C. (Clemens) von, Mintz, G.S. (Gary), Vrey, E.A. (Evelyn) de, Kimura, T. (Takeshi), Popma, J.J. (Jeffrey), Airiian, S.G. (Segei), Leon, M.B. (Martin), Serruys, P.W.J.C. (Patrick), Feyter, P.J. (Pim) de, Nobuyoshi, M. (Masakiyo)
المصدر: Heart vol. 79 no. 2, pp. 137-142
مصطلحات موضوعية: Image Processing, Computer-Assisted, Ultrasonography, Interventional, Coronary Angiography, Coronary Artery Disease/radiography/*ultrasonography, Coronary Vessels/ultrasonography, Female, Humans, Male, Middle Aged
الوصف: OBJECTIVE: To compare vessel, lumen, and plaque volumes in atherosclerotic coronary lesions with inadequate compensatory enlargement versus lesions with adequate compensatory enlargement. DESIGN: 35 angiographically significant coronary lesions were examined by intravascular ultrasound (IVUS) during motorised transducer pullback. Segments 20 mm in length were analysed using a validated automated three dimensional analysis system. IVUS was used to classify lesi
وصف الملف: application/pdf
العلاقة: http://repub.eur.nl/pub/4961Test; urn:hdl:1765/4961
الإتاحة: http://repub.eur.nl/pub/4961Test
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10دورية أكاديمية
المؤلفون: Birgelen, C. (Clemens) von, Vrey, E.A. (Evelyn) de, Mintz, G.S. (Gary), Nicosia, A., Bruining, N. (Nico), Li, W. (Wenguang), Serruys, P.W.J.C. (Patrick), Feyter, P.J. (Pim) de, Roelandt, J.R.T.C. (Jos), Slager, C.J. (Cornelis)
المصدر: Circulation (Baltimore) vol. 96 no. 9, pp. 2944-2952
مصطلحات موضوعية: coronary disease, imaging, ultrasonics
الوصف: Background Automated systems for the quantitative analysis of three-dimensional (3D) sets of intravascular ultrasound (IVUS) images have been developed to reduce the time required to perform volumetric analyses; however, 3D image reconstruction by these nongated systems is frequently hampered by cyclic artifacts. Methods and Results We used an ECG-gated 3D IVUS image acquisition workstation and a dedicated pullback device in atherosclerotic coronary segments of 30 patients to evaluate (1) the feasibility of this approach of image acquisition, (2) the reproducibility of an automated contour detection algorithm in measuring lumen, external elastic membrane, and plaque+media cross-sectional areas (CSAs) and volumes and the cross-sectional and volumetric plaque+media burden, and (3) the agreement between the automated area measurements and the results of manual tracing. The gated image acquisition took 3.9±1.5 minutes. The length of the segments analyzed was 9.6 to 40.0 mm, with 2.3±1.5 side branches per segment. The minimum lumen CSA measured 6.4±1.7 mm2, and the maximum and average CSA plaque+media burden measured 60.5±10.2% and 46.5±9.9%, respectively. The automated contour-detection required 34.3±7.3 minutes per segment. The differences between these measurements and manual tracing did not exceed 1.6% (SD<6.8%). Intraobserver and interobserver differences in area measurements (n=3421; r=.97 to.99) were <1.6% (SD<7.2%); intraobserver and interobserver differences in volumetric measurements (n=30; r=.99) were <0.4% (SD<3.2%). Conclusions ECG-gated acquisition of 3D IVUS image sets is feasible and permits the application of automated contour detection to provide reproducible measurements of the lumen and atherosclerotic plaque CSA and volume in a relatively short analysis time.
وصف الملف: application/pdf
العلاقة: http://repub.eur.nl/pub/4975Test; urn:hdl:1765/4975
الإتاحة: http://repub.eur.nl/pub/4975Test
