المؤلفون: Matuozzo D., Talouarn E., Marchal A., Zhang P., Manry J., Seeleuthner Y., Zhang Y., Bolze A., Chaldebas M., Milisavljevic B., Gervais A., Bastard P., Asano T., Bizien L., Barzaghi F., Abolhassani H., Abou Tayoun A., Aiuti A., Alavi Darazam I., Allende L. M., Alonso-Arias R., Arias A. A., Aytekin G., Bergman P., Bondesan S., Bryceson Y. T., Bustos I. G., Cabrera-Marante O., Carcel S., Carrera P., Casari G., Chaibi K., Colobran R., Condino-Neto A., Covill L. E., Delmonte O. M., El Zein L., Flores C., Gregersen P. K., Gut M., Haerynck F., Halwani R., Hancerli S., Hammarstrom L., Hatipoglu N., Karbuz A., Keles S., Kyheng C., Leon-Lopez R., Franco J. L., Mansouri D., Martinez-Picado J., Metin Akcan O., Migeotte I., Morange P. -E., Morelle G., Martin-Nalda A., Novelli G., Novelli A., Ozcelik T., Palabiyik F., Pan-Hammarstrom Q., de Diego R. P., Planas-Serra L., Pleguezuelo D. E., Prando C., Pujol A., Reyes L. F., Riviere J. G., Rodriguez-Gallego C., Rojas J., Rovere-Querini P., Schluter A., Shahrooei M., Sobh A., Soler-Palacin P., Tandjaoui-Lambiotte Y., Tipu I., Tresoldi C., Troya J., van de Beek D., Zatz M., Zawadzki P., Al-Muhsen S. Z., Alosaimi M. F., Alsohime F. M., Baris-Feldman H., Butte M. J., Constantinescu S. N., Cooper M. A., Dalgard C. L., Fellay J., Heath J. R., Lau Y. -L., Lifton R. P., Maniatis T., Mogensen T. H., von Bernuth H., Lermine A., Vidaud M., Boland A., Deleuze J. -F., Nussbaum R., Kahn-Kirby A., Mentre F., Tubiana S., Gorochov G., Tubach F., Hausfater P., Al-Muhsen S., Al-Mulla F., Anderson M. S., Andreakos E., Feldman H. B., Belot A., Biggs C. M., Bogunovic D., Bondarenko A., Bousfiha A. A., Brodin P., Bustamante C. D., Chakravorty S., Christodoulou J., Desai M., Drolet B. A., Baghdadi J. E., Espinosa-Padilla S., Froidure A., Hagin D., Henrickson S. E., Hsieh E. W. Y., Husebye E., Imai K., Itan Y., Jarvis E. D., Karamitros T., Kisand K., Ku C. -L., Ling Y., Lucas C. L., Marodi L., Milner J. D., Mironska K., Morio T., Ng L. F. P., O'Farrelly C., Okada S., Planas A. M., Quintana-Murci L., Renia L., Resnick I., Sancho-Shimizu V., Sediva A., Seppanen M. R. J., Shcherbina A., Slaby O., Snow A. L., Spaan A. N., Tancevski I., Tangye S. G., Ramaswamy S., Turvey S. E., Uddin F., Uddin M. J., Vinh D. C., Casanova J. -L., Vacher Y., Gysembergh-Houal A., Demerville L., Chachoua A., Abad S., Abassi R., Abdellaoui A., Abdelmalek A., Abdoul H., Abergel H., Abeud F., Abgrall S., Abisror N., Adechian M., Aderdour N., Admane H. F., Adnet F., Afritt S., Agostini H., Aguilar C., Agut S., Aiello T. F., Kaci M. A., Oufella H. A., Ajeenthiravasan G., Alauzy V., Alby-Laurent F., Allard L., Alyanakian M. -A., Borrero B. A., Amam S., Amrouche L., Andronikof M., Anglicheau D., Anguel N., Annane D., Aounzou M., Aparicio C., Aratus G., Arlet J. -B., Arzoine J., Aslangul E., Assefi M., Aubry A., Audiffred L., Audureau E., Auger C. N., Auregan J. -C., Awotar C., Milla S. A., Azan D., Azemar L., Azzouguen B., Elrufaai M. B., Badsi A., Bakouboula P., Balcerowiak C., Balde F., Baldivia E., Bangamingo E. -F., Baptiste A., Baran-Marszak F., Barau C., Barget N., Baronnet F., Barthelemy R., Baudel J. -L., Baudry C., Baudry E., Beaugerie L., Belamri A., Belaube N., Belilita R., Bellassen P., Belmokhtar R., Beltran I., Benainous R., Benallaoua M., Benamouzig R., Benbara A., Benhida J., Benkhelouf A., Benlagha J., Benmostafa