المؤلفون: Toshihiro Takai

المصدر: The Journal of dermatologyREFERENCES. 48(1)

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Skin Neoplasms, Melanoma in situ, Dermatology, Sarcoidal Granuloma, Diagnosis, Differential, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, neoplasms, Melanoma, Histiocyte, Unusual case, Granuloma, business.industry, Epithelioid Melanoma, Histiocytes, General Medicine, medicine.disease, 030220 oncology & carcinogenesis, Sarcoidosis, business

الوصف: Malignant melanoma is known to show diverse cellular morphologies, including a histiocyte-like morphology. Therefore, many non-melanocytic proliferations or infiltrates can mimic melanoma, and be confusing especially when they coexist with a true melanoma. Herein, we report an unusual case of a melanoma in situ with an underlying sarcoidal granuloma, which mimicked dermal invasion of melanoma. This case expands insight into non-neoplastic lesions closely mimicking melanoma.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4368775d8768c05cc61ca4f640f9b8b6Test
https://pubmed.ncbi.nlm.nih.gov/32940353Test

المؤلفون: Massimiliano Scalvenzi, Alessia Villani, Gabriella Fabbrocini, Claudia Costa, Eleonora Cinelli, Vincenzo Greco

المساهمون: Villani, A., Costa, C., Fabbrocini, G., Cinelli, E., Greco, V., Scalvenzi, M.

المصدر: International journal of dermatology. 59(12)

مصطلحات موضوعية: medicine.medical_specialty, Skin Neoplasms, business.industry, Melanoma, Incidence, Melanoma in situ, Dermatology, medicine.disease, Age Distribution, Italy, Epidemiology, medicine, Humans, Center (algebra and category theory), Registries, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec4d58d180a42cfbe49eb20025ff4bcTest
https://pubmed.ncbi.nlm.nih.gov/32597497Test

المؤلفون: Allison Crawford, Vijaya T. Daniel, Catarina I. Kiefe, Bassel H. Mahmoud

المصدر: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 47(1)

مصطلحات موضوعية: Male, medicine.medical_specialty, Skin Neoplasms, medicine.medical_treatment, Melanoma in situ, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Mohs surgery, Surveillance, Epidemiology, and End Results, Humans, Melanoma, business.industry, Hazard ratio, Extremities, General Medicine, Middle Aged, Thoracic Neoplasms, Mohs Surgery, Trunk, Confidence interval, United States, Surgery, 030220 oncology & carcinogenesis, Cohort, Female, Neoplasm Recurrence, Local, business, Carcinoma in Situ, SEER Program

الوصف: Background Recent studies demonstrate comparable outcomes of Mohs micrographic surgery (MMS) versus local excision (LE) for melanoma in situ. These studies are limited by their focus on the head and neck. Objective The primary objective was to compare 5-year overall and melanoma-specific mortality among patients with melanoma in situ of the trunk or extremities who undergo MMS versus LE. The secondary objective was to compare 5-year local recurrence among the same cohort of patients who undergo MMS versus LE. Materials and methods The Surveillance, Epidemiology, and End Results (SEER) database (2000-2015) was queried to identify patients who underwent MMS versus LE for melanoma in situ of the trunk, upper extremities, or lower extremities. Outcomes were 5-year recurrence, melanoma-specific mortality, and overall mortality. Multivariable regression analyses were performed. Results Thirty three thousand nine hundred eighty-three patients underwent surgical treatment (MMS 3%; LE 97%). In adjusted analyses, there was no difference in local recurrence (hazard ratio [HR] 1.00, 95% confidence interval [CI] 0.56-1.78), melanoma-specific mortality (HR 0.89, 95% CI 0.12-6.47), nor overall mortality (HR 1.10, 95% CI 0.82-1.48) between MMS versus LE. Conclusion There is no difference of 5-year local recurrence, melanoma-specific mortality, nor overall mortality associated with MMS versus LE for melanoma in situ of the trunk or extremities.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503b7c42aa462b0490b306354e8a732dTest
https://pubmed.ncbi.nlm.nih.gov/33347001Test

المؤلفون: Rajan Ramji, Marius Rademaker, Amanda Oakley

المصدر: Pigment cellmelanoma researchREFERENCES. 34(2)

مصطلحات موضوعية: 0301 basic medicine, In situ, Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Melanoma in situ, Positive control, Pattern analysis, Dermoscopy, Dermatology, Malignancy, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Multiple time, Medicine, Humans, Neoplasm Invasiveness, Melanoma, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Middle Aged, medicine.disease, Prognosis, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cohort, Female, business, Skin lesion, Carcinoma in Situ, Follow-Up Studies

