المؤلفون: Park, Se‐Ra, Min, Eun‐kyung, Kim, Soo‐Rim, Kim, Suk‐Kyung, Na, Kun‐Hee, Park, Chan Hum, Jung, YunJae, Oh, Byung‐Chul, Hong, In‐Sun

المساهمون: National Research Foundation of Korea

المصدر: Advanced Science ; ISSN 2198-3844 2198-3844

الوصف: Adapted immune cells are known to develop memory functions that increase resistance to subsequent infections after initial pathogen exposure, however, it is unclear whether non‐immune cells, like tissue‐resident stem cells, have similar memory functions. Here, it is found that tissue‐resident stem cells crucial for tissue regeneration show diminished adverse effects on diverse stem cell functions against successive exposure to foreign antigen (β‐glucan) to maintain tissue homeostasis and stability both in vitro and in vivo. These data suggest that endometrial stem cells may possess a robust memory function, in contrast, fully differentiated cells like fibroblasts and vesicular cells do not show these memory mechanisms upon consecutive antigen exposure. Moreover, the pivotal role of Angiopoietin‐like 4 (ANGPTL4) in regulating the memory functions of endometrial stem cells is identified through specific shRNA knockdown in vitro and knockout mice in vivo experiments. ANGPTL4 is associated with the alteration of diverse stem cell functions and epigenetic modifications, notably through histone H3 methylation changes and two pathways (i.e., PI3K/Akt and FAK/ERK1/2 signaling) upon consecutive antigen exposure. These findings imply the existence of inherent self‐defense mechanisms through which local stem cells can adapt and protect themselves from recurrent antigenic challenges, ultimately mitigating adverse consequences.

الإتاحة: https://doi.org/10.1002/advs.202307545Test

المؤلفون: Park, Se-Ra, Kim, Soo-Rim, Min, Eun-Kyung, Oh, Byung-Chul, Jung, YunJae, Kim, Yong Ho, Lee, Hwa-Yong

المساهمون: National Research Foundation of Korea, Research Grant from Kangwon National University

المصدر: Cell Communication and Signaling ; volume 21, issue 1 ; ISSN 1478-811X

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الوصف: Background Although acetylsalicylic acid has been widely used for decades to treat and prevent various diseases, its potential effects on endometrial receptivity and subsequent pregnancy rates are still controversial due to conflicting data: many reports have shown positive effects of acetylsalicylic acid, whereas others have found that it has no effect. Furthermore, the direct effects of acetylsalicylic acid on various functions of normal endometrial cells, especially endometrial stem cells, and their underlying molecular mechanisms have not yet been proven. Recently, studies have revealed that a reduced number of active stem/progenitor cells within endometrial tissue limits cyclic endometrial regeneration and subsequently decreases pregnancy success rates, suggesting that endometrial stem cells play a critical role in endometrial regeneration and subsequent endometrial receptivity. Methods We assessed whether aspirin treatment can inhibit various endometrial stem cell functions related to regenerative capacity, such as self-renewal, migration, pluripotency/stemness, and differentiation capacity, in vitro . Next, we evaluated whether SERPINB2 regulates the effects of aspirin on endometrial stem cell functions by depleting SERPINB2 expression with specific shRNA targeting SERPINB2. To further investigate whether aspirin also inhibits various endometrial stem cell functions in vivo, aspirin was administered daily to mice through intraperitoneal (i.p.) injection for 7 days. Results In addition to its previously identified roles, to the best of our knowledge, we found for the first time that acetylsalicylic acid directly inhibits various human endometrial stem cell functions related to regenerative capacity (i.e., self-renewal, migration, differentiation, and capacity) through its novel target gene SERPINB2 in vitro. Acetylsalicylic acid exerts its function by suppressing well-known prosurvival pathways, such as Akt and/or ERK1/2 signaling, through a SERPINB2 signaling cascade. Moreover, we also found that ...

