المؤلفون: Scalzitti S., Mariani D., Setti A., Colantoni A., Lisi M., Bozzoni I., Martone J.

المساهمون: Scalzitti, S., Mariani, D., Setti, A., Colantoni, A., Lisi, M., Bozzoni, I., Martone, J.

مصطلحات موضوعية: DHX36 helicase, G-quadruplex, long ncRNA, myogenesi, post-transcriptional regulation, Acyl-CoA Dehydrogenase, animal, cell differentiation, DEAD-box RNA Helicase, G-Quadruplexe, gene expression regulation, developmental, human, mice, microfilament protein, muscle development, muscle, nerve tissue protein, protein conformation, RNA processing, post-transcriptional, RNA, long noncoding, messenger, RNA-binding protein, transcription factors

الوصف: The destiny of a messenger RNA is determined from a combination of in cis elements, like peculiar secondary structures, and in trans modulators, such as RNA binding proteins and non-coding, regulatory RNAs. RNA guanine quadruplexes belong to the first group: these strong secondary structures have been characterized in many mRNAs, and their stabilization or unwinding provides an additional step for the fine tuning of mRNA stability and translation. On the other hand, many cytoplasmic long non-coding RNAs intervene in post-transcriptional regulation, frequently by direct base-pairing with their mRNA targets. We have previously identified the lncRNA SMaRT as a key modulator of the correct timing of murine skeletal muscle differentiation; when expressed, lnc-SMaRT interacts with a G-quadruplex-containing region of Mlx-γ mRNA, therefore inhibiting its translation by counteracting the DHX36 helicase activity. The “smart” mode of action of lnc-SMaRT led us to speculate whether this molecular mechanism could be extended to other targets and conserved in other species. Here, we show that the molecular complex composed by lnc-SMaRT and DHX36 also includes other mRNAs. We prove that lnc-SMaRT is able to repress Spire1 translation through base-pairing with its G-quadruplex-forming sequence, and that Spire1 modulation participates to the regulation of proper skeletal muscle differentiation. Moreover, we demonstrate that the interaction between DHX36 and lnc-SMaRT is indirect and mediated by the mRNAs present in the complex. Finally, we suggest an extendibility of the molecular mechanism of lnc-SMaRT from the mouse model to humans, identifying potential functional analogues.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34863993; info:eu-repo/semantics/altIdentifier/wos/WOS:000807264900012; volume:434; issue:2; numberofpages:16; journal:JOURNAL OF MOLECULAR BIOLOGY; http://hdl.handle.net/11573/1610567Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85121271313

الإتاحة: https://doi.org/10.1016/j.jmb.2021.167384Test
http://hdl.handle.net/11573/1610567Test

المؤلفون: Boraldi F., Lofaro F. D., Cossarizza A., Quaglino D.

المساهمون: Boraldi, F., Lofaro, F. D., Cossarizza, A., Quaglino, D.

مصطلحات موضوعية: COVID-19, Elastase, Elastin, Inflammation, Lung, NET, Neutrophil, SARS-CoV-2, Animal, Elastic Tissue, Extracellular Matrix, Extracellular Matrix Protein, Extracellular Trap, Fibrillin, Human, Microfibril, Microfilament Protein, Protein-Lysine 6-Oxidase, Tropoelastin

الوصف: Elastin represents the structural component of the extracellular matrix providing elastic recoil to tissues such as skin, blood vessels and lungs. Elastogenic cells secrete soluble tropoelastin monomers into the extracellular space where these monomers associate with other matrix proteins (e.g., microfibrils and glycoproteins) and are crosslinked by lysyl oxidase to form insoluble fibres. Once elastic fibres are formed, they are very stable, highly resistant to degradation and have an almost negligible turnover. However, there are circumstances, mainly related to inflammatory conditions, where increased proteolytic degradation of elastic fibres may lead to consequences of major clinical relevance. In severely affected COVID-19 patients, for instance, the massive recruitment and activation of neutrophils is responsible for the profuse release of elastases and other proteolytic enzymes which cause the irreversible degradation of elastic fibres. Within the lungs, destruction of the elastic network may lead to the permanent impairment of pulmonary function, thus suggesting that elastases can be a promising target to preserve the elastic component in COVID-19 patients. Moreover, intrinsic and extrinsic factors additionally contributing to damaging the elastic component and to increasing the spread and severity of SARS-CoV-2 infection are reviewed.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35163482; info:eu-repo/semantics/altIdentifier/wos/WOS:000756134400001; volume:23; issue:3; firstpage:1559; lastpage:N/A; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11380/1267904Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85123538030

