المؤلفون: Clotilde Roy, Alisson Slimani, Christophe de Meester, Mihaela Amzulescu, Agnes Pasquet, David Vancraeynest, Christophe Beauloye, Jean-Louis Vanoverschelde, Bernhard L. Gerber, Anne-Catherine Pouleur

المصدر: Journal of Cardiovascular Magnetic Resonance, Vol 20, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: Diffuse myocardial fibrosis, Cardiac magnetic resonance, Prognosis, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Background Increased myocardial fibrosis may play a key role in heart failure with preserved ejection fraction (HFpEF) pathophysiology. The study aim was to evaluate the presence, associations, and prognostic significance of diffuse fibrosis in HFpEF patients compared to age- and sex-matched controls. Methods We prospectively included 118 consecutive HFpEF patients. Diffuse myocardial fibrosis was estimated by extracellular volume (ECV) quantified by cardiovascular magnetic resonance with the modified Look-Locker inversion recovery sequence. We determined an ECV age- and sex-adjusted cutoff value (33%) in 26 controls. Results Mean ECV was significantly higher in HFpEF patients versus healthy controls (32.9 ± 4.8% vs 28.2 ± 2.4%, P 33% demonstrating significant prediction of risk and validated this score in a validation cohort of 53 patients. Kaplan–Meier curves showed a significant difference according to tertiles of the probability score (P

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12968-018-0477-4Test; https://doaj.org/toc/1532-429XTest

الوصول الحر: https://doaj.org/article/143967eb1ae2429487bb8c03f89c127cTest

المؤلفون: Roy, Clotilde, Lejeune, Sibille, Slimani, Alisson, de Meester, Christophe, Ahn AS, Sylvie A., Rousseau, Michel F., Mihaela, Amzulescu, Ginion, Audrey, Ferracin, Benjamin, Pasquet, Agnès, Vancraeynest, David, Beauloye, Christophe, Vanoverschelde, Jean‐Louis, Horman, Sandrine, Gruson, Damien, Gerber, Bernhard L., Pouleur, Anne‐Catherine

المساهمون: Fondation Damman and Fondation Saint Luc, Fondation Nationale de la Recherche Scientifique of the Belgian Government

المصدر: ESC Heart Failure ; volume 7, issue 5, page 2494-2507 ; ISSN 2055-5822 2055-5822

الوصف: Aims Besides regulating calcium‐phosphate metabolism, fibroblast growth factor 23 (FGF‐23) has been associated with incident heart failure (HF) and left ventricular hypertrophy. However, data about FGF‐23 in HF and preserved ejection fraction (HFpEF) remain limited. The aim of this study was to assess the association between FGF‐23 levels, clinical and imaging characteristics, particularly diffuse myocardial fibrosis, and prognosis in HFpEF patients. Methods and results We prospectively included 143 consecutive HFpEF patients (78 ± 8 years, 61% female patients) and 31 controls of similar age and gender (75 ± 6 years, 61% female patients). All subjects underwent a complete two‐dimensional echocardiography and cardiac magnetic resonance with extracellular volume (ECV) assessment by T1 mapping. FGF‐23 was measured at baseline. Among the patients, differences in clinical and imaging characteristics across tertiles of FGF‐23 levels were analysed with a trend test across the ordered groups. Patients were followed over time for a primary endpoint of all‐cause mortality and first HF hospitalization and a secondary endpoint of all‐cause mortality. Median FGF‐23 was significantly higher in HFpEF patients compared with controls of similar age and gender (247 [115; 548] RU/mL vs. 61 [51; 68] RU/mL, P < 0.001). Among HFpEF patients, higher FGF‐23 levels were associated with female sex, higher incidence of atrial fibrillation, lower haemoglobin, worse renal function, and higher N terminal pro brain natriuretic peptide levels ( P for trend < 0.05 for all). Regarding imaging characteristics, patients with higher FGF‐23 levels had greater left atrial volumes, worse right ventricular systolic function, and more fibrosis estimated by ECV ( P for trend < 0.05 for all). FGF‐23 was moderately correlated with ECV ( r = 0.46, P < 0.001). Over a mean follow‐up of 30 ± 8 months, 43 patients (31%) died and 69 patients (49%) were hospitalized for HF. A total of 87 patients (62%) reached the primary composite endpoint ...

