المؤلفون: Damla Cetinkaya Tezer, Ayşegül Gündüz, Melih Tütüncü, Mehmet Ali Akalın, Nurten Uzun Adatepe, Feray Karaali Savrun, Meral Erdemir Kızıltan

المصدر: Neurological Sciences and Neurophysiology, Vol 39, Iss 1, Pp 14-20 (2022)

مصطلحات موضوعية: chronic inflammatory demyelinating polyneuropathy, hereditary neuropathy, myoclonus, polyneuropathy, tremor, Neurology. Diseases of the nervous system, RC346-429

الوصف: Objective: Our goal was to identify the frequency and types of involuntary movements in immune mediated and hereditary polyneuropathies. Methods: In this prospective study, we included all consecutive patients with immune mediated or hereditary polyneuropathy between January 2017 and November 2019. The presence and type of the involuntary movements were determined by the clinical examination and multichannel surface electromyography. Results: We identified 23 (48.9%) patients with involuntary movements among 47 patients with immune mediated or hereditary polyneuropathy in the study period. All patients with an involuntary movement had postural tremor with accompanying action and/or rest tremor. Short duration and high-amplitude myoclonus was accompanying in 18 (38.3%) patients. The demographic and clinical characteristics and features of nerve conduction studies were similar between patients with and without involuntary movements. Discussion: Tremor and myoclonus were frequent in our cohort. Postural tremor was the most frequent subtype. There was no significant relationship between myoclonus or tremor and clinical/electrophysiological features. Conclusion: For assessing movement disorders in polyneuropathies not only clinical examination, but also electrophysiological studies such as multichannel surface electromyography should be used.

وصف الملف: electronic resource

العلاقة: http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2022;volume=39;issue=1;spage=14;epage=20;aulast=TezerTest; https://doaj.org/toc/2636-865XTest

الوصول الحر: https://doaj.org/article/6808947403504dcbb867a68ac3dcab93Test

المؤلفون: Yeşim Gülen Abanoz, Yasin Abanoz, Yasemin Akıncı, Ayşegül Gündüz, Eser Buluş, Melih Tütüncü, Sabahattin Saip, Meral Erdemir Kızıltan

المصدر: Türk Nöroloji Dergisi, Vol 24, Iss 3, Pp 243-247 (2018)

مصطلحات موضوعية: Posterior auricular muscle response, blink reflex, brainstem, multiple sclerosis, stroke, Medicine, Neurology. Diseases of the nervous system, RC346-429

الوصف: Objective: Posterior auricular muscle response (PAMR) is a myogenic potential recorded over PAM after auditory stimulation. Its circuit is formed by cochlear and facial nerves with the generator in the brainstem. Here, we investigated whether the addition of a PAMR examination would add additional use in determining or localizing isolated brainstem lesions given that the importance of blink reflex (BR) in determining or localizing brainstem lesions is known. Our hypothesis was that examination of both reflexes would increase clinical utility. Materials and Methods: We included 34 patients with isolated brainstem lesions (multiple sclerosis, ischemic stroke and cerebellopontine angle schwannoma) and 41 healthy subjects. PAMRs were recorded over the PAM after auditory stimulation. BR was elicited by the electrical stimulation of the supraorbital nerve. Results: PAMR was present in 82.9% of healthy subjects, whereas the presence was quite low in the patient group (38.2%, p=0.001). The mean latency of PAMR was delayed in patients compared with healthy subjects (p=0.001). BR was obtained in all healthy subjects, whereas prolonged latencies or absence of BR was observed in the patient group. There were no differences according to the different etiologies or localization. Conclusion: Although the presence of PAMR is quite high, its absence does not always indicate a pathology. However, prolonged latencies almost always suggest an involvement of the PAMR pathway. Likewise, absent PAMR with an abnormal BR provides information for the involvement of brainstem facial nucleus or the proximal part of the facial nerve.