الإتاحة: https://doi.org/10.3390/ijms23031559Test
http://hdl.handle.net/11380/1267904Test

المؤلفون: Heinze, Anika, Schuldt, Cara, Khudayberdiev, Sharof, van Bommel, Bas, Hacker, Daniela, Schulz, Toni G, Stringhi, Ramona, Marcello, Elena, Mikhaylova, Marina, Rust, Marco B

المساهمون: A. Heinze, C. Schuldt, S. Khudayberdiev, B. van Bommel, D. Hacker, T.G. Schulz, R. Stringhi, E. Marcello, M. Mikhaylova, M.B. Rust

مصطلحات موضوعية: Actin dynamic, Actin turnover, Postsynaptic density, Synaptic actin, Synaptic plasticity, Actin Cytoskeleton, Synapse, Microfilament Protein, Synapsin, Actin, Dendritic Spines, Settore BIO/14 - Farmacologia

الوصف: The vast majority of excitatory synapses are formed on small dendritic protrusions termed dendritic spines. Dendritic spines vary in size and density that are crucial determinants of excitatory synaptic transmission. Aberrations in spine morphogenesis can compromise brain function and have been associated with neuropsychiatric disorders. Actin filaments (F-actin) are the major structural component of dendritic spines, and therefore, actin-binding proteins (ABP) that control F-actin dis-/assembly moved into the focus as critical regulators of brain function. Studies of the past decade identified the ABP cofilin1 as a key regulator of spine morphology, synaptic transmission, and behavior, and they emphasized the necessity for a tight control of cofilin1 to ensure proper brain function. Here, we report spine enrichment of cyclase-associated protein 1 (CAP1), a conserved multidomain protein with largely unknown physiological functions. Super-resolution microscopy and live cell imaging of CAP1-deficient hippocampal neurons revealed impaired synaptic F-actin organization and dynamics associated with alterations in spine morphology. Mechanistically, we found that CAP1 cooperates with cofilin1 in spines and that its helical folded domain is relevant for this interaction. Moreover, our data proved functional interdependence of CAP1 and cofilin1 in control of spine morphology. In summary, we identified CAP1 as a novel regulator of the postsynaptic actin cytoskeleton that is essential for synaptic cofilin1 activity.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36264429; info:eu-repo/semantics/altIdentifier/wos/WOS:000870762800002; volume:79; issue:11; firstpage:1; lastpage:21; numberofpages:21; journal:CELLULAR AND MOLECULAR LIFE SCIENCES; https://hdl.handle.net/2434/945869Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85140233809

الإتاحة: https://doi.org/10.1007/s00018-022-04593-8Test
https://hdl.handle.net/2434/945869Test

المؤلفون: Daini E., Hagmeyer S., De Benedictis C. A., Cristovao J. S., Bodria M., Ross A. M., Raab A., Boeckers T. M., Feldmann J., Gomes C. M., Zoli M., Vilella A., Grabrucker A. M.

المساهمون: Daini, E., Hagmeyer, S., De Benedictis, C. A., Cristovao, J. S., Bodria, M., Ross, A. M., Raab, A., Boeckers, T. M., Feldmann, J., Gomes, C. M., Zoli, M., Vilella, A., Grabrucker, A. M.