C., Benothmane S., Bentifraouine M., Berard L., Bernier Q., Berti E., Bertier A., Berton L., Bessis S., Beurton A., Bianco C., Bianquis C., Bidar F., Blanche P., Blayau C., Bleibtreu A., Blin E., Bloch-Queyrat C., Boissier M. -C., Bollens D., Bolzoni M., Bompard R., Bonnet N., Bonnouvrier J., Botha S., Boucenna W., Bouchama F., Bouchaud O., Bouchghoul H., Boudjebla T., Boudjema N., Bouffard C., Bougle A., Bouguerra M., Bouras L., Bourcier A., Durand A. B., Bourrier A., Bouscarat F., Bouvry D., Bouziri N., Bouzrara O., Bribier S., Brugier D., Brunel M., Bui E., Buisson A., Bukreyeva I., Bureau C., Cadranel J., Cailhol J., Calin R., Vega C. C., Canavaggio P., Cancella M., Cantin D., Cao A., Carbillon L., Carlier N., Cassard C., Castor G., Cauchy M., Cha O., Chaigne B., Challal S., Champion K., Chariot P., Chas J., Chauveau S., Chauvin A., Chauvin C., Chavarot N., Chebbout K., Cherai M., Cherubini I., Chevalier A., Chiarabini T., Chinet T., Chocron R., Choinier P., Chommeloux J., Choquet C., Choupeaux L., Chousterman B., Ciocan D., Clarke A., Clavere G., Clavier F., Clement K., Clerc S., Cohen Y., Cohen F., Cohen A., Coilly A., Colboc H., Colin P., Collet M., Comarmond C., Combacon E., Combes A., Comparon C., Constantin J. -M., Cordel H., Cordier A. -G., Costantini A., Chalumeau N. C., Couffignal C., Coupeau D., Creange A., Lamarre Y. C., Da Silveira C., Kayani S. D. G. E., De Castro N., De Rycke Y., Del Pozo L., Delannoy Q., Delay M., Deleris R., Delforge J., Delphine L., Demare N., Demeret S., Demoule A., Deniau A., Depret F., Derolez S., Derradji O., Derridj N., Descamps V., Deschamps L., Desconclois C., Desnos C., Desongins K., Dhote R., Diallo B., Didier M., Diemer M., Diez S., Djadi-Prat J., Monnory F. -Z. D., Djebara S., Djebra N., Djietcheu M., Djillali H., Djouadi N., Donneger S., Dos Santos C., Dournon N., Dres M., Droctove L., Drogrey M., Dropy M., Drouet E., Dubosq V., Dubreucq E., Dubus E., Duchemann B., Duchenoy T., Dudoignon E., Dufau R., Dumas F., Duran C., Duron E., Durrbach A., Duvivier C., Ebstein N., Khalifa J. E., Elabbadi A., Elie C., Ernotte G., Esling A., Etienne M., Eyer X., Fartoukh M., Fayali T., Fermaut M., Fiorentino A., Fliss S., Fournier M. -C., Fournier B., Francois H., Freynet O., Frigout Y., Fromont I., Fuentes A., Furet T., Galand J., Garnier M., Gaubert A., Gaudry S., Gaugain S., Gauthier D., Gautier M., Georgin-Lavialle S., Geromin D., Ghalayini M., Ghaleh B., Ghezal M., Gibelin A., Gimeno L., Girard B., Leprieur B. G., Gomes D., Gomes-Pires E., Gouge A., Gouja A., Goulet H., Goupil S., De Bouille J. G., Gras J., Greffe S., Grimaldi L., Guedeney P., Guidet B., Guillo M., Gulczynski M., Hadjam T., Haguenauer D., Hammal S., Hammoudi N., Hanon O., Harrois A., Hautem C., Hekimian G., Heming N., Hermine O., Ho S., Houllier M., Huot B., Huscenot T., Saied W. I., Ikherbane G., Imarazene M., Ingiliz P., Iratni L., Jaureguiberry S., Jean-Marc J. -F., Jeyarajasingham D., Jouany P., Jouis V., Jourdaine C., Kafif O., Kallala R., Katsahian S., Kelesyan L., Keo V., Ketz F., Khamis W., Khelili E., Khellaf M., Youkou C. G. K., Kounis I., Kpalma G., Krause J., Labbe V., Lacombe K., Lacorte J. -M., Lafont A. G., Lafont E., Lagha L., Lamhaut L., Lancelot A., Landman C., Lanternier F., Larcheveque C., Combe C. L., Lassel L., Laverdant B., Lavergne C., Lavillegrand J. -R., Lazureanu P., Le Guennec