المؤلفون: Kulasekararaj, Austin G., Lehtinen, Anna-Elina, Forsyth, Cecily, Gandhi, Shreyans, Griffin, Morag, Körper, Sixten, Mikala, Gabor, Muus, Petra, Overgaard, Ulrik, Patriquin, Christopher J., Pullon, Humphrey, Shen, Yu Min, Spearing, Ruth, Szer, Jeff, de la Borderie, Guillemette, Duda, Petra W., Farzaneh-Far, Ramin, Ragunathan, Sharan, Sayegh, Camil E., Vadysirisack, Douangsone D., Schrezenmeier, Hubert

المساهمون: HUS Comprehensive Cancer Center, Department of Oncology

مصطلحات موضوعية: 3122 Cancers

الوصف: Non peer reviewed

وصف الملف: application/pdf

العلاقة: The authors would like to acknowledge the following contributors: Stephen Babcock, MS, of UCB Pharma, for support as Clinical Project Manager for the studies; Anita Hill, MD, PhD, formerly of the National Health Service, UK, for work as a study investigator; and Veronica Porkess, PhD, CMPP, of UCB Pharma, for publication and editorial support. Studies 201, 202, and 203 were funded by Ra Pharmaceuticals (Cambridge, MA, USA; now a part of UCB Pharma [Brussels, Belgium]). Medical writing and editorial assistance were provided by Jessica Deckman, PhD, CMPP, of The Lockwood Group (Stamford, CT, USA), and funded by UCB Pharma, in accordance with Good Publications Practice (GPP) 2022 guidelines; Kulasekararaj , A G , Lehtinen , A-E , Forsyth , C , Gandhi , S , Griffin , M , Körper , S , Mikala , G , Muus , P , Overgaard , U , Patriquin , C J , Pullon , H , Shen , Y M , Spearing , R , Szer , J , de la Borderie , G , Duda , P W , Farzaneh-Far , R , Ragunathan , S , Sayegh , C E , Vadysirisack , D D & Schrezenmeier , H 2024 , ' Phase II trials of zilucoplan in paroxysmal nocturnal hemoglobinuria ' , Haematologica , vol. 109 , no. 3 , pp. 929-935 . https://doi.org/10.3324/haematol.2022.281780Test; http://hdl.handle.net/10138/574635Test; 45b8690e-0ad1-4be0-9aae-4c1cee4ac87e; 85186744903; 001182209400033

الإتاحة: http://hdl.handle.net/10138/574635Test

المؤلفون: Pour, Ludek, Micheva, Ilina, Usenko, Ganna, Mikala, Gabor, Masszi, Tamas, Simeonova, Kameliya, Thuresson, Marcus, Huledal, Gunilla, Norin, Stefan, Bakker, Nicolaas A., Minarik, Jiri

المصدر: Clinical Lymphoma Myeloma and Leukemia ; ISSN 2152-2650

مصطلحات موضوعية: Cancer Research, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.clml.2024.02.012Test
https://api.elsevier.com/content/article/PII:S2152265024000910?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2152265024000910?httpAccept=text/plainTest

المؤلفون: Avivi, Irit, Vesole, David H, Davila-Valls, Julio, Usnarska-Zubkiewicz, Lidia, Olszewska-Szopa, Magdalena, Milunovic, Vibor, Baumert, Bartłomiej, Osękowska, Bogumiła, Kopińska, Anna, Gentile, Massimo, Puertas-Martinez, Borja, Robak, Paweł, Crusoe, Edvan, Rodriguez-Lobato, Luis Gerardo, Gajewska, Małgorzata, Varga, Gergely, Delforge, Michel, Cohen, Yael, Gozzetti, Alessandro, Pena, Camila, Shustik, Chaim, Mikala, Gabor, Zalac, Klara, Alexander, H Denis, Barth, Peter, Weisel, Katja, Martínez-López, Joaquín, Waszczuk-Gajda, Anna, Krzystański, Mateusz, Jurczyszyn, Artur

المساهمون: Avivi, Irit, Vesole, David H, Davila-Valls, Julio, Usnarska-Zubkiewicz, Lidia, Olszewska-Szopa, Magdalena, Milunovic, Vibor, Baumert, Bartłomiej, Osękowska, Bogumiła, Kopińska, Anna, Gentile, Massimo, Puertas-Martinez, Borja, Robak, Paweł, Crusoe, Edvan, Rodriguez-Lobato, Luis Gerardo, Gajewska, Małgorzata, Varga, Gergely, Delforge, Michel, Cohen, Yael, Gozzetti, Alessandro, Pena, Camila, Shustik, Chaim, Mikala, Gabor, Zalac, Klara, Alexander, H Deni, Barth, Peter, Weisel, Katja, Martínez-López, Joaquín, Waszczuk-Gajda, Anna, Krzystański, Mateusz, Jurczyszyn, Artur