مصطلحات موضوعية: Animal, Brain, Female, Genetic Predisposition to Disease, Homeostasi, Mice, Microfilament Protein, Nerve Tissue Protein, Pregnancy, S100 Calcium Binding Protein beta Subunit, Autism Spectrum Disorder, Zinc

الوصف: Autism Spectrum Disorders (ASD) are caused by a combination of genetic predisposition and nongenetic factors. Among the nongenetic factors, maternal immune system activation and zinc deficiency have been proposed. Intriguingly, as a genetic factor, copy-number variations in S100B, a pro-inflammatory damage-associated molecular pattern (DAMP), have been associated with ASD, and increased serum S100B has been found in ASD. Interestingly, it has been shown that increased S100B levels affect zinc homeostasis in vitro. Thus, here, we investigated the influence of increased S100B levels in vitro and in vivo during pregnancy in mice regarding zinc availability, the zinc-sensitive SHANK protein networks associated with ASD, and behavioral outcomes. We observed that S100B affects the synaptic SHANK2 and SHANK3 levels in a zinc-dependent manner, especially early in neuronal development. Animals exposed to high S100B levels in utero similarly show reduced levels of free zinc and SHANK2 in the brain. On the behavioral level, these mice display hyperactivity, increased stereotypic and abnormal social behaviors, and cognitive impairment. Pro-inflammatory factors and zinc-signaling alterations converge on the synaptic level revealing a common pathomechanism that may mechanistically explain a large share of ASD cases.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34741005; info:eu-repo/semantics/altIdentifier/wos/WOS:000731670100001; volume:11; issue:1; firstpage:562; lastpage:562; journal:TRANSLATIONAL PSYCHIATRY; http://hdl.handle.net/11380/1275375Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118559396

الإتاحة: https://doi.org/10.1038/s41398-021-01694-zTest
http://hdl.handle.net/11380/1275375Test

المؤلفون: Wallis S. S., Ventimiglia L. N., Otigbah E., Infante E., Cuesta-Geijo M. A., Kidiyoor G. R., Carbajal M. A., Fleck R. A., Foiani M., Garcia-Manyes S., Martin-Serrano J., Agromayor M.

المساهمون: S.S. Walli, L.N. Ventimiglia, E. Otigbah, E. Infante, M.A. Cuesta-Geijo, G.R. Kidiyoor, M.A. Carbajal, R.A. Fleck, M. Foiani, S. Garcia-Manye, J. Martin-Serrano, M. Agromayor

مصطلحات موضوعية: ESCRT, LINC complex, mechanosensing, membrane repair, nuclear envelope, Actin, Cell Movement, Cell Nucleu, Cytoskeleton, Endosomal Sorting Complexes Required for Transport, HeLa Cell, Human, Mechanical Phenomena, Microfilament Protein, Nerve Tissue Protein, Settore BIO/11 - Biologia Molecolare

الوصف: Transient nuclear envelope ruptures during interphase (NERDI) occur due to cytoskeletal compressive forces at sites of weakened lamina, and delayed NERDI repair results in genomic instability. Nuclear envelope (NE) sealing is completed by endosomal sorting complex required for transport (ESCRT) machinery. A key unanswered question is how local compressive forces are counteracted to allow efficient membrane resealing. Here, we identify the ESCRT-associated protein BROX as a crucial factor required to accelerate repair of the NE. Critically, BROX binds Nesprin-2G, a component of the linker of nucleoskeleton and cytoskeleton complex (LINC). This interaction promotes Nesprin-2G ubiquitination and facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site. Thus, BROX rebalances excessive cytoskeletal forces in cells experiencing NE instability to promote effective NERDI repair. Our results demonstrate that BROX coordinates mechanoregulation with membrane remodeling to ensure the maintenance of nuclear-cytoplasmic compartmentalization and genomic stability.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34818527; info:eu-repo/semantics/altIdentifier/wos/WOS:000729283100007; volume:56; issue:23; firstpage:3192; lastpage:3202.e8; numberofpages:11; journal:DEVELOPMENTAL CELL; https://hdl.handle.net/2434/915371Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85120169353

الإتاحة: https://doi.org/10.1016/j.devcel.2021.10.022Test
https://hdl.handle.net/2434/915371Test

المؤلفون: Pellegrino B., Cavanna L., Boggiani D., Zamagni C., Frassoldati A., Schirone A., Caldara A., Rocca A., Gori S., Piacentini F., Berardi R., Brandes A. A., Foglietta J., Villa F., Todeschini R., Tognetto M., Naldi N., Bortesi B., Montemurro F., Ardizzoni A., Boni L., Musolino A.