وصف الملف: electronic resource

العلاقة: http://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-57255Test; https://doaj.org/toc/1301-062XTest; https://doaj.org/toc/1309-2545Test

الوصول الحر: https://doaj.org/article/e8efdb1ba34645f590c64d1e64186440Test

المؤلفون: Merve Çebi, Hacer Durmus, Fikret Aysal, Berker Özkan, Gizem Engin Gül, Arman Çakar, Mehmet Hocaoglu, Metin Mercan, Sibel P. Yentür, Melih Tütüncü, Vildan Yayla, Onur Akan, Öner Dogan, Yeşim Parman, Güher Saruhan-Direskeneli

المصدر: Frontiers in Immunology, Vol 11 (2020)

مصطلحات موضوعية: T follicular helper cells, PD-1, ICOS, IL-21, IL-4, IL-17, Immunologic diseases. Allergy, RC581-607

الوصف: Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies predominantly against the acetylcholine receptor (AChR). Specific T cell subsets are required for long-term antibody responses, and cytokines secreted mainly from CD4+ T cells regulate B cell antibody production. The aim of this study was to assess the differences in the cytokine expressions of CD4+ T cells in MG patients with AChR antibodies (AChR-MG) and the effect of immunosuppressive (IS) therapy on cytokine activity and to test these findings also in MG patients without detectable antibodies (SN-MG). Clinically diagnosed AChR-MG and SN-MG patients were included. The AChR-MG patients were grouped as IS-positive and -negative and compared with age- and sex-matched healthy controls. Peripheral blood mononuclear cells were used for ex vivo intracellular cytokine production, and subsets of CD4+ T cells and circulating follicular helper T (cTfh) cells were detected phenotypically by the expression of the chemokine and the costimulatory receptors. Thymocytes obtained from patients who had thymectomy were also analyzed. IL-21, IL-4, IL-10, and IL-17A productions in CD4+ T cells were increased in AChR-MG compared to those in healthy controls. IS treatment enhanced IL-10 and reduced IFN-γ production in AChR-MG patients compared to those in IS-negative patients. Increased IL-21 and IL-4 productions were also demonstrated in SN-MG patients. Among CD4+ T cells, Th17 cells were increased in both disease subgroups. Treatment induced higher proportions of Th2 cells in AChR-MG patients. Both CXCR5+ and CXCR5− CD4+ T cells expressed higher programmed cell death protein 1 (PD-1) and inducible costimulatory (ICOS) in AChR-MG and SN-MG groups, mostly irrespective of the treatment. Based on chemokine receptors on CXCR5+PD-1+ in CD4+ T (cTfh) cells, in AChR-MG patients without treatment, the proportions of Tfh17 cells were higher than those in the treated group, whereas the Tfh1 cells were decreased compared with those in the controls. The relevance of CXCR5 and PD-1 in the pathogenesis of AChR-MG was also suggested by the increased presence of these molecules on mature CD4 single-positive thymocytes from the thymic samples. The study provides further evidence for the importance of IL-21, IL-17A, IL-4, and IL-10 in AChR-MG. Disease-related CD4+T cells are identified mainly as PD-1+ or ICOS+ with or without CXCR5, resembling cTfh cells in the circulation or probably in the thymus. AChR-MG and SN-MG seem to have some similar characteristics. IS treatment has distinctive effects on cytokine expression.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fimmu.2020.00809/fullTest; https://doaj.org/toc/1664-3224Test

الوصول الحر: https://doaj.org/article/3433655cfa5e48098fc6b896eeae965eTest

المؤلفون: Melih Tütüncü, Gülçin Benbir Şenel, Burcu Zeydan, Derya Karadeniz, Hülya Apaydın

المصدر: Türk Uyku Tıbbı Dergisi, Vol 5, Iss 2, Pp 46-49 (2018)

مصطلحات موضوعية: Sleep-related violence, sleep disorders, parasomnia, epilepsy, polysomnography, Medicine, Medicine (General), R5-920

الوصف: Parasomnia constitutes an important group among the situations that can lead to sleep-related violence scene. Parasomnia attacks are characterized by complex motor behaviors of various degrees, violent behaviors may result in life-threatening and rarely lethal conditions for patients and their relatives. Here is presented a patient with right temporoparietal bone fracture, pneumocephalus and hemotympanum in right ear due to head trauma during a parasomnia attack. The diagnosis could be made by a detailed history taking and polysomnography only after many other investigations. In this context, we aimed to emphasize that not only nocturnal epilepsies, especially frontal lobe epilepsies, but also parasomnia attacks should be kept in mind in differential diagnosis of sleep-related violence.