مصطلحات موضوعية: SPM, multiple myeloma, second primary malignancy, therapy

الوصف: Background: There is an increased risk of second primary malignancies (SMPs) in patients with multiple myeloma (MM). This multinational 'real-world' retrospective study analyzed the characteristics and outcomes of MM patients that developed SPMs.Results: 165 patients were analyzed: 62.4% males; 8.5% with a prior cancer; 113 with solid SPMs, mainly =stage 2; and 52 with hematological SPM (hemato-SPM), mainly MDS/AML. Patients with hemato-SPM were younger (p = 0.05) and more frequently had a prior AutoHCT (p = 0.012). The time to SPM was shorter in the older (>65 years) and more heavily pretreated patients. One hundred patients were actively treated at the time of SPM detection. Treatment was discontinued in 52, substituted with another anti-MM therapy in 15, and continued in 33 patients. Treatment discontinuation was predominant in the patients diagnosed with hemato-SPM (76%). The median OS following SPM detection was 8.5 months, and the main cause of death was SPM. A poor ECOG status predicted a shorter OS (PS 3 vs. 0, HR = 5.74, 2.32-14.21, p < 0.001), whereas a normal hemoglobin level (HR = 0.43, 0.19-0.95, p = 0.037) predicted longer OS.Conclusions: With the continuing improvement in OS, a higher proportion of MM patients might develop SPM. The OS following SPM diagnosis is poor; hence, frequent surveillance and early detection are imperative to improve outcomes.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37686635; info:eu-repo/semantics/altIdentifier/wos/WOS:001070067400001; volume:15; issue:17; firstpage:1; lastpage:14; numberofpages:14; journal:CANCERS; https://hdl.handle.net/11365/1248357Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85170380030; https://www.mdpi.com/2072-6694/15/17/4359Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487060Test/

الإتاحة: https://doi.org/10.3390/cancers15174359Test
https://hdl.handle.net/11365/1248357Test
https://www.mdpi.com/2072-6694/15/17/4359Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487060Test/

المؤلفون: Csacsovszki, Ottó, Alizadeh, Hussain, Bátai, Árpád, Kriván, Gergely, Marton, Imelda, Mikala, Gábor, Pfliegler, György, Masszi, Tamás

مصطلحات موضوعية: Orvostudományok, Klinikai orvostudományok

الوصف: LB

وصف الملف: application/pdf

العلاقة: Hematológia - Transzfuziológia. -56 : 2 (2023), p. 76-80. -Hematol. Trasnzfuziol. - 1786-5913; https://hdl.handle.net/2437/367527Test; https://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM119476Test; https://akjournals.com/view/journals/2068/56/2/article-p76.xmlTest; http://dx.doi.org/10.1556/2068.2023.00168Test

الإتاحة: https://doi.org/10.1556/2068.2023.00168Test
https://hdl.handle.net/2437/367527Test
https://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM119476Test
https://akjournals.com/view/journals/2068/56/2/article-p76.xmlTest

المؤلفون: Nagy, Ákos, Bátai, Bence, Kiss, Laura, Gróf, Stefánia, Király, Péter Attila, Jóna, Ádám, Demeter, Judit, Sánta, Hermina, Bátai, Árpád, Pettendi, Piroska, Szendrei, Tamás, Plander, Márk, Körösmezey, Gábor, Alizadeh, Hussain, Kajtár, Béla, Méhes, Gábor, Krenács, László, Timár, Botond, Csomor, Judit, Tóth, Erika, Schneider, Tamás, Mikala, Gábor, Matolcsy, András, Alpár, Donát, Masszi, András, Bödör, Csaba

مصطلحات موضوعية: Orvostudományok, Klinikai orvostudományok

الوصف: kzs

وصف الملف: application/pdf

العلاقة: Journal Of Internal Medicine. -294 : 3 (2023), p. 295-313. -J. Intern. Med. - 0954-6820; https://hdl.handle.net/2437/357669Test; https://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM113529Test; http://dx.doi.org/10.1111/joim.13674Test; 001002920800001; 85161580863

الإتاحة: https://doi.org/10.1111/joim.13674Test
https://hdl.handle.net/2437/357669Test
https://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM113529Test

المؤلفون: Kotmayer, Lili, László, Tamás, Mikala, Gábor, Kiss, Richárd, Lévay, Luca, Hegyi, Lajos László, Gróf, Stefánia, Nagy, Tibor, Barna, Gábor, Farkas, Péter, Weisinger, Júlia, Nagy, Zsolt, Balogh, Alexandra, Masszi, Tamás, Demeter, Judit, Sulák, Adrienn, Kohl, Zoltán, Alizadeh, Hussain, Egyed, Miklós, Pettendi, Piroska, Gergely, Lajos, Plander, Márk, Pauker, Zsolt, Masszi, András, Matolcsy, András, Szász, Róbert, Bödör, Csaba, Alpár, Donát