الوصف: Sequential digital dermoscopic imaging (SDDI) compares surface microscopy images of skin lesions over multiple time points. We utilized a retrospective SDDI cohort to investigate the development of dermoscopic features associated with malignancy in melanoma in situ (MIS). A total of 124 in situ melanomas were assessed from 110 Caucasian patients aged ≥18 years, with ≥2 serial images obtained between 1999 and 2017 and followed for a mean 41 months (3-142). As a positive control group, 58 invasive melanomas from 53 patients were also reviewed. Change in MIS size or number of colours correlated to time (both p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bffc382ee3a1226b6be27b26fc35bfTest
https://pubmed.ncbi.nlm.nih.gov/32860494Test

المؤلفون: Asad Loya, Kevin Phan, Vignesh Ramachandran

المصدر: Cureus

مصطلحات موضوعية: medicine.medical_specialty, Dermatology, 030204 cardiovascular system & hematology, mis, survival, seer, head and neck, 03 medical and health sciences, Otolaryngology, melanoma in situ, 0302 clinical medicine, Internal medicine, Epidemiology, medicine, gender, database, business.industry, Proportional hazards model, Melanoma, Hazard ratio, General Engineering, association, Cancer, Retrospective cohort study, medicine.disease, Confidence interval, Otorhinolaryngology, Epidemiology/Public Health, business, 030217 neurology & neurosurgery

الوصف: Introduction While prior studies have addressed the gender-specific survival of malignant melanoma, such investigation is lacking for melanoma in situ (MIS) and for the sun-exposed head and neck areas. Understanding the role of patient characteristics on disease prognosis is essential in determining optimal patient treatment and follow-up. We conducted a retrospective cohort study of patients diagnosed with MIS of the head and neck to assess the association of gender with long-term survival. Methods First primary cases of MIS diagnosed between 1998 and 2015 were extracted from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database. Cox regression analysis adjusting for demographic, tumor, and treatment characteristics was used to evaluate all-cause and cancer-specific mortality risks. Results After adjusting for demographic, tumor, and treatment data, males demonstrated significantly poorer overall survival (hazard ratio [HR] 1.484; 95% confidence interval [CI] 1.332, 1.653; P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1ad05e5db06338bcb3ff57f6e3a25cTest
https://pubmed.ncbi.nlm.nih.gov/32190477Test

المؤلفون: Eugen Stancut, H. Harris Reynolds, C. Blake Phillips, Conway C. Huang, Peter G. Pavlidakey

المصدر: Journal of the American Academy of Dermatology. 83(4)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Skin Neoplasms, Biopsy, Melanoma in situ, Dermatologic Surgical Procedures, MEDLINE, Dermatology, Young Adult, Margin (machine learning), medicine, Humans, Neoplasm Invasiveness, Young adult, Melanoma, Permanent Section, Aged, Neoplasm Staging, Retrospective Studies, medicine.diagnostic_test, business.industry, Margins of Excision, Retrospective cohort study, Middle Aged, Head and Neck Neoplasms, Neoplasm staging, Female, Radiology, Neoplasm Recurrence, Local, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85657620a9c3f2a7962c38aac088b4c2Test
https://pubmed.ncbi.nlm.nih.gov/32473972Test

المؤلفون: Alon Scope, Margaret Oliviero, Katalin Ferenczi, Naiara Fraga-Braghiroli, Harold S. Rabinovitz, Jane M. Grant-Kels

المصدر: Journal of the American Academy of Dermatology. 83(4)

مصطلحات موضوعية: Reflectance confocal microscopy, Adult, Male, Pathology, medicine.medical_specialty, Round cells, Skin Neoplasms, Cross-sectional study, Melanoma in situ, Dermatology, law.invention, Diagnosis, Differential, 030207 dermatology & venereal diseases, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Confocal microscopy, law, Atypia, medicine, Humans, skin and connective tissue diseases, neoplasms, Melanoma, Aged, Retrospective Studies, Aged, 80 and over, Microscopy, Confocal, integumentary system, business.industry, Middle Aged, medicine.disease, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Langerhans Cells, Melanocytes, Female, Dermatopathology, business, Dysplastic Nevus Syndrome

