نتائج البحث - "Meyer, Fredric B."

1

دورية أكاديمية

Patients with Carotid Intraplaque Hemorrhage Have Higher Incidence of Cerebral Microbleeds

المؤلفون: Nardi, Valentina, Benson, John C, Saba, Luca, Bois, Melanie C, Meyer, Fredric B, Lanzino, Giuseppe, Lerman, Lilach O, Lerman, Amir

المساهمون: Nardi, Valentina, Benson, John C, Saba, Luca, Bois, Melanie C, Meyer, Fredric B, Lanzino, Giuseppe, Lerman, Lilach O, Lerman, Amir

الوصف: Aims: Carotid intraplaque hemorrhage (IPH) is considered a marker of plaque vulnerability. Cerebral microbleeds (CMBs) are recognized on magnetic resonance imaging (MRI) in patients with cerebrovascular disease. Any connection between carotid IPH and CMBs remains scantly investigated. This study aimed to determine whether the histologic evidence of carotid IPH is related to CMBs. Methods: We retrospectively enrolled 101 consecutive patients undergoing carotid endarterectomy with symptomatic (ischemic stroke, TIA, and amaurosis fugax) or asymptomatic ipsilateral carotid artery disease. The presence and the extent (%) of IPH were identified on carotid plaques stained with Movat Pentachrome. CMBs were localized on T2*-weighted gradient-recalled echo or susceptibility-weighted imaging sequence on brain MRI before surgery. The degree of carotid stenosis was measured by neck CTA. Results: IPH was identified in 57 (56.4%) patients, and CMBs were found in 24 (23.7%) patients. CMBs were more commonly observed in patients with carotid IPH compared to those without [19 (33.3%) vs 5 (11.4%); P=0.010]. The carotid IPH extent was significantly higher in patients with CMBs than in those without [9.0 % (2.8-27.1%) vs 0.9% (0.0-13.9%); P=0.004] and was associated with the number of CMBs (P=0.004). Logistic regression analysis demonstrated an independent association between carotid IPH extent and the presence of CMBs [OR 1.051 (95% CI 1.012-1.090); P=0.009]. Additionally, patients with CMBs had a lower degree of ipsilateral carotid stenosis compared to those without [40% (35-65%) vs 70% (50-80%); P=0.049]. Conclusions: CMBs may be potential markers of the ongoing process of carotid IPH, especially in those with nonobstructive plaques.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37172877; info:eu-repo/semantics/altIdentifier/wos/WOS:000894947901188; volume:48; issue:9; numberofpages:22; journal:CURRENT PROBLEMS IN CARDIOLOGY; https://hdl.handle.net/11584/365791Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85161276172

الإتاحة: https://doi.org/10.1016/j.cpcardiol.2023.101779Test
https://hdl.handle.net/11584/365791Test

View record in BASE

2

مؤتمر

Machine Learning-Based Model to Predict Long-Term Tumor Control and Additional Interventions following Pituitary Surgery

المؤلفون: Shinya, Yuki, Ghaith, Abdul Karim, Atkinson, John L., Meyer, Fredric B., Link, Michael J., Pollock, Bruce E., Celda, Maria Peris, Bydon, Mohamad, Neto, Carlos D. Pinheiro, Bancos, Irina, Davidge-Pitts, Caroline J., Herndon, Justine S., Erickson, Dana, Bon-Nieves, Antonio, Hong, Sukwoo, Van Gompel, Jamie J.

المصدر: 33rd Annual Meeting North American Skull Base Society ; Journal of Neurological Surgery Part B: Skull Base ; ISSN 2193-634X

الإتاحة: https://doi.org/10.1055/s-0044-1780007Test

View record in BASE

3

دورية أكاديمية

Letter: Visual Field Defects in the Setting of Suprasellar Lesions: Could Vascularization Patterns of the Optic Chiasm Play a Role?