المساهمون: Pellegrino B., Cavanna L., Boggiani D., Zamagni C., Frassoldati A., Schirone A., Caldara A., Rocca A., Gori S., Piacentini F., Berardi R., Brandes A.A., Foglietta J., Villa F., Todeschini R., Tognetto M., Naldi N., Bortesi B., Montemurro F., Ardizzoni A., Boni L., Musolino A.

مصطلحات موضوعية: breast cancer, eribulin, gemcitabine, metastatic, pharmacogenetic, TNBC, Antineoplastic Combined Chemotherapy Protocol, Deoxycytidine, Female, Furan, Human, Ketone, Microfilament Protein, Prospective Studie, Triple Negative Breast Neoplasms

الوصف: Background: The combination of a microtubule inhibitor (eribulin) with a nucleoside analog (gemcitabine) may synergistically induce tumor cell death, particularly in triple negative breast cancer (TNBC) characterized by high cell proliferation, aggressive behavior, and chemo-resistance. Patients and methods: This is an open-label, multicenter phase II study evaluating the combination of eribulin (0.88 mg/m2) plus gemcitabine (1000 mg/m2) on days 1 and 8 of a 21-day cycle as either first- or second-line treatment of locally advanced or metastatic TNBC. The primary endpoint was the objective response for evaluable patients. A prospective, molecular correlative study was carried out to assess the role of germinal BRCA pathogenic variants and single nucleotide polymorphisms (SNPs) in predicting efficacy and toxicity of the combination regimen. Results: From July 2013 to September 2016, 83 evaluable patients were enrolled. They received a median number of six cycles of treatment. An overall response rate (ORR) of 37.3% (31 patients) was observed, with a complete response rate of 2.4% and a partial response rate of 34.9%; the clinical benefit rate was 48.8%. With a median follow-up of 28.8 months, the median response duration was 6.6 months, the median progression-free survival (PFS) was 5.1 months, and the median overall survival (OS) was 14.5 months. The most common grade 3-4 adverse events were aminotransferase elevation (in 25% of the patients) and neutropenia (in 23.8%). Women with BRCA1/2 pathogenic variants were associated with worse ORR, PFS, and OS than BRCA1/2 wild-type carriers. CYP3A4 and FGD4 SNPs were associated with increased risk of liver toxicity. Three different SNPs in CDA∗2, RRM1, and CYP2C8 genes were significantly associated with poorer OS. Conclusions: The combination of eribulin and gemcitabine showed promising activity and a moderate toxicity profile in metastatic TNBC. BRCA status and pharmacogenetics tests may help identify patients with high probability of response with negligible toxicity. ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33399082; info:eu-repo/semantics/altIdentifier/wos/WOS:000631402900017; volume:6; issue:1; firstpage:1; lastpage:8; numberofpages:8; journal:ESMO OPEN; http://hdl.handle.net/11585/851662Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100641127; https://doi.org/10.1016/j.esmoop.2020.100019Test

الإتاحة: https://doi.org/10.1016/j.esmoop.2020.100019Test
http://hdl.handle.net/11585/851662Test

المؤلفون: Sormani G., Rodriguez A., Laio A.

المساهمون: Sormani, G., Rodriguez, A., Laio, A.

مصطلحات موضوعية: Animal, Carbon, Chicken, Cluster Analysi, Kinetic, Markov Chain, Microfilament Protein, Molecular Dynamics Simulation, Protein Conformation, Protein Folding, Thermodynamics