الإتاحة: https://doi.org/10.1186/s12964-023-01339-2Test

المؤلفون: Min, Eun-kyung, Kim, Soo-Rim, Lee, Choon-Mi, Na, Kun-Hee, Park, Chan Hum, Oh, Byung-Chul, Jung, YunJae, Hong, In-Sun

المساهمون: National Research Foundation of Korea

المصدر: Molecular Therapy ; ISSN 1525-0016

مصطلحات موضوعية: Drug Discovery, Pharmacology, Genetics, Molecular Biology, Molecular Medicine

الإتاحة: https://doi.org/10.1016/j.ymthe.2024.04.006Test
https://api.elsevier.com/content/article/PII:S1525001624002223?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1525001624002223?httpAccept=text/plainTest

المؤلفون: Min, Eun Kyung

المصدر: Milton Quarterly ; volume 57, issue 4, page 189-190 ; ISSN 0026-4326 1094-348X

الإتاحة: https://doi.org/10.1111/milt.12470Test

المؤلفون: Min, Eun Kyung, Lee, Hye-Soo

المصدر: Robinson Crusoe in Asia ; Asia-Pacific and Literature in English ; page 221-238 ; ISSN 2524-7638 2524-7646 ; ISBN 9789811640506 9789811640513

الإتاحة: https://doi.org/10.1007/978-981-16-4051-3_11Test

المؤلفون: MIN, EUN KYUNG

المصدر: ELH, 2010 Apr 01. 77(1), 105-127.

الوصول الحر: https://www.jstor.org/stable/40664625Test

المؤلفون: Min, Eun Kyung

المصدر: Eighteenth-Century Studies, 2010 Apr 01. 43(3), 307-324.

الوصول الحر: https://www.jstor.org/stable/25642203Test

المؤلفون: Min, Eun Kyung¹ (AUTHOR)

المصدر: Eighteenth-Century Studies. Summer2023, Vol. 56 Issue 4, p629-631. 3p.

مصطلحات موضوعية: *TRANSLATING & interpreting, *TRANSLATORS, *LANGUAGE ability, *PRIESTS, *HAZARDS, *FATHERS, BRITISH colonies

مستخلص: Harrison divides her book almost equally between Li Zibiao and George Thomas Staunton, evidently in the interest of striking a narrative balance between the Qing and British accounts. Henrietta Harrison, The Perils of Interpreting: The Extraordinary Lives of Two Translators between Qing China and the British Empire (Princeton: Princeton Univ. [Extracted from the article]

المؤلفون: Min, Eun Kyung

المصدر: The Eighteenth Century, 2004 Jul 01. 45(2), 115-129.

الوصول الحر: https://www.jstor.org/stable/41467942Test

المؤلفون: Min, Eun Kyung

مصطلحات موضوعية: transnationalism, cosmopolitanism, diaspora, China, cultural theory, globalization, citizenship

الوصف: As America becomes less "multicultural" and more "diasporic," its connection to the lands of former migrants becomes both more significant and fraught. The Chinese diaspora in America is a strong case in point. This paper attempts to show that the recent rise of three concepts of globality-namely, transnational ism, cosmopolitanism and diaspora-is intimately tied to the effort of diasporic Chinese intellectuals to theorize a "Chineseness" that is distinct from the Chinese nation state. The paper reviews the cultural theory of Aihwa Ong, len Ang and Pheng Cheah, three critics whose work is arguably changing the contours of U.S. cultural theory. Aihwa Ong's analysis of a new class of Chinese migrants offers a strong challenge to metropolitan theories of postcoloniality as well as coreperiphery models of economic development. Ong characterizes the transnational practices of this group of overseas Chinese as resistant to national, statesponsored culture, deeply strategic and pragmatic, aggressively capitalistic, disciplinary and patriarchal in familial practice, and flexible in choice of political citizenship. If Ong attends to a Chinese transnational ism that is politically and culturally ambiguous, Ang and Cheah are more interested in theorizing Chinese forms of "minor transnational ism" that are resistant to the centralizing ambitions of the Chinese diaspora and attuned to interventionist politics. Both Ang and Cheah adopt a cautionary attitude toward celebratory models of Chinese transnationalism and diaspora. What is certain is that the new Chinese diasporas of our moment complicate the traditional associations of diaspora with forced exile, while also retaining a distance from the celebratory notion of diaspora as sheer diversity and multiplicity.

العلاقة: 미국학, Vol.31 No.1, pp. 207-227; http://hdl.handle.net/10371/88619Test

الإتاحة: http://hdl.handle.net/10371/88619Test