L., Leberre L., Leblanc C., Leboyer M., Lecomte F., Lecorre M., Leenhardt R., Lefebvre M., Lefebvre B., Legendre P., Leger A., Legros L., Legrosse J., Lehuunghia S., Lemarec J., Leporrier-Ext J., Lesein M., Lesur H., Levy V., Levy A., Lopes E., Lopes A., Lopez V., Lopinto J., Lortholary O., Louadah B., Loze B., Lucas M. -L., Lucasamichi A., Luong L. B., Magazimama-Ext A., Maingret D., Mameri L., Manivet P., Mansouri C., Marcault E., Marey J., Marin N., Marois C., Martin O., Martineau L., Martinez-Lopez C., Martyniuck P., De Farcy P. M., Marzouk N., Masmoudi R., Mebazaa A., Mechai F., Mecozzi F., Mediouni C., Megarbane B., Meghadecha M., Mejean E., Mekinian A., Abdelhadi N. M., Mekni R., Meliti T. S., Lima B. M., Meng P., Merbah S., Messani F., Messaoudi Y., Mewasing B. -I., Meziane L., Michelot-Burger C., Mignot F., Minka F. H., Miyara M., Moine P., Molina J. -M., Montegnies-Boulet A., Monti A., Montlahuc C., Montout A. -L., Moores A., Morbieu C., Mortelette H., Mouly S., Muzaffar R., Nacerddine C. I., Nadal M., Nadif H., Nassarmadji K., Natella P., Ndingamondze S., Neraal S., Nguyen C., N'Guyen B., Larmurier I. N., Nlomenyengue L., Noel N., Nunes H., Omar E., Ouazene Z., Ouedraogo E., Ouelaa W., Oukhedouma A., Amara Y. O., Oya H., Oziel J., Padilla T., Paillaud E., Paiva S., Parfait B., Parize P., Parizot C., Parrot A., Pavot A., Peaudecerf L., Pene F., Pepin M., Pernet J., Pernin C., Petit M., Peyrony O., Pietri M. -P., Pietri O., De Chambrun M. P., Pinson M., Pintado C., Pires C., Planquette B., Poirier S., Pomel A. -L., Pons S., Ponscarme D., Pourcelot A., Pourcher V., Pouvaret A., Prever F., Previlon M., Prevost M., Provoost M. -J., Quemeneur C., Rafat C., Rami A., Ranque B., Raphael M., Raphalen J. H., Rastoin A., Raux M., Rebai A., Reby M., Regent A., Regrag A., Resche-Rigon M., Ressaire Q., Richard C., Richard M., Robert M., Rohaut B., Rolland-Debord C., Ropers J., Roque-Afonso A. -M., Rosso C., Rousseaux M., Rousseaux N., Roux S., Roux L., Rouzaud C., Rozes A., Rubenstein E., Sabate J. -M., Sabet S., Sacleux S. -C., Kermanach N. S., Saliba F., Salmon D., Savale L., Savary G., Sberro R., Scemla A., Schlemmer F., Schwartz M., Sedfi S., Sefir-Kribel S., Seksik P., Sellier P., Selves A., Sembach N., Semerano L., Senat M. -V., Sene D., Serris A., Sese L., Sghiouar N., Sigaux J., Siguier M., Silvain J., Simon N., Simon T., Skandri L. I., Slimani M., Snauwaert A., Sokol H., Soliman H., Soltani N., Soyer B., Steg G., Suarez L., Szwebel T. -A., Taffame K., Tantet C., Tateo M., Theodose I., Thiebaud P., Thomas C., Tiercelet K., Tisserand J., Tomczak C., Torelino K., Touam-Ext F., Toumi L., Toury G., Toy-Miou M., Lien O. T. D. T., Trandinh A., Treluyer J. -M., Trinque B., Truchot J., Tunesi S., Turpin M., Turpin A., Urbina T., Narvaez R. U., Uzunhan Y., Vaittinadaayar P., Valent A., Valentian M., Valin N., Vallet H., Vaz M., Vazquezibarra M. -A., Vedie B., Velly L., Verstuyft C., Viallette C., Vicaut E., Vignes D., Vimpere D., Virlouvet M., Voiriot G., Voisot L., Weiss E., Weiss N., Winchenne A., Yordanov Y., Zafrani L., Zaidan M., Zaidi W., Zak C., Zarhrate-Ghoul A., Zatout O., Zeino S., Zeitouni M., Zemirli N., Zerah L., Zia O., Ziol M., Zolario O., Zuber J., Andrejak C., Angoulvant F., Bachelet D., Bartoli M., Basmaci R., Behilill S., Beluze M., Benkerrou D., Bhavsar K., Bouadma L., Bouchez S., Bouscambert