الوصف: By using an approach that allows computing the free energy in high-dimensional spaces together with a clustering technique capable of identifying kinetic attractors stabilized by conformational disorder, we analyze a molecular dynamics trajectory of the Villin headpiece from Lindorff-Larsen, K.; et al. How fast-folding proteins fold. Science 2011, 334, 517-520. We compute its free-energy landscape in the space of all its Cα carbons. This landscape has the shape of a 12-dimensional funnel with the free energy decreasing monotonically as a function of the native contacts. There are no significant folding barriers. The funnel can be partitioned in five regions, three mainly folded and two unfolded, which behave as Markov states. The slowest relaxation time among these states corresponds to the folding transition. The second slowest time is only twice smaller and corresponds to a transition within the unfolded state. This indicates that the unfolded part of the funnel has a nontrivial shape, which induces a sizable kinetic barrier between disordered states.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31809040; info:eu-repo/semantics/altIdentifier/wos/WOS:000508474800007; volume:16; issue:1; firstpage:80; lastpage:87; numberofpages:8; journal:JOURNAL OF CHEMICAL THEORY AND COMPUTATION; https://hdl.handle.net/11368/3034881Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85077220118

الإتاحة: https://doi.org/10.1021/acs.jctc.9b00800Test
https://hdl.handle.net/11368/3034881Test

المؤلفون: Biancospino M., Buel G. R., Nino C. A., Maspero E., di Perrotolo R. S., Raimondi A., Redlingshofer L., Weber J., Brodsky F. M., Walters K. J., Polo S.

المساهمون: M. Biancospino, G.R. Buel, C.A. Nino, E. Maspero, R.S. di Perrotolo, A. Raimondi, L. Redlingshofer, J. Weber, F.M. Brodsky, K.J. Walter, S. Polo

مصطلحات موضوعية: Actin, Adaptor Proteins, Signal Transducing, Caco-2 Cell, Cell Culture Technique, Clathrin Light Chain, Clathrin-Coated Vesicle, Coated Pits, Cell-Membrane, Cyst, Endocytosi, Human, Magnetic Resonance Spectroscopy, Microfilament Protein, Myosin Heavy Chain, Protein Binding, Protein Conformation, Protein Isoforms, Settore MED/04 - Patologia Generale

الوصف: Clathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Unique functions for these evolutionary conserved paralogs remain elusive, and their role in clathrin-mediated endocytosis in mammalian cells is debated. Here, we find and structurally characterize a direct and selective interaction between CLCa and the long isoform of the actin motor protein myosin VI, which is expressed exclusively in highly polarized tissues. Using genetically-reconstituted Caco-2 cysts as proxy for polarized epithelia, we provide evidence for coordinated action of myosin VI and CLCa at the apical surface where these proteins are essential for fission of clathrin-coated pits. We further find that myosin VI and Huntingtin-interacting protein 1-related protein (Hip1R) are mutually exclusive interactors with CLCa, and suggest a model for the sequential function of myosin VI and Hip1R in actin-mediated clathrin-coated vesicle budding.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31672988; info:eu-repo/semantics/altIdentifier/wos/WOS:000493438700022; volume:10; issue:1; numberofpages:15; journal:NATURE COMMUNICATIONS; http://hdl.handle.net/2434/801707Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85074249548

الإتاحة: https://doi.org/10.1038/s41467-019-12855-6Test
http://hdl.handle.net/2434/801707Test

المؤلفون: Nilesh Vikram Lande, Pragya Barua, Sunil Kumar, Subhra Chakraborty, Niranjan Chakraborty, Akanksha Pareek

المصدر: Plant Physiology and Biochemistry. 170:75-86

مصطلحات موضوعية: Proteomics, Physiology, Dissection, Microfilament Proteins, Oryza, Plant Science, Microfilament Protein, Biology, Microfilament, Microtubules, DNA-binding protein, Cell biology, Actin Cytoskeleton, Microtubule, Polyribosomes, Polysome, Organelle, Proteome, Genetics, Cytoskeleton