مصطلحات موضوعية: Orvostudományok, Klinikai orvostudományok

الوصف: kzs

وصف الملف: application/pdf

العلاقة: International Journal Of Molecular Sciences. -24 : 6 (2023), p. 1-15. -Int. J. Mol. Sci. - 1422-0067; http://dx.doi.org/10.3390/ijms24065802Test; https://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM111494Test; 85151466619; https://hdl.handle.net/2437/352693Test; https://www.mdpi.com/1422-0067/24/6/5802Test; 000958273300001

الإتاحة: https://doi.org/10.3390/ijms24065802Test
https://hdl.handle.net/2437/352693Test
https://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM111494Test
https://www.mdpi.com/1422-0067/24/6/5802Test

المؤلفون: Crees, Zachary D., Rettig, Michael P., Jayasinghe, Reyka G., Stockerl-Goldstein, Keith, Larson, Sarah M., Illés, Árpád, Milone, Giulio A., Martino, Massimo, Stiff, Patrick, Sborov, Douglas, Pereira, Denise, Micallef, Ivana, Moreno-Jiménez, Gemma, Mikala, Gábor, Coronel, Maria Liz Paciello, Holtick, Udo, Hiemenz, John, Qazilbash, Muzaffar H., Hardy, Nancy, Latif, Tahir, García-Cadenas, Irene, Vainstein-Haras, Abi, Sorani, Ella, Gliko-Kabir, Irit, Goldstein, Inbal, Ickowicz, Debby, Shemesh-Darvish, Liron, Kadosh, Shaul, Gao, Feng, Schroeder, Mark A., Vij, Ravi, DiPersio, John F.

مصطلحات موضوعية: Orvostudományok, Klinikai orvostudományok

الوصف: kzs

وصف الملف: application/pdf

العلاقة: Nature Medicine. -29 : 4 (2023), p. 869-879. -Nat. Med. - 1078-8956; http://dx.doi.org/10.1038/s41591-023-02273-zTest; https://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM113622Test; 85153100489; https://hdl.handle.net/2437/357795Test; https://www.nature.com/articles/s41591-023-02273-zTest; 000989808500004

الإتاحة: https://doi.org/10.1038/s41591-023-02273-zTest
https://hdl.handle.net/2437/357795Test
https://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM113622Test
https://www.nature.com/articles/s41591-023-02273-zTest

المؤلفون: Czakó, Cecilia, Gerencsér, Dóra, Kormányos, Kitti, Kéki-Kovács, Klaudia, Németh, Orsolya, Tóth, Gábor, Sándor, Gábor László, Csorba, Anita, Langenbucher, Achim, Nagy, Zoltán Zsolt, Varga, Gergely, Gopcsa, László, Mikala, Gábor, Kovács, Illés, Szentmáry, Nóra

مصطلحات موضوعية: ddc:610, monoclonal gammopathy, multiple myeloma, hyperviscosity syndrome, optical coherence tomography angiography

الوصف: Background: Monoclonal gammopathy (MG) is characterized by monoclonal protein overproduction, potentially leading to the development of hyperviscosity syndrome. Objective: To assess retinal circulation using optical coherence tomography angiography (OCTA) parameters in patients with monoclonal gammopathy. Methods: OCTA measurements were performed using the Optovue AngioVue system by examining 44 eyes of 27 patients with MG and 62 eyes of 36 control subjects. Superficial and deep retinal capillary vessel density (VD SVP and DVP) in the whole 3 × 3 mm macular and parafoveal area, foveal avascular zone (FAZ) area, and central retinal thickness (CRT) were measured using the AngioAnalytics software. The OCTA parameters were evaluated in both groups using a multivariate regression model, after controlling for the effect of imaging quality (SQ). Results: There was no significant difference in age between the subjects with monoclonal gammopathy and the controls (63.59 ± 9.33 vs. 58.01 ± 11.46 years; p > 0.05). Taking into account the effect of image quality, the VD SVP was significantly lower in the MG group compared to the control group (44.54 ± 3.22% vs. 46.62 ± 2.84%; p < 0.05). No significant differences were found between the two groups regarding the other OCTA parameters (p > 0.05). Conclusions: A decreased superficial retinal capillary vessel density measured using OCTA in patients with MG suggests a slow blood flow, reduced capillary circulation, and consequent tissue hypoperfusion. An evaluation of retinal circulation using OCTA in cases of monoclonal gammopathy may be a sensitive method for the non-invasive detection and follow-up of early microcirculatory dysfunction caused by increased viscosity.