الإتاحة: https://doi.org/10.1002/ehf2.12816Test

المؤلفون: Clotilde Roy, Alisson Slimani, Christophe de Meester, Mihaela Amzulescu, Agnès Pasquet, David Vancraeynest, Jean-Louis Vanoverschelde, Anne-Catherine Pouleur, Bernhard L. Gerber

المصدر: Journal of Cardiovascular Magnetic Resonance, Vol 19, Iss 1, Pp 1-12 (2017)

مصطلحات موضوعية: T1 mapping, T2 mapping, T2* mapping, Extracellular volume, 3 T, Normal values, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Background Myocardial T1, T2 and T2* imaging techniques become increasingly used in clinical practice. While normal values for T1, T2 and T2* times are well established for 1.5 Tesla (T) cardiovascular magnetic resonance (CMR), data for 3T remain scarce. Therefore we sought to determine normal reference values relative to gender and age and day to day reproducibility for native T1, T2, T2* mapping and extracellular volume (ECV) at 3T in healthy subjects. Methods After careful exclusion of cardiovascular abnormality, 75 healthy subjects aged 20 to 90 years old (mean 56 ± 19 years, 47% women) underwent left-ventricular T1 (3-(3)-3-(3)-5 MOLLI)), T2 (8 echo- spin echo-imaging) and T2 * (8 echo gradient echo imaging) mapping at 3T CMR (Philips Ingenia 3T and computation of extracellular volume after administration of 0.2 mmol/kg Gadovist). Inter- and intra-observer reproducibility was estimated by intraclass correlation coefficient (ICC). Day to day reproducibility was assessed in 10 other volunteers. Results Mean myocardial T1 at 3T was 1122 ± 57 ms, T2 52 ± 6 ms, T2* 24 ± 5 ms and ECV 26.6 ± 3.2%. T1 (1139 ± 37 vs 1109 ± 73 ms, p

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12968-017-0371-5Test; https://doaj.org/toc/1532-429XTest

الوصول الحر: https://doaj.org/article/7a36244cb2004f9fb66e883f11b81b4dTest

المؤلفون: Raphaël Mottale, Abraham J. Beun, Mihaela Amzulescu, Philippe Unger, Alexandre Unger

المصدر: Acta Cardiologica. 77:676-682

مصطلحات موضوعية: Male, medicine.medical_specialty, Sarcoidosis, business.industry, General Medicine, Cardiac sarcoidosis, Middle Aged, medicine.disease, Pericardial effusion, Pericardial Effusion, Electrocardiography, Myocarditis, Pericarditis, Acute pericarditis, Internal medicine, cardiovascular system, Cardiology, medicine, Humans, Cardiology and Cardiovascular Medicine, business, Pericardium, Pericardial disease

الوصف: Cardiac sarcoidosis typically involves the myocardium. Pericardial effusion is uncommon, and symptomatic pericardial disease is even more infrequent. We report the case of a patient presenting with pericarditis as the first manifestation of sarcoidosis. A 50-year-old previously healthy man presented with chest pain and dyspnoea. The electrocardiogram confirmed the diagnosis of pericarditis. Computed tomography of the thorax showed pulmonary infiltrates with mediastinal and hilar adenopathies. Histological analysis of a lymph node biopsy was consistent with sarcoidosis. There was no evidence of myocardial involvement on Magnetic Resonance Imaging (MRI). We reviewed the available English literature and identified 31 cases with sarcoidosis and pericardial involvement. The majority of cases presented as pericardial effusion, which was often the first clinical manifestation of the disease. Pathological diagnosis usually occurs at extra-cardiac locations. Myocardial involvement, an important cause of morbidity and mortality, was found in 25.8% (8/31) of cases. Sarcoidosis should be considered in the differential diagnosis of patients presenting with pericardial disease. The optimal treatment regimen and long-term outcome remain largely unknown. Research in cardiac sarcoidosis should include pericardial disease as a separate manifestation in order to improve the management of this rare but likely underdiagnosed condition.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc5e75f8b63e5856e52edaa48c31f8cTest
https://doi.org/10.1080/00015385.2021.1983284Test

المؤلفون: Aurelia David-Cojocariu, Philippe Unger, Adel Aminian, Steven Droogmans, Stijn Lochy, Mihaela Amzulescu, Michael Rietz

المساهمون: Cardiology, Clinical sciences, Cardio-vascular diseases, Intensive Care

مصطلحات موضوعية: Cardiac Catheterization, medicine.medical_specialty, medicine.medical_treatment, heart failure, guideline directed medical therapy, 030204 cardiovascular system & hematology, Bridge (interpersonal), 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Cardiac Surgical Procedures, Heart Valve Prosthesis Implantation, Mitral valve repair, Mitral regurgitation, business.industry, transcatheter edge-to-edge mitral valve repair, Mitral Valve Insufficiency, General Medicine, Guideline, medicine.disease, Surgery, Treatment Outcome, Heart failure, cardiovascular system, Mitral Valve, business, secondary mitral regurgitation, Cardiology and Cardiovascular Medicine, Medical therapy