الوصف: The plant cytoskeleton persistently undergoes remodeling to achieve its roles in supporting cell division, differentiation, cell expansion and organelle transport. However, the links between cell metabolism and cytoskeletal networks, particularly how the proteinaceous components execute such processes remain poorly understood. We investigated the cytoskeletal proteome landscape of rice to gain better understanding of such events. Proteins were extracted from highly enriched cytoskeletal fraction of four-week-old rice seedlings, and the purity of the fraction was stringently monitored. A total of 2577 non-redundant proteins were identified using both gel-based and gel-free approaches, which constitutes the most comprehensive dataset, thus far, for plant cytoskeleton. The data set includes both microtubule and microfilament-associated proteins and their binding proteins comprising hypothetical as well as novel cytoskeletal proteins. Further, various in-silico analyses were performed, and the proteins were functionally classified on the basis of their gene ontology. The catalogued proteins were validated through their sequence analysis. Extensive comparative analysis of our dataset with the non-redundant set of cytoskeletal proteins across plant species affirms unique as well as overlapping candidates. Together, these findings unveil new insights of how cytoskeletons undergo dynamic remodeling in rice to drive seedling development processes in rapidly changing in planta environment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7713ed77f4016b387ba973b306b2eb3eTest
https://doi.org/10.1016/j.plaphy.2021.11.037Test

المؤلفون: Neri M., Frati A., Turillazzi E., Cantatore S., Cipolloni L., Di Paolo M., Frati P., La Russa R., Maiese A., Scopetti M., Santurro A., Sessa F., Zamparese R., Fineschi V.

المساهمون: Neri, M., Frati, A., Turillazzi, E., Cantatore, S., Cipolloni, L., Di Paolo, M., Frati, P., La Russa, R., Maiese, A., Scopetti, M., Santurro, A., Sessa, F., Zamparese, R., Fineschi, V.

مصطلحات موضوعية: Aquaporin, Computed tomography (CT) scan, Edema, Genetic analysi, Hypoxia, Microglia activation, Traumatic brain injury, Adult, Aged, Antigens, CD, Differentiation, Myelomonocytic, Aquaporin 4, Base Sequence, Brain Edema, Brain Injuries, Traumatic, Calcium-Binding Protein, DNA-Binding Protein, Female, Glial Fibrillary Acidic Protein, Human, Hypoxia-Inducible Factor 1, alpha Subunit, Immunohistochemistry, Lewis X Antigen, Male, Microfilament Protein, Middle Aged

الوصف: Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. Our understanding of its pathobiology has substantially increased. Following TBI, the following occur, edema formation, brain swelling, increased intracranial pressure, changes in cerebral blood flow, hypoxia, neuroinflammation, oxidative stress, excitotoxicity, and apoptosis. Experimental animal models have been developed. However, the difficulty in mimicking human TBI explains why few neuroprotective strategies, drawn up on the basis of experimental studies, have translated into improved therapeutic strategies for TBI patients. In this study, we retrospectively examined brain samples in 145 cases of death after different survival times following TBI, to investigate aquaporin-4 (AQP4) expression and correlation with hypoxia, and neuroinflammation in human TBI. Antibodies anti-glial fibrillary acid protein (GFAP), aquaporin-4 (AQP4), hypoxia induced factor-1α (HIF-1α), macrophage/phagocytic activation (CD68), ionized calcium-binding adapter molecule-1 (IBA-1), and neutrophils (CD15) were used. AQP4 showed a significant, progressive increase between the control group and groups 2 (one-day survival) and 3 (three-day survival). There were further increases in AQP4 immunopositivity in groups 4 (seven-day survival), 5 (14-dayssurvival), and 6 (30-day survival), suggesting an upregulation of AQP4 at 7 to 30 days compared to group 1. GFAP showed its highest expression in non-acute cases at the astrocytic level compared with the acute TBI group. Data emerging from the HIF-1α reaction showed a progressive, significant increase. Immunohistochemistry with IBA-1 revealed activated microglia starting three days after trauma and progressively increasing in the next 15 to 20 days after the initial trauma. CD68 expression demonstrated basal macrophage and phagocytic activation mostly around blood vessels. Starting from one to three days of survival after TBI, an increase in the number of CD68 cells was progressively observed; at 15 and ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30423808; info:eu-repo/semantics/altIdentifier/wos/WOS:000451528500260; volume:19; issue:11; firstpage:3544; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11568/1067007Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85056543279

الإتاحة: https://doi.org/10.3390/ijms19113544Test
http://hdl.handle.net/11568/1067007Test