المؤلفون: Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.

المصدر: Cell Stem Cell ; volume 26, issue 3, page 458 ; ISSN 1934-5909

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Medicine

الإتاحة: https://doi.org/10.1016/j.stem.2020.01.015Test
https://api.elsevier.com/content/article/PII:S1934590920300151?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1934590920300151?httpAccept=text/plainTest

المؤلفون: Oh, Hidemasa, Bradfute, Steven B., Gallardo, Teresa D., Nakamura, Teruya, Gaussin, Vinciane, Mishina, Yuji, Pocius, Jennifer, Michael, Lloyd H., Behringer, Richard R., Garry, Daniel J., Entman, Mark L., Schneider, Michael D.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2003 Oct . 100(21), 12313-12318.

الوصول الحر: https://www.jstor.org/stable/3147948Test

المؤلفون: Oh, Hidemasa, Wang, Sam C., Prahash, Arun, Sano, Motoaki, Moravec, Christine S., Taffet, George E., Michael, Lloyd H., Youker, Keith A., Entman, Mark L., Schneider, Michael D.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2003 Apr . 100(9), 5378-5383.

الوصول الحر: https://www.jstor.org/stable/3139720Test

المؤلفون: Dewald, Oliver, Frangogiannis, Nikolaos G., Zoerlein, Martin, Duerr, Georg D., Klemm, Christina, Knuefermann, Pascal, Taffet, George, Michael, Lloyd H., Crapo, James D., Welz, Armin, Entman, Mark L.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2003 Mar 01. 100(5), 2700-2705.

الوصول الحر: https://www.jstor.org/stable/3139591Test

المؤلفون: Minamino, Tetsuo, Yujiri, Toshiaki, Terada, Naohiro, Taffet, George E., Michael, Lloyd H., Johnson, Gary L., Schneider, Michael D.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2002 Mar . 99(6), 3866-3871.

الوصول الحر: https://www.jstor.org/stable/3058218Test

المؤلفون: Oh, Hidemasa, Taffet, George E., Youker, Keith A., Entman, Mark L., Overbeek, Paul A., Michael, Lloyd H., Schneider, Michael D.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2001 Aug . 98(18), 10308-10313.

الوصول الحر: https://www.jstor.org/stable/3056525Test

المؤلفون: Kurrelmeyer, Karla M., Michael, Lloyd H., Baumgarten, Georg, Taffet, George E., Peschon, Jacques J., Sivasubramanian, Natarajan, Entman, Mark L., Mann, Douglas L.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2000 May 01. 97(10), 5456-5461.

الوصول الحر: https://www.jstor.org/stable/122355Test

المؤلفون: Fiedler, Lorna R., Chapman, Kathryn, Xie, Min, Maifoshie, Evie, Jenkins, Micaela, Golforoush, Pelin Arabacilar, Bellahcene, Mohamed, Noseda, Michela, Faust, Dörte, Jarvis, Ashley, Newton, Gary, Paiva, Marta Abreu, Harada, Mutsuo, Stuckey, Daniel J., Song, Weihua, Habib, Josef, Narasimhan, Priyanka, Aqil, Rehan, Sanmugalingam, Devika, Yan, Robert, Pavanello, Lorenzo, Sano, Motoaki, Wang, Sam C., Sampson, Robert D., Kanayaganam, Sunthar, Taffet, George E., Michael, Lloyd H., Entman, Mark L., Tan, Tse-Hua, Harding, Sian E., Low, Caroline M.R., Tralau-Stewart, Catherine, Perrior, Trevor, Schneider, Michael D.

المساهمون: BHF, European Commission, European Research Council, MRC-BHF Cardiovascular Stem Cell Research Strategic Development Grant, MRC-Imperial Confidence in Concept Fund, NIH, Wellcome Trust

المصدر: Cell Stem Cell ; volume 24, issue 4, page 579-591.e12 ; ISSN 1934-5909

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Medicine

الإتاحة: https://doi.org/10.1016/j.stem.2019.01.013Test
https://api.elsevier.com/content/article/PII:S193459091930013X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S193459091930013X?httpAccept=text/plainTest

المؤلفون: Thompson, William A., Ferry, Pamela G., King, Jason E., Martinez-Wedig, Cindy, Michael, Lloyd H.

المصدر: Academic Medicine. May 2003 78(5):454-459.

تمت مراجعته من قبل الزملاء: Y

Page Count: 6

الواصفات: Cultural Pluralism, Developmental Studies Programs, Diversity (Student), Higher Education, Hispanic American Students, Medical Education, Medical Schools, Minority Groups, Program Descriptions, Student Recruitment

مستخلص: Describes the Premedical Honors College (PHC), an eight-year, BS-MD program created by Baylor College of Medicine and the University of Texas-Pan American to increase the number of physicians addressing underserved populations in Texas. An outcomes study comparing PHC matriculants with students of similar academic ability, ethnicity, and interest in medicine revealed that the odds of medical school matriculation were seven times higher for PHC students than for non-PHC students. (EV)

المؤلفون: Durgan, David J., Pulinilkunnil, Thomas, Villegas-Montoya, Carolina, Garvey, Merissa E., Frangogiannis, Nikolaos G., Michael, Lloyd H., Chow, Chi-Wing, Dyck, Jason R.B., Young, Martin E.

المصدر: Circulation Research ; volume 106, issue 3, page 546-550 ; ISSN 0009-7330 1524-4571

الوصف: Rationale : Cardiovascular physiology and pathophysiology vary dramatically over the course of the day. For example, myocardial infarction onset occurs with greater incidence during the early morning hours in humans. However, whether myocardial infarction tolerance exhibits a time-of-day dependence is unknown. Objective : To investigate whether time of day of an ischemic insult influences clinically relevant outcomes in mice. Methods and Results : Wild-type mice were subjected to ischemia/reperfusion (I/R) (45 minutes of ischemia followed by 1 day or 1 month of reperfusion) at distinct times of the day, using the closed-chest left anterior descending coronary artery occlusion model. Following 1 day of reperfusion, hearts subjected to ischemia at the sleep-to-wake transition (zeitgeber time [ZT]12) resulted in 3.5-fold increases in infarct size compared to hearts subjected to ischemia at the wake-to-sleep transition (ZT0). Following 1 month of reperfusion, prior ischemic event at ZT12 versus ZT0 resulted in significantly greater infarct volume, fibrosis, and adverse remodeling, as well as greater depression of contractile function. Genetic ablation of the cardiomyocyte circadian clock (termed cardiomyocyte-specific circadian clock mutant [CCM] mice) attenuated/abolished time-of-day variations in I/R outcomes observed in wild-type hearts. Investigation of Akt and glycogen synthase kinase-3β in wild-type and CCM hearts identified these kinases as potential mechanistic ties between the cardiomyocyte circadian clock and I/R tolerance. Conclusions : We expose a profound time-of-day dependence for I/R tolerance, which is mediated by the cardiomyocyte circadian clock. Further understanding of I/R tolerance rhythms will potentially provide novel insight regarding the etiology and treatment of ischemia-induced cardiac dysfunction.

الإتاحة: https://doi.org/10.1161/circresaha.109.209346Test