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11
المؤلفون: Kelvin K. C. Sham, Lewis D. Pennington, Paul E. Harrington, Matthew R. Lee, Michele McElvain, Xuxia Zhang, Heather A. Arnett, Min Wong, Alexander J. Pickrell, Anthony B. Reed, Henry Morrison, Victor J. Cee, Mike Fiorino, Christopher H. Fotsch, Michael J. Frohn, Yang Xu, Michael Croghan, Han Xu, Brian A. Lanman, Andrew Tasker, Michelle Horner
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:527-531
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, In vitro, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine, Potency, Structure–activity relationship, Selectivity, Molecular Biology, Nuclear chemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5e9317f7724366d80a0b866a4ab4fecaTest
https://doi.org/10.1016/j.bmcl.2011.10.085Test -
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المؤلفون: Michael Croghan, Andrew Tasker, Matthew R. Lee, Xuxia Zhang, Heather A. Arnett, Victor J. Cee, Anthony B. Reed, Kelvin K. C. Sham, Michele McElvain, Henry Morrison, Alexander J. Pickrell, Lewis D. Pennington, Mike Frohn, Yang Xu, Paul E. Harrington, Min Wong, Han Xu, Brian A. Lanman, Mike Fiorino, Christopher H. Fotsch
المصدر: ACS Medicinal Chemistry Letters. 3:74-78
مصطلحات موضوعية: Agonist, Orally active, Pharmacokinetics, business.industry, medicine.drug_class, Organic Chemistry, Drug Discovery, Medicine, Pharmacology, business, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513454b43d7abc3801057fdc295f1e0aTest
https://doi.org/10.1021/ml200252bTest -
13
المؤلفون: Min Wong, Heather A. Arnett, Michael Croghan, Michele McElvain, Yang Xu, Xuxia Zhang, Matthew R. Lee, Lewis D. Pennington, Paul E. Harrington, Henry Morrison, Victor J. Cee, Anthony B. Reed, Michael J. Frohn, Alexander J. Pickrell, Mike Fiorino, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Christopher H. Fotsch, Michelle Horner
المصدر: ACS Medicinal Chemistry Letters. 2:752-757
مصطلحات موضوعية: Agonist, Trifluoromethyl, Nicotinamide, medicine.drug_class, business.industry, Lymphocyte, Organic Chemistry, Pharmacology, Biochemistry, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Drug Discovery, medicine, Potency, business, Receptor, Selectivity, EC50
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888681fe352e70d553e6a823a8d63a57Test
https://doi.org/10.1021/ml2001399Test -
14
المؤلفون: Min Wong, Yang Xu, Scot Middleton, Matthew R. Lee, Anu Gore, Mike Fiorino, Alex Pickrell, Kristine M. Muller, Andrea Itano, Mike Frohn, Heather A. Arnett, Janet Buys, Michelle Horner, Dalia Rivenzon-Segal, Jennifer E. Golden, Victor J. Cee, Hugo M. Vargas, Roland Burli, Susana C. Neira, Michael Schrag, Han Xu, Brian A. Lanman, Michele McElvain, Xuxia Zhang, Jerry Siu
المصدر: ACS Medicinal Chemistry Letters. 2:107-112
مصطلحات موضوعية: Agonist, business.industry, medicine.drug_class, Lymphocyte, Sphingosine-1-phosphate receptor, Organic Chemistry, Experimental autoimmune encephalomyelitis, Inflammation, Pharmacology, medicine.disease, Biochemistry, Blood lymphocyte, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Drug Discovery, Pyridine, Medicine, medicine.symptom, Receptor, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469aac7dbf0531b12b4eec83f252b55dTest
https://doi.org/10.1021/ml100306hTest -
15
المؤلفون: Hugo M. Vargas, Yang Xu, Jerry Siu, Janet Buys, Michelle Horner, Jian Lin, Ashis Saha, Han Xu, Michele McElvain, Anurag Sharadendu, Scot Middleton, Roland Burli, Yael Marantz, Dalia Segal, Kevin Salyers, Mercedes Lobera, Dilara Mccauley, Srinivas Chereku, Xiang Yu, Nili Schutz, Michael Schrag
المصدر: ACS Medicinal Chemistry Letters. 2:97-101
مصطلحات موضوعية: Agonist, business.industry, medicine.drug_class, Sphingosine-1-phosphate receptor, Organic Chemistry, Pharmacology, Biochemistry, In vitro, Bioavailability, chemistry.chemical_compound, chemistry, Drug Discovery, Medicine, Potency, Benzofuran, business, Selectivity, ADME
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8291efcc95ecdaf3a6ce8e57343599Test
https://doi.org/10.1021/ml100227qTest -
16
المؤلفون: Kelly Regal, Randall W. Hungate, Mike Frohn, Vellarkad N. Viswanadhan, Matthew Adlam, Han Xu, Philip Tagari, Min Wong, Kristine M. Muller, Roland Burli, Jennifer E. Golden, Xiaoming Zou, Matthew H. Plant, Michele McElvain
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3713-3718
مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Anti-Inflammatory Agents, Administration, Oral, Pharmaceutical Science, Inflammation, Pharmacology, Biochemistry, Anti-inflammatory, Mice, In vivo, Drug Discovery, medicine, Animals, Humans, Receptors, Lipoxin, Receptor, Molecular Biology, G protein-coupled receptor, Formyl peptide receptor, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Receptors, Formyl Peptide, In vitro, Disease Models, Animal, Immunology, Molecular Medicine, medicine.symptom
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19e4048cb68caaf96dd2c0a6c5b8b6aTest
https://doi.org/10.1016/j.bmcl.2006.04.068Test -
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المؤلفون: Yang Xu, Mike Fiorino, Elizabeth Tominey, Min Wong, Lisa Sherman, Victor J. Cee, Roland Burli, Brad Henkle, Han Xu, Jerry Siu, Keith Kelley, Matt Adlam, Michele McElvain
المصدر: Journal of biomolecular screening. 18(9)
مصطلحات موضوعية: MAPK/ERK pathway, Arrestins, Protein Conformation, Biology, Pharmacology, Biochemistry, Lymphocyte Depletion, Analytical Chemistry, Adenylyl cyclase, Small Molecule Libraries, chemistry.chemical_compound, In vivo, Predictive Value of Tests, Sphingosine, Drug Discovery, Humans, Phosphorylation, Receptor, Extracellular Signal-Regulated MAP Kinases, beta-Arrestins, Drug discovery, In vitro toxicology, Biological activity, In vitro, Organophosphates, Kinetics, Receptors, Lysosphingolipid, chemistry, Gene Expression Regulation, Adenylyl Cyclase Inhibitors, Molecular Medicine, Biological Assay, Calcium, Biotechnology, Adenylyl Cyclases, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603ba7984cf81c79f7957f8df7df0d1aTest
https://pubmed.ncbi.nlm.nih.gov/23686102Test -
18
المؤلفون: Lewis D, Pennington, Michael D, Croghan, Kelvin K C, Sham, Alexander J, Pickrell, Paul E, Harrington, Michael J, Frohn, Brian A, Lanman, Anthony B, Reed, Matthew R, Lee, Han, Xu, Michele, McElvain, Yang, Xu, Xuxia, Zhang, Michael, Fiorino, Michelle, Horner, Henry G, Morrison, Heather A, Arnett, Christopher, Fotsch, Andrew S, Tasker, Min, Wong, Victor J, Cee
المصدر: Bioorganicmedicinal chemistry letters. 22(1)
مصطلحات موضوعية: Multiple Sclerosis, Chemistry, Physical, In Vitro Techniques, Quinolones, Rats, Kinetics, Receptors, Lysosphingolipid, Structure-Activity Relationship, Models, Chemical, Cardiovascular Diseases, Rats, Inbred Lew, Area Under Curve, Drug Design, Animals, Humans, Female, Lymphocytes, Immunosuppressive Agents
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::34de576670bcc161a469d7104d79e55cTest
https://pubmed.ncbi.nlm.nih.gov/22104144Test -
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المؤلفون: Mike, Frohn, Victor J, Cee, Brian A, Lanman, Alexander J, Pickrell, Jennifer, Golden, Dalia, Rivenzon-Segal, Scot, Middleton, Mike, Fiorino, Han, Xu, Michael, Schrag, Yang, Xu, Michele, McElvain, Kristine, Muller, Jerry, Siu, Roland, Bürli
المصدر: Bioorganicmedicinal chemistry letters. 22(1)
مصطلحات موضوعية: Chemistry, Physical, Chemistry, Pharmaceutical, Green Fluorescent Proteins, CHO Cells, Ketones, Rats, Receptors, G-Protein-Coupled, Receptors, Lysosphingolipid, Cricetulus, Models, Chemical, Rats, Inbred Lew, Cell Line, Tumor, Cricetinae, Drug Design, Animals, Humans, Female, Benzothiazoles, Lymphocytes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::a247b4fe72d40dd1e5f354990a4182ddTest
https://pubmed.ncbi.nlm.nih.gov/22100314Test -
20
المؤلفون: Michelle Horner, Kristine M. Muller, Xuxia Zhang, Xiang Yu, Nili Schutz, Jerry Siu, Dalia Rivenzon-Segal, Roland Burli, Zhang Zhaoda, Susana C. Neira, Hugo M. Vargas, Alexander J. Pickrell, Jennifer E. Golden, Yang Xu, Victor J. Cee, Michael Schrag, Scot Middleton, Jian Lin, Yael Marantz, Andrea Itano, Mercedes Lobera, Han Xu, Brian A. Lanman, Michele McElvain, Janet Buys, Anu Gore, Srinivasa R Cheruku, Anurag Sharadendu, Mike Fiorino, Mike Frohn
مصطلحات موضوعية: Agonist, business.industry, medicine.drug_class, Lymphocyte, Sphingosine-1-phosphate receptor, Organic Chemistry, Inflammation, Pharmacology, Biochemistry, Minimal activity, Blood lymphocyte, chemistry.chemical_compound, medicine.anatomical_structure, Benzothiazole, chemistry, Drug Discovery, medicine, medicine.symptom, business, Lead compound
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4114b66ba763963fd644e7ff1f508317Test
https://europepmc.org/articles/PMC4018108Test/