وصف الملف: electronic resource

العلاقة: http://jtsm.org/archives/archive-detail/article-preview/relationship-between-sleep-related-violence-and-nr/19840Test; https://doaj.org/toc/2148-1504Test

الوصول الحر: https://doaj.org/article/4bdd39b8b83e4b26af40cb307a56e72dTest

المؤلفون: Ezel Erşen, Burcu Kılıç, Hasan Volkan Kara, Mehlika İşcan, İsmail Sarbay, Ahmet Demirkaya, Selim Bakan, Melih Tütüncü, Akif Turna, Kamil Kaynak

المصدر: Videosurgery and Other Miniinvasive Techniques, Vol 13, Iss 3, Pp 376-382 (2018)

مصطلحات موضوعية: video-assisted thoracoscopic surgery, thymus, myasthenia graves, thymoma, open surgery, Medicine

وصف الملف: electronic resource

العلاقة: https://www.termedia.pl/Comparative-study-of-video-assisted-thoracoscopic-surgery-versus-open-thymectomy-for-thymoma-and-myasthenia-gravis,42,32803,1,1.htmlTest; https://doaj.org/toc/1895-4588Test; https://doaj.org/toc/2299-0054Test

الوصول الحر: https://doaj.org/article/11ce93311ae6499bb9a5d8ea5d2eaf10Test

المؤلفون: Barış Metin, Melih Tütüncü, Derya Kaynak, Hakan Kaynak

المصدر: Türk Nöroloji Dergisi, Vol 13, Iss 2, Pp 127-130 (2007)

مصطلحات موضوعية: WD has the potential to disrupt sleep regulatory mechanisms and to cause sleep disturbances like other neurodegenerative diseases. Sleep in WD has not been extensively studied before. OBJECTIVES: A late onset WD patient who applied to our out-patient clinic for sleep related problems has been extensively evaluated with clinical and laboratory measures. MATERIALS-METHODS: We performed three polysomnographic evaluations, one followed by continuous daytime recording. RESULTS: We diagnosed various abnormalities including breathing, Wilson’s disase, sleep, polysomnography, Medicine, Neurology. Diseases of the nervous system, RC346-429

الوصف: Scientific BACKGROUND: Wilson’s disease (WD) is an autosomal recessive degenerative disorder of copper metabolism. As a degenerative disease affecting many parts of CNS, WD has the potential to disrupt sleep regulatory mechanisms and to cause sleep disturbances like other neurodegenerative diseases. Sleep in WD has not been extensively studied before. OBJECTIVES: A late onset WD patient who applied to our out-patient clinic for sleep related problems has been extensively evaluated with clinical and laboratory measures. MATERIALS-METHODS: We performed three polysomnographic evaluations, one followed by continuous daytime recording. RESULTS: We diagnosed various abnormalities including breathing, circadian rhythm and movement disorders related to sleep. CONCLUSIONS: Sleep disorders in WD might be a major contributor to morbidity and mortality

وصف الملف: electronic resource

العلاقة: https://www.journalagent.com/tjn/pdfs/TJN_13_2_127_130.pdfTest; https://doaj.org/toc/1301-062XTest; https://doaj.org/toc/1309-2545Test

الوصول الحر: https://doaj.org/article/c6df4fb35bc1469b8b9eaadf824654fdTest

المؤلفون: Timucin Avsar, İlknur Melis Durası, Uğur Uygunoğlu, Melih Tütüncü, Nuri Onat Demirci, Sabahattin Saip, O Uğur Sezerman, Aksel Siva, Eda Tahir Turanlı

المصدر: PLoS ONE, Vol 10, Iss 5, p e0122045 (2015)

مصطلحات موضوعية: Medicine, Science

الوصف: Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS) with a heterogeneous clinical presentation and course. There is a remarkable phenotypic heterogeneity in MS, and the molecular mechanisms underlying it remain unknown. We aimed to investigate further the etiopathogenesis related molecular pathways in subclinical types of MS using proteomic and bioinformatics approaches in cerebrospinal fluids of patients with clinically isolated syndrome, relapsing remitting MS and progressive MS (n=179). Comparison of disease groups with controls revealed a total of 151 proteins that are differentially expressed in clinically different MS subtypes. KEGG analysis using PANOGA tool revealed the disease related pathways including aldosterone-regulated sodium reabsorption (p=8.02x10-5) which is important in the immune cell migration, renin-angiotensin (p=6.88x10-5) system that induces Th17 dependent immunity, notch signaling (p=1.83x10-10) pathway indicating the activated remyelination and vitamin digestion and absorption pathways (p=1.73x10-5). An emerging theme from our studies is that whilst all MS clinical forms share common biological pathways, there are also clinical subtypes specific and pathophysiology related pathways which may have further therapeutic implications.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4420287?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/06e768ed585c4ccdb304110374274f75Test