الوصف: Melanoma in situ and dysplastic nevi with severe atypia present overlapping histopathologic features. Reflectance confocal microscopy findings can be integrated with the dermatopathology report to improve differentiation between melanoma and dysplastic nevi with severe atypia.To compare prevalence of reflectance confocal microscopy findings between melanoma in situ and dysplastic nevi with severe atypia.This retrospective observational study compared reflectance confocal microscopy findings in dermatopathologically diagnosed dysplastic nevi with severe atypia and melanoma in situ, collected between 2007 and 2017 at a private pigmented-lesion clinic. Concordant pathologic diagnosis was defined as unanimous agreement between 3 dermatopathologists who independently reviewed all cases; all other cases were classified as discordant.The study included 112 lesions, 62 concordant melanomas in situ, 28 concordant dysplastic nevi with severe atypia, and 22 discordant lesions. In comparing reflectance confocal microscopy findings in concordant cases, melanoma in situ showed more frequently than dysplastic nevi with severe atypia the presence of epidermal atypical melanocytes as round cells (19/62 vs 0/28; P .001) and dendritic cells (50/62 vs 6/28; P .001), as well as a diffuse distribution of epidermal atypical melanocytes (50/54 vs 3/6; P = .002). In contrast, dysplastic nevi with severe atypia showed the presence of dense melanocytic nests more frequently than melanoma in situ did (15/28 vs 14/62; P = .003).The study was based on a limited number of lesions originating from a single clinic.Reflectance confocal microscopy findings may help differentiate a subset of dysplastic nevi with severe atypia from melanoma in situ.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feab29bf69efff0eef7b3bfd582e033fTest
https://pubmed.ncbi.nlm.nih.gov/32442695Test

المؤلفون: Georgi Tchernev, Torello Lotti, James W. Patterson, Valeri Malev

المصدر: Dermatologic therapyREFERENCES. 33(2)

مصطلحات موضوعية: medicine.medical_specialty, Surgical margin, Skin Neoplasms, business.industry, Melanoma, Melanoma in situ, Cancer, Margins of Excision, Dermatology, General Medicine, Disease, medicine.disease, Primary tumor, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Current management, 030220 oncology & carcinogenesis, medicine, Humans, Surgical excision, Radiology, business, Dysplastic Nevus Syndrome

الوصف: Malignant melanoma is an oncologic disease, whose current management among others includes surgical and immunological therapy. According to the current recommendations of the American Joint Committee on Cancer, the surgical excision of the primary tumor should be performed in two operative sessions, which has several consequences. The following paper will present and discuss six cases of pigmented lesions and the advantages of the one-step melanoma surgery in their management.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bce4b28a054a04b16b118123213f7eTest
https://pubmed.ncbi.nlm.nih.gov/32043684Test

المؤلفون: Jorge Ocampo-Garza, Jorge Ocampo-Candiani

المصدر: Clinical Cases in Melanoma ISBN: 9783030508197

مصطلحات موضوعية: business.industry, Melanoma in situ, Fitzpatrick Skin Type III, Index finger, Right index finger, Anatomy, Asymptomatic, medicine.anatomical_structure, Female patient, medicine, medicine.symptom, Longitudinal melanonychia, business, Nail matrix

الوصف: A 52-year-old female patient, with Fitzpatrick skin type III, presented with a 1-year history of an asymptomatic band of longitudinal melanonychia affecting her right index finger. Physical examination revealed a 2 mm band of longitudinal melanonychia with homogenous pigmentation in the central part of the right index finger (Fig. 10.1). Dermoscopy showed a 2 mm regular, homogenous band and the micro-Hutchinson sign (Fig. 10.2).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::34bc30e2fc9ffa97b664c486e71b611fTest
https://doi.org/10.1007/978-3-030-50820-3_10Test

المؤلفون: Danica Tiodorovic

المصدر: Clinical Cases in Dermoscopy of Skin Cancers ISBN: 9783030294465

مصطلحات موضوعية: medicine.diagnostic_test, business.industry, Melanoma in situ, Irregular shape, Physical examination, Anatomy, Melanocytic nevus, medicine.disease, Lesion, medicine, Brown color, Surgical excision, Pigmented lesion, medicine.symptom, business

الوصف: A 35-year old lady was referred for a dermatological consultation due to a recently changing and long-standing melanocytic nevus, located on the patient’s left upper arm. The clinical examination of the lesion showed two shades of brown color, namely, light and darker brown, as well as the irregular shape of the lesion. The dermoscopic examination was performed and revealed a fine reticular pigment network, while in the central part, a prominent pigment network was noticed, leading to schedule a surgical excision and pathological examination, which revealed melanoma in situ.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::10b0999934b5a83a00e9f04dc0897e08Test
https://doi.org/10.1007/978-3-030-29447-2_16Test