الوصف: Transcatheter edge-to-edge mitral valve repair (TMVR) improves symptoms and outcomes in selected patients with severe chronic secondary mitral regurgitation (MR) while on guideline-directed medical...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297f0aed0e0870d6548fa011119223f5Test
https://biblio.vub.ac.be/vubir/transcatheter-edgetoedge-mitral-valve-repair-as-a-bridge-to-optimal-guidelinedirected-medical-therapyTest(712c332c-84b8-4dab-b2ea-f32e159606a2).html

المؤلفون: Slimani, Alisson, Melchior, Julie, Roy, Clotilde, De Mesteer, Christophe, Mihaela, Amzulescu, Pierard, Sophie, Beauloye, Christophe, Vancraeynest, David, Pouleur, Anne-Catherine, Pasquet, Agnes, Gerber, Bernhard, Vanoverschelde, Jean-Louis

المصدر: Journal of the American College of Cardiology ; volume 71, issue 11, page A1542 ; ISSN 0735-1097

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/s0735-1097Test(18)32083-7
https://api.elsevier.com/content/article/PII:S0735109718320837?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0735109718320837?httpAccept=text/plainTest

المؤلفون: Jean-Luc Vachiery, Aurelia David-Cojocariu, Michael Rietz, Mihaela Amzulescu, Philippe Unger, Marianne Paesmans

المصدر: Heart and Vessels

مصطلحات موضوعية: medicine.medical_specialty, Longitudinal strain, Intraclass correlation, business.industry, Heart Ventricles, Ventricular Dysfunction, Right, Strain imaging, Fractional shortening, Predictive value, Right ventricular function, Free wall, ROC Curve, Echocardiography, Internal medicine, Rv function, medicine, Cardiology, Ventricular Function, Right, Humans, Sinus rhythm, Original Article, Right Ventricular Free Wall, Cardiology and Cardiovascular Medicine, business, Speckle tracking

الوصف: Purpose Because of its diagnostic and prognostic value, right ventricular strain assessed by speckle-tracking imaging (RVS) has been incorporated into echocardiographic guidelines. However, it suffers from limitations including the need of good image quality and of dedicated software with inter-vendor variability. We hypothesized that RV free wall longitudinal fractional shortening (LFS) could be used as a substitute to RVS, without suffering from the aforementioned limitations. Methods We aimed to establish in a series of non-selected consecutive patients in sinus rhythm the value of LFS, calculated as [-(TAPSE/RVdiastolic length)] and of several common echocardiographic and Doppler parameters to predict an abnormal RV function, defined as RVS > - 20.2%. Results Among 144 consecutive patients, poor image quality precluded the assessment of RVS and of LFS in 31 and 4 patients, respectively (P = 0.0018), resulting in a final study group of 113 patients. The intraclass correlation coefficients for inter- and intra-observer variability were 0.97 (95% CI 0.92; 0.98) and 0.93 (CI 0.92; 0.98) for LFS and RVS, respectively. Among all tested RV function indices, LFS best correlated with RVS (R 0.97, 95% CI 0.81; 0.91). Bland-Altman analysis for the comparison between LFS and RVS showed no systematic bias. The area under the ROC-curve of the various RV function indices to detect abnormal RVS was best for LFS (0.97, 95% CI 0.94-1), with sensitivity, specificity, negative and positive predictive value of 83%, 96%, 96%, and 83%, respectively. Conclusion LFS performs reasonably well to predict abnormal RVS and is more often feasible than RVS.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68d4c358a8f7075d032a9fda18e4544Test
https://pubmed.ncbi.nlm.nih.gov/34402942Test

المؤلفون: Didier De Cannière, Aurelia David-Cojocariu, Mihaela Amzulescu, Philippe Unger, Patrizio Lancellotti

المصدر: Archives of Cardiovascular Diseases. 112:430-440

مصطلحات موضوعية: medicine.medical_specialty, Aortic Valve Insufficiency, Clinical Decision-Making, Regurgitation (circulation), 030204 cardiovascular system & hematology, Ventricular Function, Left, Transcatheter Aortic Valve Replacement, Lesion, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Prevalence, Humans, Medicine, 030212 general & internal medicine, Heart valve, Heart Valve Prosthesis Implantation, Patient Care Team, Mitral regurgitation, business.industry, Hemodynamics, Mitral Valve Insufficiency, Recovery of Function, General Medicine, medicine.disease, Pathophysiology, Treatment Outcome, medicine.anatomical_structure, Aortic Valve, Infective endocarditis, Redo surgery, cardiovascular system, Cardiology, Etiology, Mitral Valve, medicine.symptom, Cardiology and Cardiovascular Medicine, business