المؤلفون: Uğur Uygunoğlu, Melih Tütüncü

المصدر: Türk Nöroloji Dergisi, Vol 22, Iss 2, Pp 97-98 (2016)

مصطلحات موضوعية: Medicine, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

العلاقة: http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-88896Test; https://doaj.org/toc/1301-062XTest

الوصول الحر: https://doaj.org/article/34dee8bbd4bb4375a8f925c2cca623c3Test

المؤلفون: Ceren Bibinoğlu Amirov, Sema Saltık, Cengiz Yalçınkaya, Melih Tütüncü, Sabahattin Saip, Aksel Siva, Uğur Uygunoğlu

المصدر: European Journal of Paediatric Neurology. 43:1-5

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health, Neurology (clinical), General Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::44e65357848fa09782a1db1751b58408Test
https://doi.org/10.1016/j.ejpn.2023.01.011Test

المؤلفون: Melih Tütüncü, Serkan Demir, Gökhan Arslan, Öykü Dinç, Sedat Şen, Tuncay Gündüz, Cihat Uzunköprü, Haluk Gümüş, Mesude Tütüncü, Rüveyda Akçin, Serkan Özakbaş, Mesrure Köseoğlu, Sena Destan Bünül, Ozan Gezen, Damla Çetinkaya Tezer, Cavid Baba, Pınar Acar Özen, Rabia Koç, Tuğrul Elverdi, Uğur Uygunoğlu, Murat Kürtüncü, Yeşim Beckmann, İpek Güngör Doğan, Ömer Faruk Turan, Cavit Boz, Murat Terzi, Asli Tuncer, Sabahattin Saip, Rana Karabudak, Bekir Kocazeybek, Hüsnü Efendi, Uğur Bilge, Aksel Siva

مصطلحات موضوعية: Neurology, Neurology (clinical), General Medicine

الوصف: Background: COVID-19 vaccines are recommended for people with multiple sclerosis (pwMS). Adequate humoral responses are obtained in pwMS receiving disease-modifying therapies (DMTs) after vaccination, with the exception of those receiving B-cell-depleting therapies and non-selective S1P modulators. However, most of the reported studies on the immunity of COVID-19 vaccinations have included mRNA vaccines, and information on inactivated virus vaccine responses, long-term protectivity, and comparative studies with mRNA vaccines are very limited. Here, we aimed to investigate the association between humoral vaccine responses and COVID-19 infection outcomes following mRNA and inactivated virus vaccines in a large national cohort of pwMS receiving DMTs. Methods: This is a cross-sectional and prospective multicenter study on COVID-19-vaccinated pwMS. Blood samples of pwMS with or without DMTs and healthy controls were collected after two doses of inactivated virus (Sinovac) or mRNA (Pfizer-BioNTech) vaccines. PwMS were sub-grouped according to the mode of action of the DMTs that they were receiving. SARS-CoV-2 IgG titers were evaluated by chemiluminescent microparticle immunoassay. A representative sample of this study cohort was followed up for a year. COVID-19 infection status and clinical outcomes were compared between the mRNA and inactivated virus groups as well as among pwMS subgroups. Results: A total of 1484 pwMS (1387 treated, 97 untreated) and 185 healthy controls were included in the analyses (male/female: 544/1125). Of those, 852 (51.05%) received BioNTech, and 817 (48.95%) received Sinovac. mRNA and inactivated virus vaccines result in similar seropositivity; however, the BioNTech vaccination group had significantly higher antibody titers (7.175±10.074) compared with the Sinovac vaccination group (823±1.774) (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1944fc2585d69f26fdff210c2db9d0Test
https://avesis.deu.edu.tr/publication/details/e5b3fb6b-a010-478f-a08d-7bdb7bdc68dd/oaiTest