العلاقة: Journal of Clinical Medicine 12 (16): 5227 (2023); http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-403886Test; hdl:20.500.11880/36309; http://dx.doi.org/10.22028/D291-40388Test

الإتاحة: https://doi.org/10.22028/D291-40388Test
https://doi.org/10.3390/jcm12165227Test
http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-403886Test

المؤلفون: Korózs, Dorina, Jenőfi, Nóra, Szabó, Bálint Gergely, Szlávik, János, Mikala, Gábor

مصطلحات موضوعية: RC Internal medicine / belgyógyászat

الوصف: A SARS-CoV-2 megjelenésével a myeloma multiplexben szenvedők leggyakoribb halálozási okának számító fertőző ágensek köre tovább bővült. Az absztrakt szövegezésekor világszerte domináló SARS-CoV-2 omikron variáns (PANGO B.1.1.529) bár kisebb valószínűséggel okoz fatális kimenetelű fertőzést immunkompetensekben a korábbi delta variánshoz (PANGO B.1.617.2) képest, hatékonyabb transzmissziós képessége miatt az átfertőzöttek incidenciája valószínűleg nem alacsony. A COVID–19 súlyos vagy kritikus lefolyásának valószínűségét növeli a myeloma multiplexben szenvedő betegek esetén az alapbetegség, annak célzott hematológiai kezelése, valamint a betegséghez társuló egyéb komorbiditások (például veseelégtelenség) okozta komplex humorális és celluláris immunszuppresszió. A minél korábban megkezdett antivirális terápiák, a pre- vagy posztexpozíciós profilaxisként alkalmazott monoklonális antitestkészítmények, valamint a rekonvaleszcensplazma-terápia megakadályozhatja a fertőzés klinikai progresszióját. Míg az átlagpopulációban a COVID–19-et kísérő, közösségben szerzett koinfekciók incidenciája nem magas, myeloma multiplex esetén a légúti vírusbetegségeket követő Streptococcus pneumoniae fertőzés kb. 150-szer nagyobb eséllyel okozhat invazív betegséget. A modern onkohematológiai kezelések hatására a myeloma multiplex mára krónikus, többszöri relapsussal kísért entitássá vált, az ebben szenvedőket a fenti két kórokozóval szemben immunizálni szükséges. Cikkünkben citokinviharral komplikált COVID–19-ben, valamint invazív Streptococcus pneumoniae betegségben szenvedő, majd kórházi ellátása során de novo myeloma multiplexszel diagnosztizált felnőtt beteg esetét ismertetjük, végül röviden áttekintjük az ezzel kapcsolatos legfontosabb irodalmi adatokat. | With the appearance of SARS-CoV-2, the range of infections, considered the most common cause of death for people with multiple myeloma, has expanded. Although the omicron variant (PANGO B.1.1.529) of SARS-CoV-2, that dominates the world at the time of manuscript writing, is less ...

وصف الملف: text

العلاقة: http://real.mtak.hu/174305/1/650-article-p763.pdfTest; Korózs, Dorina and Jenőfi, Nóra and Szabó, Bálint Gergely and Szlávik, János and Mikala, Gábor (2023) „A baj nem jár egyedül” – de novo diagnosztizált myeloma multiplex invazív Streptococcus pneumoniae fertőzéssel citokinviharral szövődött COVID–19-ben = „When it rains, it pours” – de novo diagnosed multiple myeloma with invasive Streptococcus pneumoniae infection in severe COVID–19 complicated with cytokine storm. ORVOSI HETILAP, 164 (20). pp. 763-769. ISSN 0030-6002

الإتاحة: https://doi.org/10.1556/650.2023.32785Test
http://real.mtak.hu/174305Test/
http://real.mtak.hu/174305/1/650-article-p763.pdfTest

المؤلفون: Bátai, Bence, Nagy, Ákos, Kiss, Laura, Gróf, Stefánia, Attila Király, Péter, Jóna, Ádám, Demeter, Judit, Santa, Hermina, Batai, Arpad, Pettendi, Piroska, Szendrei, Tamás, Béla Plander, Márk, Kőrösmezey, Gábor, Alizadeh, Hussain, Kajtár, Béla, Méhes, Gábor, Krenács, László, Timár, Botond, Csomor, Judit, Tóth, Erika, Schneider, Tamás, Mikala, Gabor, Matolcsy, András, Alpar, Donat, Masszi, András, Bödör, Csaba

المصدر: HemaSphere ; volume 7, issue S3, page e303289c ; ISSN 2572-9241

الإتاحة: https://doi.org/10.1097/01.hs9.0000971872.30328.9cTest