M., Cervantes-Gonzalez M., Chair A., Coelho A., d'Ortenzio E., Debray M. -P., Deconinck L., Deplanque D., Descamps D., Desvallee M., Diallo A., Diouf A., Dorival C., Dubos F., Duval X., Elharrar B., Eloy P., Enouf V., Esperou H., Esposito-Farese M., Devouge E. F., Gault N., Gaymard A., Ghosn J., Gigante T., Gilg M., Guedj J., Hoctin A., Hoffmann I., Houas I., Hulot J. -S., Jaafoura S., Kaguelidou F., Kali S., Khalil A., Khan C., Laouenan C., Laribi S., Le M., Le Hingrat Q., Le Mestre S., Le Nagard H., Lescure F. -X., Levy Y., Lingas G., Lucet J. C., Malvy D., Mambert M., Meziane A., Mouquet H., Mullaert J., Neant N., Nguyen D., Noret M., Nseir S., Papadopoulos A., Paul C., Peiffer-Smadja N., Perpoint T., Petrov-Sanchez V., Peytavin G., Pham H., Picone O., Puechal O., Rabaud C., Rosa-Calatrava M., Rossignol B., Rossignol P., Roy C., Schneider M., Su R., Tardivon C., Tellier M. -C., Teoule F., Terrier O., Timsit J. -F., Tual C., Van Der Werf S., Vanel N., Veislinger A., Visseaux B., Wiedemann A., Yazdanpanah Y., Alavoine L., Behillil S., Burdet C., Charpentier C., Dechanet A., Ecobichon J. -L., Frezouls W., Houhou N., Lehacaut J., Letrou S., Lina B., Manchon P., Nouroudine M., Piquard V., Quintin C., Thy M., Vignali V., Chahine A., Waucquier N., Migaud M. -C., Djossou F., Mergeay-Fabre M., Lucarelli A., Demar M., Bruneau L., Gerardin P., Maillot A., Payet C., Laviolle B., Laine F., Paris C., Desille-Dugast M., Fouchard J., Pistone T., Perreau P., Gissot V., Goas C. L. E., Montagne S., Richard L., Chirouze C., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefevre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Christelle K., Nicolas L., Roufai L., Amat K., Couffin-Cadiergues S., Hendou S., Foti G., Bellani G., Citerio G., Contro E., Pesci A., Valsecchi M. G., Cazzaniga M., Abad J., Accordino G., Achille C., Aguilera-Albesa S., Aguilo-Cucurull A., Ozkan E. A., Albisures J. A. R., Aldave J. C., Ramos M. A., Khan T. A., Aliberti A., Nadji S. A., Alkan G., AlKhater S. A., Allardet-Servent J., Alshahrani M. S., Alsina L., Amoura Z., Antoli A., Arrestier R., Aubart M., Auguet T., Avramenko I., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Barrou B., Basso S., Bayhan G. I., Bezrodnik L., Bilbao A., Blanchard-Rohner G., Blanco I., Blandinieres A., Blazquez-Gamero D., Bloomfield M., Bolivar-Prados M., Borghesi A., Borie R., Botdhlo-Nevers E., Bousquet A., Boutolleau D., Bouvattier C., Boyarchuk O., Bravais J., Briones M. L., Brunner M. -E., Bruno R., Bueno M. R. P., Bukhari H., Bustamante J., Agra J. J. C., Capra R., Carapito R., Carrabba M., Casasnovas C., Caseris M., Cassaniti I., Castelle M., Castelli F., de Vera M. C., Castro M. V., Catherinot E., Celik J. B., Ceschi A., Chalumeau M., Charbit B., Cheng M. P., Clave P., Clotet B., Codina A., Comoli P., Corsico A. G., Sozeri B., Coskuner T., Cvetkovski A., Cyrus C., Dalmau D., Danion F., Darley D. R., Das V., Dauby N., Dauger S., De Munter P., de Pontual L., Dehban A., Delplancq G., Desguerre I., Di Sabatino A., Diehl J. -L., Dobbelaere S., Dominguez-Garrido E., Dubost C., Ekwall O., Bozdemir S. E., Elnagdy M. H., Emiroglu M., Endo A., Erdeniz E. H., Aytekin S. E., Lasa M. P. E., Euvrard R., Fabio G., Faivre L., Falck A., Faure M., Arquero M. F., Ferrer R., Ferreres J., Francois B., Fumado V., Fung K. S. C., Fusco F., Gagro A., Solis