المؤلفون: Agosti, Edoardo, Alexander, A. Yohan, Pinheiro-Neto, Carlos D., Link, Michael J., Meyer, Fredric B., Peris-Celda, Maria

المساهمون: Agosti, Edoardo, Alexander, A. Yohan, Pinheiro-Neto, Carlos D., Link, Michael J., Meyer, Fredric B., Peris-Celda, Maria

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35876674; info:eu-repo/semantics/altIdentifier/wos/WOS:000837297300009; volume:91; issue:3; firstpage:e102; lastpage:e103; journal:NEUROSURGERY; https://hdl.handle.net/11379/591164Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85135599346

الإتاحة: https://doi.org/10.1227/neu.0000000000002069Test
https://hdl.handle.net/11379/591164Test

View record in BASE

4

دورية أكاديمية

Recognized focused practice: Does sub-specialty designation offer value to the neurosurgeon?

المؤلفون: Babu, Maya A, Liau, Linda M, Meyer, Fredric B

المصدر: PLOS ONE. 12(12)

مصطلحات موضوعية: Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Neurosciences, Pediatric, Adult, Aged, 80 and over, Humans, Middle Aged, Neurosurgeons, United States, General Science & Technology

الوصف: Vehicles for life-long assessment such as Maintenance of Certification tend to focus on generalist neurosurgical knowledge. However, as neurosurgeons advance in their careers, they tend to narrow their practice and increase volumes in certain specific types of operations. Failing to test the type of procedures most relevant to the practitioner is a lost opportunity to improve the knowledge and practice of the individual neurosurgeon. In this study, we assess the neurosurgical community's appetite for designations of board-recognized Recognized Focused Practice (RFP). We administered a validated, online, confidential survey to 4,899 neurosurgeons (2,435 American Board of Neurological Surgery (ABNS) Diplomates participating in MOC, 1,440 Diplomates certified prior to 1999 (grandfathered), and 1,024 retired Diplomates). We received 1,449 responses overall (30% response rate). A plurality of respondents were in practice 11-15 years (18.5%), in private practice (40%) and participate in MOC (61%). 49% of respondents felt that a RFP designation would not be helpful. For the 30% who felt that RFP would be helpful, 61.3% felt that it would support recognition by their hospital or practice, it would motivate them to stay current on medical knowledge (53.4%), or it would help attract patients (46.4%;). The most popular suggestions for RFP were Spine (56.2%), Cerebrovascular (62.9%), Pediatrics (64.1%), and Functional/Stereotactic (52%). A plurality of neurosurgeons (35.7%) felt that RFP should recognize neurosurgeons with accredited and non-accredited fellowship experience and sub-specialty experience. Ultimately, Recognized Focused Practice may provide value to individual neurosurgeons, but the neurosurgical community shows tepid interest for pursuing this designation.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6n5312n5Test

View record in eScholarship

5

دورية أكاديمية

Reliability and Predictors of Intraoperative Neuromonitoring Changes During Intramedullary Tumor Resection: A Multicenter Experience

المؤلفون: Otamendi-Lopez, Andrea, Akinduro, Oluwaseun O., de Macedo Filho, Leonardo, Goyal, Anshit, De Biase, Gaetano, Ghaith, Abdul Karim, McKevitt, Chase, Kalani, Maziyar A., Meyer, Fredric B., Marsh, W. Richard, Clarke, Michelle J., Krauss, William E., Bydon, Mohamad, Quinones-Hinojosa, Alfredo

المصدر: Neurosurgery ; volume 70, issue Supplement_1, page 206-207 ; ISSN 0148-396X 1524-4040

الوصف: INTRODUCTION: Intraoperative neuromonitoring (IONM) is used in real-time to alert neurosurgeons of potential neurological changes when resecting intramedullary spinal cord tumors (IMSCTs). Previous studies have reported variable reliability of IONM. METHODS: A multicenter retrospective study was performed on patients undergoing IMSCTs surgery with neuromonitoring at the three Mayo Clinic sites between 2005 to 2022. Demographics, SSEP, MEP changes and postoperative outcomes were recorded. Specificity, sensitivity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Variables found significant on univariate analysis (p < 0.05) were applied to a multivariate model to identify predictors for IONM SSEP and MEP changes. RESULTS: 135 patients underwent surgical resection for IMSCTs using IONM. The mean age at diagnosis was 45 ± 17.9 years. Laminectomy was the most frequent index operation (96.3%). A total of 8.9% of patients presented with short-term improvement, while 70.4% presented long-term improvement on their baseline McCormick Scale. Sensitivity, specificity, PPV, NPV, accounted for 86.2%, 51%, 5.2%, 99.2% for MEP; 77.8%, 48.2%, 4.4%, 98.6% for SSEP. We found predictors of IONM changes: poorly defined MEP baseline (OR 3.004, 95% CI 1.22-7.397, p = 0.017), WHO grade II tumors (OR 2.334, 95% CI 1.043-5.223, p = 0.039), cervicomedullary junction location (OR 0.103, 95% CI 0.011-0.983, p = 0.048). Only WHO grade II tumors (OR 2.85, 95% CI 1.208-6.727, p = 0.017) was a predictor for SSEP changes. CONCLUSIONS: Our study represents the largest cohort describing sensitivity, specificity, and predictive factors for intraoperative changes and postoperative outcomes of resection of IMSCTs. A poorly defined baseline and cervicomedullary tumor location were predictors of IONM MEP changes, whiIe WHO grade II tumors were a predictor for both IONM SSEP and MEP changes.