الوصف: The combination of aortic and mitral regurgitation is a typical example of a frequent yet understudied multiple valve disease scenario. The aetiology is often rheumatic or degenerative; less frequently it can be induced by drugs or radiation, or caused by infective endocarditis or congenital valvular lesions. Aortic regurgitation resulting in secondary mitral regurgitation is also not uncommon. There are limited data to guide the management of combined aortic and mitral regurgitation. Left ventricular dysfunction is frequent at initial presentation, and even more so postoperatively, suggesting that surgical management should not be delayed, particularly when symptoms occur or when there is evidence of even subtle left ventricular dysfunction. The decision to operate on one or both valves not only depends on the severity of each lesion, but also on several other factors, including age, co-morbidities and frailty, the increased operative risk of double valve surgery, the increased risk of long-term thrombotic and bleeding complications with multiple mechanical valves, the risk of leaving one valve unoperated and the probability of requiring redo surgery. The role of a multidisciplinary heart valve team is critical in this setting to optimize management and outcomes. The role of transcatheter approaches is currently limited, but technological advances will probably soon change the management paradigm.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbee522198b980e8ccb875edd8c2a8eTest
https://doi.org/10.1016/j.acvd.2019.04.003Test

المؤلفون: Marianne Paesmans, Mihaela Amzulescu, Philippe Unger, Aurelia David-Cojocariu

المصدر: European Heart Journal - Cardiovascular Imaging. 22

مصطلحات موضوعية: medicine.medical_specialty, Longitudinal strain, business.industry, Diastole, General Medicine, Tracking (particle physics), Speckle pattern, Internal medicine, medicine, Cardiology, Echocardiography transthoracic, Radiology, Nuclear Medicine and imaging, Right Ventricular Free Wall, Systole, Cardiology and Cardiovascular Medicine, business, Apical four chamber view

الوصف: Funding Acknowledgements Type of funding sources: None. Background The diagnostic and prognostic value of right ventricular strain assessed by speckle-tracking imaging (STI-RV) has recently emerged in various clinical situations and this parameter has been incorporated into echocardiographic guidelines. However, it suffers from several limitations including the fundamental but often unmet requirement of good image quality and from the need for dedicated software with inter-vendor variability. Purpose We hypothesized that RV free wall (fw) longitudinal shortening, i.e. the ratio of tricuspid annular plane systolic excursion (TAPSE) to end-diastolic RV longitudinal length (RVDL) could be used as a surrogate of RVfw strain, without suffering from the abovementioned limitations. We therefore compared -(TAPSE/RVDL) to STI-RVfw strain in a series of non-selected patients undergoing echocardiography. Patients and methods 144 consecutive ≥18 y-o patients in sinus rhythm referred to our echocardiographic laboratory underwent transthoracic echocardiography using a Vivid E9 platform (GE Vingmed, Horten, Norway). STI-RVfw strain was obtained using a RV focused apical four chamber view and -(TAPSE/RVDL) was obtained from the apical four-chamber view. Images and loop were stored digitally and analyzed offline using EchoPac 2.02 software (GE Vingmed). Results Poor image quality precluded the assessment of STI-RVfw strain - but not of -(TAPSE/RVDL) - in 27 patients (18.8%) and of both parameters in 4 patients (2.8%); the study group consisted in the remaining 113 patients. Among all tested RV function indices, -(TAPSE/RVDL) best correlated with STI-RVfw strain (Panel A), without significant bias between the two methods (Panel B). The area under the ROC-curve for -(TAPSE/RVDL) to detect abnormal STI-RVfw strain (using a threshold of -20.2%) was 0.97 [IC 95% 0.94-1], and sensitivity, specificity, negative and positive predictive value were 83%, 96%, 96%, and 83%, respectively. Conclusion In this unselected series of patients, the assessment of -(TAPSE/RVDL) performed reasonably well to predict abnormal STI-RVfw strain and was more often feasible than the latter. Its prognostic value should be prospectively tested. Abstract Figure 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1a430ed4b66e1ec180ff12f536a88324Test
https://doi.org/10.1093/ehjci/jeaa356.124Test

المؤلفون: Aurelia David-Cojocariu, Ludovica Lauretta, Mihaela Amzulescu, Philippe Unger, Giulia Casalino

المصدر: European heart journal. Cardiovascular Imaging. 21(7)

مصطلحات موضوعية: Diagnostic Imaging, medicine.medical_specialty, business.industry, Ultrasonography, Doppler, General Medicine, Doppler imaging, Sensitivity and Specificity, symbols.namesake, symbols, Medical imaging, medicine, Humans, Radiology, Nuclear Medicine and imaging, Sensitivity (control systems), Radiology, Ultrasonography, Ultrasonography, Doppler, Color, Cardiology and Cardiovascular Medicine, business, Doppler effect, Sign (mathematics)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341316339057cabdf6eb3ebc5ca337ffTest
https://pubmed.ncbi.nlm.nih.gov/32025713Test