B. G., Garcon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A. G., Girona-Alarcon M., Godinez K. A. C., Goffard J. -C., Gonzales N., Gonzalez-Granado L. I., Gonzalez-Montelongo R., Guerder A., Gulhan B., Gumucio V. D., Hanitsch L. G., Gunst J., Hadjadj J., Hariyan T., Heppekcan D., Hernandez-Brito E., Ho P. -K., Holanda-Pena M. S., Horcajada J. P., Hraiech S., Humbert L., Hung I. F. N., Iglesias A. D., Inigo-Campos A., Jamme M., Arranz M. J., Jimeno M. -T., Jordan I., Yuksek S. K., Kara Y. B., Karahan A., Yasar K. K., Kasapcopur O., Kashimada K., Demirkol Y. K., Kido Y., Kizil C., Kilic A. O., Klocperk A., Koutsoukou A., Krol Z. J., Ksouri H., Kuentz P., Kwan A. M. C., Kwan Y. W. M., Kwok J. S. Y., Lagier J. -C., Lam D. S. Y., Lampropoulou V., Le Bourgeois F., Leo Y. -S., Leung D., Levin M., Levy M., Levy R., Li Z., Lilleri D., Lima E. J. A. B., Linglart A., Lopez-Collazo E., Lorenzo-Salazar J. M., Louapre C., Lubetzki C., Lung K. -C., Luyt C. -E., Lye D. C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J. M., Pueyo D. M., Marzana I., Mata-Martinez C., Mathian A., Matos L. R. B., Matthews G. V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mege J. -L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J. -F., Merlani P., Akcan O. M., Mezidi M., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B. P., Mojoli F., Moncomble E., Melian A. M., Martinez A. M., Morandeira F., Mordacq C., Mouly S. J., Munoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J. F., Ng Y. -Y., Nielly H., Medina Y. N., Cuadros E. N., Ocejo-Vinyals J. G., Okamoto K., Oualha M., Ouedrani A., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Pellecer N. C. G., Pellegrini S., Perez-Fernandez X. L., Philippe A., Philippot Q., Picod A., Piralla A., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M. S., Pourshahnazari P., Qiu-Chen J. L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A. -S., Redin C., Resmini L., Ricart P., Richard J. -C., Rigo-Bonnin R., rivet N., Rocamora-Blanch G., Rodero M. P., Rodrigo C., Rodriguez L. A., Rodriguez-Palmero A., Romero C. S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., del Prado M. Y. R., Ruiz-Rodriguez J. C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sanchez-Montalva A., Sanchez-Ramon S., Schidlowski L., Schmidt J., Schmidt M., Schuetz C., Schweitzer C. E., Scolari F., Seijo L., Seminario A. G., Seng P., Senoglu S., Seppanen M., Llovich A. S., Siguret V., Siouti E., Smadja D. M., Smith N., Solanich X., Sole-Violan J., Soler C., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Trouillet-Assant S., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Oz S. K. T., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Veliz S. P. Z., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Volokha A., Vuotto F., Wauters E., Wauters J., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Boulanger C., Vanderlinden D., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Cloherty O. C. A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geijtenbeek S. G. T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Heunks S. M. H. L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Danielson J. J., Biondi A., Bettini L. R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Meyts I., Zhang S. -Y., Puel A., Notarangelo L. D., Boisson-Dupuis S., Su H. C., Boisson B., Jouanguy E., Zhang Q., Abel L., Cobat A.