الإتاحة: https://doi.org/10.1227/neu.0000000000002810_123Test

View record in BASE

6

دورية أكاديمية

In Reply: Commentary: Letter: Visual Field Defects in the Setting of Suprasellar Lesions: Could Vascularization Patterns of the Optic Chiasm Play a Role?

المؤلفون: Agosti, Edoardo, Alexander, A. Yohan, Pinheiro-Neto, Carlos D., Link, Michael J., Meyer, Fredric B., Peris-Celda, Maria

المصدر: Neurosurgery ; volume 94, issue 5, page e83-e83 ; ISSN 0148-396X 1524-4040

الإتاحة: https://doi.org/10.1227/neu.0000000000002909Test

View record in BASE

7

دورية أكاديمية

431 The Role of Stroke Prophylaxis in Traumatic Vertebral Artery Injury: A Literature-Based Cohort Study

المؤلفون: Bambakidis, Peter, Katsos, Konstantinos, Michalopoulos, Giorgos, Pennington, Zach, Lakomkin, Nikita, Meyer, Fredric B., Bydon, Mohamad

المصدر: Neurosurgery ; volume 70, issue Supplement_1, page 131-131 ; ISSN 0148-396X 1524-4040

الوصف: INTRODUCTION: Vertebral artery injury (VAI) can precipitate posterior circulation strokes acutely following blunt trauma. VAI severity is conventionally classified by the Denver grading system, but at present, there remain no guidelines that translate Denver injury grade to antiplatelet or anticoagulant recommendations. METHODS: Four databases (Ovid MEDLINE, Ovid Embase, Cochrane Central, and Scopus) were queried to identify all studies evaluating stroke risk following blunt VAI. Stroke rates following VAI were compared for patients managed with observation only or antiplatelets. Sub-analyses stratifying outcomes by injury severity (Denver grade) were performed. Effectiveness of antiplatelet use was summarized by the number needed to prevent (NNP) post-VAI stroke. RESULTS: Of 2,256 unique studies identified, 34 comprising 1,138 patients were incluced. Overall VAI-related stroke risk was 1.75% before admission and 3.40% after admission. Grades I and II had a cumulative stroke risk of 2.43% (95% CI: 0.98-4.94), which differed significantly (p < 0.01) from Grade IV-associated risk (10.10%; 95% CI: 4.95-17.79). Overall stroke risk in patients without prophylactic treatment was 10.00% (95% CI: 9.07-10.9), and 0.43% (95% CI: 0.01-1.06) in their counterparts who received antiplatelets (NNP = 10). Patients with grade I-II VAI receiving no treatment had 5.19% (95% CI: 1.43-12.77) stroke risk compared to 0.55% (95% CI: 0.01-3.02) treated with antiplatelet agents (NNP = 22). Among grade IV VAI, the stroke risk among patients that received no treatment was 21.21% (95% CI: 8.98-38.91), while none of the patients that received antiplatelet therapy developed stroke (NNP = 5). CONCLUSIONS: The majority of VAI-related stroke occurs after initial presentation, suggesting a potential for prevention of post-VAI stroke. Antiplatelet treatment was associated with significantly lower odds of post-VAI stroke among patients with Grade I, II, or IV injury, with the impact increasing within injury grade. The results suggest the ...

الإتاحة: https://doi.org/10.1227/neu.0000000000002809_431Test

View record in BASE