المساهمون: Matuozzo, D., Talouarn, E., Marchal, A., Zhang, P., Manry, J., Seeleuthner, Y., Zhang, Y., Bolze, A., Chaldebas, M., Milisavljevic, B., Gervais, A., Bastard, P., Asano, T., Bizien, L., Barzaghi, F., Abolhassani, H., Abou Tayoun, A., Aiuti, A., Alavi Darazam, I., Allende, L. M., Alonso-Arias, R., Arias, A. A., Aytekin, G., Bergman, P., Bondesan, S., Bryceson, Y. T., Bustos, I. G., Cabrera-Marante, O., Carcel, S., Carrera, P., Casari, G., Chaibi, K., Colobran, R., Condino-Neto, A., Covill, L. E., Delmonte, O. M., El Zein, L., Flores, C., Gregersen, P. K., Gut, M., Haerynck, F., Halwani, R., Hancerli, S., Hammarstrom, L., Hatipoglu, N., Karbuz, A., Keles, S., Kyheng, C., Leon-Lopez, R., Franco, J. L., Mansouri, D., Martinez-Picado, J., Metin Akcan, O., Migeotte, I., Morange, P. -E., Morelle, G., Martin-Nalda, A., Novelli, G., Novelli, A., Ozcelik, T., Palabiyik, F., Pan-Hammarstrom, Q., de Diego, R. P., Planas-Serra, L., Pleguezuelo, D. E., Prando, C., Pujol, A., Reyes, L. F., Riviere, J. G., Rodriguez-Gallego, C., Rojas, J., Rovere-Querini, P., Schluter, A., Shahrooei, M., Sobh, A., Soler-Palacin, P., Tandjaoui-Lambiotte, Y., Tipu, I., Tresoldi, C., Troya, J., van de Beek, D., Zatz, M., Zawadzki, P., Al-Muhsen, S. Z., Alosaimi, M. F., Alsohime, F. M., Baris-Feldman, H., Butte, M. J., Constantinescu, S. N., Cooper, M. A., Dalgard, C. L., Fellay, J., Heath, J. R., Lau, Y. -L., Lifton, R. P., Maniatis, T., Mogensen, T. H., von Bernuth, H., Lermine, A., Vidaud, M.

مصطلحات موضوعية: COVID-19, Immunity, Rare variants, Type I interferon

الوصف: Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60years old.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37020259; info:eu-repo/semantics/altIdentifier/wos/WOS:001022167700001; volume:15; issue:1; journal:GENOME MEDICINE; https://hdl.handle.net/20.500.11768/146716Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85160044322; https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-023-01173-8Test

الإتاحة: https://doi.org/20.500.11768/146716Test
https://doi.org/10.1186/s13073-023-01173-8Test
https://hdl.handle.net/20.500.11768/146716Test

المؤلفون: Hammami, M.A., Ben Ayed, K., Ali, A., Zouita, S., Marzougui, H., Moran, J., Clark, C.C.T., Mekni, R., Zouhal, H.

المساهمون: Université de Jendouba (UJ), Massey University, Université de la Manouba Tunisie (UMA), University of Essex, Coventry University, Institut International des Sciences du Sport (2I2S), Laboratoire Mouvement Sport Santé (M2S), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), None

المصدر: ISSN: 0765-1597.

مصطلحات موضوعية: Adolescent elites, Annual training, Development, Performance indicators, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Backround and objectives: In comparison to their European counterparts, there are scarce data regarding skill performance in young elite female North African soccer players. The objectives of this study were to evaluate the effects of a season-long training regime on anthropometric and physical performance characteristics, agility, and soccer skills in Tunisian youth elite female players. Materials and methods: Forty-eight females (24 soccer players SG; 24 non-playing controls, CG) were evaluated at the start of a preparatory period (T1) in September, and 10 months later in June (T2), the end period of the competitive season. Anthropometrics (body mass, body composition), soccer-specific cardiorespiratory endurance (Yo-Yo Intermittent Recovery Test Level 1; YYIRT1), muscle power (countermovement jump [CMJ]; squat-jump [SJ]; 5-Jump-Test [5JT]), agility (T-test with and without ball), soccer skill (Loughborough Soccer Passing Test, LSPT) and sprint speed (30 m sprint with 5 and 10 m splits) were measured. Results: The SG experienced significant performance improvements in all tests across the period of the competitive season, demonstrating better improvements in height (P < 0.0001, ES = 1.69), weight (P < 0.0001, ES = 0.92) and BF (P < 0.0001, ES = 1.63). Better CMJ (P < 0.0001, ES = 1.63), SJ (P < 0.0001, ES = 1.33), and 5JT performances than the CG (P < 0.004, ES = 0.39). Similarly, the SG performed better in the sprint, agility, and LSPT tests and covered longer distances in YYIRTL1 (P < 0.0001) compared to the CG. Conclusion: Soccer season training contributed to significant variations in anthropometric characteristics, physical fitness, and soccer skills in Tunisian elite female youth soccer players compared to control group that are beyond those which could be expected through biological maturation alone.

العلاقة: hal-04164647; https://hal.science/hal-04164647Test; https://hal.science/hal-04164647/documentTest; https://hal.science/hal-04164647/file/Hammami%20et%20al%20-%202023%20-%20The%20effects%20of%20a%20soccer%20season%20on%20anthropometric%20characteristics%20_%20Sc%20%26%20Sport%20Hammami%2029%20decembre.pdfTest

الإتاحة: https://doi.org/10.1016/j.scispo.2022.08.002Test
https://hal.science/hal-04164647Test
https://hal.science/hal-04164647/documentTest
https://hal.science/hal-04164647/file/Hammami%20et%20al%20-%202023%20-%20The%20effects%20of%20a%20soccer%20season%20on%20anthropometric%20characteristics%20_%20Sc%20%26%20Sport%20Hammami%2029%20decembre.pdfTest

المؤلفون: Hammami, Mohamed Ali, Ben Klifa, W., Ben Ayed, K., Mekni, R., Saeidi, A., Jan, J., Zouhal, Hassane

المساهمون: Laboratoire Mouvement Sport Santé (M2S), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ISSEP Kef, University of Jandouba, Islamic Azad University, Clinique mutualiste La Sagesse

المصدر: ISSN: 0765-1597.

مصطلحات موضوعية: Training, Performances, Physical fitness, Anthropometery, Women's football, [SDV]Life Sciences [q-bio]

الوصف: National audience ; The reasons why North African women's football teams do not progress to the final phases of world cup competitions may be related to anthropometry and physical fitness. Therefore, the aim of this study was to compare anthropometric and physical fitness characteristics of young elite Tunisian female players with age-specific international standards. Twenty-four elite female players from the Tunisian national under 17 team (U17; 16.5 ± 0.4 y) participated in this study. Players were tested for anthropometry (body mass, body composition), football-specific cardiorespiratory endurance (Yo-Yo Intermittent Recovery Test Level 1; YYIRT1), power (countermovement jump, CMJ; squat-jump, SqJ; five-jump-test, 5JT), agility (t-test with and without ball), soccer skill (Loughborough Soccer Passing Test, LSPT) and speed (30 m sprint with 5 and 10 m splits). The results show that body mass and body fat percentage of Tunisian U17 elite female soccer players are higher than international standards and that endurance qualities and agility performances are similar to international data for the same age. However, in terms of strength and speed, performances of Tunisian female players are low or even very low compared with international standards. Consequently, physical training programmes of Tunisian female soccer should focus on increasing strength and speed fitness to be ready for international soccer competitions. © 2019 Elsevier Masson SAS

العلاقة: hal-02310491; https://univ-rennes.hal.science/hal-02310491Test

الإتاحة: https://doi.org/10.1016/j.scispo.2019.06.005Test
https://univ-rennes.hal.science/hal-02310491Test